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P2P Live Streaming System for Stable and High Quality Distribution
Takayuki Hisada,Shusuke Yamazaki,Yusuke Hirota,Hideki Tode,Koso Murakami 한국멀티미디어학회 2009 한국멀티미디어학회 국제학술대회 Vol.2009 No.-
With the appearance of P2P live streaming distribution services, load of distributor is reduced. In existing systems for business services, however, transmission load of distributor still remains in high level to improve robustness. Thus, it is difficult for content distributors to reduce load of his node. This paper presents and evaluates P2P live streaming system suitable for private distribution in which a distributor node has insufficient performance. In this system, a set of the selected broadband nodes provide contents to peers instead of Origin with large amount of transmission bandwidth. As a result, this P2P system considering transmission bandwidth of each node is expected to achieve the private distribution.
Effect of the Inspiratory Method and Timing of Voluntary Cough on Peak Cough Flow
Fumiya Kotajima,Masakiyo Yatomi,Takeshi Hisada 대한재활의학회 2023 Annals of Rehabilitation Medicine Vol.47 No.2
Objective To define the effect of the inspiratory method and cough timing on peak cough flow (PCF). Methods We investigated the effect of measurement conditions on PCF in healthy subjects (n=10). We then compared obstructive and restrictive pulmonary diseases (n=20) to assess for similar results in respiratory diseases. The PCF was measured under four conditions: before coughing, without maneuver 1 or with maneuver 2 a temporary respiratory pause (4–6 seconds) after rapid inspiration, and without maneuver 3 or with maneuver 4 a temporary respiratory pause after slow inspiration. After the measurements were completed, the PCF between the four conditions was compared for each subject group, and the effect size was calculated. Results PCF of maneuvers 1 and 3 were significantly higher than maneuver 4 in healthy subjects (476.34±102.05 L/min and 463.44±107.14 L/min vs. 429.54±116.83 L/min, p<0.01 and p<0.05, respectively) and patients with restrictive pulmonary disease (381.96±145.31 L/min, 354.60±157.36 L/min vs. 296.94±137.49 L/min, p<0.01 and p<0.05, respectively). In obstructive pulmonary disease, maneuver 1 was significantly higher than maneuver 4 (327.42±154.73 L/min vs. 279.48±141.10 L/min, p<0.05). The largest effect sizes were shown by maneuvers 4 and 1. Conclusion PCF depends on changes in inspiratory speed before coughing and on temporary respiratory pauses after maximal inspiration. It will become necessary to unify the measurement methods for coughing strength and present appropriate coughing methods.
Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
Okada, Jun-ichi,Washio, Takumi,Sugiura, Seiryo,Hisada, Toshiaki The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and relaxation and generation of blood pressure and blood flow, based on the molecular aspects of the cardiac electrophysiology and excitation-contraction coupling. In this paper, we present a brief review of the practical use of UT-Heart. As an example, we focus on its application for predicting the effect of cardiac resynchronization therapy (CRT) and evaluating the proarrhythmic risk of drugs. Patient-specific, multiscale heart simulation successfully predicted the response to CRT by reproducing the complex pathophysiology of the heart. A proarrhythmic risk assessment system combining in vitro channel assays and in silico simulation of cardiac electrophysiology using UT-Heart successfully predicted drug-induced arrhythmogenic risk. The assessment system was found to be reliable and efficient. We also developed a comprehensive hazard map on the various combinations of ion channel inhibitors. This in silico electrocardiogram database (now freely available at http://ut-heart.com/) can facilitate proarrhythmic risk assessment without the need to perform computationally expensive heart simulation. Based on these results, we conclude that the heart simulator, UT-Heart, could be a useful tool in clinical medicine and drug discovery.