Stem Cell Factor(SCF)와 Interleukin-3(IL-3)

윤휘중 대한내과학회 1999 대한내과학회지 Vol.57 No.4

Malassezia sympodialis가 동정된 신생아 Malassezia 농포증 1예

김휘준,이무형,안규중 대한의진균학회 2001 대한의진균학회지 Vol.6 No.4

Neonatal Malassezia pustulosis can be defined as pustules on face and neck, age at onset younger than 1 month, isolation of Malassezia by direct microscopy in pustular material, elimination of other causes of neonatal pustuloses, and response to topical ketoconazole therapy. We report a case of neonatal Malassezia pustulosis in a 20-day-old male. Direct microscopic examination on smears for pustules showed forms of Malassezia yeasts and culture yielded Malassezia sympodialis. The lesions were remarkably improved by topical ketoconazole cream for 14 days. [Kor J Med Mycol 6(4): 229-231] Key Words: Neonatal Malassezia pustulosis

치료경험이 있는 A형 혈우병 환자에서 그린모노^�의 약동학 및 안전성 : 전향적 다기관 공동 임상시험

윤휘중,이순용,황태주,손영택 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1

배 경 : 최근 국내에서 사용 가능해 진 단클론항체를 이용한 고순도의 제 8응고인자 그린모노^R에 대하여, 제품의 약동학적 측면을 관찰하고, 급성 이상반응 발생 측면의 안전성을 관찰하고자 하였다. 방 법 : 과거 응고인자 치료경험이 있는 제 8응고인자치 5% 미만의 A 형 혈우병 환자를 대상으로, 그린모노를 체중 1kg당 50units 정맥주사한 후 약물역동학적 분석을 시행하였다. 약물 투여 후 48시간까지 이상반응을 관찰하고, 약물투여 전 및 48시간 까지 이상반응을 관찰하고, 약물투여 전 및 48시간 후에 일반혈액 검사, 혈액생화학검사, 요검사 등을 측정하여 비교하였다. 제8응고인자 억제인자를 Bethesda assay를 이용하여 투여 전 및 투여 3~7일 후 검사하였다. 결 과 : 15명의 환자중 연구를 완료한 13명의 자료를 분석하였다. Recovery rate는 99±22%(범위, 71~ 136%) 였으며, 2-compartment model을 이용한 beta phase의 반감기는 15.7±6.6시간(범위, 9.7~35.9시간)이었다. 그린모노^ R 투여후 의미있는 이상반응은 없었으며, 검사성적의 의미있는 변화도 발견할 수 없었다. 제8응고인자 억제인자는 시험약 투여 전후 모두 0.6 BU 미만으로 유지되었다. 결 론: 그린모노^R는 약동학적으로 유효하고, 급성이상 반응이 없어, 임상 이용에유용하리라 생각한다.

최신 항암제

윤휘중 경희대학교 2002 慶熙醫學 Vol.18 No.2

전자현미경의 활용방안에 관한 견해

이승휘,권중균 호남대학교 1999 호남대학교 학술논문집 Vol.20 No.2

The purpose and background of this paper is to intensify the application and accumulation on some biological specimens, some medical specimens, and etc., with biological techniques for electron microscopy. For example, this paper deals with the retinal ultrastructure of hermaphroditic rivulus and the ultrastructral spermatology on some fishes. The discussion of this paper is to introduce the need for using electron microscopy.

건강한 성인과 성인편마비의 표면열 적용시 사지에서의 동통역치 변화에 관한 연구

김중휘,홍도선,이정원 한국전문물리치료학회 1996 한국전문물리치료학회지 Vol.3 No.2

RAPD 다형성 및 ABO 유전자형 분석을 통한 사상체질간 유전적 거리에 관한 연구

이휘철,조동욱,조중호,이창수 건국대학교 자연과학연구소 1999 建國自然科學硏究誌 Vol.10 No.2

본 연구는 사상체질인 태음인, 소음인 그리고 소양인간의 유전적 상관관계를 Random Amplified Polymorphic DNA(RAPD) 분석법 및 ABO 유전자형의 대립유전자의 빈도 분석을 통하여 실시하였다. 체질간 DNA 다형성을 검출할 수 있는 RAPD 분석용의 primer의 빠른 선별을 위해 체질별 혼합된 DNA 시료를 분석에 사용하였다. 일차적으로 200종류의 RAPD primer로부터 다형성을 보이는 7종류의 primer를 선별하였다. RAPD밴드로터 체질간 bandsharing(BS) 값은 0.68에서 0.71범위에 있었고, 유전적 거리는 BS 값에 의해 구했다. RAPD의 BS값에 의한 태음인과 소음인간 유전적 거리는 0.002이고, 이 두 체질과 소양인간에는 0.005로 분석되었다. 또한 체질별 ABO 유전형을 조사하여 그들의 대립유전자 빈도를 추정해 체질간 유전적 거리를 산출했다. 그 결과 태음인과 소음인사이에 유전적 거리는 0.014이고, 소양인과 나머지 두 체질간에는 0.032였다. 위와 같이 RAPD 분석법과 ABO 대립유전자의 빈도분석에 의한 체질간 상관관계는 두 방법 모두에서 태음인과 소음인이 소양인 체질보다 유전적으로 더 가깝게 나타났다. This study was carried out to be establish genetic understanding of Sasang constitutions of Teaumin, Soumin and Soyangin by Random Amplified Polymorphic DNA(RAPD) and ABO alleles frequencies analysis. We have applied RAPD analysis to pooled DNA sample as a means to achieve rapid screening of large numbers of primers for their capacity to reveal constitutions-specific polymorphisms. From initial 200 primers, 7 polymorphic primers between different constitutions were selected. The RAPD bandsharings(BS) values ranged from 0.68 to 0.71 for between three constitutions. The genetic distance between three constitutions was measured by BS values. Genetic distance by RADP analysis was 0.002 between Teaumin and Soumin, and 0.005 between Soyangin and the others. Three Sasang constitutions were investigated by the genotyping of ABO genotypes, and genetic distance was calculated from ABO allele frequencies in each constitution. As a result, genetic distance was 0.014 between Teaumin and Soumin, and 0.032 between Soyangin and the others. In conclusion, the genetic distance of Teaumin and Soumin was closer than that of Soyangin in the analysis of RAPD and ABO alleles frequencies.

이중혈류유발 심폐소생술이 심정지를 유발한 개의 단기 생존율에 미치는 영향

황성오,조준휘,강구현,김성환,문중범,이강현,이승환,윤정한,최경훈,홍은석 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background and Objectives: We previously reported that, compared with standard cardiopulmonary resuscitation(S-CPR), better hemodynamic effects could be achieved by simultaneous sterno-thoracic cardiopulmonary resuscitation(SST-CPR) in which we compressed the sternum and constricted the thorax circumferentially during the systolic period by using a device. This study was designed to assess whether SST-CPR, compared with S-CPR, improve the survival rate of dogs with cardiac arrest. Subjects and methods: Twenty-five mongrel dogs(19∼31㎏) were enrolled in this study. After four minutes of ventricular fibrillation induced by an AC current, animals were randomized to resuscitate with either S-CPR(n=13) or SST-CPR(n=12). Epinephrine(1 ㎎) was injected into the right atrium every three minutes after the beginning of CPR. Defibrillation was attempted after 6 minutes of CPR. Standard advanced cardiac life support was started if defibrillation was not successful. Results: SST-CPR resulted in significantly(p<0.001) higher systolic arterial pressure(91±47 vs 47±24 ㎜ Hg), diastolic pressure(43±24 vs 17±10 ㎜ Hg), coronary perfusion pressure(35±25 vs 13±9㎜ Hg), and end tidal CO2 tension(9±4 vs 3±2 ㎜ Hg). Two of 13 animals(15 %) resuscitated with S-CPR and six of 12 animals(50%) resuscitated with SST-CPR survived until 12 hours after cardiac arrest(p<0.05). Donclusion: SST-CPR, compared with S-CPR, improves the short-term survival rate in canine cardiac arrest.

보행에서 Central Pattern Generator의 이해 : Understanding the Central Pattern Generator in Human Gait

황병용,김중휘 용인대학교 자연과학연구소 2001 自然科學硏究所論文誌 Vol.6 No.1

An essential feature of human gait is the ability to move from one place to another. The gait, rhythmic and alternating movements of the two legs, is automatic and less cognitive neuronal activity. A central pattern generator(CPG) is a neuronal network capable of generating a rhythmic pattern of motor activity in the absence of phasic sensory input from peripheral receptors. CPG have been identified and analyzed in more than 50 rhythmic motor systems, including those controlling such diverse behaviors as walking, swimming, feeding, respiration, and flying. The basic pattern produced by a CPG is usually modified by sensory information from peripheral receptors and signals from other regions of the central nervous system.

심초음파로 결정된 응급 심낭천자술의 천자부위

김성환,황성오,이강현,조준휘,강구현,문중범,이승환,윤정한,최경훈,김영식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: The aim of this study was to determine whether the conventional subcostal approach is suitable for emergency pericardiocentesis in patients with cardiac tamponade or impending cardiac tamponade. Methods: This study was a prospective, observational study conducted at the emergency department of a tertiary hospital, Patients who had symptomatic pericardial effusion and who needed emergency pericardiocentesis in the emergency department were included in this study. We measured the epicardium-to-pericardium distance at the subcostal, parasternal, and apical area with two-dimensional echocardiography to determine the appropriate puncture site for pericardiocentesis. An epicardium-to-pericardium distance of more than 1.0 cm was considered as the primary safety factor in determining the Puncture site for pericardiocentesis. The skin-to-pericardium distance was considered as secondary safety factor. Results: Ninety-five consecutive patients(55 males and 40 females; total mean age: 53 year old) with cardiac tamponade or impending cardiac tamponade were enrolled in this study. The puncture site for pericardiocentesis, as determined by echocardiography, was the subcostal area in 43 patients(45%), the apical area in 40 patients(42%), the left parasternal area In 11 patients(12%), and the right parastemal area in one patient(1%). Pericardiocentesis failed in 2 patients(2%) with the subcostal approach and in one patient(1%) with the apical approach. The average epicardium-to-pericardium distance was 31 ±21 mm in patients with the subcostal approach and 21±8 mm in patients with other approaches. There were no differences in the amount of pericardial fluid and in the intraperical pressure among patient groups according to puncture site. There were two procedure related complications: a puncture of the right ventricle with the subcostal approach and a ventricular tachycardia with the apical approach.