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      • 크로이츠펠트-야콥 병

        구본대,신동익,한현정,나덕렬,,이상복 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

        Creutzfeldt-Jacob disease (CJD) is one of the fatal prion diseases. Diagnosis of CJD is mainly based on clinical symptomatology of established criteria, characteristic electroencephalogram, specific cerebrospinal fluid protein measurement, prion protein gene analysis, prion protein isoform detection, and neuropathology. But spongiform change of brain pathology is the only definitive diagnosis of CJD. Clinical symptomatology of CJD includes behavioral disturbances, progressive dementia, cerebellar, pyramidal, and extrapyramidal signs. Most patients show progressive myoclonic jerks that involve either limbs or the entire body. The approximate incidence of CJD is 1 per million and occurs as sporadic, familial and iatrogenic forms. Variant CJD has the strong possibility of cross species transmission between human and cow. It has some differences in clinical and pathological aspects from sporadic CJD. Protease resistant prion protein of scrape isoform may lead to diverse neuronal death in CJD. Recent advannces in CJD reveal that apoptosis, proinflammatory cytokine expression and oxidative stress may play an important role of CJD pathogenesis. There areseveral therapeutic trials in CJD but no therapeutic regimensshow effective results. Although there is much progression about CJD in recent days, a lot of things still remained to be reveled.

      • 대학생 흡연자의 금연경험에 따른 건강신념차이

        구정일,김민정,김동희,백정희,안현실,은가희,우혜령,이명희,이수현,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

        It has been generally known that smoking is one of the worst factor increasing disease and mortality in human health since in 1950's and nowadays. But regardless of various proofs about social or economical problems due to smoking, current smoking rate has not been decreased in our country. Until now, most of tobacco use and its addiction researches have been focused on the adolescent or adult women smokers not on the university students. Therefore, the purpose of this study was to investigate smoking cessation of university smokers and analyze the health belief-perceived sensitivity, severity, benefits and barriers- difference, then to provide basic data for effective smoking cessation strategy for university smokers. The subjects were comprised of 181 university smokers from 15 universities in Seoul. The data were collected by structured questionaires. The questionaires were designed to measure general characteristics, smoking cessation and health belief, based on Ahn(2003)'s result on the Study of Smoking attitude, Behavior and Smoking Cessation of Adult Male and Lee(1987)'s result on Relationships Between the Health Belief Model and Smoking Habits. The data were collected from May 5 to 16. The collected data were analyzed by SPSS program. The actual number, percentiles, means, standard deviation, t-test and ANOVA were done. The result of this study were as follows; 1. The general characteristics of the subjects of this study The range of age was from 18 to 34 and the averaging age was 23. The subjects of this study were 141 males and 40 females. The religions were Christianity 25.4%(46), Buddhism 12.7%(23), Catholic 23.2%(42), no religion 37.0%(67). The residential forms were living with family 59.1%(107), cooking food for oneself 28.7%(52), dormitory 5.0%(9), boarding house 1.7%(3). Smoking starting age were university 43.1 %(78), high school 29.8%(54), middle school 14.9%(27), in the army 6.1 %(11), elementary school 1.1 %(2). 2. The smoking cessation of the subjects 80% of current smokers showed quitting smoking decision and 20% have not tried. The frequency of quitting smoking decision were from 1 to above 8 and mean was 3.06. As for smoking cessation plan, 54.7%(99) current smokers answered yes, 3.9%(7) said no, 35.4%(64) had no idea and 6.1 %(11) didn't answer. As for the reason of never quitting smoking decision, 71.42%(25 among total 35) have no need to quit smoking and the others said difficulty of smoking cessation. As for the main reason of smoking cessation decision, 54.7%(99) answered for the health, 7.2%(13) family advice, 15.5%(28) girl/boy friend's advice, 1.7%(3) to save money. As for the reason to fail smoking cessation, 56.7%(68) were will-lack, 17.5%(21) stress, 15%(18) smoking mood, 10%(12) withdrawl symptom. As for the smoking cessation method, 85.0%(125) were oneself-will, 2.7%(4) way acquired by mass-media, 2%(3) doctor's prescription, 2%(3) religion's help, 0.7%(1) smoking cessation school. As for the difficulty in smoking cessation, 42.2%(62) were drinking meeting, 23.1 %(34) no alternative of stress release, 12.2%(18) withdrawl symptom, 11.6%(17) having nothing to do, 7.5%(11) friend's encouragement. As for the most difficult cigarette to quit, 67.8%(99) were all-day smoking except the first smoking in the morning, 32.2%(47) the first smoking in the morning. 3. Health belief as for general characteristics Gender - The total point in benefits showed higher in male(28.5177) than female(26.6750). There was significant difference(t=.778, p<.05). The total point in health belief showed higher in male (105.8298) than female(l00.5000). So there was significant difference(t=.345, p<.05). Age - There was significant difference in benefits between age(10's-25.83, 20's-28.39, 30's-32.00)(F=3.73, p<.05). Smoking starting age - There was significant difference in total point of sensitivity and health belief(sensitivity F=4.00, p<.Ol, health belief F=2.843, p<.05). As for sensitivity, subjects who started smoking in the army showed the highest(33.36) and ones in high school showed the lowest(26.96). The total point in health belief showed the highest in elementary school(l19.00) and the lowest in high school(100.98). 4. Health belief as for smoking cessation There was significant difference in health belief as for smoking cessation(t=0.189, p=0.OO2). Sensitivity point showed higher in smoking quitting trial smokers(29.2) than non-trial smoker (26.9). Severity point showed higher in trial smokers (30.7) than non-trial smokers(28.9). Benefit point showed higher in trial smokers(28.6) than non-trial smokers(26.2). There was no significant difference in barriers point.

      • TFM 방식을 이용한 건물의 동적 열성능해석 기법 연구(Ⅰ)

        구현덕,이순화,이진숙,송인춘 忠南大學校 産業技術硏究所 1993 산업기술연구논문집 Vol.8 No.1

        This study presents the methodology application of hour-by-hour computation for an extensive analysis in building. The approach to equipment selection based on air-conditioning equipment and air distribution systems with sufficient capacity to cope with maximum design load evolved when all design calculations were performed manually. At that time, extensive design analysis was impractical: now, computers, used frequently for rountine design calculations, make anaysis practical. Consequently, this study describes the fundamental methodology used in calculating a space load and gives basic equations for determining hour-by-hour load factors given in tabular forms in the ASHRAE FUNDAMENTALS, 1985 and 1989. It is possible to construct computerized routines to duplicate results obtained with the tabular data, and to examine the effect of various systems and operating schedules on the space energy analysis. This study deals with fundamental calculation procedures for 1. Heat gain through exterior walls and roofs using transfer function coefficients. 2. Hrat gain through interior patitions, ceilings and floors using transfer function coefficients. 3. Conversion of all heat gain components into appropriate room/space loads. 4. Extention of the procedures to calculate the space air temperature and heat extraction rate obtained with a particular type and size of terminal unit. By applicating this procedures to computerization, three basical calcualtion routines are made and verified as the proper simulation methodology. As results. 1. Houry conduction rate has only 0.48% err in average. 2. Houry radiation rate has only 0.041% err in average. 3. Houry temperature variation has only 0.001% err in average. 4. Houry predicted heat extration rate has only 0.005% err in average. From the above results, it is possible to use TFM computerization methodology for energy analysis in building. By applicating three basical comuper calculations, more complicate computer simulation can be interpreted to be needed for annual energy analysis.

      • KCI등재

        여행상품 인증제도 도입 방안에 관한 연구

        조구현 한국호텔관광학회 2001 호텔관광연구 Vol.3 No.2

        Travel industry in Korea has growed quickly in quality and quantity since the liberalization measures. However, some travel agents tend to copy the travel services and packages developed and offered by other agents. This has caused the disturbance in the structure of distribution. For this reason, it is essential to introduce the certification for excellent travel services and packages. If such a system is introduced, consumers will have the opportunity to choose the best one available. In addition, it will add in the development of domestic travel industry by acting publicity campaign for excellent services and packages both Korea and abroad. There are several steps which must be taken to introduce and effectively settle the certification system for travel services and packages. First, an method of assessment should be constructed. This method should be understood by travel agents and consumers. Second, the government should give incentive to travel agencys which develop good travel services and packages. Third, the government should be careful when they decide the area of application and select committee who will investigate which services and packages are the best. In conclusion, the certification for travel services and packages will make a contribution to an increase in the rate of competition among domestic travel agencys. In order to maintain this, the government should continuously review travel services and packages and perform quality control and check on a regular basis.

      • 광선각화증, 각화극세포종과 Bowen's병에서 p53과 p21의 표출 양상

        조명구,조현득,양승하,김의한 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

        Background The function of the p53 protein was known to regulate cell proliferation by inhibiting cells entering Sphase. So DNA damaged cell proliferation was inhibited by apoptosis. P21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought go mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 were expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis were important. The authors analyzed immunohistochemical expression of mutant p53 and p21 protein in some skin tumors. Method Thirteen cases of actinic keratosis, 7 cases of keratoacanthoma and 8 cases of Bowen's disease were immunohistochemically stained with p53 and p21 monoclonal antibodies. Results; 1. In cases of positive p53 protein and negative p21 protein, the expressed p53 protein was suggested as mutant form. 2. Positive expression of p53 protein and p21 protein in prickle cell layer of actinic keratosis and Bowen's disease was suggesded that the composing cells of prickle cell layer were transformed into the proliferated cell. The p21 protein expression was suggested to be induced by the p53 independent pathway. 3. Negative expression of p53 protein and p21 protein in prickle cell layer of keratoacanthoma was suggested that the composing cells of prickle cell layer were completely mature cells, so the keratoacanthoma had good prognosis.

      • KCI등재

        건축도자의 기능과 역할에 관한 연구

        공현구 한국공예학회 2001 조형디자인연구 Vol.4 No.2

        Modern architecture is not the concept of a residence any longer, but it has taken rapid strides in modern times, seeking any types of better life and psychical domain which is more convenient life. And also man is developing the architecture into a concept of "Art" from the simple concept of" Build". Accordingly, a function & duty of environment ceramics art for architectural design is quite emphasized with roles of mud at architecture. Therefore, ceramic artists need to do their own roles which is same position as architect & designer with a harmony of art and technique, using much improved ceramic marketing.

      • KCI등재

        패션 브랜드의 웹사이트 활용 실태 분석

        권현주,구양숙 한국의류산업학회 2005 한국의류산업학회지 Vol.7 No.1

        The purpose of this study was to analyze the utilization of Fashion Brands Web-site. This analysis was done by 6C Concept(Contents, Community Commerce, Connection, Customizing, Communication) which was Internet Marketing Strategy. The review of previous studies and empirical investigations through the Internet were processed for this study 151 fashion brands in deixwtment stores, Daegu, Korea were surveyed from January to February 2004. Data were analyzed by using frequency and percentage. Total 105 brands established their Web-Site of Internet out of 151(69.5%) fashion brands. There were four characters on Contents, six characters on Connection and five characters on Communication. And there were a establishing rate of 38.1 percent on Online Community and 3(15 percent on Online Shop-ping Mall. On Customizing, 73.3 percent of brands had e-CRM systems.

      • KCI등재

        外來觀光客 誘致를 위한 觀光商品 開發에 관한 硏究 : A Study on the Tourism Product Development for In-Bound Foreign Tourists

        조구현 한국호텔관광학회 1999 호텔관광연구 Vol.1 No.1

        This study is designed to identify the relationship between professionalism, trustworthiness and self-disclosure perceived by surgical patients and provide fundamental data for therapeutical human relationship between patient and nurse. The subjects were 160 surgical patients from one university hospital. The data collection was conducted by using the structured questionaire from September 28 to October 10, 1998. The instruments used for this study were the Counselor Rating Form Scale developed by Kim, Joung Wha and the Self-disclosure Questionaire developed by Dawson. The data were analyzed by descriptive statistics, Pearson Correlation, using the SPSS program. The results were as follows: 1. The mean score of perceived nurse‘s professionalism was 3.96. 2. The mean score of perceived nurse‘s trustworthiness was 3.97. 3. The mean score of patient‘s self-disclosure was 1.82. The rank order of self-disclosure subcategories were Reaction to health care, Life style and Personal problem & feeling. 4. The relationship between perceived nurse's professionalism and trustworthiness revealed a significant correlation (γ=.841,p<.00l). The relationship between perceived nurse`s professionalism and self-disclosure revealed not a significant correlation( γ=.179, p>.05). The relationship between perceived nurse‘s trustworthiness and self-disclosure revealed not a significant correlation(γ=.148, p.05).

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