운동 직후 고온 침수가 EPOC와 TG/ fatty acid cycling에 미치는 영향

조현철,김종규,강민철,홍완표,박노혁 龍仁大學校 體育科學硏究所 2005 體育科學硏究論叢 Vol.15 No.1

The purpose this study was to estimate effects of EPOC and TG/fatty acid cycling on warm water immersion of immediately after exercise. To elucidate the role of fatty metabolism, a sequence of five experiments was performed. Seven physically active, male subjects volunteered to participate in the presented study. The mean values for age, body mass and hight were 25±1.52 yr, 79.2±9.52kg, 177.2±4.62cm, respectively. After giving consent, participant visited the laboratory on six occasion: 1) 30min of treadmill exercise VO2max 55% and a further 60min recovery, 2) 30min partial body warm water immersion in a 39℃ and a further 60min recovery, 3) 30min whole body warm water immersion in a 39℃ and a further 60min recovery, 4) 30min of treadmill exercise VO2mas 55% and in 30min partial body warm water immersion in a 39℃, 5) 30min of treadmill exercise VO2max 55% and in 30min whole body warm water immersion in a 39℃. When compared by recover period within repeat on the base of changes of subjects average body temperature, not effective interactions among repeat. However, partial and whole body warm water immersion immediately after exercise shows it as the best effective exercise for VO2max 55%, partial and whole body warm water immersion. When compared by recover period within repeat on the base of changes of subjects EPOC, effective interactions among repeat(p<.05). Partial and whole body warm water immersion immediately after exercise shows it as the best effective exercise for VO2mas 55%, partial and whole body warm water immersion. The catecholamines concentration was significantly higher partial and whole body warm water immersion than exercise of VO2max 55%(p<.05). The TG concentration and free fatty acid was significantly higher partial and whole body warm water immersion immediately after exercise than exercise of VO2max 55% than Partial and whole body warm water immersion(p<.05). Based on the facts that we have discussed above, human metabolism is increased by both exercise and conditions of immersion and partial and whole body warm water immersion immediately after exercise than exercise of VO2maw 55% shows it as better effective treatment for increasing TG/Fatty acid cycling activation. Due to extremely heavy stress complained by subjects during whole body immersion, it is thought that more researches on it should be required.

신장기능영상용 방사성의약품 Bz - MAG3 ( Benzoylmercaptoacetylglycylglycylglycine ) 의 키트화 및 체내분포

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),김영주(Young Ju Kim),정재민(Jae Min Jeong),장영수(Young Soo Chang),조정혁(Jung Hyuk Cho) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3

N/A The MAG3 is a tubular excreting radiopharmaceutical for renal image. We synthe-sized benzoyl MAG3 (Bz-MAG3) and made a kit for labeling with Tc-99m. We checked the labeling effeciency of Tc-99m labeled MAG3 and biodistribution. Labeling efficiency was checked by TLC- SG (acetonitrile/H2O=2/1). After injecting of 1 mCi of Tc-99M-MAG3 to ICR-mice, Tmax(min), T1/2(min) were obtained in the renogram. Sequencial images (30sec, 2min, 5min, 10min, 15min, 20min) of TC-99m-MAG3 were compared with those of commercial Tc-99m-DTPA (Du Pont Merck Pharmaceutical Co.) kit. 1) The Rf value of synthesized Tc-99m-MAG3 was 0.78 and labeling efficiency was 97.5±1.9% (n=10). 2) The dynamic images of the Tc-99m-MAG3 were better than those of the Tc-99m-DTPA. 3) The Tmax(min.) and T1/2(min.) of Tc-99m-MAG3 (n=10) were 1.5±0.5 (left), 1.4±0.4(right), and 4.3±1.4 (left), 4.8±2.0 (right), respectivel. The Tmax(min.) and T1/2(min.) of Tc-99m-DTPA (n=7) were 2.7±1.6 (left), 2.7±1.6 right), and 3.8±1.7 (left), 4.5±2.7 (right), respectively. The quaility of image and labeling efficiency of the synthesized Bz-MAG3 kit were excellent, that it was supposed to be used in routine clinical work.

DVB-S2 기반 고속 LDPC 복호를 위한 효율적인 CNU 계산방식에 관한 연구

임병수,김민혁,정지원,Lim, Byeong-Su,Kim, Min-Hyuk,Jung, Ji-Won 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.9

본 논문은 DVB-S2 기반 고속 LDPC 복호를 하기 위한 효율적인 CNU(Check Node Update) 계산방식에 대해 분석하였다. LDPC의 복호 속도는 CNU 계산 과정에 의존한다. 기존의 CNU 계산방식에서 LUT를 고려한 SP(Sum-Product)방식은 속도가 늦어지는 단점이 있다. 이에 본 논문에서는 SC-NMS(Self-Corrected Normalized Min-Sum) 방식을 제안한다. LUT 연산을 제거한 MS(Min-Sum) 방식에 정규화 계수 '${\alpha}$'를 곱하는 Normalized Min-Sum(NMS) 방식은 MP 방식보다 성능은 약간 감소하지만 critical path를 없애고 클럭 주기를 줄일 수 있어 구현에 있어서 고속화를 위한 효율적인 CNU 계산방식이다. 또한, 복호과정에서 반복 시 이전 반복에서의 엣지 값과 현재 반복에서의 엣지 값을 비교하여 부호가 바뀌면 신뢰성이 없음을 간주하여 현재 엣지에 "0"을 할당하는 SC(Self-Corrected) 방식을 연구하였다. SC-NMS 방식을 적용하여 시뮬레이션 한 결과, SC-NMS 방식은 SP 방식에 비해 0.1dB의 성능열화를 보였지만, 계산의 복잡도와 복호 속도를 고려했을 때, SC-NMS 방식이 최적의 CNU 계산 방식이라는 것을 확인하였다. In this paper, efficient CNU(Check Node Update) algorithms are analyzed for high speed LDPC decoding in DVB-S2 standard. In aspect to CNU methods, there are some kinds of CNU methods. Among of them, MP (Min Product) method is quite often used in LDPC decoding. However MP needs LUT (Look Up Table) that is critical path in LDPC decoding speed. A new SC-NMS (Self-Corrected Normalized Min-Sum) method is proposed in the paper. NMS needs only normalized scaling factor instead of LUT and compensates the overestimation of MP approximation. In addition, SC method is proposed. It gives a faster convergence toward a decoded codeword. If a message change its sign between two iterations, it is not reliable and to avoid to propagate noisy information, its module is set to 0. The performance of SC-NMS has a little degrade compare to MP by 0.1 dB, however considering computational complexity and decoding speed, SC-NMS algorithm is optimal method for CNU algorithm.

선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가

민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.

Endoscopic submucosal tunnel dissection salvage technique for ulcerative early gastric cancer.

Choi, Hyuk Soon,Chun, Hoon Jai,Seo, Min Ho,Kim, Eun Sun,Keum, Bora,Seo, Yeon Seok,Jeen, Yoon Tae,Lee, Hong Sik,Um, Soon Ho,Kim, Chang Duck,Ryu, Ho Sang WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.27

<P>Endoscopic submucosal dissection is an effective treatment modality for early gastric cancer (EGC), though the submucosal fibrosis found in ulcerative EGC is an obstacle for successful treatment. This report presents two cases of ulcerative EGC in two males, 73- and 80-year-old, with severe fibrosis. As endoscopic ultrasonography suggested that the EGCs had invaded the submucosal layer, the endoscopic submucosal tunnel dissection salvage technique was utilized for complete resection of the lesions. Although surgical gastrectomy was originally scheduled, the two patients had severe coronary heart disease, and surgeries were refused because of the risks associated with their heart conditions. The endoscopic submucosal tunnel dissection salvage technique procedures described in these cases were performed under conscious sedation, and were completed within 30 min. The complete en bloc resection of EGC using endoscopic submucosal tunnel dissection salvage technique was possible with a free resection margin, and no other complications were noted during the procedure. This is the first known report concerning the use of the endoscopic submucosal tunnel dissection salvage technique salvage technique for treatment of ulcerative EGC. We demonstrate that endoscopic submucosal tunnel dissection salvage technique it is a feasible method showing several advantages over endoscopic submucosal dissection for cases of EGC with fibrosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.</P>

HSS 기반의 고속 LDPC 복호기 FPGA 설계

김민혁(Min-Hyuk Kim),박태두(Tae-Doo Park),정지원(Ji-Won Jung) 한국전자파학회 2012 한국전자파학회논문지 Vol.23 No.11

본 논문에서는 DVB-S2에 제시된 LDPC 복호기에 대하여 효율적인 알고리즘을 제안하고 고속화 하여, 이에 따른 FPGA구현 결과를 제시하였다. 고속 LDPC 복호기를 구현하기 위해서는 알고리즘 측면과 구현 측면에서 여러가지 문제점이 있다. 알고리즘 측면에서는 첫째, LDPC 부호화 방식은 큰 블록 사이즈 및 많은 반복 횟수를 요구하므로 복호 속도를 높이기 위해서는 동일한 성능을 유지하면서 반복 횟수를 줄일 수 있는 알고리즘이 필요하다. 본 논문에서는 이를 위해 체크 노드를 기반으로 하여 복호화 과정을 거치는 horizontal shuffle scheduling(HSS) 알고리즘을 적용하여 기존의 반복 횟수를 줄일 수 있는 방안을 연구하였다. 구현 측면에서 복호 속도를 높이기 위해서는 데이터의 많은 병렬 처리가 필요하다. 이러한 병렬 처리에 의해 노드 업데이트 연산 역시 병렬처리가 가능하다. Check Node Update의 경우 look up table(LUT)이 필요하다. 이는 critical path의 주요 원인이 되는 부분으로 LUT 연산을 하지 않고 성능 열화를 최소화 하는 self-correction normalized min sum(SC-NMS) 연산방식을 제안하였고, 최적의 CNU 연산 방식에 따른 복호기 구조를 제안하고 FPGA 구현 결과, 복호 속도가 약 40 % 개선됨을 알 수 있다. LDPC decoder architectures are generally classified into serial, parallel and partially parallel architectures. Conventional method of LDPC decoding in general give rise to a large number of computation operations, mass power consumption, and decoding delay. It is necessary to reduce the iteration numbers and computation operations without performance degradation. This paper studies horizontal shuffle scheduling(HSS) algorithm and self-correction normalized min-sum(SC-NMS) algorithm. In the result, number of iteration is half than conventional algorithm and performance is almost same between sum-product(SP) and SC-NMS. Finally, This paper implements high-speed LDPC decoder based on FPGA. Decoding throughput is 816 Mbps.

Effect of Ar Plasma Treatment for Surface of Insert Metal on Property of TLP Bonding Joint for Power Module

Baek Seungju,Yu Dong-Yurl,Son Jun-Hyuk,Bang Junghwan,Kim Jungsoo,Kim Min-Su,Lee Han-Bo-Ram,고용호 대한용접접합학회 2020 대한용접·접합학회지 Vol.38 No.4

In this study, we investigated the effect of plasma treatment for the surface of an insert bonding metal on the prop�erties of a transient liquid phase (TLP) bonding joint for a power module. Sn preforms, as the insert bonding metal for the TLP bonding, were used with and without Ar plasma treatment. To investigate the effect of Ar plasma treat�ment, the TLP bonding for two structures of Cu-finished Si chip/Sn preform/organic solderability preservative (OSP)-finished direct bond copper (DBC) substrate (Cu/Sn/Cu), and Ni-finished Si chip/Sn preform/Ni(P)-finished DBC substrate (Ni/Sn/Ni) was performed with 1 MPa at 300 ℃ and the bonding times were 10, 30, and 60 min, respectively. After the TLP bonding, we observed interfacial reactions and formations of intermetallic compounds (IMCs) under various bonding conditions. To evaluate mechanical properties, a shear test was also performed. Compared to the TLP bonding joint that used bare Sn preforms without Ar plasma treatment, growth of IMCs at the bonding joint that used Sn preforms with Ar plasma treatment occurred faster, and the IMCs could be formed through the entire joint despite the bonding time of 10 min. Meanwhile, by increasing the bonding time, Cu6Sn5 and Cu3Sn were formed at the Cu/Sn/Cu TLP bonding joint, whereas Ni3Sn4, Ni-Sn-P, and Ni3P were observed at the Ni/Sn/Ni joint. In the case of the Cu/Sn/Cu joint, we observed that increasing Cu3Sn formation while increasing the bonding time could be beneficial to the shear strength of the joint. Further, shear strengths of the joint were not sig�nificantly changed under the bonding conditions after Ni3Sn4, Ni-Sn-P, and Ni3P IMCs were formed at the entire joint of the Ni/Sn/Ni.

HSS 기반 초고속 LDPC 복호를 위한 구조

이인기(In-Ki Lee),김민혁(Min-Hyuk Kim),오덕길(Deock-Gil Oh),정지원(Ji-Won Jung) 한국통신학회 2013 韓國通信學會論文誌 Vol.38 No.2B

본 논문은 위성방송 전송 규격인 DVB-S2의 기반 채널 부호로 사용되는 LDPC를 고속 복호를 위해 HSS(Horizontal Shuffle Scheduling) 방식을 기반으로 고속 복호기 구조를 연구하였다. 첫째로 HSS방식에서 발생하는 메모리 충돌을 극복하는 방식을 제시한다. 둘째로 고속 복호를 위해 LUT(Look Up Table)을 이용하는 Sum-Product 알로리즘 대신 min값에서 scaling factor를 곱하는 Normalized Min-Sum 알고리즘을 사용하였으며, 성능 향상을 위해 check node에서 bit node로 입력되는 값의 부호를 확인하여 신뢰성 없는 값을 삭제하는 Self-Correct 방식을 제시하여 sum-product 방식에서 발생하는 bottle neck 현상을 하였다. 마지막으로 고속화를 위한 효율적인 메모리 구조를 제안한다. This paper proposes the high speed LDPC decoder structure base on the DVB-S2. Firstly, We study the solution to avoid the memory conflict. For the high speed decoding process the decoder adapts the HSS(Horizontal Shuffle Scheduling) scheme. Secondly, for the high speed decoding algorithm normalized Min-Sum algorithm is adapted instead of Sum-Product algorithm. And the self corrected is a variant of the LDPC decoding that sets the reliability of a Mc→v message to 0 if there is an inconsistency between the signs of the current incoming messages Mv’→c and the sign of the previous incoming messages Moldv’→c This self-corrected algorithm avoids the propagation on unreliable information in the Tanner graph and thus, helps the convergence of the decoder.Start after striking space key 2 times. Lastly, and this paper propose the optimal hardware architecture supporting the high speed throughput.

일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성

주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-

Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.

향류마치스 효과를 갖는 새로운 히스톤 Hl 단백질 (p961)의 횐쥐와 토끼에 대한 약물동태

우수경(Su Kyung Woo),윤민혁(Min Hyuk Yun),이재홍(Jae Heung Lee),권광일(Kwang Il Kwon) 대한약학회 2001 약학회지 Vol.45 No.4

A purified histone Hl protein, p961, which plays a role in mediating the condensation of DNA into chromatin, was recently proved as an arthritis-suppressing agent in the mouse CIA model. The pearmacokinetics of p961 was carried out in rats and rabbits. The rat's blood, bile and urine samples were semially collected from the femoral vein, common bile duct, and bladder respective1y; after bolus I.v. injection at low (10 mghg) and high (30 mg/mg) doses. The rabbit's blood samples were also collected from the marginal ear vein after bolus I.Y. injection at a dose 10 mg/kg. P961 and its major metabolite in the physiological samples were analyzed by reverse-phase HPLC using a Vydac C4 protein column and a multistep water-acetonitrile gradient containing 0.24% trifluoroacetic acid. The major pharmacokinetic parameters (AUC, Cmax, MRT t1/2, Vss and Cl) were estimated from the time course of plasma p961 and metabolite concentrations using WinNonlin. A two- compartment model was chosen for p961 as the most appropriate pharmacokinetic model. After I.v, injection of p961 at doses of 10 mghg and 30 mg/kg, more than 80% of p961 was removed rapidly from the plasma within 15 min. The plasma half-life of p961 in rats and rabbits was found not to exceed 12 min. p961 (22448.9 mot wt) was rapidly cleaved to 21612 mol wt fragment and the breakdown product appeared rapidly in the circulation with no lag phase. P961 and metabolite were not detected in rat urine and bile.