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Honami Miyazaki,Yoko Okamoto,Aya Motoi,Takafumi Watanabe,Shigeru Katayama,Sei-ichi Kawahara,Hidefumi Makabe,Hiroshi Fujii,Shinichi Yonekura 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.1
BACKGROUND/OBJECTIVES: Alzheimer’s disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein (Aβ) in the brain may be closely correlated with the development of Alzheimer’s disease. In this study, the effects of an adzuki bean extract on the aggregation of Aβ were examined; moreover, the anti-Alzheimer’s activity of the adzuki extract was examined. MATERIALS/METHODS: First, we undertook thioflavin T (ThT) fluorescence analysis and transmission electron microscopy (TEM) to evaluate the effect of an adzuki bean extract on Aβ42 aggregation. To evaluate the effects of the adzuki extract on the symptoms of Alzheimer’s disease in vivo, Aβ42-overexpressing Drosophila were used. In these flies, overexpression of Aβ42 induced the formation of Aβ42 aggregates in the brain, decreased motor function, and resulted in cognitive impairment. RESULTS: Based on the results obtained by ThT fluorescence assays and TEM, the adzuki bean extract inhibited the formation of Aβ42 aggregates in a concentration-dependent manner. When Aβ42-overexpressing flies were fed regular medium containing adzuki extract, the Aβ42 level in the brain was significantly lower than that in the group fed regular medium only. Furthermore, suppression of the decrease in motor function, suppression of cognitive impairment, and improvement in lifespan were observed in Aβ42-overexpressing flies fed regular medium with adzuki extract. CONCLUSIONS: The results reveal the delaying effects of an adzuki bean extract on the progression of Alzheimer’s disease and provide useful information for identifying novel prevention treatments for Alzheimer’s disease.
Temperature measurement of microfluids with high temporal resolution by laser-induced fluorescence
Masahiro Motosuke,Dai Akutsu,Shinji Honami 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.7
Temperature of microfluidic system is greatly sensitive because of fast heat conduction and small heat capacity due to the scale effect. The purpose of this study is the development of a measurement system for the temperature field of liquids in a microfluidic device with high spatial- and temporal- resolution. Measurement method employed in this study is laser-induced fluorescence using fluorescein with the temperature dependence of fluorescent intensity. In order to measure the transient temperature field, an image-intensified high-speed camera was utilized. The signal-to-noise ratio can be improved by the time- or phase- averaging scheme. Applying the synchronization mechanism, phaseaveraged temperature data with the time resolution of 500 μs can be obtained. Spatial resolution estimated from the Rayleigh limit was approximately 530 nm. The validity of the developed measurement system was confirmed by the experiments for the transient behavior of the liquid temperature undergoing the laser heating in the microfluidic device.
NUMERICAL INVESTIGATION ON BOTTOM GAP OF MICRO FLOW SENSOR
Abdullahl Mohd Zulkiefly,Kouta T,Kamijo Takuma,Yamamoto Makoto,Honami Shinji,Kamiunten Shoji Korea Society of Computational Fluids Engineering 2005 한국전산유체공학회지 Vol.10 No.1
Micro sensor is very useful for flow measurements in a number of engineering applications. Especially, it is necessary for the development of MEMS. This paper presents the 3D numerical simulation of flows around a micro flow sensor, which is mounted on a flat plate. The effects of the sensor configuration (i.e. bottom gap) and the Reynolds number on the flow field are numerically investigated. The numerical results indicate that the bottom gap clearly affects the flow fields over the top surface of the sensor. The Reynolds numbers also show a significant influence on the flow nature, especially on the recirculation zone at downstream of the sensor. The present results illustrate a certain improvement on the flow field for the sensor installed at O.5mm above the wall with four pillars, comparing with that directly mounted on the wall.
NUMERICAL INVESTIGATION ON BOTTOM GAP OF MICRO FLOW SENSOR
Mohd Zulkiefly Abdullah,T. Kouta,Takuma Kamijo,Makoto Yamamoto,Shinji Honami,Shoji Kamiunten 한국전산유체공학회 2005 한국전산유체공학회지 Vol.10 No.1
Micro sensor is very useful for flow measurements in a number of engineering applications. Especially, it is necessary for the development of MEMS. This paper presents the 3D numerical simulation of flows around a micro flow sensor, which is mounted on a flat plate. The effects of the sensor configuration (i.e. bottom gap) and the Reynolds number on the flow field are numerically investigated. The numerical results indicate that the bottom gap clearly affects the flow fields over the top surface of the sensor. The Reynolds numbers also show a significant influence on the flow nature, especially on the recirculation zone at downstream of the sensor. The present results illustrate a certain improvement on the flow field for the sensor installed at 0.5mm above the wall with four pillars, comparing with that directly mounted on the wall.