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      • KCI등재

        Vibration-based identification of rotating blades using Rodrigues’ rotation formula from a 3-D measurement

        Chin-Hsiung Loh,Yu-Ting Huang,Wan-Ying Hsiung,Yuan-Sen Yang,Kenneth J. Loh 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.6

        In this study, the geometrical setup of a turbine blade is tracked. A research-scale rotating turbine blade system is setup with a single 3-axes accelerometer mounted on one of the blades. The turbine system is rotated by a controlled motor. The tilt and rolling angles of the rotating blade under operating conditions are determined from the response measurement of the single accelerometer. Data acquisition is achieved using a prototype wireless sensing system. First, the Rodrigues' rotation formula and an optimization algorithm are used to track the blade rolling angle and pitching angles of the turbine blade system. In addition, the blade flapwise natural frequency is identified by removing the rotation-related response induced by gravity and centrifuge force. To verify the result of calculations, a covariance-driven stochastic subspace identification method (SSI-COV) is applied to the vibration measurements of the blades to determine the system natural frequencies. It is thus proven that by using a single sensor and through a series of coordinate transformations and the Rodrigues' rotation formula, the geometrical setup of the blade can be tracked and the blade flapwise vibration frequency can be determined successfully.

      • SCIESCOPUS

        Vibration-based identification of rotating blades using Rodrigues' rotation formula from a 3-D measurement

        Loh, Chin-Hsiung,Huang, Yu-Ting,Hsiung, Wan-Ying,Yang, Yuan-Sen,Loh, Kenneth J. Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.21 No.6

        In this study, the geometrical setup of a turbine blade is tracked. A research-scale rotating turbine blade system is setup with a single 3-axes accelerometer mounted on one of the blades. The turbine system is rotated by a controlled motor. The tilt and rolling angles of the rotating blade under operating conditions are determined from the response measurement of the single accelerometer. Data acquisition is achieved using a prototype wireless sensing system. First, the Rodrigues' rotation formula and an optimization algorithm are used to track the blade rolling angle and pitching angles of the turbine blade system. In addition, the blade flapwise natural frequency is identified by removing the rotation-related response induced by gravity and centrifuge force. To verify the result of calculations, a covariance-driven stochastic subspace identification method (SSI-COV) is applied to the vibration measurements of the blades to determine the system natural frequencies. It is thus proven that by using a single sensor and through a series of coordinate transformations and the Rodrigues' rotation formula, the geometrical setup of the blade can be tracked and the blade flapwise vibration frequency can be determined successfully.

      • The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

        Hsiung, Chao Agnes,Lan, Qing,Hong, Yun-Chul,Chen, Chien-Jen,Hosgood III, H. Dean,Chang, I-Shou,Chatterjee, Nilanjan,Brennan, Paul,Wu, Chen,Zheng, Wei,Chang, Gee-Chen,Wu, Tangchun,Park, Jae Yong,Hsiao, Public Library of Science 2010 PLoS genetics Vol.6 No.8

        <▼1><P>Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10<SUP>−7</SUP> or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases, 585 controls) among Han Chinese in Taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p = 1.30×10<SUP>−11</SUP>). This finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls (p = 5.38×10<SUP>−11</SUP>). A pooled analysis achieved genome-wide significance for rs2736100. This SNP marker localizes to the <I>CLPTM1L</I>-<I>TERT</I> locus on chromosome 5p15.33 (p = 2.60×10<SUP>−20</SUP>, allelic risk = 1.54, 95% Confidence Interval (CI) 1.41–1.68). Risks for heterozygote and homozygote carriers of the minor allele were 1.62 (95% CI; 1.40–1.87), and 2.35 (95% CI: 1.95–2.83), respectively. In summary, our results show that genetic variation in the <I>CLPTM1L-TERT</I> locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.</P></▼1><▼2><P><B>Author Summary</B></P><P>Worldwide, approximately 15% of lung cancer cases occur among nonsmokers. Genome-wide association studies (GWAS) of lung cancer conducted in populations of European background have identified three regions on chromosomes 5, 6, and 15 that harbor genetic variants that confer risk for lung cancer. Prior studies were conducted primarily in cigarette smokers, raising the possibility that the associations could be related to tobacco use, lung carcinogenesis, or both. A GWAS of lung cancer among never-smokers is an optimal setting to discover effects that are independent of smoking. Since most women in Asia do not smoke, we conducted a GWAS of lung adenocarcinoma among never-smoking females (584 cases, 585 controls) in Taiwan, and observed a region on chromosome 5 significantly associated with risk for lung cancer in never-smoking women. The finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls. To our knowledge, this study is the first reported GWAS of lung cancer in East Asian women, and together with the replication studies represents the largest genetic association study in this population. The findings provide insight into the genetic contribution of common variants to lung carcinogenesis.</P></▼2>

      • SSCISCOPUSKCI등재
      • KCI우수등재

        Ultrahigh Vacuum Technologies Developed for a Large Aluminum Accelerator Vacuum System

        Hsiung, G.Y.,Chang, C.C.,Yang, Y.C.,Chang, C.H.,Hsueh, H.P.,Hsu, S.N.,Chen, J.R. The Korean Vacuum Society 2014 Applied Science and Convergence Technology Vol.23 No.6

        A large particle accelerator requires an ultrahigh vacuum (UHV) system of average pressure under $1{\times}10^{-7}$ Pa for mitigating the impact of beam scattering from the residual gas molecules. The surface inside the beam ducts should be controlled with an extremely low thermal outgassing rate under $1{\times}10^{-9}Pa{\cdot}m^3/(s{\cdot}m^2)$ for the sake of the insufficient pumping speed. To fulfil the requirements, the aluminum alloys were adopted as the materials of the beam ducts for large accelerator that thanks to the good features of higher thermal conductivity, non-radioactivity, non-magnetism, precise machining capability, et al. To put the aluminum into the large accelerator vacuum systems, several key technologies have been developed will be introduced. The concepts contain the precise computer numerical control (CNC) machining process for the large aluminum ducts and parts in pure alcohol and in an oil-free environment, surface cleaning with ozonized water, stringent welding process control manually or automatically to form a large sector of aluminum ducts, ex-situ baking process to reach UHV and sealed for transportation and installation, UHV pumping with the sputtering ion pumps and the non-evaporable getters (NEG), et al. The developed UHV technologies have been applied to the 3 GeV Taiwan Photon Source (TPS) and revealed good results as the expectation. The problems of leakage encountered during the assembling were most associated with the vacuum baking which result in the consequent trouble shootings and more times of baking. Then the installation of the well-sealed UHV systems is recommended.

      • KCI등재

        Evaluation of Regional Knowledge Innovation System in China: An Economic Framework Based on Dynamic Slacks-based Approach

        Sheng-Hsiung CHIU,Tzu-Yu LIN 한국유통과학회 2019 The Journal of Asian Finance, Economics and Busine Vol.6 No.3

        The paper proposes a knowledge innovation performance model by the dynamic data envelopment analysis with slacks-based measure approach for evaluating the effectiveness of 30 regional knowledge innovation activities in China from 2010 to 2016. In recent years, China has paid more attention to knowledge innovation activities, as central and local governments have pushed on with their innovation projects by lots of investment whatever the difficulties may be. Decision-maker is usually interested in judge its knowledge innovation performance relative to target benchmark by exploring whether one provincial administration region performs better among others and/or if the growth of economy will be benefited greatly by the knowledge innovation activities. To acquire the managerial insight about this issue from a comprehensively designed performance evaluation model, knowledge innovation activity is conceptualized as an intertemporal production process. Invention patent and regional gross product are imposed on desirable outputs, highlighting the need for knowledge economy. The empirical result shows that knowledge innovation has a positive effect on economic development. At the same time, decision-maker should be interest in the economic effect of patents’ type and quality. The government should then encourage new technical applications with greater commercial value from a market-oriented perspective, in order to benefit the most from the innovation process in the short-run.

      • Effects of Wedge Visual Support on User Metacognitive Strategy and Wayfinding Behavior within a Virtual Environment

        ( Chien Hsiung Chen ),( Shih Chieh Chen ),( Yu Chang Huang ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-

        The purpose of this study is to investigate 2D wedge visual support design used in a 3D virtual environment pertinent to user wayfinding behavior. The independent variables adopted for the experiment are interaction mode (i.e., touch sensitive vs. body movement), viewing perspective (the first-person vs. the third-person), and gender (male vs. female). A total of 56 participants (28 males and 28 females) were recruited to take part in the wayfinding task experiment by convenient sampling method. The results generated from the experiment revealed that: (1) The participant who conducted touch sensitive interaction mode performed better than those who used body movement interaction mode due to better interaction flow. (2) The participant who adopted the third-person perspective performed better than those who adopted the first-person perspective. (3) The gender effect indicated that males performed better than females under the perceptual information followed by abstract information (P-A) type of task. It is concluded that within a 3D virtual environment, users who adopt touch sensitive mode with the third-person perspective can perform better wayfinding behavior.

      • SCOPUSKCI등재

        Study on the Alkaloids from Thalictrum fauriei

        Chung-Hsiung Chen 한국생약학회 1986 생약학회지 Vol.17 No.1

        To explore the biological activities of Thalictrum alkaloids, a study was initiated to investigate the alkaloidal constituents from T. fauriei, a species indigenous to Taiwan. Extensive fractionation of the ethanolic extract provided three known apor phines, (+)-oconovine (Ia), (+)-isocorydine (Ib), and (+)-corydine (Ic) from nonphenolic tertiary base fraction. From quaternary base fraction two new protoberberi nium salts, thalifaurine (IIa), dehydrodiscretine (IIb), in addition to magnoflorine (III), were isolated. The structure of both new compounds were confirmed by total syntheses. Fractionation of phenolic bases yielded a dihydromorphinandienone, (-)-ocobotrine (IV), as well as a novel aporphine-pavine dimer, tentatively named EP-10. The structure of EP-10 was established by means of 2D NMR studies. Preliminary study indicated a weak activity of lyzing Hela cells, in vitro, for EP-10.

      • Applying Mobile Agent to a Mobile Stock Intermediary Services System Development

        Wen-Hsiung Wu,Po-Chang Ko,Ping-Chen Lin,Ming-Hua Su 보안공학연구지원센터 2008 International Journal of Smart Home Vol.2 No.2

        Due to the radical changing of the global economy, a more precise stock valuation helps providing important judgment principles to decision-makers and investors. With the advent of the third-generation (3G) or future forth-generation (4G) Internet, the mobile commerce (MCommerce) will become increasingly important. In addition, the mobile stock investment decision support system attracts great interests for professionals, such as stockholders, bondholders, financial analysts, governmental officials, and even the general public, recently. This study introduces a Mobile Agent-based Stock Intermediary Services System (MASISS) framework based on the mobile agent perspective to provide ubiquitous and seamless transaction activities for financial institutions. It also helps customers to make a more precise decision in the current intense commercial competition environment. For building distributed enterprise systems, The MASISS framework is developed in an integration of J2ME and J2EE environment with cross-platform portability, a huge server-side and client-side deployment base, and coverage for most W3C standards..

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