Glucose deprivation으로 유발된 Neuro 2A 세포의 산화적 손상에 대한 七氣湯의 보호효과

성기호(Ki-Ho Seong),이정섭(Jung-Sup Lee),신선호(Sun-Ho Shin) 대한한의학회 2010 대한한의학회지 Vol.31 No.2

혈액암환자에서 조혈모세포 이식 후 따르는 헤르페스 바이러스 감영 양상

이호섭,탁희상,신성훈,김양수,남성진,김혜수,박진희,정수현,김성빈,김예나 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

배경 : 헤르페스바이러스과에는 단순포진 바이러스(HERPES SIMPLEX VIRUS, HSV), 수두대상포진 바이러스 (VARICELLA-ZOSTER VIRUS, VZV), 엡스타인-바 바이러스 (EPSTEIN-BARR VIRUS, EBV), 그리고 거대세포 바이러스 (CYTOMEGALOVIRUS, CMV) 등이 있다. 헤르페스바이러스 감염은 혈액암환자에서 조혈모세포 이식 환자에서 전파 (dissemination), 이차감염, 세균 중복 감염의 심각한 합병증을 일으킬 수 있다. 하지만 항암약물치료를 받는 림파종 환자에서 항 바이러스 약제의 사용 용량과 기간에 대한 concensus는 없다. 헤르페스바이러스 감염에 대한 발생율과 위험인자를 후향성으로 분석하였다. 방법 : 고신대학교 복음 병원에서 1995년 6월부터 2009 년 2월 사이에 새롭게 진단되어 조혈모세포 이식을 받은 전체 58명의 환자들이 후향적으로 현 연구에 등록했다. 헤르페스 바이러스 감염은 임상적 진단, 혈청학적 검사 또는 병리학적 진단에 기초하여 확진한다. 환자들의 특성은 다음과 같다: 평균 연령은 44세 (범위 19-62세)였고 남녀비는 30:28이었다. 등록된 질환은 백혈병 (n=9, 15.5%), 림프종 (n=30, 51.7%), 다발성 골수종 (n=12, 20.7%), 재생불량성 빈혈 (n=6, 10.3%) 그리고 골수이형성증후군 (n=1, 1.7%)이 포함되었다. 결과는 chi-squre test나 independent samples T test를 사용하여 분석되었다. Multivariate analysises에 대해 logistic regression test를 사용하였다. 결과 : 15명의 환자들 (25.9%)에서 조혈모세포 이식후 헤르페스 바이러스 감염이 발생하였다. 조혈모세포 이식 5년간 누적 발생율은 53.9%였다. Univariate analyses에서 헤르페스 바이러스 감염에 대한 유의한 위험 인자는 없었다. 하지만 조혈모세포 이식후 생존 기간(40.18 ± 30.14 months vs 20.06 ± 26.67 months, p=0.018)은 헤르페스 바이러스 감염의 낮은 발병율과 유의한 관련성이 있었다. 이식 편대 숙주질환 (GVHD)의 존재 (37.5% in developed GVHD vs 0% in no GVHD, p=0.200), 동종조혈 모세포 이식에서 면역억제요법의 기간 (15.98 ± 14.02 months vs 6.78 ± 3.67 months, p = 0.374)은 헤르페스 바이러스 감염에 대한 위험인자가 아니었다. 결론 : 조혈모세포 이식 후 생존 기간은 어사이클로비어 예방을 받은 혈액암 환자에서 헤르페스 바이러스 감염의 낮은 발병율과 연관성이 있는 것으로 보인다. 저용량의 어사이클로비어 예방은 헤르페스 바이러스 감염의 고위험군인 조혈모세포 이식을 받은 혈액암 환자에 필요하리라 생각된다. Background : Herpesviridae family includes herpes simplex virus, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus, etc. Herpesviridae viral infection (HVI) can lead to serious complications including dissemination, secondary infection, bacterial superinfection in patients with hematologic malignancy following hematopoietic stem cell transplantation (HSCT). But there was no consensus on the dose and duration of antiviral agents prophylaxis in patients undergoing chemotherapy. We retrospectively analyzed the incidence and the risk factors for HVI. Method : A total of 58 patients who newly diagnosed and received HSCT with prophylaxis of acyclovir at the Kosin University Gospel Hospital, Busan, Korea between June 1995 and February 2009 were enrolled retrospectively in the current study. HVI was confirmed based on clinical diagnosis, serologic test or pathologic diagnosis. The characteristics of the patients were as follows: the median age was 44 years (range 19-62 years) with a female-to-male ratio of 30:28. The enrolled diseases included leukemia (n=9, 15.5%), lymphoma (n=30, 51.7%), multiple myeloma (n=12, 20.7%), aplastic anemia (n=6, 10.3%) and myelodysplastic syndrome (n=1, 1.7%). The results were analyzed using a chi-square test and independent samples T test. For the multivariate analysis, we used logistic regression test. Results : Fifteen patients (25.9%) developed HVI after HSCT. The cumulative incidence of HVI was 53.8% at 5 years after HSCT. In univariate analysis, there was no significant risk factor for HVI. The presence of graft-versus-host disease (GVHD) (37.5% in developed GVHD vs. 0% in no GVHD, p=0.200), duration of immunosuppressive therapy (IST) in allo-SCT (15.98 ± 14.02 months vs. 6.78 ± 3.67 months, p = 0.374) were not risk factors for HVI. Conclusion : The incidence of HVI was similar to that in historical other studies. There was no risk factor associated with development of HVI. Most of the HVI occurred within the first 24 months after transplantation. So long term use of antiviral prophylaxis may be needed to prevention of HVI after HSCT.

다발성 골수종 환자에서 자가 조혈모세포 이식 중 장기간 비경구적 영양요법 후 발생한 베르니케 뇌증의 1례

이호섭 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

급성 백혈병, 림프종, 다발성 골수종을 포함한 다양한 혈액종양 질환을 치료하기 위한 최선의 방법은 조혈모세포 이식으로 알려져 있다. 그러나, 조혈모세포 이식에 따른 부작용들도 많은 것으로 알려져 있는데, 특히 오심, 구토, 설사, 구내염 등의 증상 때문에 식이 섭취의 부족으로 인해 영양 결핍이 초래될 수 있다. 그 중에서 비타민 B1 (thiamine) 의 결핍에 따른 베르니케 뇌증의 발생이 드물지만 있을 수 있다. 저자는 다발성 골수종 환자에서 자가조혈모세포 이식 시행후 발생한 베르니케 뇌증의 1 례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Wernicke’s encephalopathy is an acute neurologic disease which results from vitamin B1 (thiamin) deficiency. Clinical symptoms are ataxia, opthalmoplegia and mental change. This disease affects the thalamus, midbrain and mammillary bodies. The diagnosis of Wernicke’s encephalopathy is made with brain Magnetic resonance imaging (MRI) and its clinical symptoms. but The confirming test is not known as yet. Most common causes of this disease are chronic alcoholism, total parenteral nutrition, total gastrectomy, and severe anorexia but rare cases reported about occurrence of Wernicke’s encephalopathy after chemotherapy or hematopoietic stem cell transplantation. An author present a case of Wernicke’s encephalopathy developed after autologous stem cell transplantation followed by total parenteral nutrition in a patient with multiple myeloma.

1990년대 이후 일본의 재정위기의 성격과 원인 분석

김호섭 현대일본학회 2003 日本硏究論叢 Vol.17 No.-

이 글에서는 90년대 이후 일본의 재정위기 상황의 성격과 그 원인을 설명한 논의를 비판적으로 고찰하고 그 주요 논쟁점을 분석하였다. 재정재건이 지연되는 일반적 이유와 90년대 일본의 이유를 비교하였다. 일본에서 재정개혁이 진전되지 않는 이유로는 (1)국민의 민의와 정치를 지배하는 논리와의 괘리; (2)재정재건의 성과에 관한 시장의 약한 신뢰; (3)취약한 연립정권을 지적하였다. 공공사업의 규모가 축소되지 않는 이유로서 중앙정부와 지방정부의 관계, 지역간의 이해대립 및 지방의 기득권을 지적하였다. 이 글에서는 재정적자가 지속적으로 확대되고 재정재건이 지체되고 있는 원인을 정부 요인론, 사회적 요인론 및 경제부문론으로 분류하여 분석하였다. 경제 부문론을 채택하는 견해에 의하면 정부 요인론이나 사회적 요인론은 같은 정권시기에 대립되는 정책이 채택되는 상황을 설명하기 어렵다고 주장한다. 이 글에서는 정부와 경제부문 간의 연계를 모색하는 결정은 집권정당이 하여야 하며 경제부문과의 연계를 정치적 자원으로 동원할 수밖에 없는 상황은 역시 집권여당의 권력기반이 취약하기 때문이라고 주장한다. 즉 일본 사회의 정치적 자원분포가 실질적으로 변화되었으나 정치적 제도가 기득권의 주장에 의해서 지속적으로 유지되기 때문에 재정확대가 계속된다고 주장하였다. The purpose of this paper is to analyze the issues of the Japanese budget crisis since the 1990s, and to critically review the hypotheses explaining its nature and causes. Theis paper characterizes the particular nature and causes of Japanese budget crisis, and points out three reasons why the Japanese political system cannot remedy the crisis. Those are the gap between the political logic and the political norms based on public needs, the week trust of the market to the budget reform, and the week political leadership of the coalition cabinet. As the reason why the expenses of public works have not decreased, this paper points out the relationship between the central government and local government, interest conflict based on regionalism and vested interests of local governments. As the main reason why the Japanese political system continues to expand budget deficits, this paper argues that although the distribution of political resources has been changed according to the change of the Japanese society in various respects, the political system does not reflect this change but follow the vest interests of the old system.

精神症狀에 대한 韓國人의 態度調査

元鎬澤,洪元植,張煥日,陳聖太,金光日,李基南,嚴龍燮,金明正 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.1

Korean psychiatrists are more apt to take the abnormal drinking behavior lightly and regard the psychosomatic symptoms as more serious, comparing with American psychiatrists. On the other hand, physicians as well as adults from the population in Korea are less concerned about the neurotic and psychosomatic symptoms and alcoholic behavior as psychiatric problems. It is the authors' concern to understand such differences in opinion about abnormal behaviors from the cultural and social psychiatric view point. The authors used Dohrenwend's questionaire form of 45 mental symptoms and three additional items i. e., homosexual behavior, symptom of senile psychosis and delusion of jealousy following the authors' interests. Each item was rated by three point cale (psychiatrically very serious=2 points, somewhat serious=1, not serious at all=0) and evaluated with critical ratio. As a preliminary study, the reliability of this questionaire was confirmed by the test-retest method; Spearman's rho was 0,93. The subjects in this study consist of 50 psychiatrists, 49 physicians, 54 herb practitioners and 154 adults from the normal population(60 urban samples and 94 rural samples). The collection was carried out by individual interviews for the physicians and normal samples, by letters for the psychiatrists and the herb practitioners. And the data of American psychiatrists compared in this study were quoted from Dohrenwend's report(27). This study has two parts: one is the cross-cultural comparison between American psychiatrists and Korean ones, the other is intracultural comparison among psychiatrists, physicians, herb practitioners and normal population samples. Inspite of the general notion that Korean psychiatry has been much oriented to American psychiatry for over twenty years, there are definite differences in opinion about the severity of abnormal behaviors between American and Korean psychiatrist, especially about alcoholic behavior and psychosomatic symptoms. Such differences are possibly interpreted as arising from the cultural differences. The American psychiatrists seem to be more concerned about alcoholic behavior probably due to the strict attitude of people and/or the fact that the United States reveals the highest incidence of alcoholism throughout the world. The Korea psychiatrists, however, have much tolerable attitude toward alcoholic behavior according to the cultural tradition. Solitary drinking is hardly found in Korea; drinking in Korea is a suitable way of interpersonal contact. They drink slowly and are not so intensively dependent upon alcohol itself. Dependency need to alcohol can be diffused to the other persons. And they take alcohol with many kinds of side-dishes. These drinking manners seem to be cultural virtues for low incidence of alcoholism in Korea. Thus, Korean psychiatrists as well as adults from normal population have highly tolerable attitude toward alcoholic behavior. Even when some person reveals a destructive behavior after drinking, they grant it as a personal charm. Korea psychiatrists, therefore, are not so nervous about the alcoholic behavior. On the other hard, the psychosomatic problems seem to be serious in Korean mental patients. They are easily apt to express their emotional problems as somatic symptoms possibly due to the disease concept of oriental herb medicine that has a high tendency of projection of emotional conflicts unto the soma. So most of Korean people are not aware that psychosomatic symptoms are originated from the emotional problems, and quite contrary to it, the psychiatrists may be highly conscious of psychosomatic symptoms. Another significant difference is seen in suicidal idea and suspiciousness: American psychiatrists regard them as more serious, and reversely Korean psychiatrists regard them as less serious. Such a pattern may also be derived from the socio-cultural differences. When Koreans are either dissapointed or delighted, they say frequently "I want to die" or "It's funny to death" and so on. This idiomatic expression is far from the real death wish but rather an expression of magnification. And the suicidal idea itself is frequently seen in normal population even suicidal attempt is evaluated as abnormal in Korea. With such reasons, Korean psychiatrists may notice suicidal idea as less serious than American psychiatrists. And the suspiciousness may be a way of living for the people under the historical turmoil and vigorous aculturation, that it is perceived as not so abnormal. The next problem is the marked discrepancy of opinion about abnormal behaviors among psychiatrists, physicians, herb practitioners and normal population samples. The agreement of physicians, herb practitioners, urban samples and rural samples with the psychiatrists on the relative severity of symptoms revealed as Spearman's rho of 0.79, 0.59, 0.58 and 0.44 respectively. It is the main point of problem that physicians are less aware of neurotic symptoms which can appear in the somatic illness, and of psychosomatic symptoms as psychiatric problem. Possible reason is that Korean physician have been oriented to the somatic medicine without proper psychosomatic orientation. On the other hand, the herb practitioners are apt to ignore the severity of psychotic symptoms and on the other, regard the neurotic and psychosomatic symptoms as much as psychiatrists' opinion. And the samples of normal population regard the neurotic symptoms as more serious than the psychotic symptoms, and are not aware of the psychosomatic symptoms as psychiatric problems. Physicians, herb practitioners and samples from the normal population underestimate the alcoholic behavior more than psychiatrists do. The alcoholism according to physicians' opinion is rather somatic problem than psychological one. The herb practitioners and adults from normal population manifest the prominently tolerable attitude toward alcoholic behavior. In conclusion, two kinds of problems can be suggested. One is that the difference between Korean and American psychiatrists in the evaluation on the severity of abnormal behaviors, is possibly due to sociocultural differences. The other is the intracultural difference among psychiatrists, physicians, herb practitioners and adults from normal population. Such a difference suggests that there is a considerable cultural lag in the disease concept and attitude between the modern psychiatry and the cultural tradition. This discrepancy can result in the undesirable wandering of patients for seeking the treatment and some hardship in modern psychiatric practitioning in Korea.

Proflavine과 Coriphosphine(cp)의 誘導體들에 대한 光學的 吸收Spectra에 관한 硏究

崔虎燮 群山大學校 1984 論文集 Vol.7 No.-

The optical absorption spectra of several derivatives of proflavine(PF) and coriphosphine (CP) were measured in agueous solution at 25c. The effect of the perturbation of one both of the exonuclear amino groups on the spectral behavior was studied in order to explore the relationship between the spectra and the chemical structures of the symmetric 3.6-disubstituted acridine dyes which can bind to various polyelectrolytes, often showing metachromasy. The metachromatic spectra of the complexes between 3.6-diaminoacridine dyes and polyanions were reproduced reasonably well when one of the two groups of PF was converted to an acylamino group. A similar result was observed when the amino group of CP was acetylated. In these cases, the spectra show two absorption bands of nearly equal intensity on both sides of the single peak of PF and CP in the visible region. These results are indicative of the close similarity in chemical structures between the monoacylamino PF and the PF bound to the electron-rich sites of polyanions.

특성치의 총계와 비에 대한 종복추정

김호일,이태섭 안양대학교 자연과학연구소 1995 自然科學硏究 Vol.2 No.-

가구조사에 있어서 추출방법에는 두 가지가 있다. 첫째는 가구에 근거한 어떤 특성치에 대한 조사를 그 가구에서만 보고하게 하는 기존의 방법에 근거한 조사이고, 둘째는 어떠한 특성을 지닌 가구가 그가 거주하고 있는 곳 뿐 아니라 형제나 친척등에 의한 다른 가구에서도 보고될 수 있는 경우이다. 후자의 경우를 중복조사라 한다. 이 논문에서는 중복조사가 한 가구에서 한 번만 보고되는 기존의 조사보다 총계나 비의 분산이 작게 추정된다는 것을 예를 통해 보였다. 그러나 보편적으로 중복을 통한 조사는 기존방법에 의한 조사보다 더 많은 노력과 비용이 요구된다는 점을 고려해야 한다. There are two types of sampling: The convention sampling links each population element to only one household unit. Multiplicity sampling distributes population element among household units such that every element is linked at least one household. We demonstrate that multiplicity rule may exist that would produce estimators that are more efficient than any conventional estimator. Also we know that multiplicity estimator may be less efficient than any conventional estimator because multiplicity estimate require more information and then such factors make multiplicity estimator more expensive.

Interleukin-2가 Mouse간의 인산염분해효소의 활성에 미치는 영향

이규식,김원규,정호삼,강성섭 한양대학교 의과대학 1989 한양의대 학술지 Vol.9 No.1

In recent years, interleukin-2, a lymphokine produced by antigen or mitogenstimulated lymphocytes, has been intensively with the development of immunooncology and chemoimmunotherapy of the malignant tumor. Interleukin-2 mediates antitumor effect by stimulating the proliferation of helperand cytotoxic T cells, augmenting the cytolytic activities of cytotoxic T-lymphocytes and differentiating T-lymphocytes into a lymphokine-activated killer cell in vivo. Thus interleukin-2 induces the therapeutic effects on various sarcoma and carcinoma and regresses the pulmonary, hepatic and peritoneal metastases of various tumors. Although interleukin-2 is very effective for the treatment of various malignancy, it develops many side effects including fever, chill, malaise, mental confusion, diarrhea, vomiting and oliguria and causes pulmonary, hepatic and renal toxicities. Especially interleukin-2 results in increase of capillary permeability with weight gain, pulmonary edema, and ascites. In this experiment, the author studied the effect of interleukin-2 on the mouse liver, histochemically observing the changes in the activities of alkaline phosphatase, acid phosphatase and adenosine triphosphatase. Male mice, DDY strain, weighing 20gm, were used as experimental animals. The experimental animals were sacrificed at 3, 6, 12, 24 and 48 hours after intraperitoneal administration of two milions unit of interleukin-2 per kilogram of body weight. The specimens obtained from the liver were fixed in 10% neutral buffered formalin solution for 24 hours at 4℃ and sliced at 16㎛ thickness in a frozen cryostat. The activities of alkaline phosphatase and acid phosphatase were observed by the Gomori's method and the activity of adenosine triphosphatase was observed by the Wachstein and Meisel's method for histochemical study. The results obtained were as follows. 1. The acid phosphatase activity was strong positive at 12 hours and 24 hours groups in the central and portal zones of the liver lobules, but weak positive and moderate positive at 48 hours group in the central and portal zones of the liver lobules, respectively. 2. The alkaline phosphatase activity was weak positive at 6 hours and 12 hours groups and moderate positive at 48 hours group in the central and portal zone of the liver lobules. 3. The adenosine triphosphatase activity was trace positive in the central zone and weak positive in the portal zone of the liver lobules at 6 hours group but moderate positive at 48 hours group in the central and portal zones of the liver lobules. Consequently, it is suggested that interleukin-2 induce degenerative changes of the hepatocytes of the mouse, but it is recovered with time.

양극성 장애의 우세삽화와 임상양상 간의 연관성 : 예비연구

서호준,우영섭,채정호,전태연,김광수,박원명 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objective : This study was performed to fmd clinical implications ofdistinctive pattems in bipolar patients with predominance of depressive episodes or manic episodes and to find possibilities to predict predominant episodes in bipolar disorder. Methods : The recmitment period was between 2002 and 2004, among inpatients who had received psychiatric treatment for bipolar disorder. The data about the number and the polarity of the past episodes were collected through medical records, and Sub-jects were divided into depressive or manic episode predominant groups. The two groups were compared regarding Sociodemo-graphic and clinical variables. Results : 74 patients met the inclusion criteria during the study period. 21 subjects were classified as depressive episode Pre-dominant group (depressive episode group), and 53 subjects as manic episode predominant group (manic episode group). There were no differences in sociodemographic data, the number of total episodes and hypomanic episodes, and onset age. However, 90.5% (n=19) subjects of depressive episode group showed depressive episode as first episode, and 88.7% (n=47) of manicepisode group experienced manic episode as first episode (χ²=42.13, df=1, P<0.00l). Psychotic symptomswere significantly more prominent in the manic episode group (χ²=6.85, df=1, P=0.009), and the number ofsubjects who had suicide attempt experience was higher in the depressive episode group (χ²=7.39, df=1, P=0.007). In the comparison of highest GAF scores during the past year, significant difference was found between the two group (p=0.046), as the mean scores of depressive epi-sode group was 68.337±7.47 and manic episode groupwas 71.51±5.42. Conclusion : The results ofthis study show that there are differences in clinical features according to predominant episodes in bipolar disorder. The type of onset episode appears to be related to predominant episode in this study, and it would be a valid Pa-rameter with therapeutic implication in bipolar patients.

치주질환 심도에 따른 조직내 림프구 및 NK 세포의 변화에 관한 면역조직학적 연구

최호근,이만섭,권영혁 慶熙大學校 齒科大學 1993 慶熙齒大論文集 Vol.15 No.1