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안호범(Ahn Ho Beom),윤재룡(Yoon Jae Rhyong) 대한체질인류학회 1993 대한체질인류학회지 Vol.6 No.1
하요적관절은 상요적관절과 같이 회내 회외운동을 하며 관절원판은 하요적관절과 요골수근관정 사이에 존재하고 있다 관절원편은 하요척관절의 안정을 유지시키는데 중요한 구조로서 섬유대 또는 섬유연골대가 적고 경상돌기에서 요골하단부내연을 연결하고 있다. 수근관절의 발생에 관해서는 양은 연구보고가 있으나 하요적관절 발육에 관한 보고는 드물고 관정원판의 선자현미경석 관찰은 없는 듯 하다. 저자는 좌고 30mm 부터 260mm 까지의 인태아를 대상으로 하요적관절과 관절원판의 발육과정을 광학 및 전자현미경적 관찰로 다응과 같은 결과를 얻었다. 좌고 40mm(태령 10주 ) 태아때 하요척관절과 요골수근관절의 원시강이 줄현하였고 100mm( 태 령 15주 ) 태아때는 관절강의 완성을 관찰하였다. 관설원판의 원기는 좌고 40mm 태아때 미분화 간엽세포의 밀집대로 줄현하였고 이세포에는 대량의 유리리보솜과 소량의 조연내형절망 사립제 및 골지복합제를 함유하고 있었다. 좌고 100mm( 태령 15 주 ) 태아때 관절원판의 외측부에는 방주상의 섬유모세포들이 치밀하게 배열하고 있었고 중간부에는 작은 원형의 섬유모세포들이 소생으로 배열하고 있었다. 좌고 150mm( 태령 19 주 ) 태아때 관절원판의 섬유모세포의 크기가 증대되었고 교년 섬유는 미량 존재하고 있였다. 좌고 200mm ( 대령23주) 부터 260mm (태령 30주) 태아까지의 관철원판 외즉부에는 섬유모세포와 다량의 교원섬유블이 출현하였고 중간부에는 섬유모세포와 교원섬유가 엉켜 존재하고 있었다. 이와같은 결과로 미루어 인태아 하요적관절의 관절원판은 태생기에 섬유모세포로 존재하고 생후에 섬유연골세표로 분화 발육하리라 생각된다.
정숭룡(Soong Rhyong Jung),김영운(Young Woon Kim),박준아(Jun Ah Park),정종철(Jong Cheol Cheong),오희균(Hee Kyun Oh),이종호(Jong Ho Lee),류선열(Sun Youl Ryu),최흥란(Hong Ran Choi) 대한구강악안면외과학회 1994 대한구강악안면외과학회지 Vol.20 No.4
Pleomorphic adenoma is a circumscribed tumor characterized microscopically by its pleomorphic or mixed apprearance, and its clearly recognizable epithelial tissue intermingled with areas of mucoid, mixed, or chondroid appearance. Pleomorphic adenoma, the most common tumor of the salivary glands, is now generally accepted as epithelial and benign adenoma, The palate is the most common location for minor salivary gland tumor. The neoplasm has been found in all age groups, the majority being in the fifth decade with an age ranged from 30 to 50. Minor salivary gland lesions appear a decade later, ranging in age from 40 to 60. We experienced three cases of pleomorphic adenoma occuring in the palate. They were treated with complete local exicision and reconstructed with pedicled temporal fascial, flap, pedicled buccal fat pad, and palatal islands flap each.
윤재룡,안호범,남광일,Yoon, Jae-Rhyong,Ahn, Ho-Beom,Nam, Kwang-Il 한국현미경학회 1996 Applied microscopy Vol.26 No.2
The development of flexor digital tendon of the hand was studied by electron microscopy in human fetuses ranging from 9 mm to 260 mm crown rump length. The primordium of tendons was first identified as discrete collection of mesenchymal cells at 25 mm fetus. Synovial sheath formation had commenced by 40 mm fetus and was complete by 70 mm fetus. Cell junction or adhesion sites at all ages were noted between the tendon cells. When dilatation of the synovial cavity occurred, two types of synovial cells were observed. A-type cells had numerous vesicles and large vacuoles. In contrast, B-type cells were characterized by abundant rough endoplasmic reticulum and well-developed Golgi complex. By $150mm{\sim}260mm$ fetuses, a mojority of the synovial cells were type B. The most remarkable difference between the synovial cells of full-term fetus and adult was the larger amount of collagen fibers in the latter. The vascular buds were first observed between the individual fibril bundles in the interfascicular space at 150 mm fetus. At 25 mm fetus, collagen fibrils were first noted within narrow cytoplasmic recesses which were continued with the extracellular space. Collagen fibrils were filled in almost entire extracellular space at 150 mm fetus. Besides collagen fibrils in the extracellular space small elastic fibers were also identified and followed in their development.
인태아(人胎兒) 척추(脊椎) 연골관(軟骨管)에 관(關)한 전자현미경적(電子顯微鏡的) 연구(硏究)
윤재룡,이병호,오창석,Yoon, Jae-Rhyong,Lee, Byung-Ho,Oh, Chang-Seok 한국현미경학회 1993 Applied microscopy Vol.23 No.1
The relationship of cartilage canals to initial osteogenesis of primary ossification center of developing vertebrae in human fetuses ranging from 50mm to 260mm in crown rump length was studied by light and electron microscopy. The cartiage canals of the thoracic vertebrae were first observed at 60mm fetus. Cartilage canals were identified as vascular channels arising from perichondrium surfaces. A number of cartilage canals were observed around the primary center of ossification at 80mm fetus. At 120mm fetus, cartilage canals of the bodies of vertebra were increased. Eventually the canals were eroded from the main medullary cavity and remained at only peripheral regions of growth cartilage. Superficial, intermediate, and deep canals were identified by the characteristics of cartilage cells. Fibroblasts, undifferentiated mesenchymal cells, and vacuolated macrophages were observed adjacent to the matrix of resting cartilage cells in the superficial canal. Fibroblasts and mesenchymal cells were densely packed at the tip of canal, giving an epithelial appearance to the clustered cell in the intermediate canal. Vacuolated macrophages were in contact with matrix of hypertrophied cartilage. The thick-walled vessels in the intermediate and deep canals consisted of typical endothelial cells, but in the newly formed vessels contained mesenchymal cells and fibroblasts incorporated into the vessel wall. During lengthening of cartilage canal, the matrix of cartilage cells were invaded by newly formed capillaries and vacuolated macrophages. At the deep canal, the lateral wall of the canal terminated in matrix containing calcified cartilage. The mesenchymal cells began to differentiate into osteoblasts adjacent to the calcified matrix. The results indicate that the connective tissue cells within the cartilage canals proliferate and differentiate into osteoblasts at the site of primary ossification center.
김영운(Young Woon Kim),정숭룡(Soong Rhyong Jung),박준아(Jun A Park),정종철(Jong Cheul Jung),오희균(Hee Kyun Oh),이종호(Jong Ho Lee),류선열(Sung Youl Ryu) 대한구강악안면외과학회 1994 대한구강악안면외과학회지 Vol.20 No.4
Necrotizing fasciitis is a rapidly progressing necrotizing process which affects subcutaneous tissue and fascia and is accompanied by severe systemic toxicity. Although necrotizing fasciitis can affect any part of the body including the back and neck, it is rather a rare entity in the head and neck. The rate of spread is remarkably rapid, with the tendency towards systemic toxicity related to delayed initiation of treatment. The infection process may be caused by any type of trauma. The infectious process usually begins 2 to 4 days after the initial insult. The skin becomes smooth, tense, and shiny: no sharp demarcation is seen between normal and affected skin. As the disease progresses, the pathognomonic sign of necrotizing fasciitis appears: a dusky discoloration of the skin as small purplish patches with ill-defined borders. An early exploration and drainage of all the involved fascial planes is important. We have had much difficulty in differentiating necrotizing fasciitis from other infections diseases. When infection is present in the oral & maxillofacial area, we thin abscess and cellulitis first of all. With failure of the lesion to respond to conventional treatment, we have to rule out the necrotizing fasciitis due to its alarming toxicity. Successful treatment of necrotizing fasciitis is bases on the early recognition of the infection process, aggressive surgical intervention systemic medical and supportive therapy, and intensive antibiotic therapy, with emphasis placed on early surgical care. The early exploration and drainage of al the involved fascial planes is critical. We experienced two cases of necrotizing fasciitis of the face. With early recognition of the infection process, aggressive fasciotomy and various medically supported therapy, we resolved the edema and exudate with offering the best chance for core. The patient was treated successfully.
가미자음강화탕(加味滋陰降火湯)이 SHR의 혈압에 미치는 영향
백경민,조현경,유호룡,김윤식,설인찬,Baek, Kyung-Min,Jo, Hyun-Kyung,Yoo, Ho-Rhyong,Kim, Yoon-Sik,Seol, In-Chan 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1
Objective : This study was done to investigate the effect of KJT on hypertension. Methods : Spontaneous Hypertensive Rats were sensitized and challenged with Kamijaeumganghwatang(KJT) for 5 weeks. Experimental group was treated with $200mg/day/2m{\ell}$ of KJT orally and control group was treated with $2m{\ell}/day$ of normal saline instead. Results : 1. KJT significantly showed significant protection against cytotoxicity and toxicity in the liver and the kidney. 2. KJT significantly decreased the blood pressure in SHR. 3. KJT significantly decreased the levels of aldosterone in SHR. 4. KJT significantly decreased the levels of dopamine, norepinephrine and epinephrine in SHR. 5. KJT significantly decreased the levels of sodium and potassium in SHR, but it did not decrease the levels of chloride in SHR. Levels of calcium in SHR increased, but only insignificantly. 6. KJT significantly decreased the levels of IL-6 in SHR, and significantly increased the levels of IL-10 in SHR. 7. For histological effects, KJT dillated capillary vessels in the kidney, significantly decreased eosinophilic changes in heart cells, and significantly decreased endothelial damage in the aorta. Conclusion: These results suggest that KJT is useful in treatment of hypertension.
고cholesterol 식이 자발성 고혈압 백서(白鼠)에서의 가미방풍통성산(加味防風通聖散)이 고혈압에 미치는 영향
김종원,조현경,유호룡,설인찬,김윤식,Kim, Jong-Won,Jo, Hyun-Kyung,Yoo, Ho-Rhyong,Seol, In-Chan,Kim, Yoon-Sik 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
This experiment was performed to determine the effects of Kamibangpungtongsungsan on hypertension in spontaneous hypertensive rats fed a hyperlipidemic diet (H-SHR). The results are summarized as follows : 1. Kamibangpungtongsungsan significantly decreased the blood pressure and pulse of rats in H-SHR. 2. Kamibangpungtongsungsan significantly decreased the levels of Aldosterone in H-SHR. 3. Kamibangpungtongsungsan significantly decreased the levels of dopamine and epinephrine in H-SHR, but did not significantly reduce the levels of norepinephrine, in H-SHR. 4. Kamibangpungtongsungsan did not significantly reduce the levels of electrolytes in H-SHR. 5. Kamibangpungtongsungsan significantly decreased the TNF-$\alpha$ and IL-6 levels in H-SHR but the IL-10 level increase no significant. These results suggest that the Kamibangpungtongsungsan might be usefully applied for the treatment of hypertension with hyperlipidemia.