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Lung Transplantation in Six Patients with Idiopathic Pulmonary Artery Hypertension
( Hyeonhwa Kim ),( Dongkwan Kim ),( Sehoon Choi ),( Geundong Lee ),( Dongkyu Oh ),( Hocheol Kim ),( Jaeseung Lee ),( Sungho Jung ),( Pilje Kang ),( Won Kim ),( Seungil Park ),( Sangbum Hong ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Idiopathic pulmonary artery hypertension (IPAH) is an incurable and invariably fatal disease. Lung transplantation is a useful therapeutic option in patients who are unresponsive to medical treatment; however, lung transplantation performed for pulmonary hypertension is associated with significantly high perioperative mortality rates. We report a case series of six patients who underwent lung transplantation for IPAH between October 2008 and June 2021. Patients’ median age was 28.5 years, and the study included 5 of 6 women (83%). Pre-transplantation hemodynamic parameters showed mean right atrial pressure of 12.0±7.1 mmHg and mean pulmonary artery pressure of 62.2±29.5 mmHg. Two of six patients received extracorporeal membrane oxygenation (ECMO) therapy as a bridge to transplantation over 14 and 17 days, and four patients underwent elective transplantation. Two patients required prolonged postoperative venoarterial (V-A) ECMO support. Grade 3 primary graft dysfunction occurred in one patient; however, the clinical course improved following prolonged V-A ECMO therapy. Five patients (83.3%) required intervention for postoperative bleeding control; one of these patients died of uncontrolled bleeding concomitant with disseminated intravascular coagulation, on the 14th postoperative day, and we observed no other perioperative deaths. One patient died of carbapenem-resistant Acinetobacter baumannii bacteremia, a year postoperatively. The 1-month, 6-month, and 1-year survival rates were 83.3%, 83.3%, and 66.7%, respectively. In view of the poor prognosis of IPAH, lung transplantation (1-year mortality rates <40%) merits consideration as a useful therapeutic option in this patient population. However, postoperative bleeding tends to occur in most patients; therefore, close monitoring is important during post-transplantation management.
블루베리 농축식초 제조 및 이들의 항산화 및 항균 활성
오현화(Hyeonhwa Oh),장소원(Sowon Jang),전현일(Hyun-Il Jun),정도연(Do-Youn Jeong),김영수(Young-Soo Kim),송근섭(Geun-Seoup Song) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.6
본 연구에서는 다양한 생리활성을 가졌다고 알려진 블루베리의 식품산업 이용률을 높이고자 블루베리 농축식초를 제조하였으며, 종초가 블루베리 농축식초의 이화학적 특성, 항산화 활성 및 항균 활성에 미치는 영향을 조사하였다. 선정된 주모용 효모(Saccharomyces cerevisiae SRCM 100610), 종초용 초산균(Acetobacter pasteurianus SRCM 101342) 및 블루베리 농축액을 활용하여 제조한 블루베리 농축식초의 당도, pH, 총산도, 총 페놀성 화합물, 갈변도(280 nm과 420 nm)는 각각 11.05~12.70°Brix, 2.63~2.98, 1.65~5.72%, 3.03~4.24 mg/mL, 0.95~1.50 및 0.11~0.20이었으며, 종초 첨가량이 증가할수록 당도와 총산도는 증가하였으나 pH, 총 페놀성 화합물 및 갈변도는 감소하였다. 항산화 활성은 DPPH 라디칼 검정, ABTS 라디칼 검정 및 환원력에서는 control이 가장 낮은 EC50 값(23.80, 19.48 및 79.21배의 희석배율)을 보였으나 SOD 유사 활성에서는 종초 40% 첨가구가 가장 낮은 EC50 값(46.19배의 희석배율)을 나타내었다. 항균 활성은 종초 40% 첨가구의 clear zone diameter 값이 Escherichia coli KACC 10115에서는 4.31, Staphylococcus aureus KACC 1927에서는 4.59, Listeria monocytogenes KACC 10764에서는 5.81 및 Bacillus cereus KACC 10097에서는 3.97로 가장 높게 나타났다. 한편 항산화 활성은 총 페놀성 화합물 함량, 갈변도(at 280nm), pH 및 총산도의 결정계수(R<SUP>2</SUP>) 값이 0.82~0.99를, 항균 활성에서는 pH와 총산도의 R<SUP>2</SUP> 값이 0.92~0.99 이상의 높은 값을 나타내어 강한 상관성을 보였다. 결과적으로 선정된 주모용 효모, 종초용 초산균 및 블루베리 농축액을 활용하여 제조한 블루베리 농축식초는 건강 기능성 식품으로의 가능성이 있다고 판단된다. This study was carried out to investigate the effects of seed vinegar on antioxidant activity and antimicrobial activities of concentrated blueberry vinegar (CBV). Of the nine strains of yeast and six strains of acetic acid bacteria provided by the Microbial Institute for Fermentation Industry, each strain of yeast (Saccharomyces cerevisiae SRCM 100610, showing the highest ethanol content) and acetic acid bacteria (Acetobacter pasteurianus SRCM 101342, showing the highest total acidity) was selected for production of CBVs. Sugar content, pH, total acidity, total phenolic content (TPC), and browning intensity (280 nm and 420 nm) in CBVs using concentrated blueberry juice were 11.05∼12.70°Brix, 2.63∼2.98, 1.65∼5.72%, 3.03∼4.24 mg/mL, 0.95∼1.50, and 0.11∼0.20, respectively. Sugar content and total acidity of CBVs increased upon addition of seed vinegar, whereas pH, TPC, and browning intensity decreased. Of all CBVs with various additions of seed vinegar, the control showed the lowest EC50 values in DPPH radical scavenging assay, ABTS radical scavenging assay, and reducing power (23.80, 19.48, and 79.21 dilution factor, respectively), whereas the 40% seed vinegar group showed the highest clear zone diameter values for Escherichia coli, Staphylococcus aureus, Listeria monocytogenes, and Bacillus cereus (4.31, 4.59, 5.81, and 3.97, respectively). Antioxidant activities of CBVs were closely correlated with their TPC, browning intensity at 280 nm, pH, and total acidity values, showing correlation determination coefficient (R<SUP>2</SUP>) values higher 0.82. However, antimicrobial activities of CBVs were closely correlated with their pH and total acidity values, showing higher R<SUP>2</SUP> values more than 0.92. These results suggest that CBVs using concentrated blueberry juice, S. cerevisiae SRCM 100610, and A. pasteurianus SRCM 101342 may be useful as potentially functional foods for enhancing health.
종합병원 간호사의 환자안전문화 인식이 환자안전간호 활동에 미치는 영향
홍현화 ( Hyeonhwa Hong ),이은주 ( Eunjoo Lee ) 이화간호과학연구소 2021 Health & Nursing Vol.33 No.2
Purpose: This study aimed to identify the relationships between patient safety culture perception and patient safety care activities, and address the factors influencing patient safety care activities. Methods: Participants comprised 247 nurses working at three general hospitals located in the Changwon, South Korea area. Self-questionnaires were used to collect the data, and were administered between January 25 and 31, 2018. Data were analyzed using descriptive statistics, t-tests, Pearson's correlation coefficients, and multiple regression analysis with SPSS/WIN 21.0 software. Results: There were significant positive relationships between patient safety culture perception and patient safety care activities (r=.57, p<.001). Factors influencing patient safety care activities among the participants were identified as patient safety knowledge and attitude (β=.20, ρ=.006), working in a non-punitive environment (β=.18, ρ=.007), and age (β=.15, ρ=.040). The explanation power of the regression model was 35.8%. Conclusion: The results suggest that to enhance patient safety care activities, it is necessary to improve nursing education concerning patient safety knowledge and attitude, especially considering age. In addition, a nurses will benefit from working in a non-punitive environment.