자가세포를 배양하여 만든 조직공학적 인공 심장 판막

이택연,방정현 침례병원 2003 浸禮病院學術誌 Vol.19 No.-

일부 농촌지역 주민의 모발중 금속 농도 분포

고현송,심운택,조영채 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

In order to know the concentration of some metals in human hairs from residents living in rural area, the 88 hair samples were taken from Kunbuk-Myon residents during the period from August through October, 1990. The 4 elements(Pb, Cd, Mn, and Zn) in human hair were determined by atomic absorption spectrophotomer with flame and grapite furnace atomizer systems using wet ashing procedure. The results were as follows: 1. The mean concentrations of metals in human hair of the total 88 samples were: Pb was 3.14±1.63㎍/g, Cd was 0.81±0.71㎍/g, Mn was 4.02±3.86㎍/g, Zn was 199.11± 80.33㎍/g, and in the males: Pb was 3.51±1.54㎍/g, Cd was 0.84±0.63㎍/g, Mn was 3.95±4.78㎍/g, Zn was 215.88±76.76㎍/g, and in the females: Pb was 3.34±1.69㎍/g, Cd was 0.79±0.77㎍/g, Mn was 4.08±2.95㎍/g, Zn was 186.36±82.90㎍/g 2. There were no significant differences among 4 elements (Pb, Cd, Mn, Zn) by Age groups, by exposed to pesticides and by exposed years to pesticides. 3. In males, there were negative correlation between age and Cd level(r=-0.2860, P<0.05), between Cd and Zn(r=-0.3760, P<0.01), and significant positive correlations between Pb and Zn(r=0.2881, P<0.05). In females, there was significant positive correlations between Pb and Zn(r=0.3096, P<0.01).3 4. There were positive correlations between Pb and Cd(r=0.1835, P<0.05) and between Zn and Pb(r=0.3049, P<0.01), but there was negative correlation between Mn and Cd(r=-0.1817, P<0.05).

원발성 폐암 환자의 생존율에 관한 보고

김현태,이상무,어수택,박춘식,정성환,허승재,남충희,강창희,김용훈 순천향대학교 1994 논문집 Vol.17 No.4

We analysed 404 patients with primary lung carcinoma who were treated at Soonchunhyang University Hospital from July, 1985 to september, 1993 in order to investigate the survival rate and epidemiolgical properties of primary lung cancer. They were 330 males and 74 females. The most prevalent decade was seventh. In terms of cell type, the squamous cell was 225 patients (55%), and adenocarcinoma, small cell, mixed type was 21%, 19%, 4%, respectively. Among non-small cell lung carcinoma, stage Ⅲa was the most prevalent one(92%). In case of small cell carcinoma, the limited stage was 64%. The 12-, 24-, 36- month survival rate of total patients was 57%, 31%, 22%, respectivley and median sruvival time was 15 months. The 36-month survival rate tended to be longer in non-small cell lung carcinoma than that of small cell lung cancer, but there was no difference between two groups, statistically. In non-small cell carcinoma, The 36-month survival rate and meidan survival time were longer in the stage Ⅰ and Ⅱ than those of Ⅲa, Ⅲb, Ⅳ (80% versus 38%, 22%, 0%, p<0.05). According to involvement of lymph node, the 36-month survival rate was longer in NO and N1 than those of N2, N3 (61.9%, 48.7% versus 17.7%, 17.3%, p<0.05). In small cell carcinoma, The 36-month survival rate and median survival rate were higher and longer in limited stage than those of extensive stage(16.1% and 13 month vs 10% and 8 month, p<0.05). In conclusion, we report here the incidence of primary lung carcinoma and the survival rate of paients with primary lung carcinoma who were treated in Soonchunhyang University Hospital.

하올리브 손상이 순막 조건반응의 파지 및 전이훈련에 미치는 효과

윤영화,김현택,한정수 한국심리학회 1989 한국심리학회지 생물 및 생리 Vol.1 No.1

순막조건화에 관련된 신경회로에서 소뇌가 결정적으로 중요한 구조물이라는 실험적 증거가 축적되었으며 소뇌로 들어가는 주된 입력중 하나인 등상섬유가 무조건자극정보를 소뇌로 전달할 것이라는 이론이 제안되었다. 등상섬유는 하올리브에서 기시하며 특히 눈가의 체감각정보를 받는 영역이 하올리브의 문내측 부위이다. 본연구는 순막조건화에서 하올리브의 역할을 규명하기 위하여 소리를 조건자극, 안와주변전기쇼크를 무조건자극으로 사용하여 토끼의 오른쪽눈을 순막조건화시킨 후 문내측 하올리브를 손상시켰다. 2주일간의 회복기간후 재훈련시켰다. 실험결과, 문내측 하올리브가 손상된 피험동물들은 오른쪽눈의 조건반응의 파지 및 재학습이 불가능하였으며 왼쪽눈 역시 학습되지 않았다. 이는 하올리브가 순막조건화에 관련된 신경회로에서 중요한 구조물임을 나타낸다. It has been demonstrated that the cerebellum is a critically important structure for the conditioning of nictitating membrane response(NMR). The aim of the experiment was to determine whether inferior olive is part of a neural circuit which provides unconditioned stimlus(US) information to the cerebellum during NMR conditioning. Rabbits were lesioned on the inferior olive after they were conditioned using tone as conditioned stimulus(CS) and periorbital shock as US. And then 2-week of recovery period was followed by retraining period. Lesions of the rostro-medial portions of the inferior olive(rmIO) abolished the conditioning and prevented subsequent acquisition on either side. The lesion had no effect on the performance of the unconditioned response. Lesions of the lateral portions to and those of dorsal portions above the rmIO did not impair NMR conditioning. The results suggest rmIO is an essential part for the NMR conditioning.

급속응고된 N-type Bi₂Te_(2.75)Se_(0.15) 열전재료의 미세조직과 열전특성에 미치는 압출비의 영향

김태경,이상일,임종호,손현택,김택수,천병선 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.1

The n-Type thermoelectric compounds of Bi₂Te_(2.75)Se_(0.15) doped with 0.1 wt% SbI₃ were fabricated by gas atomization process and extruded under ratio of 16:1 and 28:1 at 450℃. The effect of extrusion ratio on the microstructures and thermoelectric properties were investigated by a combination of microscopy, XRD and thermoelectric properties. Grains of extruded bars are smaller than those of heated powder at extrusion temperature (450℃) due to the dynamic recrystallization but with increasing the amount of plastic deformation, grains of specimen extruded with 28:1 were slightly coarse. The compressive strength of hot extruded bar under 28:1 is 160 MPa and with decreasing the extrusion ratio to 16:1, the value is 250 MPa. The Seebeck coefficient a and electrical resistivity p were decreased with increasing ratio, while thermal conductivity x was increased. this results from decrease of carrier scattering and increase of carrier mobility. Extruded bar under ratio of 16:1 shows the higher value of figure of merit (Z=2.50x10^(-3)/K) than that of 28:1 (Z=2.07x10^(-3)/K). (Received June 24, 2004)

위암세포주에서 Recombinant Human Interferon-r와 Adriamycin의 투여순서가 항암효과에 미치는 영향

홍원선,손영숙,김창민,강윤구,이춘택,김유철,임영혁,남현석,이진오,강태웅 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

Numerous previous studies, both in vitro and in vivo, have demonstrated that the cytotoxicity can be enhanced by the combination of chemotherapeutic agent and interferons(IFNs) in various types of cancer cells. We have previously reported that combined treatment of MKN-45, human gastric adenocarcinoma cells, with adriamycin(ADM) and recombinant human interferon-r(rh-IFN-r) increased in the cytotoxicity. In this study, the effects of combination timing of rh-IFN-r and ADM on the cytotoxicity against MKN-45 were investigated using MTT assay. MKN-45 was treated with rh-IFN-r and ADM in vitro on three schedules : Treat A ; rh-IFN-r and ADM were treated simultaneously, Treat B ; rh-IFN-r was treated 24 hours after the treatment with ADM, Treat C ; rh-IFN-r was treated for 72 hours and followed by the treatment with ADM. The survival of MKN -45 was inhibited by ADM dose-dependently. 102 and 103U/ml of rh-IFN-r significantly inhibited the survival of MKN-45(% survival : 35.1 ±-1.2% and 34.4 ±1.1% in Treat A and 42.5 ± 2.1% and 45.9-±2.5% in Treat C, respectively). However no difference in the survival was observed between 102 and 103U/ml of rh-IFN-r. Combined treatment with rh-IFN-r and ADM significantly augmented the cytotoxicity at low concentrations of ADM. Combined effects of rh-IFN-r and ADM were evaluated using IC30(,ag/ml) to ADM. IC30s of MKN-45 in Treat A, B and C at 102 U/ml of rh -IFN-r _ were 0.019 -?- 0.003, 0.045 :I:0.001 and 0.054 ± 0.012, respectively, while IC30 of MKN-45 treated with ADM alone was 0.052±0.004. IC30s of MKN-45 in ADM alone group, Treat A, Treat B and Treat C at 103U/ml of rh-IFN-r were 0.047 ±0.003, 0.004 -±0.001, 0.031 ±0.004 and 0.056 0.008, respectively. These results indicate IC30s of Treat A and B were significantly lower than those of ADM alone(p<0.05) and IC30s of Treat A was significantly lower than those of Treat B(p <0.01). IC30s of Treat C, however, were not different from those of ADM alone. From these results demonstrating that cytotoxic effects were increased by the combination of rh-IFN-r and ADM in the order, Treat A > Treat B> Treat C, it can be concluded that the simultaneous administration of rh-IFN-r and ADM may be the most effective method to combine these two therapeutic modalties.

Highly flexible dielectric composite based on passivated single-wall carbon nanotubes (SWNTs)

Hyeon-Taek Jeong,Yong-Ryeol Kim 한국유화학회 2015 한국응용과학기술학회지 Vol.32 No.1

Single-walled carbon nanotubes (SWNTs) was modified with various length of linear alkyl chains and passivated to form dielectric filler. The modified SWNTs embedded into epoxy matrix to fabricate a flexible composite with high dielectric constant. The dielectric behavior of the composite was significantly changed with various alkyl chain length(n) of pyrene. The dielectric constant of the epoxy/SWNTs composite significantly increased with respect to increase in length of alkyl chain at the frequency range from 10 to 105Hz (n=12and18).We also found that the passivated epoxy/SWNTs composite with high dielectric constant presented low dielectric loss. The resulted dielectric performances corresponded to de-bundling of nanotubes and their distribution behavior in the matrix in terms of tail length of alkyl pyrene in the passivation layer.

Stability evaluation of a proportional valve controller for forward-reverse power shuttle control of agricultural tractors

Hyeon-Ho Jeon,Taek-Jin Kim,Wan-Soo Kim,Yeon-Soo Kim,Chang-Hyun Choi,Yong-Hyeon Kim,Yong-Joo Kim 충남대학교 농업과학연구소 2021 Korean Journal of Agricultural Science Vol.48 No.3

Highly flexible dielectric composite based on passivated single-wall carbon nanotubes (SWNTs)

Hyeon-Taek Jeong,Yong-Ryeol Kim 한국유화학회 2015 한국응용과학기술학회지 Vol.32 No.1

Single-walled carbon nanotubes (SWNTs) was modified with various length of linear alkyl chains and passivated to form dielectric filler. The modified SWNTs embedded into epoxy matrix to fabricate a flexible composite with high dielectric constant. The dielectric behavior of the composite was significantly changed with various alkyl chain length(n) of pyrene. The dielectric constant of the epoxy/SWNTs composite significantly increased with respect to increase in length of alkyl chain at the frequency range from 10 to 105 Hz (n=12and18). We also found that the passivated epoxy/SWNTs composite with high dielectric constant presented low dielectric loss. The resulted dielectric performances corresponded to de-bundling of nanotubes and their distribution behavior in the matrix in terms of tail length of alkyl pyrene in the passivation layer.

Effects of 2-week repeated intratracheal instillation of vehicles on mice lung

Hyeon-Young Kim,In-Hyeon Kim,Sun-Taek Leem,Sung-Hwan Kim 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.7