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Role of severity and gender in the association between late-life depression and all-cause mortality
Jeong, Hyun-Ghang,Lee, Jung Jae,Lee, Seok Bum,Park, Joon Hyuk,Huh, Yoonseok,Han, Ji Won,Kim, Tae Hui,Chin, Ho Jun,Kim, Ki Woong Cambridge University Press 2013 INTERNATIONAL PSYCHOGERIATRICS - Vol.25 No.4
<B>ABSTRACT</B><P>Background: Mortality associated with depression may be influenced by severity of depression and gender. We investigated the differential impacts on all-cause mortality of late-life depression by the type of depression (major depressive disorder, MDD; minor depressive disorder, MnDD; subsyndromal depression, SSD) and gender after adjusting comorbid conditions in the randomly sampled elderly.</P><P>Methods: One thousand community-dwelling elderly individuals were enrolled. Standardized face-to-face clinical interviews, neurological examination, and physical examination were conducted to diagnose depressive disorders and comorbid cognitive disorders. Depressive disorders were diagnosed according to the <I>Diagnostic and Statistical Manual of Mental Disorders-IV</I> (DSM-IV) criteria and SSD to study-specific operational criteria. Five-year survivals were compared between groups using Cox proportional hazards models.</P><P>Results: By the end of 2010, 174 subjects (17.4%) died. Depressive disorder (<I>p</I> = 0.001) and its interaction term with gender (<I>p</I> < 0.001) were significant in predicting five-year survival. MDD was an independent risk factor for mortality in men (hazard ratio = 3.65, 95% confidence interval = 1.67-7.96) whereas MnDD and SSD were not when other risk factors were adjusted.</P><P>Conclusions: MDD may directly confer the risk of mortality in elderly men whereas non-major depression may be just an indicator of increased mortality in both genders.</P>
Yujin Lee,Moon-Soo Lee,Hyun-Ghang Jeong,Hyun-Chul Youn,Seung-Hyun Kim 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.2
Objective: The purpose of this study was to examine post-hospitalization outpatient drug adherence in patients with severe psychiatric illness, including bipolar disorder and schizophrenia, and to investigate factors associated with drug adherence. Methods: Eighty-one patients diagnosed with schizophrenia or bipolar disorder who were hospitalized due to aggravation of psychiatric symptoms were monitored. At hospitalization, we conducted clinical assessments such as the Clinical Global Impression-Severity, Drug Attitude Inventory, Contour Drawing Rating Scale, Multidimensional Scale of Perceived Social Support scale, and patients’ demographic factors. We measured drug adherence using the Medication Event Monitoring System (MEMS), pill count, and patients’ self-report upon out-patients visits, 4 and 24 weeks after discharge. Results: The mean values of the various measures of adherence were as follows: MEMS (4 weeks) 84.8%, pill count (4 weeks) 94.6%, self-report (4 weeks) 92.6%, MEMS (24 weeks) 81.6%, pill count (24 weeks) 90.6%, and self-report (24 weeks) 93.6%. The adherence agreement between MEMS, pill count, and self-report was moderate (4 weeks intraclass correlation [ICC]=0.54, 24 weeks ICC=0.52). Non-adherence (MEMS ≤0.08) was observed in 26.4% of the patients at 4 weeks and 37.7% at 24 weeks. There was a negative correlation between drug adherence assessed 4 weeks after discharge and Contour Drawing Rating Scale difference score (r=−0.282, p<0.05). A positive correlation was found between drug adherence assessed 24 weeks after discharge and Drug Attitude Inventory (r=0.383, p<0.01). Conclusion: Patients’ attitude towards their medication and their degree of physical dissatisfaction influenced post-hospitalization drug adherence in severe psychiatric patients.
Ghang, Ho-Young,Han, Young-Joo,Jeong, Sang-Jin,Bhak, Jong,Lee, Sung-Hoon,Kim, Tae-Hyung,Kim, Chul-Hong,Kim, Sang-Soo,Al-Mulla, Fahd,Youn, Chan-Hyun,Yoo, Hyang-Sook,The HUGO Pan-Asian SNP Consortium, T Korea Genome Organization 2011 Genomics & informatics Vol.9 No.4
In planning a model-based phylogenic study for highly related ethnic data, the SNP marker number is an important factor to determine for relationship inferences. Genotype frequency data, utilizing a sub sampling method, from 63 Pan Asian ethnic groups was used for determining the minimum SNP number required to establish such relationships. Bootstrap random sub-samplings were done from 5.6K PASNPi SNP data. DA distance was calculated and neighbour-joining trees were drawn with every re-sampling data set. Consensus trees were made with the same 100 sub-samples and bootstrap proportions were calculated. The tree consistency to the one obtained from the whole marker set, improved with increasing marker numbers. The bootstrap proportions became reliable when more than 7,000 SNPs were used at a time. Within highly related ethnic groups, the minimum SNPs number for a robust neighbor-joining tree inference was about 7,000 for a 95% bootstrap support.
Reliability and Validity of the Korean Version of the Brief Resilience Scale
Junhyung Kim,Hyun-Ghang Jeong,Moon‑Soo Lee,Seung-Hoon Lee,Sang-Won Jeon,Changsu Han 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.4
Objective: To translate the Brief Resilience Scale into Korean and evaluate its reliability and validity. Methods: To investigate the factor structure of the Brief Resilience Scale, we examined a two-factor model comprising positively and negatively worded items. Congruent and divergent validity of the Brief Resilience Scale were investigated using correlation analysis between the Brief Resilience Scale and resilience, depression, and perceived stress. By conducting an analysis of variance among groups classified by suicidality (no suicidality, only suicidal ideation, and suicidal ideation or suicidal plan groups), we evaluated how well the Brief Resilience Scale could detect people with a high risk of suicide. Results: Confirmatory factor analysis results supported the construct validity of the Brief Resilience Scale using a two-factor model. Cronbach’s alpha (0.91) and McDonald’s omega (0.91) scores indicated high internal consistency. Correlation analysis showed that the Brief Resilience Scale scores were strongly associated with a questionnaire evaluating resilience, depression, and perceived stress. Analysis of variance and post-hoc tests showed that he Brief Resilience Scale scores were highest in the no suicidality group (p < 0.001). Conclusion: The Korean version of the Brief Resilience Scale is a valid and reliable instrument for evaluating resilience as the capacity to recover from adversity and endure obstacles or stress. This study also provides important evidence regarding the sensitivity of the Brief Resilience Scale to suicidal risk.
Dasom Uh,Hyun-Ghang Jeong,Kwang-Yeon Choi,So-Young Oh,Suji Lee,Seung-Hyun Kim,조숙행 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.2
Objective: The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate biomarkers in MDD have been reported, which might be a consequence of the heterogeneity of MDD patients. Therefore, we aim to investigate how the severity of depression and various symptom domains are related to the levels of dehydroepiandrosterone sulfate (DHEA-s) in MDD patients. Methods: We recruited 117 subjects from a general practice. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). Depressive symptoms were divided into three subdomains according to BDI items; somatic symptoms, guilt and failure, and mood and inhibition. Results: In subjects with very-mild-to-moderate depression, the DHEA-s level increased as BDI score did. However, the DHEA-s levels in the subjects with severe depression were significantly lower than in subjects with moderate depression (p=0.003). DHEA-s level was correlated with the BDI subscore for guilt and failure in very-mild-to-moderate depression (r=0.365, p=0.006). Conclusion: The DHEA-s level appears to be indicative of MDD severity with respect to depressive symptoms, especially regarding guilt and failure. Our findings suggest that the upregulation of DHEA-s may be a part of a compensatory process in very-mild-to-moderate depression, and the failure of this compensation mechanism may underlie the development of severe depression.
남규현(Kyu-Hyun Nam),김지은(Ji-Eun Kim),이석재(Seok-Jae Lee),임수강(Soo-Ghang Im),홍남표(Nam-Pyo Hong),박준석(Jun-Seok Park) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10
본 논문은 주파수체배기에서 출력의 발진을 방지하려는 방법을 제안한다. 제안하는 발진을 방지하기 위한 전압제어루프는 CMOS 65nm 공정을 이용하여 설계하였으며, 피크 검출기와 비반전 증폭기로 구성되어 있다.
도현민(Do Hyun-Min),김용식(Kim Yong-Shik),김봉근(Kim Bong-Keun),이강(Lee Ghang),윤석헌(Yun Seok-Heon) 대한건축학회 2009 大韓建築學會論文集 : 構造系 Vol.25 No.3
Automation and robotization has been required in construction for several decades to reduce the cost and time and to increase the productivity and safety. Especially for steel construction in high-rise building, the needs for automation is emphasized because this is inherently a very dangerous and difficult job. As one procedure of automation, the equipment like robotic crane should carry steel frames from staging area to the installed spot automatically. To do this, the position and pose of steel frames should be known to robotic crane. This paper presents a recognition and localization method for steel frame materials to remedy this problem. In the proposed method, the shape model is acquired by RF-ID technology and the loading shape of steel frame materials in staging area is recognized by laser range finder (LRF) sensors. After clustering the scanned data into several objects, scan matching method is applied to recognize each object. Experimental results are included to verify the performance of the proposed method.
임수강(Soo-Ghang Im),김지은(Ji-Eun Kim),이석재(Seok-Jae Lee),남규현(Kyu-Hyun Nam),박준석(Jun-Seok Park) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10
본 논문에서는 윌킨슨 전력 분배기 (Wilkinson power divider)와 하이브리드 커플러 (Hybrid coupler)를 조합한 Six-port를 제안한다. 동작주파수 29 GHz를 목표로 하는 Six-port를 설계하고 시뮬레이션을 통해 삽입손실과 반사손실이 각각 -45.621 dB와 -39.349 dB를 얻을 수 있음을 확인했다.