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Hyehyun Ahn,HoJung Nam 한국디자인학회 2015 한국디자인학회 학술발표대회 논문집 Vol.2015 No.10
In the interactive agencies in the US, we have often observed in numerous projects that the clients ended up selecting rather practical and safe design options, despite their early enthusiasm about experimental design aspects. This conservatism was generally observed in other credit card companies, while innovative design elements were aggressively adopted in the banners and social media. Based on these observations, we examine the paradoxical combination of traditional and experimental design aspects found in the interactive advertisements of the financial service industry. We also discuss the trend and origin of the blend, so that future designers can better understand their clients in the financial service industry and provide realistic design solutions.
Anti-inflammatory activity of 6-O-phospho-7-hydroxycoumarin in LPS-induced RAW 264.7 cells
Hyehyun Hong,Tae-Jin Park,Sungchan Jang,Min-Seon Kim,Jin-Soo Park,Won-Jae Chi,Seung-Young Kim 한국응용생명화학회 2022 Journal of Applied Biological Chemistry (J. Appl. Vol.65 No.1
Esculetin (also known as 6, 7-dihydroxycoumarin) a type of coumarin, has been exhibited anti-inflammatory and antiaging effects. Biorenovation is the microbe-mediated enhancement of biological efficacies and structurally diversified compounds relative to their substrate compounds. The production of different kinds of esculetin derivatives using Bacillus sp. JD3-7 and their effects on lipopolysaccharide (LPS)-triggered inflammatory response in RAW 26.7 cells were assessed. One of the biorenovation products, identified as esculetin 6-O-phosphate (ESP), at concentrations of 1.25, 2.5, and 5 μM inhibited the LPSstimulated production of inflammation markers of nitric oxide synthase 2 and cyclooxygenase 2 as well as their respective enzymatic reaction products of nitric oxide and prostaglandin E2 in the order of increasing concentrations (1.25, 2.5, and 5 μM). Additionally, ESP treatment suppressed the LPS-stimulated secretion of pro-inflammatory cytokines of interleukin (IL)-1β, IL-6, and tumor necrosis factor- α. Furthermore, these antiinflammatory effect of ESP was associated with the downregulation of mitogen-activated protein kinase signaling, that is, extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase signaling pathways. This study would therefore provide interesting insights into the biorenovationassisted generation of a novel anti-inflammatory compound. ESP may be used to develop treatments for inflammatory disorders.