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젠(Zen:禪)패션에 표현된 미적 특성에 관한 연구 : 1990년대 후반을 중심으로 In the latter half of 1990s
박혜원,김영주 창원대학교 생활과학연구소 1999 생활과학연구 Vol.3 No.-
The purpose of this study is to search on domestic and overseas designer's trends of Zen fashion in the latter half of 1990s. Zen fashion is know as one of the methods to prepare for new millenium fashion trend. In order to find out the information, books related fashion affair, magazine, theory, photographs, and collections of fashion works were used. The contents of this research are checking out the origin meaning of Zen and the background of the appearance in fashion trend. In conclusion, Zen fashion, as a millennium oriental look is considered as a kind of new minimal fashion, contemporary modernness in fusion style, and representing the purism.
Lee Hye Seon,Yun Hye-Yeoung,Lee Eun-Woo,Shin Ho-Chul,Kim Seung Jun,Ku Bonsu 한국미생물학회 2022 The journal of microbiology Vol.60 No.4
High-risk genotypes of human papillomaviruses (HPVs) are directly implicated in various abnormalities associated with cellular hyperproliferation, including cervical cancer. E6 is one of two oncoproteins encoded in the HPV genome, which recruits diverse PSD-95/Dlg/ZO-1 (PDZ) domain-containing human proteins through its C-terminal PDZ-binding motif (PBM) to be degraded by means of the proteasome pathway. Among the three PDZ domain-containing protein tyrosine phosphatases, protein tyrosine phosphatase non-receptor type 3 (PTPN3) and PTPN13 were identified to be recognized by HPV E6 in a PBM-dependent manner. However, whether HPV E6 associates with PTPN4, which also has a PDZ domain and functions as an apoptosis regulator, remains undetermined. Herein, we present structural and biochemical evidence demonstrating the direct interaction between the PBM of HPV16 E6 and the PDZ domain of human PTPN4 for the first time. X-ray crystallographic structure determination and binding measurements using isothermal titration calorimetry demonstrated that hydrophobic interactions in which Leu158 of HPV16 E6 plays a key role and a network of intermolecular hydrogen bonds sustain the complex formation between PTPN4 PDZ and the PBM of HPV16 E6. In addition, it was verified that the corresponding motifs from several other highrisk HPV genotypes, including HPV18, HPV31, HPV33, and HPV45, bind to PTPN4 PDZ with comparable affinities, suggesting that PTPN4 is a common target of various pathogenic HPV genotypes.