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( Duy Hieu Truong ),( Tuan Hiep Tran ),( Thiruganesh Ramasamy ),( Ju Yeon Choi ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
The objective of the current study was to enhance dissolution and oral bioavailability of the poorlywater-soluble drug, sorafenib (SFN), by solid dispersion (SD) technique using a novel amphiphilic copolymer, polyvinyl caprolactam. polyvinyl acetate.polyethyleneglycol graft copolymer (Soluplus®). The SD formulations were prepared by the spray drying methodwith SFN, Soluplus, and sodiumlauryl sulfate (SLS) at variousweight ratios inwater. The optimized SD formulation, which showed the highest dissolution rate in distilled water, was further characterized for surface morphology, crystallinity, dissolution in pH 1.2, pH 4.0, and pH 6.8, and pharmacokinetics in rats. Powder X-ray diffraction and differential scanning calorimetry revealed the amorphous form of SFN in the formulation. In addition, at the oral dosage of 20 mg/kg SFN, the SD formulation showed increased Cmax and AUC0.48h by 1.5- and 1.8-fold, compared to those of SFN powder, respectively (p b 0.05). These findings suggest that the preparation of SFN-loaded SD using Soluplus could be a promising strategy for improvement of oral bioavailability of SFN. ⓒ 2015 Elsevier B.V. All rights reserved.
( Duy Hieu Truong ),( Tuan Hiep Tran ),( Thiruganesh Ramasamy ),( Ju Yeon Choi ),( Hee Hyun Lee ),( Cheol Moon ),( Han Gon Choi ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
To improve the solubility and oral bioavailability of erlotinib, a poorly water-soluble anticancer drug, solid self-emulsifying drug delivery system (SEDDS) was developed using solid inert carriers such as dextran 40 and Aerosil® 200 (colloidal silica). The preliminary solubility of erlotinib in various oils, surfactants, and co-surfactants was determined. Labrafil M2125CS, Labrasol, and Trunscutol HP were chosen as the oil, surfactant, and co-surfactant, respectively, for preparation of the SEDDS formulations. The ternary phase diagram was evaluated to show the self-emulsifying area. The formulations were optimized using the droplet size and polydispersity index (POI) of the resultant emulsions. Then, the optim.ized formulation containing 5% Labrafil M2125CS, 65% Labrasol, and 30% Transcutol was spray dried with dextran or Aerosil® and characterized for surface morphology, crystallinity, and pharmacoki-netics in rats. Powder X-ray diffraction (PXRO) and differential scanning calorimetry (OSC) exhibited the amorphous form or molecular dispersion of erlotinib in the formulations. The pharmacokinetic parame-ters of the optimized formulations showed that the maximum concentration (C<sub>max</sub>) and area under the curve (AUC) of erlotinib were significantly increased, compared to erlotinib powder (p<0.05). Thus, this SEDDS could be a promising method for enhancing the oral bioavailability of erlotinib.
Nguyen Luan Vu Truong,Hieu Giang Le,Thien Ngon Dang,Linh Le,Tat Linh Doan,Truong Thinh Nguyen,Moonyong Lee 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
A unified method for the fractional-order proportional-integral controller based on IMC scheme (IMC-FOPI) is proposed. The analytical tuning rules are derived for achieving the performance improvement in terms of both disturbance rejection and set-point tracking. Many illustrative examples are considered to confirm the effectiveness of the proposed algorithm for both integer and fractional-order processes with time delays. In addition, the robust stability of fractional-order systems are also carried out in order to demonstrate that the proposed controller can hold well the robustness against perturbation uncertainty in the process models.
Hien, Truong Thi,Van Lam, Do,Kim, Chunjoong,Vuong, Nguyen Minh,Quang, Nguyen Duc,Kim, Dahye,Chinh, Nguyen Duc,Hieu, Nguyen Minh,Lee, Seung-Mo,Kim, Dojin Elsevier 2016 Journal of Power Sources Vol.336 No.-
<P><B>Abstract</B></P> <P>The photoelectrochemical properties of CdS-sensitized ZnO nanorods grown on Pt-coated WO<SUB>3</SUB> nanoplates are investigated to evaluate their effectiveness in hydrogen production. WO<SUB>3</SUB> nanonanoplates are synthesized on glass substrates, followed by atomic layer deposition of Pt thin films as the terminal electrode to efficiently collect the photo-carriers generated from the ZnO/CdS absorption layers. Optimization of the fabrication process for the 3D hierarchical structure is performed, and the morphology and its effect on the photoelectrochemical performance of the electrodes are carefully studied using scanning electron microscopy, x-ray diffraction, and measurements of the photocurrent density and photo-conversion efficiencies. The enhanced PEC performance is elucidated by the 3D hierarchical geometry of the electrode. The optimized electrode shows a photocurrent density of ∼ 13 mA cm<SUP>−2</SUP> and a conversion efficiency of ∼8.0% at −0.83 V (<I>vs</I>. SCE) in 0.5 M Na<SUB>2</SUB>S solution under the illumination of simulated solar light.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fabrication of 3D hierarchical nanostructure by 2D WO<SUB>3</SUB> combined with 1D ZnO/CdS. </LI> <LI> Pt layer insertion to enhance current collecting capability of the electrode. </LI> <LI> Optimized nanostructural electrode design for the maximum performance. </LI> <LI> Extract the ultimate performance of CdS as a water-splitting photoanode. </LI> </UL> </P>
Application of Fuzzy Moving Sliding Surface Approach for Container Cranes
Quang Hieu Ngo,Ngo Phong Nguyen,Quoc Bao Truong,김경한 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.2
In this paper, we consider the fuzzy moving sliding surface anti-sway control problem for container cranes. We first introduce the dynamic model of container cranes. Then, we develop the coupled sliding surface which ensures the asymptotic stability of the closed-loop system. Based on the proposed sliding surface, we propose the continuous sliding mode control law which guarantees the reachability of the sliding variable to zero in finite time. Hence, the proposed controller first guarantees the finite-time convergence to the sliding surface and then achieves the stability of the closed-loop system in the predefined sliding surface. Besides, in order to obtain the effective gains for the proposed sliding variable, the fuzzy logic system is employed. To illustrate the efficiency of the proposed control law, simulation results are provided.
Sn Doping into Hematite Nanorods for High-Performance Photoelectrochemical Water Splitting
Hien, Truong Thi,Quang, Nguyen Duc,Hung, Nguyen Manh,Yang, Haneul,Chinh, Nguyen Duc,Hong, Soonhyun,Hieu, Nguyen Minh,Majumder, Sutripto,Kim, Chunjoong,Kim, Dojin The Electrochemical Society 2019 Journal of the Electrochemical Society Vol.166 No.15
<P>Photoelectrochemical water splitting is of great attention due to its environmental friendly generation of clean fuels. Hematite (α-Fe<SUB>2</SUB>O<SUB>3</SUB>) is considered one of the promising candidates due to its intrinsic properties for the high performance photoelectrochemical electrode such as favourable bandgap (2.0–2.2 eV), a suitable energy band position, non-toxicity, low cost, and excellent chemical stability. Herein, we report about Sn-doped hematite nanorods and their implementation as photoanodes for photoelectrochemical water splitting. We provide the simple but efficient route to incorporate the Sn into the hematite without structural damage in the nanostructure and scrutinize the effect of Sn dopant on the photoelectrochemical activity of the hematite. By the two-step heat-treatment process, Sn can be successfully incorporated into the hematite, which reveals the enhanced photoelectrochemical responses compared with undoped hematite. We elaborate the effect of Sn dopant in the hematite on the photoelectrochemical activities, thereby the optimum concentration of Sn dopant can be suggested. In addition, the catalyst layer of the cobalt phosphate is introduced to further increase the photoelectrochemical performance of Sn-doped hematite nanorods.</P>
Effect of Flexibility performance of hindwing in maneuvering flight of beetle (Allomyrina Dichotoma)
Trung-Hieu Tran,Tien Van Truong,Tuyen Le Quang,Doyoung Byun,Hoon Cheol Park 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11
High ability of maneuvering and self stability of insect flight have been interesting topic for biology researchers recently. Here we investigate kinematics and role of flexibility of hind wing of Allomyrina Dichtoma in side and back turnings. Body and wing kinematics were reconstructed into three-dimensional through DLT method. Result shows that a flexibility of hindwing can increase performance significantly in turning and stability control of beetle especially in supination and pronation phases. In the downstroke phase, hindwing has positive wing camber, inversely, it is passive deformed into negative wing camber in chordwise as well as in spanwise direction at begin of upstroke. These mechanisms can create a large variant of force and moment in magnitude and direction which can change direction and altitude of beetle in maneuvering.
Maneuvering flight of beetle (Allomyrina Dichotoma)
Trung-Hieu Tran,Tien Van Truong,Tuyen Quang Le,Hoon Cheol Park,Doyoung Byun 한국항공우주학회 2009 한국항공우주학회 학술발표회 논문집 Vol.2009 No.11
Maneuvering flight has been recognized as an important characteristic of insects and animals where these species frequently use. Here we investigate kinematics and role of flexibility of hind wing of Allomyrina Dichtoma in which body and wing kinematics were reconstructed into three?dimensional through DLT method. Result shows that a flexibility of hind wing can increase performance significantly in turning and stability control of beetle especially in supination and pronation phases. In the downstroke phase, hindwing has positive wing camber, inversely, it is passive deformed into negative wing camber in chordwise as well as in span wise direction at begin of upstroke. These mechanisms can create a large variant of force and moment In magnitude and direction which can change direction and altitude of beetle in maneuvering.