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연구논문 : 한국인 원발성 담즙성 간경변증의 임상 특징 및 예후
김경아 ( Kyung Ah Kim ),정숙향 ( Sook Hyang Jeong ),이정일 ( Jung Il Lee ),연종은 ( Jong Eun Yeon ),이헌주 ( Heon Ju Lee ),권소영 ( So Young Kwon ),장우임 ( U Im Chang ),민현주 ( Hyun Ju Min ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2
Background/Aims: This study investigated the clinical features and prognosis of primary biliary cirrhosis (PBC) in Korea. Methods: Clinical data of patients diagnosed as PBC between 1997 and 2008 at eight referral hospitals were analyzed retrospectively. PBC was diagnosed based on liver function tests, presence of serum antimitochondrial antibody (AMA), and histopathological findings. Results: In total, 251 patients (218 females, 33 males, mean age 54 years) were enrolled, and the mean follow-up duration was 33.5 months. At the diagnosis, 61% of the patients were asymptomatic, 12% had decompensated liver cirrhosis, and 98% were positive for AMA. The serum alkaline phosphate (AlP) level was 2.6 times the upper limit of normal, aspartate aminotransferase was 105 U/l, and bilirubin was 2.0 mg/dl. The mean Mayo risk score was 5.5, and the Child-Pugh class was A, B, and C in 79%, 19%, and 2% of the patients, respectively. Ursodeoxycholic acid (UDCA) was used for treatment in 88% of the patients, among which 70% exhibited biochemical responses defined as normalization or a >40% decrease in AlP at 6 months. Eight deaths occurred during the follow-up, the causes were variceal bleeding, hepatic failure, and sepsis. The overall 5-year survival rate was 95%. The poor prognostic factors were being older than 60 years, high bilirubin, low albumin, ascites, high Mayo risk score, Child-Pugh class C, and initial presence of hepatic decompensation. Conclusions: Most patients diagnosed as PBC were asymptomatic, and these patients had a favorable short-term prognosis. The prognosis of PBC was dependent on the initial severity of liver disease.
노윤우 ( No Yun U ),이증훈 ( Lee Jeung Hun ),박장규 ( Park Jang Gyu ),김유찬 ( Kim Yu Chan ),박향준 ( Park Hyang Jun ),신용우 ( Sin Yong U ),윤태영 ( Yun Tae Yeong ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.10
N/A Background : Frequent association of nevus sebaceus with other skin appendage tumors and with apocrine glands suggests that the nevus sebaceus may be derived from the primary epithelial germ. Syringocystadenoma papilliferum was found most frequently in the nevus sebaceus. A number of cases have been reported, but extensive studies on the secondary tumors of nevus sebaceus are rare in Korea. Objectives : The purpose of this study was to investigate characteristic clinical features in Korean patients with the secondary tumors of nevus sebaceus. Materials & Methods : Enrolled were total 136 patients confirmed as nevus sebceus at the Chungnam National University Hospital, the Dankook University Hospital, and the Chungbuk National University Hospital from March 1993 to February 2003 for this study. And we reviewed the Korean Journal of Dermatology and the Annals of Dermatology for nevus sebaceus with secondary tumors. Result : The results were as follows : 1. Total 45 cases were included from 23 males and 22 females. The male/female ratio was similar. Trichoblastoma(86% in female) and basal cell carcinoma(67% in female) were more frequent in female than in male. 2. Mean age was 38.7 years(range 1.5 years to 71 years). all malignant tumors except basal cell carcinoma developed beyond 40 years of age. 3. In the malignant tumors, 19(95%) or 20 cases developed in the scalp. However, in the benign tumors, 44(86.3%) of 51 cases developed in the scalp and 7(13.7%) of 51 cases in the face. 4. Tumors of one type developed in 29 cases and tumors of more than two types developed in 16 cases. 5. The total seventy eight tumors were composed of 23 malignant tumors and 55 benign tumors. Basal cell carcinoma and syringocystadenoma papilliferum were the most common tumor in each group respectively. Although trichoblastoma was not counted as the most common tumor, we suggest that it might be the most frequent tumor in secondary tumors associated with nevus sebaceus because differential diagnosis between trichoblastoma and basal cell carcinoma was so difficult that many cases of trichoblastoma were misdiagnosed as basal cell carcinoma.(Korean J Dermaton 2003;41(10) : 1338~1346)
A comparison of ankle function between adults with and without Down syndrome
Yoon, Hyang-Woon,Yu, Tae-Ho,Seo, U-Hyeok,Lee, Jee-Won,Kim, So-Yeon,Chung, Soo-Jin,Chun, Hye-Lim,Lee, Byoung-Hee korean Academy of Physical Therapy Rehabilitation 2017 Physical therapy rehabilitation science Vol.6 No.4
Objective: The purpose of this study was to compare ankle function between adults with and without Down syndrome (DS). Design: Cross-sectional study. Methods: Ten adults with DS and 18 without participated in this study and underwent manual muscle test (MMT), range of motion (ROM) assessment, star excursion balance test (SEBT), and functional movement screen (FMS). The tests were demonstrated to increase their accuracy and the actual measurements were assessed after one or two demonstrations. To minimize the standby time and fatigue, the travelled distance and measuring order were adjusted. To remove the influence of shoes on the measurements, the shoes were taken off and only socks were worn. Results: Dorsal and plantar flexion MMTs of both ankles were significantly weaker and plantar flexion ROM of both ankles were significantly lower in adults with DS compared with those without (p<0.05). However, dorsal flexion ROM of both ankles were not significantly different between them. There were significant differences in distances measured in all the directions (anterior, anterolateral, lateral, posterolateral, posterior, posteromedial, medial, and anteromedial directions) of SEBT (p<0.05). Significant differences were also demonstrated in the scores of hurdle step, inline lunge, shoulder mobility, and rotary stability among the seven items of FMS (p<0.05). Conclusions: To enhance the dynamic stability of adults with DS, it is necessary to improve ankle stability by strengthening the ankle dorsal and plantar flexors.
이진향 ( Jin Hyang Lee ),김선화 ( Sun Hwa Kim ),서우현 ( U Hyeon Seo ),이재근 ( Jae Keun Lee ) 한국전통조경학회(구 한국정원학회) 2011 한국전통조경학회지 Vol.29 No.4
서촌은 서울 도심에 위치하며 인왕산을 배경으로 자연경관이 수려하고 역사와 문화적 자원이 풍부한 한국의 대표적인 역사문화경관 지역이다. 하지만 시대의 변천과 함께 변화를 거듭해온 현재 서촌의 모습은 서촌이 지녔던 자연경관의 아름다움과 서촌만이 간직한 장소성이 경제적 논리에 밀려 그 가치를 인정받지 못하고 있다. 서촌 경관에 녹아있는 역사 문화의 잠재적 가치를 인식하고 경관의 보존과 보호를 위하여 경관 변화의 기준이 될 수 있는 경관은 무엇이며, 어떤 변천과정을 거쳐 경관이 변화되어 왔으며, 복원 시 기준이 되는 경관은 무엇인지에 관하여 논의하고자 한다. 본 연구는 경관 텍스트로 시, 유산기를 비롯한 문학작품, 회화, 경물의 명칭을 설정하여 고문헌과 현대문헌, 근·현대 지도, 회화작품 등을 현황과 비교·분석하였다. 특히 서촌의 경관은 자연경관의 원형이 잘 보전되어 있으며, 인문·사회적 장소성을 지닌 조선 후기 경관을 원형경관으로 규정하였으며, 이를 기준으로 경관변천의 원인이 되는 사회·문화적 특성을 연구하였다. 연구 결과, 서촌은 서울을 대표할 수 있는 역사와 문화적 특성을 지닌 곳으로 서촌만이 가진 정체성을 지닌 보존이 요구된다. 특히 산맥과 물길 명소별 보존을 위한 특징은 다음과 같다. 백사 이항복과 권율 장군의 집터였던 필운대는 조망권 확보 및 주변 암반 보호를 위한 문화재 복원을, 안평대군의 비해당이 있었던 수성동은 현재 복원 중인 공원화 사업을 중심으로 복원지역의 확대를, 안동 김씨의 세거지이면서 위항문학의 산실이었던 청휘각과 송석원과 선원 김상용의 별서지였던 청풍계 지역은 인물과 연계된 물길의 복원이 요구되며, 조망경관이 우수하고 현재 녹지의 보전이 비교적 양호한 세심대와 백운동 계곡은 보전을 위한 보호구역 설정이 요구된다. Seochon(``West Village``) is located in the west side of Gyeongbokgung(Gyeongbok Royal Palace) inside the old city wall of Seoul. Seochon has beautiful scenic view surrounding Mt. Inwang and has been known as the representative historical and cultural landscape region in Korea that historical and cultural resources are rich. But when the figure of Seochon which has repeated the changes with the ones of the times is considered, values of beauty of natural landscape that Seochon had and its own placeness have not been gradually recognized as it has been swept away in logic of the development on the strength of economics. This study tries to examine the original form of landscape on Seochon which can be the standard of landscape change, the causes and process of its change and possibility to conserve and restore it to recognize potential value about historical culture of Seochon landscape and conserve and protect it. For this, this study compared and analyzed literature including poems and Yusangi, paintings and names of the scenery of the seasons as the landscape texts with the current status. The study result has found that Pilwundae should rehabilitate cultural assets to secure the prospect right and protect neighboring bedrock, Suseong-dong should expand the restoration areas focusing on the projects to make parks which are now being restored, Cheonghwigak and Cheongpunggye areas should restore waterways including historicity which is connected to figures and Seshimdae and Baekun-dong green zone should set the protective area for conservation.