한방 이화주의 미백 및 피부 주름 개선 효과

이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4

본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

진도 북춤과 밀양 오북춤의 비교연구

박진희 韓國舞踊敎育學會 1998 韓國舞踊敎育學會誌 Vol.9 No.2

This study analyses the comparison of the southern west Jin-Do drum dance and the southern east Mil-yang give drum dance which has its own locational distinction and developmental procedure. The origin of Jin-do drum dance comes from the last act of the theatrical dance Jin-Do Dasire during the three nations period. It had formed as a recreational role but had been influxed into field hymn to enhance the field labor by following the drumbeats. Mil-Yang five drum dance had formed during the three provincial period as a ritual ceremony for the supplication of the harvest. Also it had formed as a recovery of the healthy life by dissolving the repression from the ruler by beating the drum. Both of these drum dances have similarities but have different origin motivations. In the form of Jin-Do drum dance, there are variety of patterns, subtle rhythms and high technical skilled movements, in which artistic value is hidden. On the other hand, in the Mil-yang five drum dance there are simple movement patterns with one count of beating, but the movements possess natural simplicity and dynamics. Performing Jin-Do dance, a drum is carried in the same way like so called Jang-Go. Instead of two drum sticks are used in Jin-do dance, in Mil-Yang dance there is only one stick is being used. These instrumental differences indicate that the Jin-Do dance reflects the social environment. In Jin-do Drum dance, there is no limitation not only of the number of members and the number of drums but also no differentiation of the gender as well. Contrary in Mil-Yang five Drum dance only men can attend, and there is storing limitation of the playing participants. However, besides the differences, two dances share some similarities. praying the nature's harvest and reflects the simplicity of peasant's movements. Beating drum, farmers threw away their labor repression nad sublimating to the tool of play.

2007년 대한감염학회 권장 성인 예방접종 권장안

강진한,김홍빈,손장욱,이상오,정문현,정희진,최영화,최정현,최준용,최희정 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

In 2007, the Korean Society of Infectious Diseases recommended an immunization schedule for adults residing in Korea. This recommendation includes four categories: standard immunization for healthy persons, supplementary immunization for persons with underlying illnesses, recommendations for health-care personnel and for international travelers. The Standard Immunization Schedule consists of universal vaccination (tetanus-diphtheria/tetanus-diphtheria-pertussis (Td/Tdap); hepatitis A vaccine for persons aged 20s; human papilloma virus vaccine for women under 26 years old; meningococcal vaccine for military recruits and college students in dormitories; influenza vaccination for persons aged 50 years or more and pregnant women; and pneumococcal vaccination for persons aged 65 years or more) and catch-up vaccination (hepatitis A vaccine for persons aged 30s; hepatitis B vaccine, varicella and MMR vaccines for persons who have uncertain specific immunities). The Supplementary Immunization Schedule recommends 4 vaccines, i.e., pneumococcal, influenza, meningococcal, and Haemophilus influenzae type b, appropriate to the underlying illnesses, and confirmation of the presence of antibodies to hepatitis A and hepatitis B. The Recommendation for Health-Care Personnel includes universal vaccination (influenza and pertussis) and catch-up vaccination (hepatitis B, measles-mumps-rubella and varicella for seronegative health-care personnel). The Recommended Immunization for International Travelers focuses reinforcement of vaccinations for healthy persons and includes certain immunizations necessary for international travel (yellow fever, meningococcal, plaque, tick-borne encephalitis, and cholera). These guidelines can be seen at www.ksid.or.kr.

2차병원에서의 소아과 환자의 응급실 및 외래 이용에 관한 연구

김진희,배진호,전진호,문정웅 인제대학교 2006 仁濟醫學 Vol.27 No.-

Objectives : To analyze the characteristics of the pediatric patients who visited the emergency room and outpatient department of secondary hospital in order to properly guide pediatric patients to use emergency room and raise the efficiency Methods : The authors investigated and analyzed sex, age, visit day, visit time, length of stay, hospitalization and diagnostic entities of the pediatric patients who visited the emergency room and outpatient department of Wallace Memorial Baptist Hospital from January 2003 to December 2005 in a retroactive approach with their medical records. Results : For the three years, the number of total patients who visited the emergency room was 56,051 and among them, the number of pediatric patients was 7,490 (13.4%). The age group of 1 to 2 years was the largest with 2,488 (33.2%). The male to female ratio was 1.34:1. Sunday was the day of the week that the largest number of patienst visited with 2,375 (31.7%) and nearly half (48.4%) of the patients visited the emergency room during the weekend. The time when the most patient visited the emergency room was between 8 pm to 12 am. Regarding the length of stay, the highest number of patients (65.0%) stayed in the emergency room for on hour or less, and the average length of visit was 1.5 hours, which was rather short. Most patients (68.8%) left the hospital after taking simple physical examination and procedure(prescription). The most frequent diagnoses for the pediatric patients who visited the emergency room were acute pharyngitis (26.0%), acute gastroenteritis (20.7%), fever (6.6%). During the same period, the total number of pediatric patients who visited the outpatient department was 125,513. The age group of 3 to 5 was the largest with 36,041 (28.7%). The male to female ratio was 1.34:1. 6.0% of total outpatients required treatment in a hospital. Most frequent diagnoses of the outpatients were asthma (24.4%), pneumonia (12.0%), vaccination (8.7%), febrile convulsion (8.4%), acute pharyngitis (6.6%), acute gastroenteritis (5.8%). Conclusion : It is considered that a large number of pediatric patients still have used emergency room for treatment of simple and mild diseases instead of visiting outpatient department and/or primary hospital. Thus further efforts are required to properly guide pediatric patients to use emergency room and to raise the efficiency of their use.

서정의 확장과 시(詩)로 쓰는 역사

김진희 ( Jin Hee Kim ) 국제비교한국학회 2011 비교한국학 Comparative Korean Studies Vol.19 No.2

여성의 역사에 대한 고정희의 시적 탐구는 문학과 역사에서 여성을 부각시킨 중요한 작업이다. 고정희의 역사시는 여성의 역사를 재구성하려 했다는 점에서 역사로서의 의미와 의의가 있으며, 한편 그 역사가 서정 장르를 통해 재구성되고 있기 때문에 서정과 서사의 경계적 특성을 갖는다. 이 글은 ``이야기 여성사`` 연작을 중심으로 미학적 특성 및 여성주의적 문제의식을 규명하고 있다. 고정희는 부패한 권력과 오염된 언어에 대한 비판이 새로운 역사 전망과 관련된 것임을 인식하고 인간의 평등과 자유를 구현할 수 있는 해방시를 만들고자 한다. 이를 위해 다양한 문학적 장치를 사용하고 있다. 우선 역사가 과거-현재-미래가 대화한다는 점을 작품에 수용하여 다성적 목소리와 상호 텍스트성을 통해 다양한 여성 삶의 이야기를 효과적으로 드러낸다. 그리고 역사가 지닌 이야기를 전달하기 위해 서간체와 장면제 시의 서사전략을 사용하여 독자의 정서적 유대감과 참여를 확대한다. 또한 작품 안의 인물을 통해 개성과 역사성을 함께 보여줌으로써 독자가 역사와 문학, 서사와 서정의 경계 부분에서 새로운 창조적 힘을 경험하게 한다. 고정희의 역사 시편들은 역사와 문학의 경계에서 남성 중심의 역사에 대한 비판을 수행하고, 여성-어머니의 가치라는 삶의 원리에 대한 지향을 통해 미래 역사에 대한 창조적 전망과 상상을 보여준다. Goh Jung Hee`s poetic survey of women`s history is an important undertaking that highlighted the place of women in literature and history. Goh`s historical poems are meaningful and significant as a history in that they attempted to reconfigure the history of women; moreover, it is critical that we consider this history within a literary framework as it is reconstructed through the genre of lyrics. This essay defines the aesthetic features and the feminist critique of Goh`s serialized poem, "The Stories of Women`s History." Recognizing that critiquing the corruption of power and the pollution of language was related to new historical views, Goh tried to create lyrics for liberation that embodied the concepts of human freedom and equality. To this end, she employed various literary devices; first, Goh demonstrated how the past, the present, and the future converse with one another in history and effectively revealed the diverse stories of women`s lives by way of polyphonous voices and intertextuality. In delivering these stories, Goh employed the epistolary style as well as the narrative strategy for presenting scenes in order to heighten the readers` sense of interconnectedness and to foster their participation. Furthermore, she showed at once the personality and the historicity of her characters as a way to help readers experience a new creative power on the border between history and literature, and between epic and lyric. Ultimately, Goh`s historical poems criticize the male-oriented history at the boundary of history and literature, and by placing value on the principle of life, particularly that of women-mothers, her poems offer a creative outlook and imagination for the future.

측뇌실내 수막종 : 임상분석 및 수술접근법 Clinical Analysis and Surgical Approach

양희진,김동규,정희원,이현구,김현집,조병규,최길수,한대희 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.10

The authors present six cases of lateral ventricle meningiomas treated at Seoul National University Hospital between 1979 and 1991. These six cases of lateral ventricular meningiomas constitute 1.8 percent of all intracranial meningiomas and 16.7 percent of mass lesions of the lateral ventricle. The mean age was 29 years ranging from 11 to 50 years, younger than that or intracranial meningiomas with a statistical significance(p<0.01). Four of the patients were women and two were men. All cases were located in the trigonal area. The most common clinical symptoms and signs were related to increased intracranial pressure such as headache, nausea and vomiting. Based on the clinical presentation and radiological features(CT. MRI and angiography), correct preoperative diagnosis was possible in five cases. Gross total removal of the tumor was achieved in all cases. There was no operative mortality. A temporal gyrus approach was used in five cases with good surgical results. The benefits and drawbacks of each surgical approach for meningiomas of the lateral ventricle is discussed with review of pertinent literatures.

VRE 감염증의 임상상, 미생물학적 특성 분석 및 유전적 관련성 비교 : 전국 6개 병원에서 분리된 VRE를 중심으로

정희진,박정원,엄중식,하경임,신종희,김정미,이혜수,박영희,김우주,박승철 대한감염학회 2002 감염 Vol.34 No.5

해조류를 이용한 항생재 대체 사료 첨가제 개발

박진용,김진욱,이희현,이송애,김진욱,이재화 신라대학교 자연과학연구소 2005 自然科學論文集 Vol.14 No.-

우리나라의 항생제 남용 문제는 세계적으로 심각 하다고 한다. 이러한 문제를 해결하기 위해서 정부는 다양한 정책을 도입하고 있으며 특히 축산물의 항생제 남용 문제를 해결하기위해 사료 관리법을 강화하여 항생제 사용을 억제하고 있어 항생제를 대체 할 물질이 필요하다. 이런 문제를 해결하기 위해서 우리나라의 다양한 해조류를 이용한 항생제 개발을 통해서 항생제 남용 문제를 해결하고 소비자들에게 믿을 수 있는 축산물을 제공 할 것으로 보인다. Feed official law was strengthened recently. The antibiotic use is suppressed with feed official law reinforcement. The antibiotic transfer material is necessary. To use the seaweeds and transfer the antibiotic. It is a possibility of a high income. This is new bio industry. This the goods production which is competitive power is possible. It is a possibility of eating the livestock where also the consumers are good.

Acidic primer를 이용한 교정용 브라켓 접착의 전단결합강도

김진희,진훈희,오장균 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.1

Acidic primer는 하나의 용액으로 conditioning과 priming을 동시에 시행하는 새로운 접착 시스템으로 치질의 손상이 적고 처리 과정이 간단한 특징을 지닌다. 본 실험은 acidic primer를 이용하여 치면처리를 시행한 후 기존의 접착제로 브라켓을 접착할 때 적절한 결합강도를 지니는지 평가하기 위하여 고안되었다. 50개의 사람 소구치를 5개군으로 나누어 4개군은 acidic primer로 법랑질을 처리한 후 Clearfil Liner bond 2R(1군), Transbond XTR(2군), Panavia 21R(3군), Fuji Ortho LCR(4군)로 브라켓을 접착하였고 1개군은 Transbond XTR를 통상적인 산부식 방법을 이용하여 접착(5군)한 후 전단 결합 강도를 측정하고 접착 파절의 양상을 평가하여 다음과 같은 결론을 얻었다. Acidic primer로 처리한 4개의 군 가운데 광중합형 글래스 아이오노머를 사용한 군(4군)의 전단결합강도(9.72 ± 3.16 MPa)와 Panavia 21R을 사용한 군(3군)의 전단 결합 강도(8.69 ± 2.72 MPa)는 37% 인산으로 처리한 후 광중합형 레진(Transbond XTR)을 사용한 군(5군)의 전단결합강도(10.48 ± 2.60 Mpa)와 유의성있는 차이를 보이지 않았다 (P〉0.05). 2. Acidic primer로 처리한 4개의 군 가운데 광중합형 글래스 아이오노머를 사용한 군(4군)과 Panavia 21R을 사용한 군(3군)의 전단 결합 강도는 Clearfil Liner bond 2R를 사용한 군(1군)의 전단 결합 강도(1.09 ± 0.53Mpa)와 광중합형 레진(Transbond XTR)을 사용한 군(2군)의 전단 결합 강도(2.70 ± 1.46Mpa)에 비해 유의하게 큰 강도를 보였다 (P〈0.05). 3. 접착제 잔류지수 측정 결과 4군(2.1 ± 1.1)과 5군(2.9 ± 0.3)의 경우 1군(0,2 ± 0.4), 2군(0.3 ± 0.9), 3군(0.2 ± 0.4)에 비해 접착제 잔류지수가 유의하게 높았다 (P〈0.05). 4. 4군과 5군의 접착제 잔류 지수간에는 유의한 차이가 없었다 (P〉0.05). 따라서 acidic primer로 치면을 처리하는 방법은 시용되는 접착제에 따라 기존의 산부식 접착법과 유사한 결합강도를 얻을 수 있어 교정용 브라켓 접착시 산부식 단계를 생략할 수 있는 가능성을 보여준다. Acidic primer is the bonding agent which combines the conditioning and priming agent into the single solution and was originally developed for the dentin bonding system. It is less harmful to the tooth structure and more convenient to manipulate than the traditional etching procedure. The purpose of this study is to evaluate the shear bond strength of various bonding materials when the enamel is treated with acidic primer for the bracket bonding procedure. Fifty recently extracted human premolars were randomly separated into five groups : Group I using Clearfil Liner Bond 2 adhesive system to the enamel treated with acidic primer, Group II using Transbond XT adhesive system to the enamel treated with acidic primer, Group III using panavia 21 adhesive system to the enamel treated with acidic primer, Group IV using Fuji-Ortho LC adhesive system to the enamel treated with acidic primer, Group V using Transbond XT adhesive system to the enamel treated with 37% phosphoric acid. The shear bond strength was measured with Instron universal testing machine after storing in 37℃ water bath for 48 hours. After debonding, the teeth and brackets were examined under scanning electron microscope (SEM) and assessed with the adhesive remnant index (ARI). The results were as follows : 1. There were no significant differences in shear bond strength between group III (8.69 ± 2.72 MPa), group IV (9.7 ± 3.16 MPa), and group V (10.48 ± 2.60 Mpa) (p〉0.05). 2. The shear bond strength of group III and group IV was significantly higher than that of group I (1.09 ± 0.53 Mpa), and Group II (2.70 ± 1.46Mpa) (p〈0.05). 3. The ARI of group IV (2.1 ± 1.1) and group V (2.9 ± 0.3) was significantly higher than that of group I (0.2 ± 0.4), group II (0.3 ± 0.9) and group III (0.2 ± 0.4) (p〈0.05). 4. There were no significant difference between the ARI of group IV and group V (p〉0.05). This result suggests that the combination of acidic primer and some bonding adhesive can provide sufficient shear bond strength for clinical orthodontics.

역번역을 활용한 한국 시조 이해 교육 연구 - 영어권 한국어 고급 학습자를 대상으로 -

김영 ( Jin Y Ing ),고정희 ( Ko Jeong-hee ) 연세대학교 언어연구교육원 한국어학당 2020 외국어로서의 한국어교육 Vol.59 No.-

This study aimed to present the availability and implications of back-translation learning methods in Korean sijo education as a foreign language. Results were based on the understanding of Korean sijo by advanced English-speaking Korean learners using back translation. In this study, the significance of back translation as a method of learning sijo is summarized as follows: First, learner-centered activities that encourage learners to participate exist; second, reading native texts can help obtain “advanced knowledge;” third, results are an exploratory process involving learners’ independent thinking; and fourth, awareness of diversity in interpretation encourages freedom to express views on texts. This study selected Hwang Jin-i’s sijo “A Long Night of Winter Solstice” as an experimental text and categorized the understanding of English-speaking advanced learners of the Korean language using back translation into “accepting the meaning of text through reading translations,” “interpretation of the meaning of text through back translations,” and “deeper understanding of the text by comparing back translations with source texts.” Advanced English-speaking Korean learners showed attitudes related to actively organizing the meaning of sijo while performing back translation; they continued to interpret the text by mobilizing their own experience and knowledge through the back translation process. The different order of words in the mother tongue and Korean also led to difficulty in switching to the target language. The following implications were derived based on the understanding of advanced English-speaking Korean learners using back translation. First, the teacher should effectively adjust the primary response the learner sees after reading the translation text. Second, proper educational measures from teachers are needed when learners spend a considerable amount of time on a single poem. Third, the cultural context of learners should be extended after comparing the back translated and source texts. (Seoul National University)