Mite Prevalence and Mite Sensitivity in China

Wen, Ting Huan,Cal, Li,Xu, Wei Hing,Wang, Hong,Xiang, Li,Hong, Shou Shu,Zhong, Jiang Min,Zhuang, Yi Jun 대한알레르기학회 1991 천식 및 알레르기 Vol.11 No.2

Thyroid-Associated Orbitopathy: Evaluating Microstructural Changes of Extraocular Muscles and Optic Nerves Using Readout-Segmented Echo-Planar Imaging-Based Diffusion Tensor Imaging

Huan-Huan Chen,Hao Hu,Wen Chen,Dai Cui,Xiao-Quan Xu,Fei-Yun Wu,Tao Yang 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.3

Objective: We aimed to investigate the ability of readout-segmented echo-planar imaging (rs-EPI)-based diffusion tensor imaging (DTI) in assessing the microstructural change of extraocular muscles (EOMs) and optic nerves in patients with thyroidassociated orbitopathy (TAO) as well as in evaluating disease activity. Materials and Methods: We enrolled 35 TAO patients and 22 healthy controls (HCs) who underwent pre-treatment rs-EPIbased DTI. Mean, axial, and radial diffusivity (MD, AD, and RD) and fractional anisotropy (FA) of the medial and lateral EOMs and optic nerve for each orbit were calculated and compared between TAO and HC groups and between active and inactive TAO groups. Factors such as age, sex, disease duration, mediation, and smoking history between groups were also compared. Logistic regression analysis was used to evaluate the predictive value of significant variables for disease activity. Results: Disease duration was significantly shorter in active TAOs than in inactive ones (p < 0.001). TAO patients showed significantly lower FA and higher MD, AD, and RD than HCs for both medial and lateral EOMs (p < 0.001), but not the AD value of lateral EOMs (p = 0.619). Active patients had significantly higher FA, MD, and AD than inactive patients for medial EOMs (p < 0.005), whereas only FA differed significantly in the lateral EOMs (p = 0.018). The MD, AD, and RD of optic nerves were significantly lower in TAO patients than HCs (p < 0.05), except for FA (p = 0.129). Multivariate analysis showed that the MD of medial EOMs and disease duration were significant predictors for disease activity. The combination of these two parameters showed optimal diagnostic efficiency for disease activity (area under the curve, 0.855; sensitivity, 68.4%; specificity, 96.9%). Conclusion: rs-EPI-based DTI is promising in assessing microstructural changes of EOMs and optic nerves and can help to indicate the disease activity of TAO, especially through the MD of medial EOMs.

Unactuated Force Control of 5-DOF Parallel Robot Based on Fuzzy PI

Shu-Huan Wen,Wei Zheng,Shi-Dong Jia,Zhi-Xin Ji,Peng-Cheng Hao,Hak-Keung Lam 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.6

This paper investigates the fuzzy position/force hybrid control for a class of 5-degree-of-freedom (DOF) redundantly actuated parallel robots. The position control law is designed based on the proportional-integraldifferential (PID) for the 5-DOF redundantly actuated parallel robot. The fuzzy proportional-integral (PI) redundant actuation force control law is designed based on the position/force hybrid control structure for the 5-DOF redundantly actuated parallel robot. The optimum driving force is obtained in the presence of interference, and the force tracking performance of the fuzzy PI controller is better than the conventional PI controller under the interference condition. Based on the fuzzy position/force hybrid controller, the tracking performance of the closed-loop system for the 5-DOF redundantly actuated parallel robot is improved by using the fuzzy position/force hybrid controller and the interference is eliminated effectively in the control system design. Finally, the co-simulation results of ADAMS and MATLAB/SIMULINK are given to show the effectiveness and advantages of the proposed methodscompared with the conventional PI controller.

Self-care Experiences of Adolescents with Spinal Muscular Atrophy

Bao-Huan Yang,Chia-Ying Chung,Wen-Chin Weng,Kao-Wen Lo,Yuh-Shiow Li 한국간호과학회 2021 Asian Nursing Research Vol.15 No.4

Purpose: We examined the self-care experiences of adolescents with spinal muscle atrophy (SMA) and their perceptions of the interactions between their body and the environment. Methods: We interviewed ten adolescents with SMA aged 13-18 years regarding personal care practices. Purposive sampling was conducted in two medical centers in northern Taiwan. Data were analyzed using the Giorgi analysis method. Results: Four constitutions were identified: (1) limited space for independent development, (2) multiple reconstructions of self-image to improve physical ability, (3) self-care of disease, and (4) developing activity styles to accommodate social culture. Conclusion: The self-care lived experiences of patients reflect dynamic changes in the body and environment. Self-existence was exhibited by adjustment, practice, and creativity of physical activity to integrate into society. Nursing staff should understand the self-care experiences and needs of adolescents with SMA to develop a database of self-care skills. This study recommended that nursing staff improve their ability to guide patients in taking care of themselves by developing body awareness self-care courses and individual care plans in response to various stages of disability to help patients delay deterioration, realize their physical potential, and promote independence and social development.

CircZNF609 Aggravated Myocardial Ischemia Reperfusion Injury via Mediation of miR-214-3p/PTGS2 Axis

Wen-Qiang Tang,Feng-Rui Yang,Ke-Min Chen,Huan Yang,Yu Liu,Bo Dou 대한심장학회 2022 Korean Circulation Journal Vol.52 No.9

Background and Objectives: Circular RNAs were known to play vital role in myocardial ischemia reperfusion injury (MIRI), while the role of CircZNF609 in MIRI remains unclear. This study was aimed to investigate the function of CircZNF609 in MIRI. Methods: Hypoxia/reoxygenation (H/R) model was established to mimic MIRI in vitro. Quantitative polymerase chain reaction was performed to evaluate gene transcripts. Cellular localization of CircZNF609 and miR-214-3p were visualized by fluorescence in situ hybridization. Cell proliferation was determined by CCK-8. TUNEL assay and flow cytometry were applied to detect apoptosis. Lactate dehydrogenase was determined by commercial kit. ROS was detected by DCFH-DA probe. Direct interaction of indicated molecules was determined by RIP and dual luciferase assays. Western blot was used to quantify protein levels. In vivo model was established to further test the function of CircZNF609 in MIRI. Results: CircZNF609 was upregulated in H/R model. Inhibition of CircZNF609 alleviated H/R induced apoptosis, ROS generation, restored cell proliferation in cardiomyocytes and human umbilical vein endothelial cells. Mechanically, CircZNF609 directly sponged miR-214-3p to release PTGS2 expression. Functional rescue experiments showed that miR-214-3p/PTGS2 axis was involved in the function of circZNG609 in H/R model. Furthermore, data in mouse model revealed that knockdown of CircZNF609 significantly reduced the area of myocardial infarction and decreased myocardial cell apoptosis. Conclusions: CircZNF609 aggravated the progression of MIRI via targeting miR-214-3p/PTGS2 axis, which suggested CircZNF609 might act as a vital modulator in MIRI.

시멘트의 분말도 변화에 따른 시멘트 모르터의 역학적 특성

文學龍,김경민,전충근,윤기원,양성환,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

This study discusses the influence of fineness of cement on mechanical properties of cement mortar. According to the result, compressive strength increases in order of C>B>OPC>A and C>B>A>OPC at mixture proportion of 1:1 and 1:3 respectively. An increase of compressive strength by increase of fineness of cement is because internal structure of concrete grows dense by an increase of hydration reaction. As for curing condition, compressive strength is higher in standard curing than in air curing at mixture proportion of 1:1 and 1:3. There is not any tendency of strength development with age and fineness of cement by 91days. Length change by drying shrinkage increases in order of C>B>OPC>A at mixture proportion of 1:1 and 1:3 due to an increase of water content by variation of W/C.

3D Markov chain based multi-priority path selection in the heterogeneous Internet of Things

( Huan Wu ),( Xiangming Wen ),( Zhaoming Lu ),( Yao Nie ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.11

Internet of Things (IoT) based sensor networks have gained unprecedented popularity in recent years. With the exponential explosion of the objects (sensors and mobiles), the bandwidth and the speed of data transmission are dwarfed by the anticipated emergence of IoT. In this paper, we propose a novel heterogeneous IoT model integrated the power line communication (PLC) and WiFi network to increase the network capacity and cope with the rapid growth of the objects. We firstly propose the mean transmission delay calculation algorithm based the 3D Markov chain according to the multi-priority of the objects. Then, the attractor selection algorithm, which is based on the adaptive behavior of the biological system, is exploited. The combined the 3D Markov chain and the attractor selection model, named MASM, can select the optimal path adaptively in the heterogeneous IoT according to the environment. Furthermore, we verify that the MASM improves the transmission efficiency and reduce the transmission delay effectively. The simulation results show that the MASM is stable to changes in the environment and more applicable for the heterogeneous IoT, compared with the other algorithms.

델파이 기법을 이용한 세계문화유산의 관리효과성 평가지표 설정에 관한 연구

서환 ( Huan Xu ),석미정 ( Mi Jeong Seok ),우문동 ( Wen Dong Yu ),강태호 ( Tai Ho Kang ) 한국전통조경학회 2013 한국전통조경학회지 Vol.31 No.2

본 연구는 ‘등재된 세계문화유산은 지금 얼마나 잘 관리되고 있는가?’ 라는 질문의 답을 모색하는 과정이다. 이를 위해 UNESCO 세계유산협약, 운영지침 및 ICOMOS 등에서 발표한 국제원칙을 기준으로 삼아 국제적으로 요구하는 세계문화유산 관리의 내용을 살펴보고, 국제적 요구사항에 부응하면서 세계문화유산의 관리특성이 반영된 관리효과성 평가후보지표들을 설정하였다. 그 결과, 상황, 계획, 환경, 유산관광, 지역사회의 5개 평가분야에서 각 13개, 7개, 9개, 10개, 7개 등 총 46개의 후보지표가 설정되었다. 또한 총 3라운드에 걸친 델파이 조사를 통해 타당도 및 신뢰도를 분석하여 후보평가지표 총 46개 중에서 14개의 평가지표들을 제거하고, 32개의 평가지표들을 최종적으로 도출하였으며, 상황, 계획, 환경, 유산관광, 지역사회 등 5개 평가분야에서 각 7개, 6개, 7개, 6개, 6개의 평가지표를 선정하였다. 이러한 결과를 중심으로 세계문화유산의 관리효과성 평가지표를 선정하였다. This research is a progress in order to answer the research question of ``how the listed World Cultural Heritage is being managed now?`` the alternate indicators of management effectiveness evaluation were set up based on international principles which were published by UNESCO, ICOMOS etc. Meanwhile the international contents of management and requirements were reflected in the alternate indicators of management effectiveness evaluation. The results were five evaluation categories included context, planning, setting, tourism and community were divided and total 46 alternate indicators in all were selected. In addition, to develop evaluation criteria for Management effectiveness evaluation of world cultural heritage by using Delphi Technique, three rounds of surveys were conducted on a selected expert group to derive and structuralize the evaluation factors. 46 factors got channeled into 32 factors after Delphi survey on appropriateness and credibility. The selected indicators were 7, 6, 7, 6 and 6 respectively in the five evaluation categories. According to the results the follow-up study, it selected management effectiveness evaluation index of world heritage.

Relationships among MTHFR a1298c Gene Polymorphisms and Methylation Status of Dact1 Gene in Transitional Cell Carcinomas

Cheng, Huan,Lu, Meng,Mao, Li-Jun,Wang, Jun-Qi,Li, Wang,Wen, Ru-Min,Chen, Jia-Cun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Objectives: The purpose of this study was to determine the relationship between methylation status of the Dact1 gene and MTHFR a1298c polymorphic forms in transitional cell carcinoma tissues in a Chinese population. Methods: Polymorphisms of folate metabolism enzyme gene MTHFR were assessed by restrictive fragment length polymorphism (RFLP) methods and PCR-based DNA methylation analysis was used to determine the CpG island methylation status of the Dact1 gene. Associations between the methylation status of the Dact1 gene and clinical characteristics, as well as MTHFR a1298c polymorphisms, were analyzed. Results: aberrant methylation of the Dact1 gene was found in 68.3% of cancer tissues and 12.4% of normal tissues,. The methylation rate of the Dact1 gene in cancer tissues was significantly higher in patients with lymph node metastasis than in those without lymph node metastasis (46.3% vs. 17.2%, P = 0.018). No association was found between aberrant DNA methylation and selected factors including sex, age, tobacco smoking, alcohol consumption and green tea consumption. After adjusting for potential confounding variables, variant allele of MTHFR a1298c was found to be associated with methylation of the Dact1 gene. Compared with wild type CC, the odds ratio was 4.33 (95% CI: 1.06-10.59) for AC and 4.95 (95% CI: 1.18-12.74) for AA. The N stage in TNM staging and the occurrence of lymph node metastasis were associated with an MTHFR 1298 AA+AC genotype (P<0.05). Conclusion: MTHFR 1298 AC and AA genotypes might help maintain a normal methylation status of the Dact1 gene, aberrant CpG island methylation of which is closely related to the genesis and progression of transitional cell carcinoma.

$L^{\infty}$-CONVERGENCE OF MIXED FINITE ELEMENT METHOD FOR LAPLACIAN OPERATOR

Chen, Huan-Zhen,Jiang, Zi-Wen 한국전산응용수학회 2000 Journal of applied mathematics & informatics Vol.7 No.1

In this paper two so-called regularized Green's functions are introduced to derive the optimal maximum norm error estimates for the unknown function and the adjoint vector-valued function for mixed finite element methods of Laplacian operator. One contribution of the paper is a demonstration of how the boundedness of $L^1$-norm estimate for the second Green's function ${\lambda}_2$ and the optimal maximum norm error estimate for the adjoint vector-valued function are proved. These results are seemed to be to be new in the literature of the mixed finite element methods.