고온·고압 처리한 키토산을 이용한 수중의 납 제거에 관한 연구

김동석,이승원,우형택 한국환경과학회 2003 한국환경과학회지 Vol.12 No.12

In order to know the effect of autoclaving on the heavy metal removal using chitosan, lead removal capacities and removal rates by various chitosans in aqueous solution were compared according to the various autoclaving time. The lead removal efficiencies and removal rates by the autoclaved chitosan were found to be on the order of 15 min(98%) > 10 min(95%) > 30 min(83%) > 5 min(53%) > 60 min(47%) > 0 min(22%) chitosan. The molecular weight of chitosan was decreased by the increase of autoclaving time. Therefore, the heavy metal removal capacity was not well correlated to the molecular weight. Langmuir isotherm was well fitted to experimental results of equilibrium adsorption on chitosan. In order to examine the process of lead removal by the autoclaved chitosan, TEMs, SEMs and FT-IR analyses were used. The surface of autoclaved chitosan was much more porous and the lead removal was mainly occurred on the surface of chitosan. The structure of autoclaved chitosan was same as that of controlled chitosan.

유기용제에 장기간 폭로된 근로자의 정신의학적 기능과 삶의 질

김석재,강순아,유지숙,국승희,윤진상,문재동,이형영 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 본 연구는 Y공단의 제조공정에서 저농도의 유기용제(solvent)에 장기간 노출된 근로자의 정신의학적 기능과 삶의 질을 평가하고자 하였다. 방법: 총 142명의 남성근로자 중 유기용제에 폭로된 군(이하 폭로군) 82명과 폭로되지 않는 군(이하 비폭로군) 60명에게 간이정신진단검사(Symptom Checklist-90-R, SCL-90-R), 인지 및 정신운동성검사 (Critical Flicker Fusion Threshold. CFFT; Choice Reaction Time, CRT;Compensatory Tracking Task, CTT;Digit-Symbol Substitution, DDS) 및 한국판 스미스클라인 비챰 삶의 질 척도(Korean version of the SmithKline Beecham 'Quality of Life' Scale, KvSBQOL) 등을 적용하였다. 두 군간의 비교는 평가치의 평균에 대해 t-검증을 하였고 또한 연령과 학력을 공변인으로한 공변량분석(ANCOVA)을 하였다. 결과: SCL-90-R의 9개 증상 차원과 3개 전체 지표 점수는 두 군이 각각 정상범위였다. 그러나 신체화 (Somatization, SOM), 우울(Depression, DEP), 적대감(Hostility, HOS), 공포불안(Phobic anx-iety, PHOB)의 증상차원과 전체심도지수(Global Severity Index, GSI), 표출증상합계(Positive Symptom Total, PST)의 전체 지표는 폭로군이 비폭로군보다 유의하게 높았다. 인지 및 정신운동성 검사와 삶의 질은 두 군간에 유의한 차이는 없었다. 결론: 이상의 결과는 유기용제가 허용치 이하일지라도 장기간 폭로되는 경우에는 정신의학적 문제를 다소 일으킬 수 있음을 시사하였다. 중심단어:유기용제·근로자·정신건강·정신운동성 기능·삶의 질. Objectives: The aim of this study was to evaluate the psychiatric function and quality of life of the chemical workers who had been exposed to long-term, low-level organic solvents in the Y industrial complex. Method: A total of 144 male workers, of whom 82 were in the exposed group and 60 in the unexposed-control group, were evaluated by using Symptom Checklist-90-R(SCL-90-R), series of neuropsychological tests(critical flicker fusion threshold, CFFT) ; choice reaction time, CRT ; compensatory tracking task, CTT) ; digit symbol substitution test, DSS), and the Korean version of the SmithKline Beecham Quality Of Life scale(KvSBQOL). For the statistical analyses, comparisons of the means of the two groups were performed for each variable with two-tailed t-test as well as ANCOVA including age and education as covariates. Results: For the SCL-90-R, the nine symptom scales and the three global indices were clinically within normal range in both groups. However, the scores on the symptom scales of 'somatization','depression','hostility' and 'phobic anxiety', and those on the global indices of 'global severity index' and 'positive symptom total', were significantly higher in the exposed group than in the unexposed group. In terms of the neuropsychological function and the quality of life, there wes no significant difference between the two groups. Conclusion: These findings suggested that the long-term eposure to mixed organic solvents, even at the low level below the permissible exposure limit, might induce some psychiatric problems. KEY WORDS: Organic solvent·Worker·Mental health·Psychomotor function·Quality of life.

Y 대학교 치과대학병원 교정과 내원환자의 지역분포와 부정교합 분류에 관한 연구

유형석,유영규,이장열 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.2

본 연구는 1992년부터 1997년까지 6년간 연세대학교 치과대학 부속병원 교정과에 내원하여 진단을 받은 부정교합환자중에서 진단용 석고모형과 진료기록부가 잘 보존되고 지역 거주지가 확실한 9159명을 대상으로 연도별 내원 환자의 성별 분포, 연령별 내원 환자의 분포, Angle씨 부정교합 분류, 제 I급 부정교합 양상의 분류 및 지역적 분포 특성들을 조사하여 다음과 같은 결론을 얻었다. 1. 본 원 교정과에 내원한 환자의 수가 1992년에 비해 1997년 86%가 증가하였으며 1995년 이후 매년 증가하는 추세를 보였다. 2. 연령별 내원 분포에서 19세 이상군의 비율이 39.9%로 가장 높게 나타났으며 사춘기전 아동의 비율은 점차 감소하는 반면, 성인 교정환자의 비중이 점차 높아지는 경향을 나타내었다. 3. Angle씨 부정교합 분류에 의한 내원 환자 분포에서 제Ⅲ급 부정교합자가 38.1%로 가장 높은 비율을 나타내었으며, 제Ⅰ급 부정교합이 33.3%, 제 II급 부정교합은 28.6%의 빈도를 보였다. 4. 제 I급 부정교합자중 총생(crowding)을 주소로 내원한 환자가 32.6%로 가장 높게 나타났다. 연도별 변화에서는 돌출(protrusion)환자는 점차 증가 양상을 보여 96년에는 33.9%로 가장 높은 비율을 보였으며 개교합과 반대교합 환자는 감소하는 추세로 나타났다. 5. 내원 환자의 지역적 분포를 보면 서울시 환자가 전체 내원 환자의 70%이상 차지하는 것으로 조사되었으며 서울시내원환자중 연세대학교 치과병원을 중심으로 반경 3-6km의 거주자가 32.3%로 가장 높게 나타났고 반경 9km이내에서 전체의 69%를 차지하였다. Distribution trends were examined in 9159 malocclusion patients who had been examined and diagnosed at department of Orthodontics, College of Density, Yonsei University over a 6 year-period from 1992 to 1997. The results were as follows: 1. The total number of orthodontic patients in 1997 increased in comparing with that of 1992(86%) and after 1995, the number of annual patients showed an increase. 2. Age distribution had shown over-19 year-old group being the largest(39.9%) but percentages of pre-adolescent patients had been decreasing while that of adult patient had gradually increased. 3. Distributions in the types of malocclusion, the Angle`s Classification had shown : 33.3% for Class I, 28.6% for Class II and the largest 38.1% for Class Ⅲ. 4. Among Class I patients, crowding showed the largest(32.6%) and protrusion group had gradually increased to 33.9% in 1996.Otherwise openbite and crossbite groups tend to decrease, annually. 5. Geographic distribution showed a majority of patients from Seoul(above 70%). Among the patients from Seoul, group within the distance 3-6Km from Yonsei dental hospital was the largest(32.3%) and group within 9Km showed 69% of total patients.

S. cerevisiae와 A. pullulans를 이용한 수용액 중의 납 제거에서 온도와 pH의 영향

김동석,서정호,우형택,송승구 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.6 No.1

The environmental factors, temperature and pH, were controlled to investigate the effects on the removal of lead in the solution by S. cerevisiae and A. pullulans. The range of experimental temperature was 20℃∼50℃, and that of Ph was 2.5∼6.5 and 2.5∼12, respectively. The optimum temperature of S. cerevisiae and A. pullulans in the removal of lead was 30℃ and 40℃, respectively. And the initial removal rate of lead by, S. cerevisiae was increased according to the increase of temperatue. The variation of the amounts of lead removal by S. cerevisiae according to the variation of temperature was steeper that by A. pullulans. The optimum pH condition was existed on both of the microorganisms, S. cerevisiae and A. pullulans, in our experimental range and that is 4.5 and 9.0, respectively.

제I급 부정교합 환자의 발치와 비발치 교정치료 전,후의 두부방사선 계측학적 비교 연구

유형석,백형선 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

연세대학교 치과대학 부속병원 교정과와 영동 세브란스 병원 치과 교정과에 내원하여 최근에 교정치료가 끝난 제 I급 부정교합 환자중 소구치를 발치하고 치료한 발치군과 비발치로 치료한 비발치 치료군 71명을 선정하고 다시 연령에 따라 청소년기와 성인으로 분류하여 교정치료 전후의 두부방사선 계측분석 사진을 통하여 치아와 연조직의 수평·수직적 변화를 비교분석하여 다음과 같은 결론을 얻었다. 1. 발치군과 비발치군간의 비교에서는 SN-MP angle, E-line에 대한 산순의 이동, 상악 제1대구치의 수직이동량, 하악 제1대구치의 수평이동량 등의 항목을 제외한 모든 치아계측항목과 연조직 계측항목에서 유의차을 나타내었다. 2. 청소년기의 발치군과 비발치군간의 비교에서는 상하악 전치의 경사도와 수직기준선으로부터의 전치부 수평변화 항목, 상악 제1대구치의 근심이동, E-line에 대한 상,하순의 위치변화에서 유의차를 나타내었다. 3. 성인에서의 발치와 비발치군간의 비교에서는 상하악 전치의 경사도와 수직기준선으로부터의 수평적 위치변화와, 상악 제1대구치의 수직고경 및 하악 제1대구치의 근심이동, E-line과 수직기준선으로부터의 상,하순의 위치 변화에서 유의차를 나타내었다. 4. 청소년기와 성인 모두에서 SN-MP angle의 변화는 발치군과 비발치군간에 유의차가 없었다. 71 Class I malocclusion samples were selected and they were divided into premolar-extraction and non-extraction groups. Vertical and horizontal cephalometric evaluations on dental and soft tissue measurements were done before and after treatment. Also, treatment results in adolescent patients and adult patients were compared. The following conclusions were obtained: 1. In comparison of extraction and non-extraction groups, all the dental and soft tissue measurements, with exception of SN-MP angle, upper lip to E-line, vertical movement of upper first molar, and horizontal movement of lower first molar, showed statistically significant differences. 2. In comparison of extraction and non-extraction groups of adolescent samples, there were statistically significant differences in upper and lower incisor inclinations, horizontal dental movements from vertical reference line, positional changes in upper and lower lips, and mesial movements of upper first molar. 3. In comparison of extraction and non-extraction groups of adult samples, there were statistically significant differences in upper and lower incisor inclinations, horizontal dental movements from vertical reference line, positional changes in upper and lower incisor inclinations, horizontal dental movements from vertical reference line, positional changes in upper and lower incisor inclinations, horizontal dental movements from vertical reference line, positional changes in upper and lower lips, and mesial movement of lower first molar. 4. There was no statistically significant difference in SN-MP angle between extraction and non-extraction groups of both adolescent and adult samples.

폐모세포종 : 1례보고 A Case Report

최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.

한국인 성인 정상교합자 치관의 설측면 특징에 관한 연구

유형석,박영철 대한치과교정학회 1992 대한치과교정학회지 Vol.22 No.3

The purpose of this study was to obtain the lingual morphology (size, angulation, contour, eminence) of adults with normal occlusion in order to provide the basic data for lingual bracket and lingual arch form in Korean. The subjects (Male : 50, Female : 50) were selected who have normal occlusion and dental casts were prepared. Tooth size, angulation, arch width, horizontal contour, lingual eminence were measured for all 28 teeth both upper and lower arch. The results were as follows : 1. Measuring items of all individual teeth for adults with normal occlusion were obtained. 2. In comparison tests, there was a statistically difference between intermolar widths(6 to 6) before occlusal reductio and intermolar width(6 to 6,7 to 7) after occlusal reduction only, all the other measuring items showed no statistically differences. 3. There was small variation in horizontal contour of lingual surface on lower incisors and upper and lower bicuspids. The other teeth showed somewhat greater variations. 4. There was offset between canine and bicuspid in upper arch while there was no prominent offset in lower arch.

한국인 정상 교합자의 정모 두부 방사선 사진을 이용한 안모비율에 관한 연구

유형석,이기주,백형선 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

두개 악안면 기형환자의 종합적인 치료를 위해서는 입체적인 평가와 진단이 중요하다. 그러나 흔히 전후방적인 골결평가에는 많은 분석방법을 시행하고 있으나, 안모 비대칭과 상 하악골 횡적인 부조화의 진단을 위해 필요한 횡적평가방법은 충분하지 못한 실정이다. 횡적인 부조화의 적절한 진단과 치료는 안정된 기능교합의 형성에 있어서 전후방 또는 수직적인 부조화보다 중요한 역할을 하며, 장기간의 안정성에도 영향을 미친다. 그리고 상하악의 횡적인 부조화에 따른 연조직의 변화가 제한되어 있기 때문에 시진을 통한 임상적 방법으로는 간과되기 쉬우며 더욱이 특정적인 안모소견을 보이는 전후방 또는 수직적인 부조화와 동반된 경우에는 감별되기 어렵다. 그로 인해 정확한 진단과 치료를 위해서는 정상 안모에 관한 정모두부 방사선 계측학적 안모 비율의 평가가 필요하게 되었다. 본 연구는 1996학년도 연세대학교 신입생중에서 협조 가능한 정상 안모와 거의 정상교합을 갖은 남녀 76명을 선정하여 안모 비대칭과 횡적인 부조화가 있는 악안면 기형 환자의 진단과 치료계획에 도움을 주는 자료를 얻고자 정모 두부 방사선 계측사진을 이용하여 수평 및 수직 계측항목과 그 비율을 통계처리하여 다음과 같은 결과를 얻었다. 1. 정모의 수평 및 수직적인 계측항목과 그 비율의 평균값과 표준편차를 구하였다. 2. 정모의 폭경에 대한 고경의 비율은 0.837(남자:0.836, 여자:841)이었다. 3. 상악골과 하악골간의 폭경비율은 0.747(남자:0.745, 여자:0.752)이며, 높은 연관성을 나타내었다. 4. 두개 안면부 폭경들간에는 서로 연관성이 나타났다.(두개 폭경, 관골전두봉합폭경, 안면폭경, 상악폭경, 하악폭경, 상악과 하악 구치부폭경) 5. 정모의 폭경이 증가할수록 안모고경과 다른 길이 계측치도 연관되어 증가하였지만 각도 계측값(Bjork의 합, 하악평면각)의 감소와, 후전 안면고경 비율증가로 인하여, Brachycephalic facial type의 안모 경향을 보였다. 이상의 결과는 악안면 기형 환자의 교정치료 및 악교정 수술치료의 계획에 기준치로써 사용될 수 있을 것이다. For the total treatment of skeletal malocclusions, 3-dimensional evaluation and diagnosis are essential. Although anteroposterior discrepancies can be evaluated through various methods, the satisfactory methods for evaluations of facial asymmetry and transverse discrepancies are yet to be found. The adequate diagnosis and treatment of transverse discrepancies may be more important in the maintenance of functional occlusion as well as for the stability of results obtained from othognathic surgery than the anteroposterior or vertical discrepancies. Since the soft tissue effects from the transverse discreapnies may not be pronounced, expecially when combined with anteroposterior or vertical discrepancies which have prominent characteristics, the differentiation of their effects may be the posteroanterior cephalometry as a reference for the accurate diagnosis and treatment. The present study evaluates 76 subjects from Yonsei University freshman with normal facial symmetry and occlusion. Posteroanterior cephalograms were taken from the subjects and the normal values and facial proportions are obtained. The results are as follows. 1. The transverse and vertical values from posteroanterior cephalometry and their ratio, with means and standard deviations are calculated. 2. The ratio of vertical values to transverse values i 0.837(male 0.745, female 0.841). 3. The proportion of maxillary and mandibular widths is 0.747(male 0.745, female 0.752), with statistically significant correlation. 4. Various degree of significant correlations are observed in the following craniofacial width;(Cranial width, Bizygomaticofrontal suture width, Facial width, Maxillary width, Upper&Lower Intermolar width, Mandibular width). 5. Although the facial height as well as other line measurements increase as the facial widths increase, angle measurement(Bjork, Sum, Mandibular Plane Angle, Gonial Angle), decreases and posterior to anterior facial height ratio increases, therefore indicating the tendency for a brachycephalic facial type. These results may be used as references for the treatment planning in orthognathic and othodontic treatments for the dentofacial deformity patients.

Sodium Nitroprusside 및 Adenosine Triphosphate를 이용한 조절저혈압이 심-혈관계에 미치는 영향

문현석,조형상 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.1

Controlled hypotension is an effective means of decreasing blood loss and of providing a better visible surgical field. Numerous drugs have been developed to lower arterial blood pressure. The ideal hypotensive drug must be effective in reducing blood pressure and at the same time controllable without any undesirable effect to vital organs. Adenosine triphosphate (ATP), a well known intracellular high energy compound, has been reported to be a hypotensive agent similar in effect to sodium nitroprusside (SNP), a drug which is frequently used as a hypotensive agent. To investigate the possibility of clinical use of ATP, we compared the cardiovascular effects of SNP- and ATP-induced hypotension and effects on acid-base balance and blood gas content. The following results were obtained. 1. Controlled hypotension by ATP was stable and rapidly reversible without tachyphylaxis and rebound hypertension. 2 .The heart rate, central venous pressure, pulmonary capillary wedge pressure and pulmonary vascular resistance were unchanged during the SNP- and ATP-induced hypotension. However, hypotension produced by ATP was associated with a greater cardiac output than that induced by SNP (p<0.01) and was also associated with a further decrease in systemic vascular resistance (p<0.01). Left and right ventricular stroke works were more improved during ATP-induced hypotension than those of SNP. The ratepressure product and coronary perfusion pressure were decreased in both groups (p<0.01). The mean pulmonary arterial pressure was increased with ATP (p<0.05). Triple index, which is the product of heart rate, systolic blood pressure, and pulmonary wedge pressure, decreased in SNP group (p<0.05). 3. Bicarbonate and base excess in venous blood were decreased with ATP group (p<0.05). On the basis of this study, compared with SNP, ATP as a hypotensive agent also provide a effective cardiovascular function during controlled hypotension. Therefore, ATP is probably a useful agent for controlled hypotension in a clinical practice.

3차원 CT 영상을 이용한 정상교합자의 안면 연조직 계측 분석

유형석,한수연,백형선,김기덕 대한치과교정학회 발행 2005 대한치과교정학회지 Vol.35 No.6

최근 들어 3차원 전산화 단층 촬영(CT, Computed Tomography) 영상을 이용한 진단기법의 개발을 위한 연구가 활발히 진행되고 있으며 여러 분야에서 3차원적인 두개악안면 분석의 필요성이 증대되고 있다. 특히 교정 치료나 악교정 수술 후의 결과에 있어서 안면 연조직의 분석은 필수적이라 할 것이다. 본 연구에서는 정상교합을 가진 성인 남자 12명, 성인 여자 11명의 CT 영상을 촬영하여 개인용 컴퓨터 상에서 V works 4.0 프로그램 (Cybermed Inc., Seoul, Korea)으로 3차원 CT 연조직 영상을 재구성한 후에 soft tissue Nasion을 기준 원점으로 하는 3차원 좌표평면의 좌표계를 설정하여 정중선상의 soft tissue Nasion, Pronasale, Subnasale, Upper lip center, Lower lip center, soft tissue B, soft tissue Pogonion, soft tissue Menton 등 8개의 계측점과 양측성인 Endocanthion, Alare lateralis, Cheilion, soft tissue Gonion, Tragus, Zygomatic point 등 총 20개의 재현 가능한 안면 연조직의 계측점을 지정하였으며 V surgery 프로그램(Cybermed Inc., Seoul, Korea)을 이용하여 이들 계측점의 3차원적인 좌표와 기준 원점으로부터 각 계측점까지의 Net (δ=√ (X^(2)+Y^(2)+z^(2))) 값의 평균과 표준편차를 구하였다. 안면 연조직 분석의 3차원적인 이해를 돕기 위해 주요 계측점 간의 거리 계측을 시행하였고, 그 결과 Na'-Sn과 En(Rt)-En(Lt)를 제외한 대부분의 계측값에서 남녀간의 유의한 차이가 있었으며, 2차원적인 두부 방사선 규격사진이나 안면 사진으로는 정확한 계측이 어려웠던 Na'-Zy, Na'-Ch, Na'-Go' (facial depth) 등의 정상치도 구하였다. 이상의 자료는 부정교합 환자와 악안면 기형 환자의 3차원적인 진단 및 치료 계획에 참고자료로 사용될 수 있을 것이다. Studies for diagnostic analysis using three-dimensional (3D) CT images are recently in progress and needs for 3D craniofacial analysis are increasing in the fields of orthodontlcs. It is especially essential to analyze the facial soft tissue after orthodontic treatment and orthognathic surgery. In this study 3D CT images of adults with normal occlusion were taken to analyze. the facial soft tissue. Norms were obtained from CT images of adults with normal occlusion (12males, 11 females) using a computer program named V works 4.0 program. 3D coordinate planes were established using soft tissue Nasion as the reference point and a total of 20 reproducible landmarks of facial soft tissue were obtained using the multiple reconstructive sectional images (axial, sagittal and coronal images) of the V works 4.0 program: soft tissue Nasion, Pronasale, Subnasale, Upper lip center, Lower lip center, soft tissue B, soft tissue Pogonion, soft tissue Menton, Endocanthion (Rt/Lt), Alare lateralis (Rt/Lt), Cheilion (Rt/Lt), soft tissue Gonion (Rt/Lt), Tragus (Rt/Lt), and Zygomatic point (Rt/Lt). According to the established landmarks and measuring method, the 3D CT images of adults with normal occlusion were measured and the normal positional measurements and their Net (δ=√ (X^(2)+Y^(2)+z^(2))) values were obtained using V surgery program. In the linear measurement between landmarks, there was a significant difference between males and females except Na'-Sn and En(Rt)-En(Lt). The normal ranges of Na'-Zy, Na'-Ch and Na'-Go' (facial depth) were obtained. which was difficult to measure by two-dimensional (2D) cephalometric analysis and facial photographs. These data may be used as references for 3D diagnosis and treatment planning for patients with malocclusion and dentofacial deformity.