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기체 크로마토그래피를 이용한 유기산 및 아미노산의 동시분석에 관한 연구
金京禮,金正漢,朴炯國,鄭恩枝 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1
N(O, S)-isobutyloxycarbonylation with subsequent solid-phase extraction and tert.-butyl-dimethylsilylation was described for the simultaneous gas chromatographic analysis of 19 protein and 12 nonprotein amino acids and 26 organic acids from aqueous samples. Linear responses in the range of 10∼100 ppm were obtained for the most of compounds studied with the correlation coefficient varying from 0.993 to 0.999. When the present method was applied to wine samples, 13 organic acids and 13 amino acids were screened simultaneously.
정신분열환자의 발병연령과 항정신병약물 투여전후의 혈장 Homovanillic Acid, 3-Methoxy-4-Hydroxyphenylglycol농도의 연관성
하형래,이인상,한규희 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.5
Objectives : The authors investigated the possibility of homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations in plasma to be biological markers before and after the pharmacological treatment of schizophrenia. Methods : Twenty-six patients with schizophrenia were enrolled after two week washout of neuroleptics. Baseline sampling was done after washout. Consequent samplings were done at two and four week time-points after neuroleptic treatment. The concentrations of HVA and MHPG were analysed with clinical variables, such as age, age of onset, duration of illness, period of hospitalization, and changes of clinical state. The HVA and MHPG were assayed using high pressure liquid Chromatography-electrochemical detection method. Results : A significant association was observed between the age of onset and plasma HVA concentration in washout state of antipsychotics. The earlier onset group had lower plasma HVA concentration than the late onset group. A significant association was observed between the age of onset and plasma MHPG concentration in washout state of antipsychotics. The earlier onset group had lower plasma MHPG concentration than the late onset group. Conclusions : The present findings suggest that the activities of dopamine and norepinephrine are different with respect to age of onset in the neuroleptic-naive schizophrenia. Plasma HVA and MHPG concentration can be biological markers for the subgrouping of schizophrenia.
李炯來 진주산업대학교 1981 論文集 Vol.19 No.-
This study was carried out to investigate the variation of daily river flow of the Nam river before and after the construction of Namgang Dam. The Nam river is one of the branch of the Nakdong river. Obtained results are as fallows: (1) Distinct fluetuation of the runoff was occured before the dam was constructed depending on the season, while frequent runoff was appeared after the dam conctruction without regard to the season. (2) Before dam construction the probability of the runoff event during the period of October, November, December, and January was 0.13 while that the period other then October, November, December, and January was 0.25. For the period ofter dam construction, the probability or runoff event during October, November, December, and January was 0.435 which shows two times higher than the probability of the runoff event before dam construction in a same period. (3) The continuity of runoff event before and ofter dam construction was confrontly short during the period of the first term(June, July August) and second term(April, May, September) and was long during the period of the third term(February, March) and fourth term (October, November, December, and January). The number of continuous day of the runoff event in the first term and fourth term, the runoff event was occured continuosly for more than two days. (4) The Distribution frequency of the runoff euent was best fit to the theoretical distribution derived by professor Choi in the period of the first and second term throughout the whole period with regard to the dem construction. After the construction of the dem. the runoff records in second period in second period was best fit to the Fujiwhara and Nakata’s theory. In the period of 3rd and 4th term, no theory was appropriate to discribe the distribution of frequency runoff event. (5) The monthly probability distribution of daily runoff discharge shows nearly same distribution in the period other than December, January, and February, without regard to the construction of the dem. The general equation represents probability distribution was ??=α log c=b, and ??=a log c/u-c+b in which the value of α and b varies greatly depending on the month. The value α varies 0.385∼1.33058 b varies -0.582∼3.258.
김낙인,조항래,김형섭 대한의진균학회 1996 대한의진균학회지 Vol.1 No.1
Cutaneous ulcers due to candida infection are very rare condition, occurring almost in immunocompromised host or occuring as cutaneous manifestation of systemic candidal infection. A 52-year-old woman presented with cutaneous ulcer on dorsum of left hand which had lasted for about 15 days. Bacterial culture showed nonpathogenic organism, Enterobacter cloacae. Mycologic studies including KOH mount and fungus culture were positive for pseudohyphae and colonies of Candida species. A biopsy specimen from the center of ulcer revealed numerous spores and fungal hyphae in the upper dermis and necrotic epidermis. Bacterial culture and fungus culture of patient's serum and urine were negative. Initial treatment with antibiotics had no effectiveness for 2 weeks. After then we treated with antifungal drug, itraconazole 100mg/day. After 6 weeks of antifungal therapy, the skin lesion was much improved. We report this case, because it showed cutaneous ulcer due to candida infection but had neither systemic candidal infection nor clinical sign of immunosuppression.
돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학
윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.
A Negative-TC Controllable Voltage Reference Using MOS PTAT
Hyoung-Rae Kim,Yoon-Kyung Choi,Myunghee Lee,Yung-Hyun Jun,Bai-Sun Kong 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
A voltage reference having a maximum TC of-0.45%/℃ is presented. The proposed scheme comprises a MOS bandgap voltage reference, a PTAT voltage reference and a voltage subtractor. This circuit is designed using a 0.18-㎛ CMOS process, whose size is 450㎛×400㎛ and power consumption is 12.3㎼ at room temperature. The proposed scheme improves immunity to both process and resistor variation by 4 times of the conventional scheme (±20% → ±5%).