상아질에 적용된 재 습윤제가 미세인장 결합강도에 미치는 영향

강희영,조영곤,김종욱,박병철,유상훈,진철희,최희영,기영재 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.2

This study investigated that the effect of rewetting agent on dentinal microtensile bond strength (μTBS). Human molars were sectioned to expose the superficial dentin surfaces. Samples were divided into two groups according to type of adhesives-Single Bond (S) and One-Step (0)], and again subdivided into five groups by different dentin surface treatment-dry for 15s (D) , blot dry (BD) or dry for 15s, and rewet with different rewetting agents[distil1ed water (DW), Gluma Desensitizer (GD) and Aqua-Prep (AP)]for 30s. After application of adhesive, composite resin was built up on the bonding surface. Each tooth was sectioned to obtain stick with 1mm^(2) cross sectional area and the μTBS was determined by EZ test. In the S group, the mean μTBS of GD, AP and BD group was significantly higher than that of DW and D group (p < 0.05). In the 0 group, the mean μTBS of AP, GD, BD and DW group was significantly higher than that of D group (p < 0.05). The data suggested that Gluma Desensitizer and Aqua-Prep could be successfully used as rewetting agents, and Distilled water could be acceptable in aceton based adhesive system only.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

선천성 수근관 증후군 1례 보고

이규훈,황치문,김민석,김희상,안경회 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.3

하악골 골절에 대한 임상통계학적 연구

이성훈,김기영,조규승,소광섭,박홍주,조요기,오희균,유선열 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

IgG GM₁ 항체와 Campylobacter jejuni 항체와 관련된 급성 운동축삭형 신경병증

홍경훈,김승현,이영배,이영주,김희태,김주한,김명호 대한신경과학회 1997 대한신경과학회지 Vol.15 No.5

상하악 전치부 치열궁 형태에 대한 새로운 접근 : 한국성인 정상교합자 모델에서

하만희,손우성,양훈철 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.3

상하악 전치부 치열은 치아의 형태 변위, 선천결손 등에 의해 종종 교합관계나 심미성에 문제점을 나타내게 된다. 이러한 문제점을 극복하기 위해 임상의는 전치부 비율을 진단시 이용하게 되나, 치열중 형태, 견치간 폭경(intercanine width), 치열궁 장경(segment depth)과 치열중 둘레(arch perimeter)에 따른 전치부 비율의 변화로 인해 이러한 비율을 전치부 교합관계 예측에 직접 적용하는데는 한계가 있다. 이에 본 연구에서는 한국성인 정상교합자 모델(남자 : 20쌍, 여자 : 20쌍)에서 상하악 전치부 치열궁 형태를 least square method로 조사하였다. 한국인 정상교합자의 상하악 전치부 치열궁 형태는 다항 함수(polynomial function), 베타 함수(beta function), 하이퍼볼릭 코사인 함수(hyperbolic cosine function) 순으로 곡선 접합(curve fitting)하였으며, 이러한 곡선 접합도는 남녀, 상하악에 관계없이 일정하였다. 또한 곡선접합(curve fitting)된 치열궁 형태를 바탕으로 견치간 폭경(intercanine width), 치열궁 장경(segment depth)과 치열궁 둘레(arch perimeter)간의 상관관계를 구하였다. 이러한 상관관계는 견치간 폭경에 따른 치열궁 형태 예측과 보다 정확한 전치부 비율에 대한 정보를 제공할 것이다. (주요 단어 : 전치부 치열궁 형태, 전치부 비율) Maxillary and mandibular anterior dental arches often have the problems of occlusal relation and esthetics by malformations of teeth, congenital missing, et at. Though the clinician usually use the anterior ratio to overcome this problems, he has the limitation of a direct application this ratio to the prediction of anterior occlusal relationship by the change of anterior ratio as dental arch form, intercanine width, segment depth and arch perimeter. So this study examine maxillary and mandibular anterior dental arch forms by least square method using Korean normal occlusion models(man : 20 casts, woman : 20 casts), Maxillary and mandibular anterior dental arches of Korean normal occlusion models are curve fitted to polynomial function, beta function, hyperbolic cosine function in order. And this accuracy of curve fitting is constant regardless of man/woman and maxilla/mandible. The relationships between intercanine width, segment depth, and arch perimeter based on this curve fitted dental arch form are acquired. This relationships will give the prediction of anterior dental arch form and the information of more accurate anterior ratio according to intercanine width. Key words : Anterior dental arch form, Anterior ratio

도시교통수요관리 정책집행에 있어서 대상집단의 불응요인 분석 : 부산시 10부제 정책을 중심으로

허용훈,이희태 釜慶大學校 1999 釜慶大學校 論文集 Vol.4 No.1

The purpose of this study is to understand and explain the noncompliance mechanism of the policy target group in transportation demand management policy. In order to accomplish this purpose, this study tried to build a comoprehensive theoretical framework for explaining and understanding policy compliance-noncompliance phenomena in the implementation process of the transportation demand management plicy. Theoretically the factors influencing the noncompliance of the policy target group were divided into four parts : plicy factors (consistency of the policy, the degree for the policy target group to support the policy, coercion, incentives, legitimacy)., policy target group factors(ability of the policy target group to understand the policy contents, the attitudes of the policy target group toward implementation institution, selfish desire, a sense of duty), intermediary group factors (roll of intermediary group), and situation factors (traffic conditions, the purpose to use the driving private vehicles). In order to test this theoretical framework empirically, data were collected through the use of self-administered questionnaire from a sample of 253 adults who dwell in Pusan Metropolitan City. And this study used various statistical methods such as multiple regression analysis to analyse the degree of relative influence of these factors. The findings of this study can be summarized as followings : the sense of duty of the policy target group was found to have the greatest influence as a result of the analysis. Furthermore, the degree of relative influence of each factors resulted in the following order : ability of the policy target group to understand the policy contents, traffic conditions, the degree for the policy target group to support the policy, coercion power of the policy, and role of the intermediary group. And the purpose to use the driving private vehicles had negative influence. However, selfish desire of the policy target group, the consistency of the policy, the legitimacy of the policy, attitudes of the policy target group, incentives which the policy provided, did not affect the noncompliance of the policy target group in the transportation demand management policy.

Rice glutathione S-transferase의 정제 및 특성

박희중,공광훈 中央大學校 遺傳工學硏究所 1996 遺傳工學硏究論集 Vol.9 No.1

Rice로부터 DEAE-Sepharose와 GSH- garose 및 Sephadex G-75 column chromatography를 이용하여 GST를 분리정제하였다. 정제된 효소는 분자량이 전기동영상에서는 약 28 kDa, gel chromatography상에서는 약 54kDa인 homodimeric 구조이다. 또한 정제된 효소는 다른 종 GST들에 공통적인 특징인 1-chloro-2,4-dinitrobenzene(CDNB)에 대해 높은 기질특이성을 보였으며, S-hexylglutathione과 benanstatin A 에 대해서도 저해효과를 보였다. 효소의 최적온도는 45℃ 를 나타내었다. Glutathione S-transferase (GST) was purified from rice by DEAE-Sepharose, GSH-agarose and Sephadex G-75 column chromatography. The molecular mass of the purified GST was determined to be 54,000 by gel chromatography and 28,000 by SDS-polyacrylamide gel electrophoresis, indicating a homodimeric structure. The enzyme had high substrate activity of the enzyme toward the substrate CDNB was inhibited by S-hexylglutathione and benanstatin A. The optimun pH of enzyme was 7.0 and the optimum temperature was 45℃ with CDNB as a substrate.

하악 매복 지치의 외과적 발거시 Methylprednisolone의 안면 부종 감소 효과에 대한 임상적 연구

신지훈,박진배,한지용,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : The third molars, expecially mandibular wisdom teeth, are commonly obliquely impacted, and surgical procedure with odontomy and osteotomy is necessary for their extraction. The surgical extracion of impacted wisdom teeth occasionally in duces variable discomfort. Especially, postoperative swelling, pain and limitation of mouth opening determine the degree of discomfort. For the reduction of these complicaions, drug therapy(antihistamine, enzyme, steroid), cole pack and pressure technique have been studied. It is known that the steroids are the most effective. Methods and Meterial : We selected fifty patients in their twenties, who visited Department of Dentistry, Pusan Paik Hospital from March to August in 1998. All of 50 patients has no other medical problems. Total 50 patients were randomly divided to 30 of experimental group and 20 of control group. The experimental group had orally administration of methyprednisolone 5㎎ every 8 hours 2 times preoperatively and 7 times postoperatively. Five points were marked on the patients' face, and the distances between the points were measured just before operation and 48 hours after operation. Results : Methyprednisolone reduces swelling about 50% after surgical extraction of obliquely impacted mandibular third molars with osteotomy and odontomy. The difference in the amount of tissue edema between experimental and control group was significant(p<0.01). However, there was no significant difference according to the operation time. Conclusion : It seems that the use of methylprednisolone is effective to reduce postoperative swelling following surgical extraction of third molars.

유산소성 운동과 홍삼투여가 당뇨환자의 혈청 MDA에 미치는 영향

박희석,양상훈 대불대학교 2003 論文集 Vol.9 No.1

This study is to investigate that aerobic exercise and the Red Ginseng taking influence of serum MDA in diabetes patients. The subjects of study were 18 non-insulin dependent diabetes mellitus patients in the fifties man, and the subjects parted into control group (CG, N=6), EXERCISE GROUP (EG, N=6) and exercise & Red Ginseng pral administration group(EGG, N=6), and exercise & Red Ginseng oral administration group(EGG, N=6), and trained to 50~70% HRmax intensity by using bicycle ergometer for 5 times a week through 12 weeks. The results were as follows; 1. The change of serum MDA among the three groups. 1) The change of serum MDA appeared no change of CG but decrease of EG and EGG(F=6.25, p<.05). Between the exercise pre and post, serum MDA is decreased more in post than pre(F=4.81, P<.001). In conclusion, aerobic exercise for 12 weeks gives a positive influence in the change of Serum MDA in the case of diabets patients. and aerobic excercise prevents a cell wall from damaging due to oxiditive stress. and it might give a influence to antioxidase in the long run. There's no big reducing in the group of aerobic exercise and the Red Ginseng taking side by side, considering the groupc that takes only exercise.