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Metabotropic Glutamate 수용체와 불안
박영민,이현륭,이승환,Park, Young-Min,Yi, Hyeon-Lyung,Lee, Seung-Hwan 대한불안의학회 2007 대한불안의학회지 Vol.3 No.1
Although treatments of anxiety symptom have been available for decades, the biological basis for anxiety disorders in humans is just beginning to emerge. Recently, there is a growing body of literature suggesting that group II metabotrpic glutamate (mGlu) receptors and group I mGlu receptors are important in the physiological and behavioral sequelae associated with stressful stimuli. Moreover, compounds selective for mGlu receptors, particularly mGlu2/3 and/or mGlu5, have proven as effective as classical anxiolytics in various animal models of anxiety without producing many of the unwanted side effects that are typical of current therapies. This article will focus on the emerging preclinical and clinical data that implicate modulation of the mGlu receptors as a potential anxiolytic strategy.
정신분열형 인격 성향이 정상인의 안면 표정 인식 능력에 미치는 영향
이현륭,김승연,추정숙,이경욱,채정호,박영민,김현,이강준,정영조,이승환,Yi, Hyeon-Lyung,Kim, Seung-Yeon,Choo, Jung-Suk,Lee, Kyoung-Uk,Chae, Jeong-Ho,Park, Young Min,Kim, Hyun,Lee, Kang Joon,Chung, Young-Cho,Lee, Seung-Hwan 대한생물정신의학회 2008 생물정신의학 Vol.15 No.4
Objectives : The purpose of this study is to investigate whether the ability of facial affect perception is associated with schizotypal personality traits in healthy normal controls. Methods : 241 normal subjects were recruited in this study. The age range of all subjects was from 19 to 63 years. The schizotypal personality questionnaire(SPQ) and facial affect identification test(FAIT), which were developed and standardized in Korea, were applied. Subjects from high 1 standard deviation(H group, N=40) and low 1 standard deviation(L group, N=26) on SPQ score were compared. Results : We found that the H group showed significantly reduced ability on the correctness of sadness and neutral compared with the L group. But, no significant association between SPQ and intensity or reaction point was observed in all subjects. Conclusion : This study suggests the individuals with high schizotypal personality trait have impairments on the facial affect identification. Also, these findings may provide the reasonable explanation of social cognition deficit of schizotypal personality disorder.