Transplantation of Bone Marrow Stromal Cells Enhances Nerve Regeneration of the Corticospinal Tract and Improves Recovery of Neurological Functions in a Collagenase-Induced Rat Model of Intracerebral Hemorrhage

Hongsheng Liang,Xiangtong Zhang,Yibo Yin,Tie Lin,Dong Guan,Bowen Ma,Changyu Li,Yuehua Wang 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.1

The reorganization of brain structures after intracerebral hemorrhage (ICH) insult is crucial to functional outcome. Although the pattern of neuronal rewiring is well-docu-mented after ischemic stroke, the study of brain plasticity after ICH has been focusing on the enhancement of dendritic complexity. Here we hypothesized that functional restoration after ICH involves brain reorganization which may be favorably modulated by stem cell transplantation. In this study, bone marrow stromal cells (BMSCs) were transplanted into the perilesional sites of collagenase-induced ICH in adult rats one day after ICH injury. Forelimb functional recovery was monitored with modified limb placing and vibrissae-elicited forelimb placement tests. Anterograde and retrograde tracing were used to assess the reorganization of bilateral forelimb areas of the sen-sorimotor cortex. We found that in rats transplanted with BMSCs after ICH injury, axonal sprouting occurred in the contralateral caudal forelimb area of the cortex, and was significantly higher than in ICH rat models that received only the vehicle (P < 0.01). The number of positive neurons in the ipsilateral rostral forelimb area of the cortex of the BMSC group was 1.5- to 4.5-fold greater than in the vehicle group (P < 0.05). No difference was found between the BMSC and vehicle groups in hemispheric atrophy or labeled neurons in the ipsilateral caudal forelimb area (P = 0.193). Scores for improved functional behavior in the BMSC group were in accord with the results from histology. Neuronal plasticity of the denervated corticospinal tract at bilateral forelimb areas of the cortex in the collagenase-induced ICH rat models was significantly enhanced by BMSC transplantation. BMSC transplantation may facilitate functional recovery after ICH injury.

Probabilistic Load Flow Calculation Method of Containing Wind Farm Considering Grid Configuration Uncertainties

Hongsheng Su,Yan Yan 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.8

Current probabilistic power flow calculation methods mostly consider the uncertainties of loads and the random failures of generators without thinking about the changing of the grids structure. Hence, this paper proposes a new probabilistic power flow calculation method comprehensively considering the influences of the uncertainties of wind farms, loads, generators, and grids structure on power flow calculation. The linear relationships are deduced between the nodes injection power and the branch active power as the circuits being at failures, and the cumulative probability distribution of each branches power flow is calculated by using semi-invariant and Gram-Charlier series expansion, and such that the complicated convolution operation is avoided. Combining compensation method and the conditional probability theory to deal with network structure changes of random factors, the paper establishes a probability flow calculation model comprehensively considering diverse factors such as random outputting power of the wind farms, random changes of the loads, and random failures of the generators, and the random variation of the grid structures and so on, the probability distribution function and probability density function of each branch can be quickly obtained by the model. Through the analysis on IEEE 14-node system, the uncertainty of grid structure has a remarkable effect on the probability distribution of the quantity to be solved. Hence, applying the proposed method can provide planners with more accurate and comprehensive information.

Reliability and Security Characteristic Analysis on Complicated Equipment Operation

Hongsheng Su 보안공학연구지원센터 2013 International Journal of Control and Automation Vol.6 No.5

Semantic Annotation of Ontology by Using Rough Concept Lattice Isomorphic Model

Hongsheng Xu,Ruiling Zhang,Chunjie Lin,Wenli Gan 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.2

Semantic annotation is the process based on ontology annotation concept class, attribute and other metadata for cyber source and its various parts. Ontology mapping is to calculate the similarity between two ontology elements. Ontology merging is two or more source ontology merging into a goal Ontology. The basic principle of the concept lattice isomorphic generating is isomorphic to the background of the isomorphic concept lattice, and as concept lattice isomorphic background can generate the concept lattice. This paper analyzes the methods of ontology mapping and merging based on rough concept lattice isomorphic model and presents semantic annotation of ontology by using rough concept lattice isomorphic model. Experiments show that this method is better than the traditional method in semantic annotation accuracy and breadth.

Preventive Maintenance Model Analysis Based on Condition

Hongsheng Su 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.4

Systematic Investigation of the Effects of Macro-elements and Iron on Soybean Plant Response to Fusarium oxysporum Infection

Hongsheng Cai,Nan Tao,Changhong Guo 한국식물병리학회 2020 Plant Pathology Journal Vol.36 No.5

Nutrient manipulation is a promising strategy for controlling plant diseases in sustainable agriculture. Although many studies have investigated the relationships between certain elements and plant diseases, few have comprehensively explored how differing mineral nutrition levels might affect plant–fungal pathogen interactions, namely plant susceptibility and resistance. Here, we systematically explored the effects of the seven mineral elements that plants require in the greatest amounts for normal development on the susceptibility of soybean plants (Glycine max) to Fusarium oxysporum infection in controlled greenhouse conditions. Nitrogen (N) negligibly affected plant susceptibility to infection in the range 4 to 24 mM for both tested soybean cultivars. At relatively high concentrations, phosphorus (P) increased plant susceptibility to infection, which led to severely reduced shoot and root dry weights. Potassium (K), calcium (Ca), magnesium (Mg), sulfur (S), and iron (Fe) induced plant resistance to infection as their concentrations were increased. For K and Ca, moderate concentrations had a positive effect on plant resistance to the pathogen, whereas relatively high doses of either element adversely affected plant growth and promoted disease symptoms. Further experiments were conducted, assessing disease suppression by selected combinations of macro-elements and Fe at screened concentrations, i.e., K (9 mM) plus Fe (0.2 mM), and S (4 mM) plus Fe (0.2 mM). The disease index was significantly reduced by the combination of K plus Fe. In conclusion, this systematic investigation of soybean plant responses to F. oxysporum infection provides a solid basis for future environmentally-friendly choices for application in soybean disease control programs.

A Link Traffic Model by Incorporating both Merits of Vertical and Horizontal Queue Concept

HongSheng Qi,DianHai Wang,Peng Chen,YiMing Bie 대한토목학회 2013 KSCE JOURNAL OF CIVIL ENGINEERING Vol.17 No.5

With the development of traffic flow theory and practice, traffic models at different levels of analysis are expected to provide comprehensive outputs with satisfactory efficiency. Accordingly, this research proposes an Equivalent Link traffic State Model (ELSM) to meet this requirement. ELSM combines both advantages of Vertical Queue Model (VQ) and Horizontal Queue Model (HQ). On one hand, the structure of ELSM is similar to VQ; on the other hand, queue dynamics at any moment along the link can be available through deriving three “characteristic points” of each cycle based on shock wave theory. Thus spatial variation of vehicle queue can be obtained. As a result, common traffic performance indexes such as delay, stops and queue length can be directly obtained in addition to the microscopic level variables such as vehicle trajectories and travel time. It is shown that with the increasing of numerical resolution, the results of CTM (Cell Transmission Model) gradually converge to ELSM.

Comparative genomics of 151 plant-associated bacteria reveal putative mechanisms underlying specific interactions between bacteria and plant hosts

Hongsheng Cai,Yan Bai,Changhong Guo 한국유전학회 2018 Genes & Genomics Vol.40 No.8

Although much work has explored how microbes can benefit plant growth, the mechanisms underlying this intriguing process remain largely unknown, especially considering the diversity of bacteria that surrounds plants. The objective of the present study was to identify bacterial genes contributing to plant–microbe associations, beneficial effects, and host specificities. For this purpose, comparative genomics investigation of 151 plant-associated bacteria was performed. A principal component analysis of seven key genomic features revealed patterns in the specific properties of these bacteria: N2- fixing bacteria were more closely related to pathogenic ones than to beneficial bacteria. A common set of genes over-represented in these plant-associated bacteria were found to be remarkably similar in terms of (1) genetic information processing, (2) amino acid metabolism, (3) metabolism of cofactors and vitamins, (4) nucleotide metabolism, (5) human diseases, and (6) metabolism of terpenoids and polyketides. Although we did not detect a common genetic basis for these beneficial effects, further in-depth analysis revealed that each of five beneficial bacterial groups shared specific gene sets. Functional annotation showed that environmental information processing, genetic information processing and cellular processes predominated in these beneficial groups. Hypothesizing that plant-associated bacteria may have overlapping strategies to colonize their plant hosts, we successfully identified many putative genes that determine host specificities. Most of these genes were classified as transcription factors, enzymes, transporters, and chemotaxis regulators. Comparative genomics provides a powerful tool for helping to identify genes that are common among species. Genome-based views of plant-associated bacteria reveal specific interactions between bacteria and plant hosts.

Duality as Narrative Stance in Gaskell’s Emancipatory Feminist Novels

( Hongsheng Sui ) 한국영어영문학회 2021 영어 영문학 Vol.67 No.2

Victorian novelist, biographer, and short fiction writer, Elizabeth Gaskell (1810-1865), occupies a rightful place in the canon of British literature and, especially in the latter half of the 20th century, much critical energy has been exerted by scholars critiquing her oeuvre. Like her progenitors, Jane Austin and the Brontë sisters, Gaskell may also be framed as an early pioneer promulgating quietly feminist responses to social conditions changing around her. The Victorian writer’s work intently critiques a morphing English landscape bearing the brunt of industrialization, and upon which performances of nationhood, class, and gender were playing out. Lizhen’s monograph The Angel and the Dove is a richly generative survey of Elizabeth Gaskell’s varied excursions into examinations of gender ideology and female consciousness. Based on deep close readings of narrative structures in play within three texts (Cranford, North and South, and Wives and Daughters), Chen’s monograph delivers a penetrating analysis of Gaskell’s position on the place of females in the discourse of power relations in Victorian England. As Chen asserts, “With a plain but valid narrative concept, contradicted but wise political horizon, stable but graceful narrative capacity, tender but principled moral concern, conservative but flamboyant spirit, critical but self-reflective tone, Gaskell wins recognition and still appeals to contemporary readers” (138-39). And so it seems, for, perhaps more than ever, feminist discourses remain not only entirely necessary, but must continue to explore the gamut of possible rhetorical strategies when speaking back to phallogocentric power.

Event-triggered Control for Switched Affine Linear Systems

Hongsheng Hu,Shipei Huang,Zhengjiang Zhang 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.11

Event-triggered control problem for switched affine linear systems with a state-dependent switching law is addressed in this paper. By constructing a piecewise differential Lyapunov function with time-scheduled matrices, an event-triggered scheme and a switching signal are proposed. The switching signal depends on the state of the trigger instant. A sufficient condition is developed to ensure that the switched affine system exponentially convergences to a small neighborhood of the desired equilibrium point. The proposed result is then generated to a disturbance attenuation performance analysis. The results are presented in the form of linear matrix inequalities (LMIs). Finally, two examples are provided to illustrate the effectiveness of the proposed results.