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조정곤,김종면,최민순,채효석,강명대,송희종 全北大學校 附設 畜産開發硏究所 1987 畜産開發硏究報告 Vol.1 No.-
A total of 444 quarters milk samples of 111 dairy cattle in Chonbuk area were examined for infection rete and causative agents of mastitis by "the laboratory procedures used in the Connecticut Mastitis Control Program (CMCP) and California mastitis Test (CMT)". The results obtained were as follows: 1. Of 444 samples, 39.2% had positive CMCP value and 24.4% positive CMT reaction. 2. One hendred and seventy four (39.2%) from 82 cattle (73.9%) were found to infected with mastitis. It was found that 8(1.8%0 of the infected quarters were clinical mastitis and all of the rest were subclinical mastitis. 3. The main causative agents were found to Staphylococcus aureus (63 quarters), Streptococcus agalactiae (56 quarters), non-Str. agalactiae streptococci (54 querters), Escherichia coli (19 quaters), the actual total number of quarters detected as mastitis would be 174, as 18 of these quarters showed multiple infection with two different organisms. 4. Having examined the number of infection quarter per head of mastitis in dairy cattle sampling, major finding were that the average number of infection quarters to total dairy cattle exemined was 1.57 quarters, and that of the infected cattle was 2.1 quarters. Infected quarters in cattle with 1, 2, 3 and 4 were noted 27(32.9%), 28(34.1%), 17(20.7%), and 10(12.3%), respectively.
하악골에 발생한 다발성 중심성 골종 : 증례보고 REPORT OF A CASE
전효상,이문희,정해송,이동근,김성곤,조병욱 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4
Osteomas are benign tumor composed of mature compact or cancellous bone. Generally, they are classified as peripheral(periosteal) osteoma and central(endosteal) osteoma by origin. Osteomas are essentially restricted to the craniofacial skeleton and are rarely diagnosed in other bones. Most jaw osteomas are detected in young adults and are generally asymptomatic, solitary lesion. The authors present a case of a endosteal osteoma of the mandible. The lesion was located beneath both the mandibular first premolars, about 2.5㎝×1.5㎝ size. Surgical excision of the lesion was performed and we obtained good result after operation.
香砂平胃散 및 加減方이 白鼠의 摘出腸管運動에 미치는 影響
宋孝元,柳道坤,韓宗鉉,康舜洙 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1
Subtracting from component drugs by nine cases in Hyangsapyengwisan(香砂平胃散), its prescription and investigated the effect on contractile force of intestine in rats. The results obtained were as follows : 1. The effect of relaxation after contraction of rat ileum could be observed by administration of Hyangsapyengwisan. 2. By pretreatment with Atropine, the contractility of Hyangsapyengwisan was suppressed. 3. No change observed in contractile response of Hyangsapyengwisan by pretreatment with Cyproheptadine. 4. By pretreatment with Propranolol, the relaxation of Hyangsapyengwisan was suppressed. 5. The effect of relaxation after contraction of Hyangsapyengwisan was similar to that of Atractylodis Rhizoma. 6. The contractile response observed in subtracted Cyperi Rhizoma and Magnoliae Cortex from Hyangsapyengwisan, while growps in subtracted Atractylodis Rhizoma, Aurantii Nobilis Pericarpium Cyperi Rhizoma, Ponciri Fructus, Agatsachis Herba, Cyperi Rhizoma and Ponciri Fructus, Ponciri Fructus and Magnoliac Cortex from Hyangsapyengwisan showed the relaxation. These results suggest that Hyangsapyengwisan has a contractile effect which may be caused by the partial action of sympathetic and parasympathetic nervous system.
崔民淳,金鍾冕,趙正坤,蔡孝錫,姜明大,宋熹鍾 全北大學校 附設 畜産開發硏究所 1987 畜産開發硏究報告 Vol.1 No.-
A total of 189 strains (Streptococcus agalactiae and non-Streptococcus agalactiae 110, Staphylococcus aureus 63, and E. coli 16) isolated from bovine mastitie milk samples by "The Connecticut Mastitis Control Program" in dairy herds were examined for drug susceptibility to 8 drugs and analysed the rate of multiple resistant patterns. 1. All of the isolates were resistant to antimicrobial agents such as penicillin (PC), streptomycin (SM), kanamycin(KM), carbenicillin (CA), lincomycin (LM), gentamicin (GM), and tetracycline (TC), singly or multiply. The isolates were more susceptible to CA (84.1%),PC (78.9%), and SM (78.4%) than the the other drugs such as GM (51.8%), KM (48.7%), TC (19.6%) and LM (19.0%) in order. 2. The multiple resistant isolates (96.3%) were more than those of singly resistant isolates (3.7%) and 58 different drug resistant patterns were observed. Among 7 singly resistant isolates, CP was the commonest. While among 182 multiple resistant isolates, CP-KM-LM-TC-GM, CP-LM-TC, CP-LM-TC-GM, PC-CP-SM-LM-TC-GM, CP-KM-LM-TC, and CP-LM patterns were frequently encounted. 3. The strains of streptococcus spp. were more susceptible to CA (90.1%) and SM (82.9%) than the other drugs such as KM (43.2%), GM (38.7%), LM (13.5%), CP (10.8%) and TC (10.8%). Among them CP-KM-LM-TC-CM pattern was frequently encounted. 4. The strains of Sta. aureus were more susceptible to PC (74.6%),CA (69.8%), SM (65.1%) and GM (63.5%) than the other drugs such as KM (46.0%), CP (22.2%), TC (15.9%) and LM (9.5%). Among them CP-LM-TC pattern was commonly encounted. 5. The strains of E. coli were more susceptible to CA (100%) and KM (75.0%) tnan TC (9.5%). But the other drugs such as PC, SM, GM, CP and LM were not. Among them PC-CP-SM-LM-TC-GM pattern was commonly encounted.
Kim, Hyo-Jin,Nam, Soon-Hyeun,Kim, Hyun-Jung,Park, Hyo-Sang,Ryoo, Hyun-Mo,Kim, Shin-Yoon,Cho, Tae-Joon,Kim, Seung-Gon,Bae, Suk-Chul,Kim, In-San,Stein, Janet L.,van Wijnen, Andre J.,Stein, Gary S.,Lian, Liss 2006 Journal of Cellular Physiology Vol.207 No.1
<P>Cleidocranial dysplasia (CCD) is an autosomal dominant disorder caused by haploinsufficiency of the RUNX2 gene. In this study, we analyzed by direct sequencing RUNX2 mutations from eleven CCD patients. Four of seven mutations were novel: two nonsense mutations resulted in a translational stop at codon 50 (Q50X) and 112 (E112X); a missense mutation converted arginine to glycine at codon 131 (R131G); and an exon 1 splice donor site mutation (donor splice site GT/AT, IVS1 + 1G > A) at exon 1–intron junction resulted in the deletion of QA stretch contained in exon 1 of RUNX2. We focused on the functional analysis of the IVS1 + 1G > A mutation. A full-length cDNA of this mutation was cloned (RUNX2Δe1) and expressed in Chinese hamster ovary (CHO) and HeLa cells. Functional analysis of RUNX2Δe1 was performed with respect to protein stability, nuclear localization, DNA binding, and transactivation activity of a downstream RUNX2 target gene. Protein stability of RUNX2Δe1 is similar to wild-type RUNX2 as determined by Western blot analysis. Subcellular localization of RUNX2Δe1, assessed by in situ immunofluorescent staining, was observed with partial retention in both the nucleus and cytoplasm. This finding is in contrast to RUNX2 wild-type, which is detected exclusively in the nucleus. DNA binding activity was also compromised by the RUNX2Δe1 in gel shift assay. Finally, RUNX2Δe1 blocked transactivation of the osteocalcin gene determined by transient transfection assay. Our findings demonstrate for the first time that the CCD phenotype can be caused by a splice site mutation, which results in the deletion of N-terminus amino acids containing the QA stretch in RUNX2 that contains a previously unidentified second nuclear localization signal (NLS). We postulate that the QA sequence unique to RUNX2 contributes to a competent structure of RUNX2 that is required for nuclear localization, DNA binding, and transactivation function. J. Cell. Physiol. 207: 114–122, 2006. © 2005 Wiley-Liss, Inc.</P>
유압식 로봇의 힘 제어를 위한 유압 서보 시스템의 특성에 관한 연구
김효곤(Hyo-gon Kim),이종원(Jong-won Lee),박상덕(Sangdeok Park),한창수(Changsoo Han) 대한기계학회 2015 大韓機械學會論文集A Vol.39 No.2
유압 서보 시스템은 구동기 단에서 부피 대비 큰 힘을 출력할 수 있으므로 로봇에 적용 시, 로봇의 팔 또는 다리를 경량화할 수 있다. 이것은 로봇의 동적 특성과 에너지 효율을 향상 시키므로 고출력이 필요한 몇몇의 근력지원용 착용형 로봇과 사족 보행 로봇들은 유압 서보 시스템을 사용한다. 이 로봇들은 사용자나 외부 환경에 순응하기 위해 힘제어를 하는 것이 유리하지만 유압식 로봇은 유압 서보 시스템이 갖는 비선형성으로 인해 정교한 힘제어가 쉽지 않다. 본 논문에서는 서보 밸브, 배관 그리고 유압 실린더로 구성되는 유압 서보 시스템의 시뮬레이션 모델을 개발하여 유압 서보 시스템의 힘제어 시 고려해야 할 사항에 대해 분석하였다. 그리고 비선형 모델을 이용한 힘제어 기법을 제안하고 시뮬레이션을 통해 효과를 검증하였다. Because a hydraulic actuator has high power and force densities, this allows the weight of the robot"s limbs to be reduced. This allows for good dynamic characteristics and high energy efficiency. Thus, hydraulic actuators are used in some exoskeleton robots and quadrupedal robots that require high torque. Force control is useful for robot compliance with a user or environment. However, force control of a hydraulic robot is difficult because a hydraulic servo system is highly nonlinear from a control perspective. In this study, a nonlinear model was used to develop a simulation program for a hydraulic servo system consisting of a servo valve, transmission lines, and a cylinder. The problems and considerations with regard to the force control performance for a hydraulic servo system were investigated. A force control method using the nonlinear model was proposed, and its effect was evaluated with the simulation program.
Moon, Hyo-Gon,Lee, Eui-Joong,Kim, Yong-Tai Land and Housing Institute 2011 LHI journal of land, housing, and urban affairs Vol.2 No.4
In the merged organization, the efforts of integration such as various PMI activities, etc. are exerted and the performance of PMI can be judged by evaluating the effectiveness of an organization. In this paper, the empirical analysis was conducted to see what effects of 'planned PMI activities' and 'voluntary integration efforts' have on the effectiveness of an organization which is 'Organizational Commitment', 'Job Satisfaction', 'Emotional Integration' and 'Shared Value Recognition'. The survey was made on the employees of LH, which is a representative case of public corporation advancement, and SPSS 17.0 and AMOS 17 were used for the analysis. As a result of the analysis of a structural equation model, it indicated that both 'planned PMI activities' and 'voluntary integration efforts' have direct influence on 4 indices of effectiveness of an organization respectively. In particular, it was found that 'planned PMI activities' affects 'Shared Value Recognition' the most and 'voluntary integration efforts' has the largest effect on 'Emotional Integration'. Through this study, it was verified that voluntary integration efforts of members as well as the planed formal PMI activities are also very important factor of effect on the integration performance of an organization.