Acceptance Model of a Mandatory Health Information System in Indonesia

Heru Santoso Wahito Nugroho,Hari Basuki Notobroto,Lilin Rosyanti 대한의료정보학회 2021 Healthcare Informatics Research Vol.27 No.2

Objectives: The purpose of this study was to develop a model of acceptance of the Mother and Child Health InformationSystem in the Ngawi Regency Health Office, Indonesia based on the technology acceptance model, by integrating organizationalsupport and personal characteristics as external variables and enjoyment as an intervening variable. Methods: Thedesign of this study was cross-sectional. The subjects of this study were 217 village midwives who had operated the Maternaland Child Health Information System in the Ngawi Regency Health Office, Indonesia. The variables studied were perceivedorganizational support, personal characteristics, perceived ease of use, perceived usefulness, perceived enjoyment, behavioralintention, and actual system use. Data were collected through questionnaires, and then analyzed using structural equationmodeling. Results: In terms of the total effect, the most meaningful factor affecting actual system use was perceived organizationalsupport (0.766), followed in descending order by behavioral intention to use (0.344), perceived enjoyment (0.238),personal characteristics (0.118), perceived usefulness (0.054), and perceived ease of use (0.048). Conclusions: In the acceptancemodel of the Mother and Child Health Information System in Ngawi Regency, perceived organizational support wasthe main determinant of actual system use, while enjoyment was the main intermediate determinant of the indirect effects ofperceived organizational support and personal characteristics on actual system use.

Paramagnetic Zn(1-x)MnxO (0.00≤x≤0.06) Nanoparticles Prepared by The Coprecipitation Method

Heru Harsono,I Nyoman Gede Wardana,Achmad As'ad Sonief,Darminto 한국전기전자재료학회 2017 Transactions on Electrical and Electronic Material Vol.18 No.1

The Zn1-xMnxO (0.00≤x≤0.06) samples have been synthesized in the form of powder by the coprecipitation methodat low temperature using Zn(CH3COO)2. 2H2O and Mn(CH3COO)2. 4H2O powders, as well as HCl and NH4OH solutionsas starting materials. Characterization was conducted using XRD, TEM, XRF, FTIR and VSM. The result shows that theZn(1-x)MnxO (0.00≤x≤0.06) nanoparticles have the wurtzite phase with a hexagonal structure and particle sizes rangingfrom 17.48 to 118.83 nm. In a qualitative analysis of XRF, the peaks that confirm the existence of the manganeseelement in Mn-doped ZnO samples were observed. Meanwhile, FTIR test result shows that there are peaks at around500 cm-1 and 400 cm-1 in the FTIR spectra for Mn doped ZnO samples which clearly reveal the existence of the (Zn,Mn)-O strain mode. The (Zn, Mn)-O absorption peak positions have shifted to a lower wave number with increasingMn doping content. The peak intensity is also lower if compared to that of the ZnO sample without doping. Fromthe VSM test, it is shown that Zn(1-x)MnxO (0.00≤x≤0.06) nanoparticles are all paramagnetic having monotonicallyincreased susceptibility as increasing Mn content.

Influence of Reproductive Status, Serum Type and Estradiol-17β Supplementation on the in vitro Maturation of Canine Oocytes

Heru, Fibrianto Yuda,Kim, Min-Kyu Institute of Agricultural Science 2008 Korean Journal of Agricultural Science Vol.35 No.2

Supplementation of serum and estrogen in in vitro maturation(IVM) medium was shown to improve embryo development and quality in several species. This study investigates the effect of ovarian estrus stage on canine oocyte quality and supplementation of medium with canine serum or estrogen on IVM of canine oocytes. As results, in experimental 1, IVM oocytes collected from follicular stage ovaries to MII stages($10.2{\pm}1.5%$) was higher (p<0.05) with 10% canine estrus stage serum than control($1.3{\pm}1.6%$), anoestrus stage serum($4.0{\pm}1.6%$), luteal stage serum($2.7{\pm}1.7%$) and 10% FBS($1.3{\pm}1.6$). In experimental 2, 10% canine estrus stage serum supplementation has highest maturation rate to MII stages($10.0{\pm}1.8%$) and there were significant differences(P<0.05) with another treatment in follicular stages group. In order to investigate the synergic effect of estrous serum and estrogen supplementation, different estrous stage groups of oocytes were cultured with 2 ug/ml estrogen plus various concentrations of different reproductive stage serum and FBS(experimental 3). As results, the rate of maturation to metaphase II(MII) stage was significantly higher(p<0.05) in oocytes from the follicular stage supplemented with estrogen and 10% canine estrus stage serum(11.5%) compared to the other groups(6.0 - 8.8%). The present study was demonstrated that canine serum and the estrus cycle of the bitch affect the meiotic competence of oocytes. Hormonal influences within the follicle may be one of the factors responsible for the greater proportion of maturation of oocyte to MII from bitches at the follicular phase.

Performance of Korean Soybean Varieties in Indonesia

( Heru Kuswantoro ),( Sutrisno ),( Won Young Han ),( Poong Yeon Lee ),( Yang Hee Cho ),( And Inyoul Baek ) 한국국제농업개발학회 2014 韓國國際農業開發學會誌 Vol.26 No.2

Expression of new germplasm is very important in breeding program because the characters are the reflection of the genes and the environment. The objective of this study is to evaluate the expression of agronomic characters of 20 Korean soybean varieties in Indonesia. The experiment was conducted at greenhouse of the Indonesian Legumes and Tuber Crops Research Institute in Malang during May to August 2012. The materials were consisted of 20 Korean soybean varieties, and four Indonesian soybean varieties as check. The experimental design was randomized completely block with three replications. Result showed that there were significant differences among germplasm for the characters of days to flowering, days to maturity, plant height, number of branches per plant, number of reproductive nodes per plant, number of filled pods per plant, number of seeds per plant, seed yield per plant, and 100-seed weight, but there were no differences on number of unfilled pods per plant. Usually, all of Korean varieties have shorter plant height than the Indonesian soybean varieties. Based on seed yield per plant, the best perfomance were showed by Daewonkong, Detam 1, Jangmikong, and Songhakkong, i.e. 12.8 g, 11.6 g, 11.4 g, and 11.3 g per plant respectively. The seed yields of these varieties were higher than the Indonesian popular variety of Anjasmoro (8.8 g).

On Detecting and Representing Bottom-up Change in Ontology Versioning

Heru Agus Santoso,Su-Cheng Haw,Chien-Sing Lee 보안공학연구지원센터 2011 International Journal of Database Theory and Appli Vol.4 No.2

Methylation Status and Immunohistochemistry of BRCA1 in Epithelial Ovarian Cancer

Pradjatmo, Heru,Dasuki, Djaswadi,Anwar, Mohammad,Mubarika, Sofia,Harijadi, Harijadi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Background: Cancer initiation and progression are controlled by genetic and epigenetic events. One epigenetic process which is widely known is DNA methylation, a cause of gene silencing. If a gene is silenced the protein which it encodes will not expressed. Objectives: 1. Identify the methylation status of BRCA1 in patients with epithelial ovarian cancer (EOC)and assess BRCA1 protein expression in tumor tissue. 2. Examine whether BRCA1 gene methylation and BRCA1 protein are associated with survival of epithelial ovarian cancer patients. Methods: The study design was a prospective-cohort study, conducted at Sardjito hospital, Yogyakarta, Indonesia. Results: A total of 69 cases were analyzed in this study. The data showed that the methylation status of BRCA1 in EOC was positive in 89.9%, with clear protein expression of BRCA1 in 31.9%. Methylation status and expression of BRCA1 were not prognosticators of EOC patients. Menarche, CA125 level, clinical stage and residual tumor were independent factors for prognosis.

Methylation Status and Expression of BRCA2 in Epithelial Ovarian Cancers in Indonesia

Pradjatmo, Heru Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

Ovarian cancer is the main cause of mortality in gynecological malignancy and extensive studies have been conducted to study the underlying molecular mechanisms. The BRCA2 gene is known to be an important tumor suppressor in ovarian cancer, thereby BRCA2 alterations may lead to cancer progression. However, the BRCA2 gene is rarely mutated, and loss of function is suspected to be mediated by epigenetic regulation. In this study we investigated the methylation status and gene expression of BRCA2 in ovarian cancer patients. Ovarian cancer pateints (n=69) were recruited and monitored for 54 months in this prospective cohort study. Clinical specimens were used to study the in situ expression of aberrant BRCA2 proteins and the methylation status of BRCA2. These parameters were then compared with clinical parameters and overall survival rate. We found that BRCA2 methylation was found in the majority of cases (98.7%). However, the methylation status was not associated with protein level expression of BRCA2 (49.3%). Therefore in addition to DNA methylation, other epigenetic mechanisms may regulate BRCA2 expresison. Our findings may become evidence of BRCA2 inactivation mechanism through DNA methylation in the Indonesian population. More importantly, from multivariate analysis, BRCA2 expression was correlated with better overall survival (HR 0.32; p=0.05). High percentage of BRCA2 methylation and correlation of BRCA2 expression with overall survival in epithelial ovarian cancer cases may lead to development of treatment modalities specifically to target methylation of BRCA genes.

The Relationship Between Firm Diversification and Firm Performance: Empirical Evidence from Indonesia

CAHYO, Heru,KUSUMA, Hadri,HARJITO, D. Agus,ARIFIN, Zaenal Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

This extended study aims to analyze empirically the influence of firm diversification on firm performance moderated by the stages of the firm life cycle, which consists of introduction, growth, maturity, and decline. The target population of this study is the firms listed on the Indonesian Stock Exchange. The sampling method uses purposive sampling in the multi-business firm in Indonesia; it includes as many as 127 firms over the period from 2011 to 2017, totaling 889 firm-year observations. The firm performance is measured using a return of equity while the level of firm diversification with the minimum number of two operating segments is proxied by the Herfindahl index. The analysis method used in this study is the estimator model of the Generalized Method of Moment (GMM). The main findings show that the firm life cycle at the stage of growth and maturity significantly strengthens the influence of firm diversification on firm performance. On the other hand, the stage of decline fails to moderate the relationship between firm diversification and firm performance. This study discusses the implications and contributions of the findings theoretically, and provide some policy justifications for potential investors before they invest their money in the capital market.

Impact of Preoperative Serum Levels of CA 125 on Epithelial Ovarian Cancer Survival

Pradjatmo, Heru Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Background: CA125 is very helpful in treatment monitoring and detection of epithelial ovarian cancer (EOC) recurrence. However there is controversy as to its accuracy and optimal usage. What is the impact of the CA125 levels before primary surgery treatment to the survival of patients? This study aimed to detect any association of preoperative serum levels with prognosis and survival in EOC patients. Materials and Methods: Our cohort comprised EOC patients in Dr. Sardjito Hospital, Yogyakarta, Indonesia, who complied with follow up. To explore the effect of preoperative CA125 levels and other variables on survival Cox's regression models were applied. Results: A total of 90 cases of EOC who had surgery were available for follow up. The level of CA125 proved to be a prognostic factor for overall survival of EOC patients, with an adjusted HR of 4.10 (p = 0.03). Adjuvant chemotherapy was another prognostic factor, 1 - 2 cycles having an adjusted HR of 0.17 (p = 0.04) and 3 - 8 cycles HR 0.39 (p = 0.06). Other factors such as age of patients adjusted HR 1.54 (p = 0.32), moderate differentiation (adjusted HR 1.61, p = 0.51) poor differentiation (adjusted HR 3.41, p = 0.15), and stage of disease (adjusted HR 1.98,p=0.27) were statistically not significant. However, this might have been because the power of the study was low. Conclusions: Preoperative level of CA125 is a prognostic factor for overall survival in EOC patients. The best cut-off for prognostic classification of CA125 serum level is 70 U/ml.

Malignancy Risk Scoring of Hydatidiform Moles

Pradjatmo, Heru,Dasuki, Djaswadi,Dwianingsih, Ery Kus,Triningsih, Ediati Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Background: Several risk factors leading to malignant transformation of hydatidiform moles have been described previously. Many studies showed that prophylactic chemotherapy for high risk hydatidiform moles could significantly decrease the incidence of malignancy. Thus, it is essential to discover a breakthrough to determine patients with high risk malignancy so that prophylactic chemotherapy can be started as soon as possible. Objectives: Development of a scoring system of risk factors as a predictor of hydatidiform mole malignant transformation. Materials and Methods: This research is a case control study with hydatidiform mole and choriocarcinoma patients as subjects. Multiple logistic regression was used to analyze the data. Odds ratios (OR), attributable at risk (AR : OR-1) and risk index ($ARx{\beta}$) were calculated for develoipment of a scoring system of malignancy risk. The optimal cut-off point was determined using receiver operating characteristic (ROC) curve. Results: This study analyzed 34 choriocarcinoma cases and 68 benign hydatidiform mole cases. Four factors significantly increased the risk of malignancy, namely age ${\geq}35$ years old (OR:4.41, 95%CI:1.07-16.09, risk index 5); gestational age ${\geq}$ 12weeks (OR:11.7, 95%CI:1.8-72.4, risk index 26); uterine size greater than the gestational age (OR:10.2, 95%CI:2.8-36.6, risk index 21); and histopathological grade II-III (OR:3.4, 95%CI:1.1-10.6, risk index 3). The lowest and the highest scores for the risk factors were zero and 55, respectively. The best cut-off point to decide high risk malignancy patients was ${\geq}31$. Conclusions: Malignant transformation of hydatidiform moles can be predicted using the risk scoring by analyzing the above four parameters. Score ${\geq}31$ implies high risk patients so that prophylactic chemotherapy can be promptly administered for prevention.