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Hungwon Tchah,Byoungkak Lim 대한안과학회 1999 Korean Journal of Ophthalmology Vol.13 No.2
To evaluate the effect of different concentrations 0.03%, 0.1% and 0.3% of FK 506 on xenograft corneal rejection, guinea pig corneas were transplanted into rats. FK 506 was then applied topically four times a day for 21 days. The grafts were inspected and scored according to opacity, edema, and graft protrusion. All grafts in the control group were rejected by the 14th postoperative day, and grafts in the FK 506 treated groups began to be rejected by the 17th postoperative day. Inflammatory cell infiltration was less dense in the FK 506 treated grafts than in the control group. Higher concentrations of FK 506 appeared to be more effective in preventing and decreasing the severity of the graft rejection. Topical FK 506 can delay the development of xenograft corneal rejection and decrease its severity in this animal model.
Scleral Lens Applications Focused on Korean Patients with Various Corneal Disorders
Ko Eun Lee(Ko Eun Lee),Su Young Moon(Su Young Moon),Sanghyu Nam(Sanghyu Nam),Joon Hyuck Jang(Joon Hyuck Jang),Jae Yong Kim(Jae Yong Kim),Hungwon Tchah(Hungwon Tchah),Hun Lee(Hun Lee) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2
Purpose: We aimed to report on the clinical outcomes of scleral lens applications in Korean patients with various corneal disorders. Methods: This retrospective review was conducted for 62 eyes of 47 patients who had been fitted with scleral lenses for variouscorneal disorders. The patients were referred for inadequate spectacle-corrected visual acuity and rigid gas permeable(RGP) or soft contact lens intolerance. Uncorrected visual acuity, habitually corrected visual acuity, best lens-corrected visualacuity, topographic indices, keratometry indices, and lens parameters were evaluated. Results: Twenty-six eyes of 19 patients with keratoconus were enrolled. Other conditions included corneal scar (13 eyes of12 patients), phlyctenules (three eyes), laceration (four eyes), chemical burn (one eye), keratitis (one eye), Peters’ anomaly (oneeye), fibrous dysplasia (one eye), ocular graft-versus-host disease (two eyes of one patient), irregular astigmatism (18 eyes of12 patients), and corneal transplant status (five eyes of four patients). The mean topographic values of the eyes include flatkeratometric value (43.0 ± 6.1 diopters [D]), steep keratometric value (48.0 ± 7.4 D), and astigmatism (4.9 ± 3.6 D). Of the eyesfitted with scleral lenses, best lens-corrected visual acuity (0.10 ± 0.22 logarithm of the minimum angle of resolution [logMAR])was significantly better than the habitually corrected visual acuity (0.59 ± 0.62 logMAR, p < 0.001). Conclusions: Scleral contact lenses are a good alternative for patients with corneal abnormalities and those who are intolerableto RGP contact lenses, resulting in both successful visual outcomes and patient satisfaction, especially concerning keratoconus,corneal scar, and corneal transplant status.
차홍원 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2
Penetrating keratoplasty in inbred Lewis rat with either Lewis donor corneas(syngeneic transplantation group) or Brown Norway donor corneas(disparate transplantation group) were performed. The kinetic changes of the inflammatory cell subtypes in the corneal transplantation site and the clinical features were studied. All grafts(10 grafts) were remained clear in the syngeneic group. There was a significant inflammatory reaction in the wound especially surrounding the sutures. These cells were mostly macrophages(OX-42). This response in the wound progressively diminished by third week. Rare T helper/inducer cells(W3/25) were noted in the graft early. By the second week this response in the graft had resolved. Nine grafts out of 10 were rejected by the third week in the disparate group. Macrophages were seen in moderate numbers in the graft and wound during the first week. By the second week T helper/inducer cells and T suppressor/cytotoxic cells(OX-8) Increased. In third or fourth week T suppressor/cytotoxic cells were most prominent cells in the rejected graft. The ratio of these three cell types(T suppressor/cytotoxic : T helper/inducer cell:macrophage) in the rejected cornea was 1.5:1:0.8.
차흥원 울산대학교 의과대학 1994 울산의대학술지 Vol.3 No.1
Corneal transplantation is the one of the most successful organ transplantation and performed more frequently than any other organ transplantation. Development of new corneal preservation media, fine microsurgial technique, and appropriate post operative management resulted in high success rate of corneal transplantation. However, 10-30% of corneal transplantation is still failed with various reasons. The concept, surgical technique and complications of corneal transplantation are discussed.
차홍원 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.1
In order to investigate the effects of epidermal growth factor(EGF), fibroblast growth factor(FGF) and transforming growth factor-β(TGF-β), rabbit corneal endothelial cells were cultured. After adding growth factors individually or in combination, DNA synthesis of corneal endothelial cells was measured. EGF and FGF increased DNA synthesis of corneal endothelial cells at all concentration tested(0.03ng/ml-300ng/ml) compared with the control. The maximum increase of DNA synthesis was shown at the concentration of 0.3-10ng/ml of EGF or 10-30ng/ml of FGF. TGF-β reduced DNA synthesis of corneal endothelial cells at all concentration tested (0.03ng/ml-10ng/ml). DNA synthesis of corneal endothelial cells was more increased when EGF and FGF were added in combination. TGF-β inhibited DNA synthesis induced by EGF or FGF when added at the same time. These results indicate that combination of EGF and FGF has maximum effect in DNA synthesis increase of rabbit corneal endothelial cells.