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Apoptosis Induced by 4-HPR on Human Stomach Adenocarcinoma Cell Line SNU1
( Hyou Youn Kim ),( Sang Woon Kim ),( Seong Yong Kim ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S
Purpose:Retinoids derived from vitamin A have diverse effects on development, morphogenesis, and homeostasis. They also have effects for prevention and treatment of cancers. In this study, the effect of N-(4-hydroxyphenyl) retinamide (4-HPR) on growth and/or proliferation of human gastric adenocarcinoma cell line SNU1 was investigated. Materials and Methods:The cytotoxic effect of 4-HPR was assessed by MTT assay. The apoptosis induced by 4-HPR was analyzed with cytoplasmic DNA Fragmentation, flow cytometry, and Western blot. 1) Results:4-HPR induced cell death of SNU1. The cytoplasmic DNA fragmentation was increased time dependently after treatment of 4-HPR and the cells in the sub-G0/G1 fraction of flow cytometric analysis were also increased time dependently after treatment of 4-HPR. The cleavage of caspase 3 and PARP were detected after treatment of 4-HPR to SNU1. The phosphorylations of Raf, ERK and AKT were induced by 4-HPR but after pre-treatment of MAPK inhibitor (PD98059) or PI-3 kinase inhibitor (LY294002) the 4-HPR-induced cytoplasmic DNA fragmentation, the cells in the sub-G0/G1 fraction fraction of flow cytometric analysis, and cleavage of caspase 3 and PARP were diminished in SNU1 cells. Conclusion:The results show that 4-HPR induces apoptosis of SNU1 and this 4-HPRinduced apoptosis may be mediated through ERK1/2 and PI3 kinase signaling pathways in SNU1.
Effectiveness of multichannel warning signal in an automated driving environment
Sang Myung Kim,Hyou Won Seo 대한인간공학회 2016 대한인간공학회 학술대회논문집 Vol.2016 No.11
Objective: This study aims to investigate the effectiveness of multichannel warning in different levels of automated driving environment. Background: As the driving environment changes from manual to fully automated setting, maintaining the driver’s situation awareness and notifying critical information to the driver gets more important. Since automated driving enables driver to perform other tasks than driving, it is important to give a timely notification according to the importance of information. Previous studies evaluated multimodal warning signal to reduce the response time and facilitate driver’s decision making, but the efficacy of multichannel warning in an automated driving was not fully validated yet. Method: We measured the reaction time to three modalities(visual, auditory and haptic) in three driving conditions(manual driving, monitored driving and automated driving) with 17 participants. Results: Statistical analysis result showed that visual channel is much more vulnerable than haptic and auditory channel. Driver’s response time is much longer in visual channel than auditory and haptic channel at all three driving conditions. Among three driving conditions, manual driving showed less change in response time than other environments. There was an interaction effect between modality and driving conditions. While the difference in modalities was significant at monitored and automated driving, there was no significant difference at manual driving. Lastly, participants were most satisfied with auditory stimuli, followed by haptic and visual stimuli. Conclusion: Contrary to our expectation that haptic and visual signals are more effective than auditory signal, in manual driving, drivers responded to auditory signal faster than others. Haptic and auditory signal showed constantly smaller variances than visual signal in all driving environments, which means that drivers can respond to auditory and haptic signal more reliably for all types of driving tasks. Application: The results of this study can help designing an effective warning signal system for automated driving environment.
이상헌,박성환,박동준,최문영,김호연,조철수,김한욱,임효영 대한내과학회 1995 대한내과학회지 Vol.48 No.2
Systemic lupus erythematosus (SLE) is an autoimmune systemic rheumatic disease that can involves various organs and systems. However, acute pancreatitis in SLE has uncommonly been reported and may be manifested as a part of the primary disease process of vasculitic or autoimmune etiology, or associated with drug therapy including corticosteroid, thiazide diuretic, and azathioprine. Two patients with SLE are reported here who developed acute pancreatitis, probably unrelated to drug therapy, confirmed by clinical manifestations, pancreatic isoenzyme elevation, and diffuse pancreatic enlargement on computerized tomography.
Joung, Hyou-Arm,Shim, Won-Bo,Chung, Duck-Hwa,Ahn, Jun-Hyoung,Chung, Bong-Hyun,Choi, Ho-Suk,Ha, Sang-Do,Kim, Keun-Sung,Lee, Kyu-Ho,Kim, Cheol-Ho,Kim, Kwang-Yup,Kim, Min-Gon Korean Society for Biotechnology and Bioengineerin 2007 Biotechnology and Bioprocess Engineering Vol.12 No.2
In this study, a specific monoclonal antibody against Listeria monocytogenes was screened using an SPR biosensor. Monoclonal antibodies were bound to protein L, after which the L. monocytogenes cells were subjected to an affinity assay. Protein L was immobilized on a carboxymethyl extran (CM-Dex) surface via an amine coupling method, and utilized repeatedly by regeneration. The monoclonal antibody, 'A18', was selected and employed for the high-sensitivity detection of L. monocytogenes. Under optimized conditions, $10^3 cells/mL$ or 50 cells were detected by the SPR biosensor.
運動選手의 身體構成 評價를 위한 體密度, 體脂肪率 推定式의 交叉妥當化 檢證
강상조,육현철,정현택,원신희,이승국,이병두,이미영,안효작,김기범,김광배,신범철,전승훈 韓國體育大學校附屬 體育科學硏究所 1995 韓國體育大學校附屬 體育科學硏究所論文集 Vol.14 No.1
The purpose of this study was to evaluate the body fat percent (%Fat) value from nine selected skinfold (SF) equations against a criterion value from hydrostatic weighing (HW) in male althetes.Nine SF equations were cross-validated in four different athletic events (n=73). Criterion percent body fat was determined by HW and computed from body density (BD) for a mixed sample of all event players (T), Swimming (SW: n=14), Taekondo (TA: n=24), Weight lifter (WL: n=l8), and Judo (JU: n=17). Results were analyzed by events using t-test. Analysis included computation of mean different (MD), correlation (r), standard error of estimation (SEE), total error (TE). Skinfolds had MDs ranging from -6.5%∼.19%(T), -3.25%~ -12.51% (SW), -4.98%~ .57% (TA). -4.3%~2.66% (WL), -6.1%~9.17% (JU), correlations (r) from .474~.563 (T), .567~.641(SW), .382-.589 (TA), .772 ~.872 (WL), .772-.821 (JU), SEEs from 3.47% ~ 3.6% (T), 2.68% ~ 2.88% (SW), 3.O2%~3.46% (TA) 1.9%~2.65% (WL), 2.9%~ 3.23%(JU), and TEs .7%~ 6.52%(T), 3.55%~12.51% (SW), 2.59%~5.02% (TA), 1.82%~ 4.5% (WL), 2.22%~ 6.06% (JU). The Kang, Lee, Lee, Cho (1994) and Kang, Lee, Lee (1995) SF equation provided the most valid prediction of HW determined %Fat in WL, demonstrating the highest correlation, lowest SEE and TE, and intercept and slope nearly closed 0.0 and 1.0, respectively.