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      • KCI등재

        A Conversation Analysis of Korean Sentence-Ending Modal Suffixes -ney, -kwun(a), and -ta: Noticing as a Social Action

        Kyu-hyun Kim 한국사회언어학회 2004 사회언어학 Vol.12 No.1

        Kim, Kyu-hyun. 2004. A Conversation Analysis of Korean Sentence-Ending Modal Suffixes -ney, -kwun(a), and -ta: Noticing as a Social Action. Sociolinguistic Journal of Korea, 12(1). Drawing upon H. S. Lee's (1993) cognitively-oriented research on the functions of three sentence-ending modal suffixes in Korean that are used to express newly perceived information, -ney, -kwun(a), and -ta, this study analyzes the distinct meanings of these suffixes from a conversation-analytic perspective (Sacks et al. 1974). The suffix -ney is used in the context in which the speaker notices a referent/event and makes an assessment on the spot in such a way that the speaker's stance displayed through the action is formulated as something that is to be immediately oriented to and contingently taken up by the hearer. In contrast, the suffix -kwun(a) is used when the speaker is mainly oriented to displaying a stance congruent with the prior talk. The action it organizes is often limited to acknowledging a point of the prior talk or having the hearer acknowledge the speaker's observation, often with a salient topic-curtailing and sequence-terminating import. The suffix -ta tends to orient the hearer to the next stage of the speaker's action (e.g., suggestion, warning, offer, etc.) to whose directive force the hearer is variably implicated as a beneficiary/facilitator. The interactional account offered in this paper is shown to complement Lee's cognitive account, with emphasis placed on examining the ways in which these suffixes are used as resources for organizing distinct types of social action.

      • KCI등재

        The Sentence-Ending Suffix -Ketun in Spoken Korean Discourse: Sequential Organization of Informing as Account-Giving

        Kyu- hyun Kim 한국사회언어학회 2010 사회언어학 Vol.18 No.1

        Kim, Kyu-hyun. 2010. The Sentence-Ending Suffix - Ketun in Spoken Korean Discourse: Sequential Organization of Informing as Account-Giving. The Sociolinguistic journal of Korea 18(1). From a conversation-analytic perspective, this paper examines the ways in which the Korean sentence-ending suffix (SES) -ketun is used in naturally occurring spoken Korean discourse. Focusing on the question of how the practice of informing implemented by the ketun-utterance provides a basis for the sequentially implemented action of account-giving (Kim & Suh 2009), it analyzes (i) the nature of the information marked by -ketun in terms of how it is grounded, (ii) the sequential contexts where the informing sequence that -ketun generate i embedded, and (iii) features of the ketun-marked account with reference to the practices of formulating non-negotiable upshot, evoking positionaJly relevant identities, unpackaging information geared to enlightening the addressee. and stance-shifting. These practices are anaJyzed as being constitutive of the action-organizational features of the ketun-marked account, whose upshot is proposed to be that of evoking and managing the information gap or disparity in knowledge asserted by the speaker to exist between the participants.

      • KCI등재

        Effects of Pilger Rolling and Heat Treatment on Microstructure and Corrosion Resistance of Ag-electroplated 304 Stainless Steel Tubes

        Hyun Park,Woo‑Jin Lee,Jae‑Han Son,Han‑Kyun Shin,Sung‑Kyu Hong,Hyo‑Jong Lee 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8

        We introduce a cost-effective method that combines electroplating with metal cold working processes to manufacture compositetubes with robust corrosion resistance. First, a 3-step electroplating process was developed to form an adhesive anduniform Ag coating on the outer wall of a 304 stainless steel tube. The process consisted of a Ni-strike step for removing thepassivation layer of the initial 304 tube, Cu deposition for smoothing the surface by adding a buffer layer, and Ag deposition. To reinforce the interfacial adhesion between the electroplated layers and the 304 tube and increase the area of the Ag coating,a pilger rolling or pilger rolling + heat-treatment process was performed after the Ag electroplating process. Scanningelectron microscopy of the composite tubes after each process indicated that the as-deposited Ag coating changed fromhaving a rough to smooth surface after only pilger rolling and with additional heat treatment. Electron backscatter diffractionanalysis of the microstructures and textures of the tubes revealed that dynamic recrystallization occurred extensively duringpilger rolling, resulting in the formation of a relatively defect-free grain structure without heat treatment. Furthermore,electrochemical polarization curves determined that the Ag-coated composite tubes are superior to the uncoated 304 tubein terms of corrosion resistance under Cl−atmosphere, owing to the formation of a AgCl passivation layer during testing. Surface analysis of the composite tubes suggests that the properties of the AgCl passivation layer are related to the grainsize of the Ag coating and the density of plastic-deformation-induced defects.

      • 위발성 위장관 악성림프종 환자에서 항암치료의 효과

        김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

        Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.

      • KCI등재후보

        지속성 외래 복막투석 환자에서 염증 지표와 고해상도 B 모드 경동맥 초음파 소견의 연관성에 관한 연구

        송현용,송영수,안철우,강신욱,최규헌,하성규,이현철,이호영,한대석 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

        배 경 : 저알부민혈증 및 C-반응 단백(C-reactive protein, CRP)이 증가된 지속성 외래 복막투석 환자의 사망률이 높은 정확한 이유는 밝혀져 않다. 혈액투석 환자에서처럼 복막투석 환자에서 저알부민혈증 및 염증반응이 심혈관계 질환 위험인자 인지 알아보고자 하였다. 방 법: 비당뇨병성 말기 신부전, 지속성 외래 복막투석 환자 93명의 심혈관계 질환 위험인자들과 복막 투과 특성 및 알부민, CRP 등의 염증지표에 따라 고해상도 초음파를 이용한 경동맥내막-중간막 두께, 내막-중간막 면적, 플라크의 유무 등을 단면적으로 비교하였다. 결 과: 복막 투과 특성은 고투과막군 14명, 중간 고투과막군 38명, 중간 저투과막군 31명, 저투과막군 10명으로 각 군간의 경동맥 내막-중간막 두께, 플라크 유무 및 내막-중간막 면적의 차이는 없었다. 기존 관상동맥 질환 환자는 8예(8.6%)로 내막-중간막 두께는 관상동맥 질환이 없는 환자보다 증가되었고(0.79±0.21 vs 0.60±0.11 mm, p<0.05) 플라크 형성은 더 많이 보이나 통계적 유의성은 없었다(75.0 vs 63.5%, p>0.05). 혈청 알부민치와 경동맥 내막-중간막 면적은 역상관관계를 보였다(r=-0.27, p<0.05). 저알부민혈증 환자(혈청 알부민 <3.5 g/dL)는 정상 알부민혈증 환자보다 내막-중간막 두께가 증가되었고(0.67±0.15 vs 0.61±0.12 mm, p<0.05), 플라크도 유의하게 많았다(68.0 vs 55.8%, p<0.05). 혈청 CRP치와 경동맥 내막-중간막 면적은 양의 상관관계가 있었으며(r=0.21, p<0.05) CRP가 높은 환자(≥0.8 mg/dL, n=18)에서플라크가 많이 관찰되었으나(65.8 vs 50.0%, p<0.05) 경동맥 내막-중간막 두께 및 내막-중간막면적은 양군간에 차이가 없었다. 다변량 회귀 분석상 경동맥 내막-중간막 두께에 영향을 미치는 인자는 고령, 높은 CRP, 기존 심혈관계질환, 낮은 혈청 알부민 순이였다. 결 론 : 복막투석 환자에서 고해상도 초음파를 이용한 경동맥 내막-중간막 두께 측정은 심혈관계 질환 유무 예측의 비침습적 검사가 될 수 있고 저알부민혈증 및 높은 CRP과 같은 만성염증 지속상태가 복막투석 환자에서 죽상 동맥 경화증의 발생을 증가시킨다고 가정할 수 있다. Background : Continuous ambulatory peritoneal dialysis(CAPD) patients with low albumin(LA) and signs of inflammation reflected by increased C-reactive protein(CRP) level have an increased mortality, but the mechanism of this phenomenon is not clear yet. Methods : To answer whether LA and inflammation also enhance cardiovascular risk in CAPD patients, we performed cross sectional study measuring carotid artery intima-media thickness(IMT), calculated intima-media area(cIM area) and the presence of plaque by high-resolution B-mode ultrasonography in 93 non-diabetic CAPD patients. Results : Patients with coronary artery disease (CAD, n=8) had significantly increased IMT(0.79± 0.21 mm vs. 0.60±0.11 mm, p<0.05) and higher prevalence of carotid plaques(75.0% vs. 63.5%) compared to the non-CAD patients. Significant inverse correlation was observed between serum albumin (SA) level and cIM area(r=-0.27, p<0.05). Those patients with LA(SA <3.5 g/dL) had significantly increased IMT compared to non-LA patients(0.67±0.15 mm vs 0.61±0.12 mm, p<0.05). Prevalence of carotid plaques was also significantly higher in LA patients (68.0% vs. 55.8%, p<0.05). CRP level revealed a significant positive correlation with cIM area(r=0.21, p< 0.05). Patients with high CRP(≥0.8 mg/dL, n=18) had higher prevalence of carotid plaques (65.8% vs. 50.0%, p<0.05) compared to those patients with CRP <0.8 mg/dL, but IMT and cIMT area were not different. By multivariate logistic regression analysis, old age, high CRP, history of CAD and low SA were the independent risk factors affecting IMT. Conclusion : Our study strongly suggests that low albumin and chronic inflammatory state of CAPD patients could be associated with increasing atherosclerotic cardiovascular disease. (Korean J Nephrol 2002;21(2):285-294)

      • SCOPUSSCIEKCI등재

        주사 전자현미경을 통하여 확인된 단락관내 소집락 형성 : 증례보고 Case Report

        남도현,왕규창,이현구,조병규 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.10

        Two patients who had bacterial colonies in shunt catheter confirmed by scanning electron microscopy(SEM) are described Coagulase negative staphylococcus had been cultured persistently from ventricular cerebrospinal fluid in spite of adequate medical treatment for shunt infection and the normalized profile of the cerebrospinal fluid. The authors controlled the shunt infection by removal of shunt catheters. Based on these SEM findings, it is mandatory to remove an infected shunt and replace it with a new one after proper antimicrobial therapy in cases with persistently positive culture.

      • KCI등재

        Topic Marker -Nun as an Exploratory Device : Shifting Domains for Stance Management in Pursuit of Intersubjectivity

        Kim, Kyu-hyun 한국사회언어학회 2017 사회언어학 Vol.25 No.2

        Kim, Kyu-hyun. 2017. “Topic Marker -Nun as an Exploratory Device: Shifting Domains for Stance Management in Pursuit of Intersubjectivity“. The Sociolinguistic Journal of Korea 25(2), 29~72. From the conversation-analytic perspective, this paper investigates the interactional import of - nun used in assessment activities. The analysis of naturally-occurring interactions suggests that the domain-shifting function of - nun is closely attuned to shifting, or even reversing, the valence of the speaker s evaluative stance in a way that invokes a hitherto unmentioned domain as grounds for soliciting the interlocutor s agreement/affiliation, expressing partial agreement, or marking oblique disagreement. Often formulated as an overstatement to be retracted and/or as a move to solicit the interlocutor s collaborative uptake through claiming knowledge (or lack thereof), the nun- utterance furnishes the speaker with a resource for obliquely implementing face-threatening actions, pursuing common ground, or upgrading affect. Embodying the speaker s ‘exploratory’ stance, the use of - nun conveys the sense that the speaker is going beyond the ‘appearance’ of the matter at hand (e.g., a sub-domain from which a new generic feature may be drawn and attributed to the referent). This practice, which is further supported by the nun- marked adverbials formulated as a ‘logical guidepost expression’, provides for the basis on which the speaker organizes assessment activities in an other-attentive way, e.g., through upgrading affiliation and downgrading disaffiliation vis-à-vis the interlocutor s prior action, while sustaining his/her baseline stance and epistemic independency.

      • KCI등재

        갑상선기능저하증에 기인한 내인성 급사 1예 보고

        이정규,전지현,김민정,이규재,김한겸,조현득,채양석 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2

        Although it is known that hypothyroidism can cause cardiac dysfunction, it is very hard to find a case report on sudden death due to hypothyroidism. There are only two reported cases on mediline; one is about a 15-year-old girl who died suddenly of Hashimoto's thyroiditis and the other is about a 31-year-old man who also died suddenly of hypothyroidism associated with chronic lymphocytic thyroiditis. Recently we found a young woman who unexpectedly died while she was sleeping. She was diagnosed as hypothyroidism when she went to hospital about a month before she died. At autopsy there were roughly four abnormal findings; Hashimoto's thyroiditis, mild chronic active hepatitis, diverticulosis and accessory spleen. Trace of chlorpheniramine was detected in gastric remains and blood alcohol level was 0.37 percent. To our knowledge, this is the first case reporting sudden and unexpected natural death associated with hypothyroidism in Korea.

      • KCI등재

        거리의 도상성원리와 영어여격교체현상

        김광현,황규홍 새한영어영문학회 2001 새한영어영문학 Vol.43 No.2

        An Iconicity-theoretic Approach to the English Dative Alternation Construction Kim, Kwang-Hyun · Hwang, Kyu-Hong This paper aims to examine the semantic and structural differences between the double-object construction and its prepositional counterpart based on Haiman's (1980, 1983, 1985) iconicity theory. The alternation phenomena have attracted a great deal of attention, and a range of proposals have been put forward to account for them. In particular, an attempt has been made among the majority of scholars to differentiate the double-object construction and its corresponding dative construction by resorting to the differences in verb meaning and those in relation between arguments. To achieve the above goal, in this paper, we attempt to identify the subtle meaning differences between the two constructions by way of the distance principle of the iconicity theory: "the linguistic distance between expressions corresponds to the conceptual distance between them." Namely, we argue that the double-object construction is used when the agent and the recipient are conceptually close, while the dative counterpart is used when the conceptual distance between the two is remote. This line of approach seems to be appealing in that it can explain the differences between the constructions more explicitly and systematically and in that it can also account for other alternation phenomena such as locative and conative constructions in a similar context.

      • KCI등재

        Effects of epigallocatechin gallate on CoCl_(2)-induced apoptosis in PC12 cells

        Yang, Kyu-Ho,Mo, Hyun-Chul,Choi, Nam-Ki,Kim, Seon-Mi,Kim,Won-Jae 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

        Neuronal apoptotic events, consequently resulting in neuronal cell death, are occurred in hypoxic/ischemic condition. This cell death has been shown to be accompanied with the production of reactive oxygen species (ROS), which can attack cellular components such as nucleic acids, proteins and phospholipid. However, the underlying mechanisms of apoptosis induced in hypoxic/ischemic condition and its treatment methods are unsettled. Cobalt chloride (CoCl_(2)) has been known to mimic hypoxic condition including the production of ROS. Epigallocatechin gallate (EGCG). a green tea polyphenol, has diverse pharmacologial activities in cell growth and death. This study was aimed to investigate the apoptotic mechanism by CoCl_(2) and effects of EGCG on CoCl_(2)-induced apoptosis in PC12 cells. Administration of CoCl_(2) decreased cell survival in dose- and time-dependent manners and induced genomic DNA fragmentation. Treatment with 100 µM EGCG for 30 min before PC12 cells were exposed to 150 µM CoCl_(2), being resulted in the cell viability and DNA fragmentation being rescued. CoCl_(2) caused morphologic changes such as cell swelling and condensed nuclei, whereas EGCG attenuated morphologic changes by CoCl_(2). EGCG suppressed the apoptotic peak and a loss of Δψ_(m) induced by CoCl_(2). CoCl_(2) decreased Bcl-2 expression but Bax expression was not changed in CoCl_(2)-treated cells. EGCG attenuated the Bcl-2 underexpression by CoCl_(2). CoCl_(2) augumented the cytochrome c release from mitochondria into cytoplasm and increased caspase-8, -9 and caspase-3 activity, a marker of the apoptotic executing stage. EGCG ameliorated the incruement in caspase-8, -9 and -3 activity, and cytochrome c release by CoCl_(2). NAC (N-acetyl-cysteine), a scavenger of ROS, attenuated CoCl_(2)-induced apoptosis in consistent with those of EGCG. These results suggest, that CoCl_(2) induces apoptotic cell death through both mitochondria- and death receptor-dependent pathway and EGCG has neuroprotective effects against CoCl_(2)-induced apoptosis in PC12 cells. 신경세포자멸사는 저산소 및 허혈환경에서 일어나며 이러한 세포죽은 reactive oxidant species (ROS) 생성을 동반함이 알려져있다. 그러나, 저산소 및 허혈환경에서 일어나는 세포자멸사의 기전 및 그 치료방법은 아직 정립되어 있지 않다. CoCl_(2)는 ROS를 생성하는 등 저산소환경과 유사한 조건을 초래하는 것으로 알려져 있다. Epigallocatechin gallate (EGCG)는 녹차의 polyphenol 성분으로서 세포성장과 죽음에 다양한 약리학적 효과를 나타냄이 알려져 있다. 본 연구는 PC12 세포에서 CoCl_(2)에 의한 세포자멸사기전을 밝히고 이에 미치는 EGCG의 효과를 조사하는데 목적이 있다. Cell viability는 MTT 측정으로 조사되었고, DNA fragmentation은 DNA laddering으로 조사되었다. Bcl-2와 Bax발현 정도는 RT-PCR로, caspase-3와 -9의 활성은 spectrophotometer, caspase-8의 활성은 flow cytometry에 의해 측정되었다. 미토콘드리아에서 세포질로 분비된 cytochrome c는 western blot으로, 분해된 DNA 양과 미토콘드리아 세포막전위 (Δψ_(m))는 FACScan으로 조사되었다. CoCl_(2)투여로 PC12 세포수는 용량 및 시간 의존형태로 감소하였고, genomic DNA fragmentation이 발생하였다. CoCl_(2)투여로 야기된 cell viability의 감소와 DNA fragmentation은 EGCG 전처치에 의해 억제되었다. CoCl_(2)은 세포용적팽창과 condensed nuclei 같은 형태적 변화를 일으켰으며, apoptotic peak, Δψ_(m)감소 및 cytochrome c 유리를 야기하였다. EGCG는 CoCl_(2)에 의한 세포형태변화, apoptotic peak, Δψ_(m)소실 및 cytochrome c 유리를 억제시켰다. CoCl_(2)는 Bcl-2 발현을 감소시켰지만, Bax 발현에는 영향을 미치지 않았다. EGCG는 CoCl_(2)에 의해 야기된 Bcl-2 발현 감소를 억제시켰다. CoCl_(2)는 caspase-3, -8, 그리고 -9의 활성을 증가시켰으며, EGCG는 CoCl_(2)에 의한 세포자멸사를 억제시켰다. 본 실험결과는 PC12 세포에서 CoCl_(2)가 미토콘드리아 의존 및 death receptor의존 기전으로 세포자멸사를 일으키며, EGCG는 세포자멸사기전을 억세지킴으로 신경보호기능을 가짐을 시사하였다.

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