Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin

Hongxi Zhao,Zhifu Yang,Xiaohong Wang,Xianzhi Zhang,Meng Wang,Yukun Wang,Qibing Mei,Zhipeng Wang 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.11

Triptolide, a compound extracted from the traditional Chinese medicine preparation of Tripterygium wilfordii Hook F., has been reported to have anti-inflammatory and anti-cancer activities. However, its effect on ovarian cancer invasion is unknown. We observed that MMP7 and MMP19 expression increased in ovarian cancer tissue. Triptolide treatment inhibited the migration and invasion of ovarian cancer cells SKOV3 and A2780 at the concentration of 15 nM. We also observed that triptolide suppressed MMP7 and MMP19 promoter activity in a dose-dependent manner,down-regulating the expressions of these promoters on mRNA and protein level. Moreover, triptolide enhanced E-cadherin expression in ovarian cancer cells. In vivo, triptolide inhibited tumor formation and metastasis in nude mice, and suppressed MMP7 and MMP19 expression; it also enhanced E-cadherin expression in tumor in a dose-dependent manner. Over expression of MMP7 and MMP19, or suppression of E-cadherin expression partially abolished the inhibitory effect of triptolide on invasion of ovarian cancer cells. To summarize, triptolide significantly inhibited the migration and invasion of ovarian cancer cells by suppression of MMP7 and MMP19 and up-regulation of E-cadherin expression. This study shows that triptolide is a good candidate for the treatment of ovarian cancer and reduction of metastasis.

Structural and physical properties of ZnO:Al films grown on glass by direct current magnetron sputtering with the oblique target

Hongxi Liu,Hong Qiu,Xiaobai Chen,Mingpeng Yu,Mingwen Wang 한국물리학회 2009 Current Applied Physics Vol.9 No.6

ZnO:Al films were deposited on glass substrates at 300 K and 673 K by direct current magnetron sputtering with the oblique target. The Ar pressure was adjusted to 0.4 Pa and 1.2 Pa, respectively. All the films have a wurtzite structure and grow with a c-axis orientation in the film growth direction. The films grow mainly with columnar grains perpendicular to the substrate and some granular grains also exist in the films. The film deposited at 673 K and 0.4 Pa has the largest grains whereas that prepared at 300 K and 0.4 Pa consists of the smallest grains and is porous. The films exhibit an n-type semiconducting behavior at room temperature. The ZnO:Al film deposited at 673 K and 0.4 Pa has the lowest resistivity (3.40 × 10-3 Ω cm), the highest free electron concentration (4.63 × 1020 cm-3) and a moderate Hall mobility (4.0 ㎠ V-1 s-1). The film deposited at 300 K and 0.4 Pa has the highest resistivity and the lowest free electron concentration and Hall mobility. A temperature dependence of the resistivity reveals that the carrier transport mechanism is Mott’s variable range hopping in the temperature region below 100 K and thermally activated band conduction above 215 K. The activation energy for the film deposited at 300 K and 0.4 Pa is 41 meV and that for the other films is about 35 meV. All the films have an average optical transmittance of over 85% in the visible wavelength range. The absorption edge of the film deposited at 300 K and 0.4 Pa shifts to the longer wavelength (redshift) relative to the films prepared under the other conditions. ZnO:Al films were deposited on glass substrates at 300 K and 673 K by direct current magnetron sputtering with the oblique target. The Ar pressure was adjusted to 0.4 Pa and 1.2 Pa, respectively. All the films have a wurtzite structure and grow with a c-axis orientation in the film growth direction. The films grow mainly with columnar grains perpendicular to the substrate and some granular grains also exist in the films. The film deposited at 673 K and 0.4 Pa has the largest grains whereas that prepared at 300 K and 0.4 Pa consists of the smallest grains and is porous. The films exhibit an n-type semiconducting behavior at room temperature. The ZnO:Al film deposited at 673 K and 0.4 Pa has the lowest resistivity (3.40 × 10-3 Ω cm), the highest free electron concentration (4.63 × 1020 cm-3) and a moderate Hall mobility (4.0 ㎠ V-1 s-1). The film deposited at 300 K and 0.4 Pa has the highest resistivity and the lowest free electron concentration and Hall mobility. A temperature dependence of the resistivity reveals that the carrier transport mechanism is Mott’s variable range hopping in the temperature region below 100 K and thermally activated band conduction above 215 K. The activation energy for the film deposited at 300 K and 0.4 Pa is 41 meV and that for the other films is about 35 meV. All the films have an average optical transmittance of over 85% in the visible wavelength range. The absorption edge of the film deposited at 300 K and 0.4 Pa shifts to the longer wavelength (redshift) relative to the films prepared under the other conditions.

Validation of Reference Genes for Quantitative Real-Time PCR in Bovine PBMCs Transformed and Non-transformed by Theileria annulata

Hongxi Zhao,Junlong Liu,Youquan Li,Congshan Yang,Shuaiyang Zhao,Juan Liu,Aihong Liu,Guangyuan Liu,Hong Yin,Guiquan Guan,Jianxun Luo 대한기생충학열대의학회 2016 The Korean Journal of Parasitology Vol.54 No.1

Clamping-diode Circuit for Marine Controlled-source Electromagnetic Transmitters

Hongxi Song,Yiming Zhang,Junxia Gao,Yu Zhang,Xinyue Feng 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2

Marine controlled-source electromagnetic transmitters (MCSETs) are important in marine electromagnetic exploration systems. They play a crucial role in the exploration of solid mineral resources, marine oil, and gas and in marine engineering evaluation. A DC–DC controlled-source circuit is typically used in traditional MCSETs, but using this circuit in MCSETs causes several problems, such as large voltage ringing of the high-frequency diode, heating of the insulated-gate bipolar transistor (IGBT) module, high temperature of the high-frequency transformer, loss of the duty cycle, and low transmission efficiency of the controlled-source circuit. This paper presents a clamping-diode circuit for MCSET (CDC-MCSET). Clamping diodes are added to the controlled-source circuit to reduce the loss of the duty ratio and the voltage peak of the high-frequency diode. The temperature of the high-frequency diode, IGBT module, and transformer is decreased, and the service life of these devices is prolonged. The power transmission efficiency of the controlled-source circuit is also improved. Saber simulation and a 20 KW MCSET are used to verify the correctness and effectiveness of the proposed CDC-MCSET.

Anti-photoaging Activities of Sorbaria kirilowii Ethanol Extract in UVB-damaged Cells

Hongxi Chen,Ji Won Jang(장지원),Spandana Rajendra Kopalli,Jin Whoa Yum(염진화),Kee Jung Yoon(윤기정),Jae Youl Cho(조재열) 한국약용작물학회 2021 한국약용작물학회 학술대회논문집 Vol.2021 No.1

Clamping-diode Circuit for Marine Controlled-source Electromagnetic Transmitters

Song, Hongxi,Zhang, Yiming,Gao, Junxia,Zhang, Yu,Feng, Xinyue The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2

Marine controlled-source electromagnetic transmitters (MCSETs) are important in marine electromagnetic exploration systems. They play a crucial role in the exploration of solid mineral resources, marine oil, and gas and in marine engineering evaluation. A DC-DC controlled-source circuit is typically used in traditional MCSETs, but using this circuit in MCSETs causes several problems, such as large voltage ringing of the high-frequency diode, heating of the insulated-gate bipolar transistor (IGBT) module, high temperature of the high-frequency transformer, loss of the duty cycle, and low transmission efficiency of the controlled-source circuit. This paper presents a clamping-diode circuit for MCSET (CDC-MCSET). Clamping diodes are added to the controlled-source circuit to reduce the loss of the duty ratio and the voltage peak of the high-frequency diode. The temperature of the high-frequency diode, IGBT module, and transformer is decreased, and the service life of these devices is prolonged. The power transmission efficiency of the controlled-source circuit is also improved. Saber simulation and a 20 KW MCSET are used to verify the correctness and effectiveness of the proposed CDC-MCSET.

CURRENT STATUES ON VLSI CAD ACTIVITIES IN CHINA

Xue,Hongxi,Hong,Xianlong,Wang,Zeyi 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1

Chinese economy progresses rapidly especially in VLSI industry and EDA technology. The increasing rate of Chinese electronic industry is very high, but the absolute value is still at the low level. There is a challenge and chance of development, so the research in this area is very active. The Current status on VLSI CAD activities in China is presented in this paper.

안동일본영사관과 부영사 김우영

이홍석(Li Hongxi) 나혜석학회 2014 나혜석연구 Vol.5 No.-

러일전쟁이후 일본은 중국침략의 중요한 거점인 안동에 영사관을 설치하였다. 이어 압록강이북 동변도지역의 10여개 현을 자기의 관할구역으로 확정지었다. 이 관할구역에 대한 관할권을 행사하기 위해, 1906년부터 1920년 사이 일본은 비밀리에 영사관내외와 미개방지의 조선인거주지에 10여개의 경찰기구를 설치하고 경찰을 주재시켰다. 결과 안동영사관은 경찰기관으로 변하였다. 1921년 일본정부는 관동청·안동영사·조선총독부의 지지 하에 조선인 김우영을 안동영사관부영사로 임명하였다. 일본이 그를 부영사로 임명한 목적은, 첫째, 조선이주민들의 조선으로의 귀환을 방지하기 위해서이고, 둘째 일본인과 조선인사이의 민족모순을 완화하기 위해서이며, 셋째, 한국독립지사들을 귀순시키기 위해서이다. 김우영의 활동은 주로 조선이주민들의 토지상조와 소작, 거주, 귀화입적, 자녀교육 등 문제에서의 중국 측의 제한정책 및 그 대책에 대한 조사연구이다. 그는 비록 친일인사이지만 시국에 대한 남다른 통찰력과 자기민족에 대한 사랑이 있었기에 대담하고도 교묘하게 일본의 조선이주민에 대한 정책의 변경을 꾀하였고 또 무작정 일본경찰세력에만 의해 조선이주민문제를 해결하려는 반중친일분자들의 무모한 작법을 금지시키고 조선이주민들의 상황에 맞는 대책을 제기할 수 있었다. 그는 비록 일본외교관이지만 한국독립을 지향하고 독립지사들의 활동도 비호하였다. After the Russo-Japanese War, Japan implemented a mainland policy in China. During that time, according to Sino-Japanese treaty, Japan established a consulate in An Dong which was a Japanese important stronghold to aggress against China. So more than a dozen county within the eastern border region to the north of the Yalu River belonged to the jurisdiction of Japan. In order to exercise the jurisdiction in this area, Japan established more than a dozen police institutes and kept polices in those police institutes from 1906 to 1920.The range of institutes includes inside and outside of the Consulate and not-opened Korean settlements. Therefore An Dong Consulate turned out to be police organ. Japanese government appointed a Korean person called Kim Wooyeng as vice consul with the support of Governor-General of Korea and An Dong Consulate of Guandong Office. There were three purposes to appoint Kim Wooyeng as vice consul. Firstly, to prevent Korean immigrants backing to Korea; Secondly, to ease the national conflict between Japanese and Korean; Thirdly, the purpose of the submission of patriots who wanted Korean independence. Kim investigated and researched Chinese restrictive policy to the problems of Korean immigrants and countermeasures to that policy. The problem of Korean immigrants includes land cooperation, tenancy, habitancy, naturalization and education for their children and so on. He is a man of unusual perception and he loves his nation very much though he is pro japanese. Therefore he wanted to change the Japanese policy to Korean immigrants boldly and skillfully. He prohibited pro Japanese elements who wanted to solve the problems of Korean immigrants only by Japanese police forces and also put forward countermeasures correspond to the situation of Korean immigrants. Though he was a Japanese diplomat, he had ambition in Korean Independence and asylumed activities of patriots.

Anti-collision Device for the One-Dimensional Scanning Probe Fitted to a Measuring Machine

Huihui Tian,Hongxi Wang,Guanwei Wang,Wenhong Liang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.11

The probe is at the heart of the measuring machine operation. A variety of probe types and designs are available today. However, many users continue to use the conventional one-dimensional scanning ones because of their low cost, adequate level of accuracy and performance. During the measurement process, impact phenomena between the probe ball and the part surface occur frequently due to inaccurate programming of the software and improper measurement operation, as well as the one-dimensional scanning probe is infinitely stiff in the motion direction along the machine axis, resulting in plastic deformation of the probe stylus and damage of the probe sensor. It is therefore desirable to protect the scanning probe against collision with a workpiece which is to be measured. A new anti-collision device incorporating a compliant mechanism and permanent magnets is designed in this paper. The analysis of dynamic performance for anti-collision system regarding contact force, magnetic force, velocity, position, has been performed and the maximum contact force in the event of collision is available. Numerical results and prototype experiments show the validity of the designed anti-collision device for the one-dimensional scanning probe.

AN ALLOCATION ALGORITHM FOR DATA PATH SYNTHESIS

Su,Ming,Xue,Hongxi 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1

A novel approach, called clustering allocation algorithm for data path synthesis of digital system, is presented The algorithm introduce equivalent set to allocate the mutually exclusive operations or variables, and globally considers the minimum cost of data path under the minimum number of functional units and registers. The algorithm has been implemented and tested by the benchmarks for data path synthesis. The experimental results show that the algorithm gets the better results than other published algorithms in less CPU time.