ICT 활용교육을 통한 자기주도적 학습력 신장 방안

고형숙 조선대학교 학생지도연구소 2004 生活指導硏究 Vol.23 No.1

The purpose of this study is to enhance self-directed learning ability, to identify the problems in the utilization of information and communication technology(ICT), to find the ways to develop and application of the technology, and to elevate students' motivation level. The conclusions were made after collecting and analyzing the data from the current states of the ICT and research literatures. The results of this study are as follows. First, utilization of the ICT in education enhanced the ability to utilize the ICT. Second, utilization of the ICT in education enhanced the learning effectiveness and learning motivation. Third, instructions on information ethics reduce the use of lingoes and vulgar languages. keep the netiquettes and the fair use of the copy right . Fourth, utilization of the ICT in education enhanced the self-directed learning ability nevertheless the in-servce teachers' criticism about the ICT.

알쯔하이머형 치매환자 뇌파의 시공간적 패턴분석 : Karhunen-Loeve 방법을 통한 뇌파분석의 임상적용을 위한 예비연구

고효진,김형래,김대진,김수용,박성종 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 뇌파의 시공간적 패턴분석(spatio-temporal pattern analysis)방법을 이용하여 알쯔하이머형 치매의 진단 특히 초기 치매환자의 진단에 대한 예비연구를 하고자 하였다. 방법: 알쯔하이머형 치매환자 10명과 정상대조군 10명을 대상으로 하여 Karhunen-Loeve 분해법을 이용한 시공간적 패턴분석을 통하여 비교하였다. 결과: 첫째, 세가지 주요패턴 중 가장 많은 빈도를 보인 으뜸패턴에서 알쯔하이머형 치매환자는 좌우측 비대 칭성이 정상대조군에 비해 뚜렷해지는 형태를 보였다. 둘째, 으뜸패턴을 비교하여 뇌의 각 부분에 대한 차이를 보았을 때 알쯔하이머형 치매환자는 대조군에 비해 주로 좌측 두정부와 측두엽 부위에서 고유값의 유의한 차이가 있었다. 셋째, 으뜸패턴 전개계수의 Fourier amplitued spectrum 분석을 통하여 알쯔하이머형 치매환자 10명중 6명에서 상당히 큰 진폭의 상승부분을 관찰할 수 있었으며 정상대조군에서는 이러한 진폭의 이상소견이 관찰되지 않았다. 결론: 본 연구의 결과는 알쯔하이머형 치매으 병태생리적 위치가 좌측 측두-두정엽에 있음을 시사하였으며 앞으로 시공간적 패턴분석 방법이 알쯔하이머형 치매환자의 진단에 유용하게 사용될 수 있도록 추후연구가 필요할 것으로 생각하였다. Objectives: We introduce a novel analysis method of spatio-temporal pattern analysis of EEG. Using it, we presents a results discriminating severe Alzheimer's disease patients from normal subjects. Methods: To the groups of 10 Alzheimer's disease patients and 10 normal aged subjects, we applied the Karhunen-Loeve decomposition method and observed their principal patterns and time-varying dynamics. Results: First, there was a first primaty pattern of the eigenvector in Alzheimer's disease patients that showed opposite polarities at the left and the right hemispheric regions. Second, the Alzheimer's disease patients had significantly different average values of the eigenvector at the left parieto-temporal area than the normal controls did. Third, some Alzheimer's disease patients had one, coherent frequency component in the Fourier amplitude spectrum of the first pattern expansion coefficient. Conclusions: Our results suggest that the pathophysiologic site of Alzheimer's dementia may be left temporo-parietal area in brain and further studies need to evaluate whether the spatio-temoral pattern analysis could be used to diagnose Alzheimer's dementia patients.

전산화단층사진을 이용한 하악골 3차원 영상에서 비대칭진단 계측항목의 재현도에 관한 연구

김고운(Go-Woon Kim),김재형(Jae-Hyung Kim),이기헌(Ki-Heon Lee),황현식(Hyeon-Shik Hwang) 대한치과교정학회 2008 대한치과교정학회지 Vol.39 No.5

본 연구는 하악골 3차원 입체영상에서 비대칭계측항목들의 재현도 비교를 통하여 안면비대칭 진단 시 유용한 계측점 설정에 도움이 되고자 시행되었다. 40명의 두경부 전산화단층사진을 이용하여 생성한 3차원 영상에서 하악골 형태를 결정짓는 부위로 하악과두, 하악우각부, 하악정중부를 선택하고 각 부위의 세부위치에 따라, 그리고 측정 시 보는 각도에 따라 구분하여 하악과두의 경우Cd<SUB>sup_</SUB><SUB>sup</SUB> 등 6개, 하악우각부의 경우Go<SUB>inf_</SUB><SUB>lat</SUB> 등 10개, 하악정중부의 경우 Me<SUB>_</SUB><SUB>ant</SUB>, Me<SUB>_</SUB><SUB>inf</SUB> 등 총 18개의 계측점을 설정한 후 이를 이용하여 하악골 비대칭 시 좌우 차이를 보일 수 있는 25개의 계측항목을 설정 및 계측한 후 조사자간 및 조사자내의 재현도를 비교 평가하였다. 조사자간 재현도의 경우 25개의 계측항목 중 3개를 제외한 모든 계측항목에서, 조사자내 재현도의 경우 2개 항목을 제외한 모든 계측항목에서 높은 재현도를 보였다. 아울러 본 연구에서 설정한 18개의 계측점 중 Go<SUB>mid_</SUB><SUB>lat</SUB>, Go<SUB>mid_</SUB><SUB>obl</SUB>가 포함된 계측항목이 조사자간 및 조사자내 재현도가 떨어지는 경향을 보였다. 이상의 연구 결과 본 연구에서 사용된 18개의 계측점 중 16개의 계측점 (과두를 나타내는 Cd<SUB>sup_</SUB><SUB>sup</SUB>, Cd<SUB>lat_</SUB><SUB>ant</SUB>, Cd<SUB>lat_</SUB><SUB>lat</SUB>, Cd<SUB>post_</SUB><SUB>lat</SUB>, Cd<SUB>post_</SUB><SUB>post</SUB>, S, 하악우각부를 나타내는 Go<SUB>inf_</SUB><SUB>lat</SUB>, Go<SUB>inf_</SUB><SUB>inf</SUB>, Go<SUB>lat_</SUB><SUB>ant</SUB>, Go<SUB>lat_</SUB><SUB>lat</SUB>, Go<SUB>post_</SUB><SUB>lat</SUB>, Go<SUB>post_</SUB><SUB>post</SUB>, Ag<SUB>_</SUB><SUB>lat</SUB>, Ag<SUB>_</SUB><SUB>inf</SUB>, 하악정중부를 나타내는 Me<SUB>_</SUB><SUB>ant</SUB>, Me<SUB>_</SUB><SUB>inf</SUB>)은 높은 재현도를 보이므로 전산화단층사진을 이용한 하악골 3차원 영상에서 안면비대칭 환자의 진단에 유용하게 사용될 수 있음을 시사하였다. Objective: The purpose of this study was to evaluate the reproducibility of measurements representing asymmetry of the mandible and to identify which landmarks would be more useful in 3-dimensional (3D) CT imaging.<br> Methods: Facial CT images were obtained from forty normal occlusion individuals. Eighteen landmarks were established from the condyle, gonion, and menton areas, and 25 measurements were constructed to represent asymmetry of the mandible; 8 for ramus length, 12 for mandibular body length, 1 for condylar neck length, 2 for frontal ramal inclination, and 2 for lateral ramal inclination. Inter- and intra-examiner reproducibility of the measurements was evaluated.<br> Results: Inter-examiner reproducibility of the measurements proved to be high except for 3 measurements. Intra-examiner reproducibility also proved to be high except for 2 measurements. Interand intra-examiner reproducibility of the measurements including Gonion proved to be low.<br> Conclusions: The results of the present study indicate that the landmarks and measurements constructed in 3D CT images can be used for the diagnosis of facial asymmetry.

전산화단층사진을 이용한 하악골 3차원 영상에서 비대칭진단 계측항목의 재현도에 관한 연구

김고운,김재형,이기헌,황현식 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.5

본 연구는 하악골 3차원 입체영상에서 비대칭계측항목들의 재현도 비교를 통하여 안면비대칭 진단 시 유용한 계측점 설정에 도움이 되고자 시행되었다. 40명의 두경부 전산화단층사진을 이용하여 생성한 3차원 영상에서 하악골 형태를 결정짓는 부위로 하악과두, 하악우각부, 하악정중부를 선택하고 각 부위의 세부위치에 따라, 그리고 측정 시 보는 각도에 따라 구분하여 하악과두의 경우 Cd_(sup_sup) 등 6개, 하악우각부의 경우 Go_(inf_lat) 등 10개, 하악정중부의 경우 Me_(ant), Me_(inf) 등 총 18개의 계측점을 설정한 후 이를 이용하여 하악골 비대칭 시 좌우 차이를 보일 수 있는 25개의 계측항목을 설정 및 계측한 후 조사자간 및 조사자내의 재현도를 비교 평가하였다. 조사자간 재현도의 경우 25개의 계측항목 중 3개를 제외한 모든 계측항목에서, 조사자내 재현도의 경우 2개 항목을 제외한 모든 계측항목에서 높은 재현도를 보였다. 아울러 본 연구에서 설정한 18개의 계측점 중 Go_(mid_lat), Go_(mid_obl)가 포함된 계측항목이 조사자간 및 조사자내 재현도가 떨어지는 경향을 보였다. 이상의 연구 결과 본 연구에서 사용된 18개의 계측점 중 16개의 계측점(과두를 나타내는 Cd_(sup_sup), Cd_(lat_ant), Cd_(lat_lat), Cd_(post_lat), Cd_(post_post), S, 하악우각부를 나타내는 Go_(inf_lat), Go_(inf_inf), Go_(lat_ant),Go_(lat_lat), Go_(post_lat), Go_(post_post), Ag_(lat), Ag_(inf), 하악정중부를 나타내는 Me_(ant), Me_(inf))은 높은 재현도를 보이므로 전산화단층사진을 이용한 하악골 3차원 영상에서 안면비대칭 환자의 진단에 유용하게 사용될 수 있음을 시사하였다. Objective: The purpose of this study was to evaluate the reproducibility of measurements representing asymmetry of the mandible and to identify which landmarks would be more useful in 3-dimensional (3D) CT imaging. Methods: Facial CT images were obtained from forty normal occlusion individuals. Eighteen landmarks were established from the condyle, gonion, and menton areas, and 25 measurements were constructed to represent asymmetry of the mandible; 8 for ramus length, 12 for mandibular body length, 1 for condylar neck length, 2 for frontal ramal inclination, and 2 for lateral ramal inclination. Inter- and intra-examiner reproducibility of the measurements was evaluated. Results: Inter-examiner reproducibility of the measurements proved to be high except for 3 measurements. Intra-examiner reproducibility also proved to be high except for 2 measurements. Interand intra-examiner reproducibility of the measurements including Gonion proved to be low. Conclusions: The results of the present study indicate that the landmarks and measurements constructed in 3D CT images can be used for the diagnosis of facial asymmetry.

자성선숙어(protogynous fish)의 성전환

이영돈,고환봉,김형배,박인석,이정재 제주대학교 해양연구소 1993 해양자원연구소연구보고 Vol.17 No.-

Studies and reviews have been based on sex reversal diagnosis of histological change and body color change by sexual dimorphism on protogynous hermaphrodite fish, Labridae, Serranidae inhabited at the costal area of Chejudo. Korea Halichorens poecilopterus, Pleragoguw flagellifera and H. teruispinis were summer season, spawing species which mainly spawn in Jun and July, but Pseudolobrus japonicus was autumn season spawing species which mainly spawn in October and November, The standard length range of sex reversal were 13.0-15.0cm H. poecilopterus 9.5-15.0cm P. flagellifer, 11.5-16.0 cm P. japonicus and 10.0-13.0cm (total length) H. teraispinis respectively. Sex reversal mainly appeared before and after spawing season. H. Poecilogterus, H. terusispirus and P. japonicus were composed of monandry and diantry, but P.flagellifera was diandry. By sex reversal, the body colors of H. poecilopterus, P.flagellifera and P. japoricus change from pale red or yellow lines to brilliant green or dark yellow lines. The body colors of H. tenurisspirnis change slight, but containe lateral stripe pattern and blue spot in body center. In P. flagellifera, 1st, 2nd spine process of dosal fin were grown with body colour change. In sex reversal process, histological change of Labridae of inner gonad showed development of various interstitial cells and blood vessel by degeneration of oocyte. Thereafter, spermatogonia and spermatocyte begin to appear at the inner edge regions of the ovarian lamellae and then converted from ovary to functional testis. Epinephelus moara of 30.0~92.3cm in TL, E. Septemfasciatus of 23.4~38.7cm in TL were female with contained oocyte of perinucleolus stage. E akaara of 22.0~33.0cm in TL appeared individuals of ovotestis.

자성선숙어(protogynous fish)의 성전환

이정재,김형배,박인석,고환봉,이영돈 濟州大學校海洋硏究所 1993 해양과환경연구소 연구논문집 Vol.17 No.-

제주 연근해에 서식하는 자성선숙형 자웅동체어인 놀래기류와 능성이류를 대상으로 성전환에 따른 생식소의 조직학적 변화와 체색의 변화 등의 성적이형 현상을 토대로 하여 성전환 특성을 고찰하였다. 1. 용치놀래기, 어렝놀래기, 놀래기는 6월과 7월에 주산란을 하는 하계산란종인 반면에 황놀래기는 10월과 11월에 산란하는 추계산란종이였다. 2. 성전환 체장범위는 용치놀리기 13. 0-15. 0㎝, 황놀래기는 11.5-16.0㎝, 그리고 놀래기 전장 10.0-13.0㎝였다. 3. 성전환은 주로 산란기 전후로 하여 나타나고 있다. 용치놀래기, 어렝놀래기, 놀래기는 1차웅과 2차웅이 혼재하고 잇으나 어렝놀래기는 2차웅만이 출현하였다. 4. 성전환에 따른 용치놀래기, 어렝놀래기, 황놀래기 체색변화는 선홍색 또는 선황색 계통에서 색조가 다양한 녹색이나 황색계통으로 전환되고 있다. 놀래기의 경우 전반적의 체색의 변화는 미미하나 몸 가운데에 파란반점과 가로줄무늬를 띠고 있다. 어렝놀래기 경우 체색의 변화와 함께 등지느러미 제1, 2극의 돌기가 신장되고 있다. 5. 성전환 과정에 따른 놀래기류의 생식소내 조직학적 변화는 난모세포의 퇴행변성에 따라 다양한 간질세포와 혈관의 발달을 보였다. 이후 난소의 박판주위에서 정원세포와 정모세포들이 출현하기 시작하여 기능적 정소로 전환되고 있다. 6. 자바리는 전장 30.0-92.3㎝, 능성어는 전장 23.4-38.7㎝에서 생식소내 주변인기 난모세포를 갖는 암컷이었고, 붉바리는 전장 22.0-33.0㎝에서 양성생식소를 갖는 개들도이 출현하고 있다. Studies and reviews have been based on sex reversal diagnosis of histological change and body color change by sexual dimorphism on protogynous hermaphrodite fish, Labridae, Serranidae inhabited at the costal area of Cheju-do, Korea. Halichoreres poealopterus, Pteragogus flagellifera and H, tenuispinis were summer season, spawing species which mainly spawn in Jun and July, but Pseudolabrus japonicus was autumn season spawing species which mainly spawn in October and November. The standard length range of sex reversal were 13. 0-15. 0㎝ H, poecuilopterus, 9. 5-15.0㎝ P,flagellifer, 11. 5-16 0㎝ P, japonicus, and 10. 0-13 0㎝ (total length) H, tenuispinis respectively. Sex reversal mainly appeared before and after spawing season. H. Poecilopterus, H. tenuispinis and P. japonicus were composed of monandry and diantry, but P. flagellifera was diandry. By sex reversal, the body colors of Ho poecilopterus, P. flagellifera and P. japonicus change from pale red or yellow lines to brilliant green or dark yellow lines. The body colors of H. tenuispinis change slight, but containe lateral stripe pattern and blue spot in body center. In P.flagellifera, 1st, 2nd spine process of dosal fin were grown with body colour change. In sex reversal process, histological change of Labridae of inner gonad showed development of various interstitial cells and blood vessel by degeneration of oocyte. Thereafter, spermatogonia and spermatocyte begin to appear at the inner edge regions of the ovarian lamellae and then converted from ovary to functional testis. Epinephelus moara of 30. 0-92.3㎝ in TL, E.Septenfasciatus of 23. 4-38.7㎝ in TL were female with contained oocyte of perinucleolus stage. E. akaara of 22.0-33.0㎝ in TL appeared individuals of ovotestis.

액정디스플레이(LCD) 판넬유리 운반로봇의 진동저감에 대한 연구

탁태오,김헌영,전형호,오용빈 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

The development of efficient and precise handling of an liquid crystal display (LCD) panel has been addressed as the sizes of LCD panels become much larger than ever. The majority part of LCD panel handling is conducted by industrial robots for the cost reduction and the quality control. A challenging problem, vibration of the panel, can be found when the robots are utilized for handling LCD panels. The vibration causes the poor product precision and the low productivity. The characteristics of LCD panels, which are the high size-to thickness ratio, the high elasticity, and the high brittleness, are the major sources of the vibration This paper introduces the vibration attenuation techniques to overcome the difficulties encountered in the LCD production using the industrial robots.

인체 자궁암 세포에서 플라보노이드에 의한 P-당단백질의 활성 조절

고은정,정수연,김나형,이화정 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

One of the possible mechanisms of multi-drug resistance found in cancer cells is the over-expression of P-glycoprotein (P-gp). Studies have shown that compounds in plants including vegetables and fruits not only have anticancer activities but may also modulate P-gp activity. The effect of flavonoids and organic isothiocyanate on P-gp activity was studied in human uterine sarcoma cell lines, MES-SA (sensitive) and MES-SA/DX5 (resistant) cells. The accumulation of daunomycin (DNM), a P-gp substrate, was approximately 10 times greater in the sensitive cell as compared to the resistant cells over the entire time course (up to 2 hours). The positive control, verapamil increased the two hour accumulation of DNM while quercetin decreased that of DNM in the resistant cells. 1-Naphtyl-isothiocyanate (NITC) showed no effect on the two hour accumulation of DNM. The IC_(50) values for DNM in the resistant cells was about 20 times higher than that observed in the sensitive cell (10.1±1.7 μM vs. 0.58±0.28 μM). Verapamil reduced the IC_(50) value for DNM whereas flavonoids (quercetin and fisetin) increased those for DNM in the resistant cells.

Comparative Analysis for In Vitro Differentiation Potential of Induced Pluripotent Stem Cells, Embryonic Stem Cells, and Multipotent Spermatogonial Stem Cells into Germ-lineage Cells

Go Young-Eun,Kim Hyung-Joon,Jo Jung-Hyun,Lee Hyun-Ju,Do Jeong-Tae,Ko Jung-Jae,Lee Dong-Ryul 한국발생생물학회 2011 발생과 생식 Vol.15 No.1

In the present study, embryoid bodies (EBs) obtained from induced pluripotent stem cells (iPSCs) were induced to differentiate into germ lineage cells by treatment with bone morphogenetic protein 4 (BMP4) and retinoic acid (RA). The results were compared to the results for embryonic stem cells (ESCs) and multipotent spermatogonial stem cells (mSSCs) and quantified using immunocytochemical analysis of germ cell-specific markers (integrin-, GFR-, CD90/Thy1), fluorescence activating cell sorting (FACS), and real time-RT-PCR. We show that the highest levels of germ cell marker-expressing cells were obtained from groups treated with 10 ng/ BMP4 or 0.01 RA. In the BMP4-treated group, GFR- and CD90/Thy-1 were highly expressed in the EBs of iPSCs and ESCs compared to EBs of mSSCs. The expression of Nanog was much lower in iPSCs compared to ESCs and mSSCs. In the RA treated group, the level of GFR- and CD90/Thy-1 expression in the EBs of mSSCs Induced pluripotent stem cells, Mouse embryonic stem cells, Multipotent spermatogonial stem cells, Germ cell lineage, Differentiation potential. was much higher than the levels found in the EBs of iPSCs and similar to the levels found in the EBs of ESCs. FACS analysis using integrin-, GFR-, CD90/Thy1 and immunocytochemistry using GFR- antibody showed similar gene expression results. Therefore our results show that iPSC has the potential to differentiate into germ cells and suggest that a protocol optimizing germ cell induction from iPSC should be developed because of their potential usefulness in clinical applications requiring patient-specific cells.

6DOF Simulation of a Floating Body on Cartesian Mesh

Hyung-Taek Ahn,Gwang-soo Go 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.11