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수소화된 비정질 규소박막의 정상상태 광전기 전도도 측정에 의한 재결합 과정의 연구
박혁렬,이주천 木浦大學校基礎科學硏究所 1985 基礎科學硏究誌 Vol.3 No.-
Steady-state photoconductivity measurements are made on thin films of hydrogenated amorphous silicon(a-Si-:H) prepared by RF glow discharge of silane(SiH₄) as a function of temperatures and excitation light intensities. The experimental results are explained on the basis of the proposed recombination model considering at least two set of localized states in addition to the extended electron and hole states.
Soo-Cheul Yoo,Bon-Hyuk Koo,Choon-Tak Kwon,Nam-Chon Paek 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Heading date and photoperiod sensitivity are fundamental traits that determine rice adaptation to a wide range of geographic environments. By quantitative trait locus (QTL) mapping and candidate gene analysis using wholegenome re-sequencing, we found that Oryza sativa Pseudo-Response Regulator37 (OsPRR37; hereafter PRR37) is responsible for the Early heading7-2 (EH7-2)/Heading date2 (Hd2) QTL which was identified from a cross of late-heading rice ‘Milyang23 (M23)’ and early-heading rice ‘H143’. H143 contains a missense mutation of an invariantly conserved amino acid in the CCT (CONSTANS, CO-like, and TOC1) domain of PRR37 protein. In the world rice collection, different types of nonfunctional PRR37 alleles were found in many European and Asian rice cultivars. Notably, the japonica varieties harboring nonfunctional alleles of both Ghd7/Hd4 and PRR37/Hd2 flower extremely early under natural long-day conditions, and are adapted to the northernmost regions of rice cultivation, up to 53° N latitude. Genetic analysis revealed that the effects of PRR37 and Ghd7 alleles on heading date are additive, and PRR37 down-regulates Hd3a expression to suppress flowering under long-day conditions. Our results demonstrate that natural variations in PRR37/Hd2 and Ghd7/Hd4 have contributed to the expansion of rice cultivation to temperate and cooler regions
양수호,전양빈,전순호,김혁,정원상,최요원,전석철,전석훈,박문향,지행옥,Yang, Soo-Ho,Chon, Yang-Bin,Chon, Soon-Ho,Kim, Hyuk,Chung, Won-Sang,Choi, Yo-Won,Chon, Suk-Chul,Chon, Suk-Hoon,Park, Moon-Hyang,Jee, Heng-Ok 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.2
악성 간엽종은 유아와 태생기에서 매우 드문 종양이다. 악성간엽종은 성인에서 극히 드물고 섬유조직이외의 둘 또는 그 이상의 간엽성분으로 구성된 종양으로 결체조직의 어떤 형태로도 분화할 가능성이 있는 태생기 간엽에서 기원한다고 생각된다. 환자는 61세 남자로 2개월 전 가래를 동반한 기침을 주소로 검사를 받던 중 우폐상부에 매우 큰 종괴를 보이는 암종으로 입원하였다. 환자는 우폐상부 미세침윤조직검사상 편평상피세포암 의심하에 우전폐절제술을 받았다. 수술장 소견상 종괴는 흉벽과 심하게 유착되었으며 우폐하부까지 침습된 소견을 보이는 악성간엽종으로 진단되었다. 환자는 수술후 5,000rad의 방사선 조사를 받고 수술후 6개월째인 현재까지 재발징후없이 경과 관찰중이다. Malignant mesenchymoma is a very rare tumor presented during the embryonic and infant period and malignant mesenchymoma in the adult is extremely rare. Tumor is composed of two or more unrelated mesenchymal derivatives apart from fibrous tissue. These tumors are thought to be originated from embryonic mesenchyme capable of differentiating into any type of connective tissue. A 61 years old man with complaints of cough and copious sputum of onset of two months was admitted after initial examinations, showing a very huge mass over the right upper lobe. Right pneumonectomy with partial rib resection of 3rd, 4th, and 5th ribs was performed due to the initial diagnostic impression of squamous cell carcinoma by the fine needle aspiration biopsy. The operative field presented a mass locating across the interlobal fissure with severe adhesions to the chest wall. Postoperatively, the patient received 5,000 rads of radiotherapy and presently, 6 months later, has shown no signs of recurrence.
Nutritional Functions of Milk and Dairy Products in Improving Human Health
Chon, Jung-Whan,Kim, Hyunsook,Kim, Dong-Hyeon,Lee, Soo-Kyung,Kim, Hong-Seok,Yim, Jin-Hyuk,Song, Kwang-Young,Kim, Young-Ji,Kang, Il-Byung,Jeong, Dana,Park, Jin-Hyeong,Jang, Ho-Seok,Seo, Kun-Ho Korean Society of Dairy Science and Biotechnology 2016 Journal of Dairy Science and Biotechnology (JMSB) Vol.34 No.1
Cow's milk and dairy products are elements of the human diet that could play an important role in improving human health. The macronutrients and micronutrients found in milk could supply the nutrients required to maintain human health. Among them, milk-derived bioactive peptides have been identified as potential ingredients found in health promoting functional foods. These bioactive peptides target diet-related chronic diseases, particularly non-communicable ones such as cardiovascular disease, diabetes and obesity. Additionally probiotics such as lactic acid bacteria (LAB) are can be considered live microorganisms that confer health benefits for the host-, when administered in adequate amounts. Further, the calcium, vitamin D, and protein content of milk and dairy products could play a role in proving bone health. The effect of milk and calcium on bone mineral density could prevent against fracture, osteoporosis and rickets. Furthermore, milk and dairy products also contain which factors that, which protect against dental caries (anti-cariogenic properties). This paper reviews the various nutritional functions of milk and dairy products in improving human health.
The clinical implications of FDG-PET/CT differ according to histology in advanced gastric cancer
Chon, Hong Jae,Kim, Chan,Cho, Arthur,Kim, Yoo Min,Jang, Su Jin,Kim, Bo Ok,Park, Chan Hyuk,Hyung, Woo Jin,Ahn, Joong Bae,Noh, Sung Hoon,Yun, Mijin,Rha, Sun Young unknown 2019 GASTRIC CANCER Vol.22 No.1
<P><B>Background</B></P><P>The prognostic impact of preoperative <SUP>18</SUP>F-FDG PET/CT in advanced gastric cancer (AGC) remains a matter of debate. This study aims to evaluate the prognostic impact of SUV<SUB>max</SUB> in preoperative <SUP>18</SUP>F-FDG PET/CT of AGC according to histologic subtype, with a focus on the differences between tubular adenocarcinoma and signet ring cell (SRC) carcinoma.</P><P><B>Methods</B></P><P>As a discovery set, a total of 727 AGC patients from prospective database were analyzed according to histologic subtype with Cox proportional hazard model and p-spline curves. In addition, another 173 patients from an independent institution was assessed as an external validation set.</P><P><B>Results</B></P><P>In multivariate analysis, high SUV<SUB>max</SUB> in preoperative <SUP>18</SUP>F-FDG PET/CT of AGC was negatively correlated with disease-free survival (DFS) and overall survival (OS) in patients with diffuse type (DFS: HR 2.17, <I>P</I> < 0.001; OS: HR 2.47, <I>P</I> < 0.001) or SRC histology (DFS: HR 2.26, <I>P</I> = 0.005; OS: HR 2.61, <I>P</I> = 0.003). This negative prognostic impact was not observed in patients with intestinal type or well or moderately differentiated histology. These findings have been consistently confirmed in a validation set. The p-spline curves also showed a gradual increase in log HR as SUV<SUB>max</SUB> rises only for SRC histology and for diffuse-type AGC. Finally, a novel predictive model for recurrence of AGC with diffuse type or SRC histology was generated and validated based on the preoperative SUV<SUB>max</SUB>.</P><P><B>Conclusions</B></P><P>Preoperative high SUV<SUB>max</SUB> of AGC is a poor prognostic factor in those with diffuse type or SRC histology. This study is the first to demonstrate the differential prognostic impact of preoperative PET/CT SUV<SUB>max</SUB> in AGC according to histologic subtype and provide a clue to explain previous discrepancies in the prognostic impact of preoperative PET/CT in AGC. Prospective studies are required to validate the role of preoperative SUV<SUB>max</SUB> in AGC.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1007/s10120-018-0847-5) contains supplementary material, which is available to authorized users.</P>
Chon, Hong Jae,Hyung, Woo Jin,Kim, Chan,Park, Sohee,Kim, Jie-Hyun,Park, Chan Hyuk,Ahn, Joong Bae,Kim, Hyunki,Chung, Hyun Cheol,Rha, Sun Young,Noh, Sung Hoon,Jeung, Hei-Cheul Lippincott, Williams, and Wilkins 2017 Annals of surgery Vol.265 No.5
<P><B>Objective:</B></P><P>The aim of this study was to analyze the clinicopathologic characteristics and prognosis of signet ring cell carcinoma (SRC) according to disease status (early vs advanced gastric cancer) in gastric cancer patients.</P><P><B>Background:</B></P><P>The prognostic implication of gastric SRC remains a subject of debate.</P><P><B>Methods:</B></P><P>A retrospective analysis was performed using the clinical records of 7667 patients including 1646 SRC patients who underwent radical gastrectomy between 2001 and 2010. A further analysis was also performed after dividing patients into three groups according to histologic subtype: SRC, well-to-moderately differentiated (WMD), and poorly differentiated adenocarcinoma.</P><P><B>Results:</B></P><P>SRC patients have younger age distribution and female predominance compared with other histologic subtypes. Notably, the distribution of T stage of SRC patients was distinct, located in extremes (T1: 66.2% and T4: 20%). Moreover, the prognosis of SRC in early gastric cancer and advanced gastric cancer was contrasting. In early gastric cancer, SRC demonstrated more favorable prognosis than WMD after adjusting for age, sex, and stage. In contrast, SRC in advanced gastric cancer displayed worse prognosis than WMD. As stage increased, survival outcomes of SRC continued to worsen compared with WMD.</P><P><B>Conclusions:</B></P><P>Although conferring favorable prognosis in early stage, SRC has worse prognostic impact as disease progresses. The longstanding controversy of SRC on prognosis may result from disease status at presentation, which leads to differing prognosis compared with tubular adenocarinoma.</P>
이상혁,김병익,전창욱,방기배,정은행,서정연,박은혜,설지수 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.1
Hepatocellular carcinoma(HCC) is the second leading cause of cancer-related deaths in South Korea. To decrease its mortality rate, its early detection is very important. Screening for HCC detection has been accepted as the management modality for patients with chronic liver disease. Reported herein is a case involving the marked rapid growth of HCC detected at an advanced stage in a screening test with a 3 months interval. A 49-year-old male patient with chronic hepatitis B was admitted to the hospital due to a liver mass detected on CT scan. The patient underwent a first CT scan 3 months earlier, and no tumor was detected. Follow-up CT scan was performed and showed a 9.1cm HCC with portal vein thrombosis. Percutaneous liver biopsy was performed, and the diagnosis of hepatocellular carcinoma was confirmed. In the pertinent guidelines, the recommended screening interval for HCC is 6-12 months, but the screening interval and additional diagnostic methods should be considered due to the variation in the HCC growth rate according to the patient’s clinical characteristics.