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( Hiroharu Kawakubo ),( Yuichiro Tanaka ),( Nanae Tsuruoka ),( Megumi Hara ),( Koji Yamamoto ),( Hidenori Hidaka ),( Yasuhisa Sakata ),( Ryo Shimoda ),( Ryuichi Iwakiri ),( Motoyasu Kusano ),( Kazuma 대한소화기기능성질환·운동학회 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.2
Background/Aims Upper gastrointestinal symptoms are more frequent and severe in female than in male outpatients in Japan. This study compared the upper gastrointestinal symptoms between healthy male and female young adult volunteers using a questionnaire. Methods In total, 581 third-grade medical students at Saga Medical School aged 22 to 30 years underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease) from 2007 to 2013. Of these 581 students, 298 who were negative for Helicobacter pylori infection and had no particular lesions on endoscopic examination were enrolled in the present evaluation. A symptom was defined as positive when the subject evaluated the frequency of the symptom as sometimes, often, or always. Results The subjects comprised of 163 males (average age, 23.7 years) and 135 females (average age, 23.1 years). Upper gastrointestinal symptoms were more frequent in the females (75 of 135, 55.6%) than males (69 of 163, 42.3%; P < 0.05), with a high score for 4 symptoms (bloated stomach, heavy feeling in the stomach after meals, subconscious rubbing of the chest with the hand, and feeling of fullness while eating meals). Of the 144 subjects (69 males and 75 females) who complained of these symptoms, the females complained of dysmotility symptoms more often than did the males, but this was not true for reflux symptoms. Conclusions This study suggests that females develop upper gastrointestinal symptoms more frequently than do males among the young healthy Japanese population. (J Neurogastroenterol Motil 2016;22:248-253)
Design and Analysis of the New Network Polymer Using the Structure with Rotaxane and Stereocomplex
최재영,Hiroharu Ajiro 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
In this study, the new network polymer was designed and formed by the pseudo-polyrotaxane with the copolymer of polylactide (PLA) and poly(ethylene glycol) (PEG), using cyclodextrin (CD). There are three kinds of interactions; a chemical network utilizing the terminal group of copolymer, a physical network utilizing the stereo complex of PLA, and a sliding network by connecting CDs. In this way, several networks exist at the same time, and the several properties have been analyzed for the discussion.
Single-Stage Endoscopic Stone Extraction and Cholecystectomy during the Same Hospitalization
Toshiaki Terauchi,Hiroharu Shinozaki,Satoshi Shinozaki,Yuichi Sasakura,Masaru Kimata,Junji Furukawa,Alan Kawarai Lefor,Yoshiro Ogata,Kenji Kobayashi 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.1
Background/Aims: The clinical impact of single-stage endoscopic stone extraction by endoscopic retrograde cholangiopancreatography(ERCP) and cholecystectomy during the same hospitalization remains elusive. This study aimed to determine the effcacy and safety ofsingle-stage ERCP and cholecystectomy during the same hospitalization in patients with cholangitis. Methods: We retrospectively reviewed the medical records of 166 patients who underwent ERCP for mild to moderate cholangitis dueto choledocholithiasis secondary to cholecystolithiasis from 2012 to 2016. Results: Complete stone extraction was accomplished in 92% of patients (152/166) at the first ERCP. Among 152 patients whounderwent complete stone extraction, cholecystectomy was scheduled for 119 patients (78%). Cholecystectomy was performed duringthe same hospitalization in 89% of patients (106/119). We compared two groups of patients: those who underwent cholecystectomyduring the same hospitalization (n=106) and those who underwent cholecystectomy during a subsequent hospitalization (n=13). In thedelayed group, cholecystectomy was performed about three months after the first ERCP. There were no significant differences betweenthe groups in terms of operative time, rate of postoperative complications, and interval from cholecystectomy to discharge. Conclusions: Single-stage endoscopic stone extraction is recommended in patients with mild to moderate acute cholangitis due tocholedocholithiasis. The combination of endoscopic stone extraction and cholecystectomy during the same hospitalization is safe andfeasible.
Asami Yonekura,Hiroharu Kawanaka,V. B. Surya Prasath,Bruce J. Aronow,Haruhiko Takase 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.3
In the field of computational histopathology, computer-assisted diagnosis systems are important in obtaining patientspecificdiagnosis for various diseases and help precision medicine. Therefore, many studies on automatic analysis methodsfor digital pathology images have been reported. In this work, we discuss an automatic feature extraction and disease stageclassification method for glioblastoma multiforme (GBM) histopathological images. In this paper, we use deep convolutionalneural networks (Deep CNNs) to acquire feature descriptors and a classification scheme simultaneously. Further,comparisons with other popular CNNs objectively as well as quantitatively in this challenging classification problem isundertaken. The experiments using Glioma images from The Cancer Genome Atlas shows that we obtain 96:5% averageclassification accuracy for our network and for higher cross validation folds other networks perform similarly with a higheraccuracy of 98:0%. Deep CNNs could extract significant features from the GBM histopathology images with highaccuracy. Overall, the disease stage classification of GBM from histopathological images with deep CNNs is verypromising and with the availability of large scale histopathological image data the deep CNNs are well suited in tacklingthis challenging problem.
MONITORING OF ROLLING WERA USING THE POTENTIAL DROP METHOD
Shimizu, Tomoharu,Ueno, Hiroharu,Iwabuchi Akira ENGINEERING TRIBOLOGY RESEARCH INSTITUTE KYUNGPOOK 1998 INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE OF TRI Vol.1998 No.-
A surface damage evaluation system was developed. The alternating current porential drop(ACPD) method was used in this system. This system consists of a personal computer, a frequency generator, a power current amplifier, two DC amplifiers and two high speed A/D converters and has a compensating technique for inductive pick-up of AC voltage. The inductive pick-up is a most important cause of measurement error at ACPD method. Middle carbon steel and bearing steel were used for rolling wear specimens, and reciprocating rolling wear tests were carried out. Signals of ACPD from durface which damaged with rolling wear and applied alternating current were measured. These signals were analyzed by computer program and the phase difference between these signals was detected. Then the inductive pick-up was compensated. We could estimate the true value of ACPD voltage successfully and show surface damage(rolling wear) with the increase of AC potential drop.