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      • KCI등재

        Synchronization of Nonlinear Coupled Delayed Networks via Intermittent Pinning Control: An Average Technique

        Hongli Zhang,Ying Guo,Zhaoqin Cao 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5

        This paper is concerned with the aperiodically intermittent pinning control (AIPC) for the synchronization of nonlinear coupled networks, where both the internal time delay and the coupling time delay are considered. We consider the aperiodicity of AIPC from the average sense. Then by extending the Halanay’s inequality to the case with two kinds different delays, we obtain two kinds of synchronization criteria: one is the upper bound of time delay must be less than the average control width but can be larger than certain control widths; the other is that the upper bound of time delay has no relationship with the average control width. We show that the two criteria lead to complementary results. The effectiveness of our results is confirmed by numerical simulations.

      • ANALYSIS OF POITIONING OF MAJOR EXHIBITION CITIES IN ASIA

        Hongli Sun,Seongseop Kim 세계문화관광학회 2006 Conference Proceedings Vol.7 No.0

        The aim of this study is to assess the positioning of exhibition cities as perceived by exhibitors who participated in exhibitions held in Hong Kong. To compare the respondents' perceptions of the six exhibition cities with regard to the 30 exhibition destination attribute items, a General Linear Model (GLM) with repeated measures was applied. Hong Kong and Singapore were perceived to be the most appropriate destinations, whereas Seoul and Beijing were relatively less favorable destinations.

      • KCI등재

        Extracellular Vesicles-Encapsulated miR-153-3p Potentiate the Survival and Invasion of Lung Adenocarcinoma

        Hongli Cao,Ping Zhang,Hong Yu,Jianing Xi 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.6

        Extracellular vesicles (EVs) play an essential role in the communication between cells and the tumor micro­environment. However, the effect of tumor-derived EVs on the growth and metastasis of lung adenocarcinoma (LUAD) remains to be explored. This study aimed to elucidate the role of miR-153-3p-EVs in the invasion and migration capabilities of LUAD cells and explore its mechanism through in vivo and in vitro experiments. We found that miR-153-3p was specifically and highly expressed in LUAD and its secreted EVs. Furthermore, the expression of BANCR was negatively regulated by miR-153-3p and identified as a target gene of miR-153-3p using luciferase reporter assays. Through further investigation, we found that the downregulation of BANCR activates the PI3K/AKT pathway and accelerates the process of epithelial-mesenchymal transition (EMT), which ultimately leads to the aggravation of LUAD. The orthotopic xenograft mouse model was established to illustrate the effect of miR-153-3p-EVs on LUAD. Animal studies showed that miR-153-3p-EVs accelerated tumor growth in mice. Besides, we found that miR-153-3p-EVs could damage the respiratory ability of mice and produce a mass of inflammatory cells around the lung tissue of mice. Nevertheless, antagomir-153-3p treatment could inhibit the deterioration of respiratory function and inhibit the growth of lung tumors in mice. In conclusion, our study reveals the potential molecular mechanism of miR-153-3p-EVs in the development of LUAD and provides a potential strategy for the treatment of LUAD.

      • SCIESCOPUSKCI등재

        Nonlinearity of Shear Response of Unidirectional Laminates under Combined Loading

        Hongli Jia(지아홍리),Hyun-Ik Yang(양현익) 한국고분자학회 2018 폴리머 Vol.42 No.6

        본 논문에서는 보완된 변형 에너지 밀도 함수를 기반으로 하여 평면내 비선형 응력-변형률 곡선 모델을 제시한다. 다방향의 적측판에 전단방향과 축방향의 응력이 조합되어 작용할 때의 전단방향의 응답을 예측하였으며, 실험값과 비교하여 제시 모델의 정확성을 검증하였다. 이 과정에서 compliance 상수는 기존 축방향의 응력에 대한 측정값과 일치하도록 결정되었다. 마지막으로 제시된 모델을 이용한 E-glass/vinylester의 전단 응력-변형률 거동은 모든 축외 각도에 대하여 실험 곡선과 일치하며, boron/epoxy와 T800H/3633 적층판의 전단 거동은 15도를 제외한 30도, 45도, 60도의 축외 각도(off-axis angle)에 대하여 실험값과 일치한다. 이는 작은 적층 각도의 변화에도 종방향의 탄성계수는 다른 탄성계수에 비하여 매우 높기 때문이다. We present the prediction of nonlinear in-plane shear stress strain curves based on complementary strain energy density function. When the [θ˚] unidirectional laminates are subjected to a combination of shear stresses and axial stresses, the predicted shear responses of laminates are compared with measured experimental data for verifying this accuracy of this model. In this process, the compliance constants are determined to match the measured test results in terms of the influence of on-axis axial stress. Finally, it is shown that the predicted shear stress strain behavior of E-glass/vinylester concurs with experimental curves for all off-axis angles, while shear behavior predictions of boron/epoxy and T800H/3633 laminates agree with experimental results for 30˚ 45˚ 60˚ off-axis angles laminates except 15˚ off-axis angle laminates. This is because the elastic longitudinal modulus is still significantly higher than the other modulus even for a small off axis angle.

      • KCI등재

        Composition and abundance of microbiota in the pharynx in patients with laryngeal carcinoma and vocal cord polyps

        Hongli Gong,Boyan Wang,Yi Shi,Yong Shi,Xiyan Xiao,Pengyu Cao,Lei Tao,Yuezhu Wang,Liang Zhou 한국미생물학회 2017 The journal of microbiology Vol.55 No.8

        The pharynx is an important site of microbiota colonization, but the bacterial populations at this site have been relatively unexplored by culture-independent approaches. The aim of this study was to characterize the microbiota structure of the pharynx. Pyrosequencing of 16S rRNA gene libraries was used to characterize the pharyngeal microbiota using swab samples from 68 subjects with laryngeal cancer and 28 subjects with vocal cord polyps. Overall, the major phylum was Firmicutes, with Streptococcus as the predominant genus in the pharyngeal communities. Nine core operational taxonomic units detected from Streptococcus, Fusobacterium, Prevotella, Granulicatella, and Veillonella accounted for 21.3% of the total sequences detected. However, there was no difference in bacterial communities in the pharynx from patients with laryngeal cancer and vocal cord polyps. The relative abundance of Firmicutes was inversely correlated with Fusobacteria, Proteobacteria, Actinobacteria, and Bacteroidetes. The correlation was evident at the genus level, and the relative abundance of Streptococcus was inversely associated with Fusobacterium, Leptotrichia, Neisseria, Actinomyces, and Prevotella. This study presented a profile for the overall structure of the microbiota in pharyngeal swab samples. Inverse correlations were found between Streptococcus and other bacterial communities, suggesting that potential antagonism may exist among pharyngeal microbiota.

      • KCI등재

        The influence of material shear nonlinearity on predictive failure envelopes of multidirectional laminates

        Hongli Jia,양현익,김창완,Hun Bong Lim 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.4

        In present study, laminates with the type of [±θ°] S and [0° 2 /±θ°] S are investigated in order to clearly show the effect of material shear nonlinearity, and then theoretical predictions are compared with experimental data. In the whole process of generating failure envelopes, secant shear modulus instead of initial shear modulus is used for accurate shear stress-strain relation. The modulus values are recalculated every time when the combining load is changed. Final failure envelopes are then compared between numerical models. It is found that the variation in the size of safe regions from nonlinear analysis is closely related to the way of combing load and fiber directions. So in the process of improving failure theories or in the applications of failure theories, the effect of material nonlinearity can be considered appropriately.

      • KCI등재

        The alum-processing mechanism attenuating toxicity of Araceae Pinellia ternata and Pinellia pedatisecta

        Hongli Yu,Hao Wu,Yaozong Pan,Xiuyun Ge,Qian Zhang,Fagen Zhu,Baochang Cai 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10

        The present study aimed at investigating thealum-processing mechanism attenuating toxicity of AraceaePinellia ternata and Pinellia pedatisecta. Animalretroperitoneal inflammatory model in vivo andmacrophagocyte release inflammatory factor model in vitrowere used to detect the effect of alum processing onraphides and lectin. Scanning electron microscopy wasused to observe the change in raphides during processing;HPLC method was used to determine the correlation betweenthe dissolution and corrosion of raphides and ion inthe alum solution; 27Al-NMR technology was used to detectthe relationship between aluminum oxalate complexformation and the dissolved and corrosion of raphides. Thechange in protein peptide sequence of lectin during theprocessing of alum solution was determined by ShotgunLC–MS assay. Raphides induced severe rabbit conjunctivaledema and an intraperitoneal injection of lectin increasedPGE2 and protein in mice peritoneal exudate, whiledecreased after treatment with alum solution processing. During the processing raphides was dissolved and corroded,then its structure was damaged. Raphides was soaked inthe alum solution and significantly decreased the oxalatecontent, and the effect was related with Al3? in the alum. Al3? in the alum combined with C2O42- of raphides into astable complex compound promoted the dissolution ofcalcium oxalate. Raphides soaked in the alum made lectinproteins dissolve, whereas protein peptide sequence oflectin was changed and the protein structure was damaged. Conclusion: Alum solution could decrease the toxicity ofP. ternata (Thunb.) Breit. and P. pedatisecta Schott. Sinceit made a special crystal structure of raphides damage andthe protein of lectin dissolve. The structure of toxic substancessignificantly changed, which decreased the inflammatoryeffect.

      • KCI등재

        The influence of material shear nonlinearity on multidirectional laminates in terms of failure envelopes

        Hongli Jia,양현익,강태원 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.12

        Influence of material shear nonlinearity on multidirectional laminates in terms of failure envelopes was investigated. In applying classic laminate theory, elastic constants were employed in transverse and longitudinal directions, while initial shear modulus was substituted by the secant shear modulus, which was achieved by means of Ramberg-Osgood model. The fracture curves were generated from maximum stress, Tsai-Wu and Puck criteria. The similarities and differences between nonlinear and linear shear models can be expressed in terms of symmetric balanced laminates [±θ°] 2 s and asymmetric laminates [0° 2 /±θ°], which are both arranged by material E-glass/MY750 oriented at different directions. All σ 1 - σ 2 failure envelopes due to material nonlinearity extend outward in tensile and compressive directions, but the phenomenon is not obvious with increasing ply angles. Similarly, the differences of all σ 1 - τ 12 failure envelopes between nonlinear shear analysis and linear shear analysis are decreasing with increased ply angles. Ply orientations and loading directions are involved in the effect of nonlinear shear properties on failure envelopes. According to the failure modes obtained from maximum stress criterion, it is reasonably derived that the influence of material shear nonlinearity will lead whether the failure envelopes from the other two failure criteria are more conservative or not.

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