프리미돈의 한국인에서의 생체이용율시험

권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.

釜山市 小規模工業經營者의 立地環境에 대한 知覺

李熙悅 부산대학교 사범대학 1990 교사교육연구 Vol.20 No.-

This study aims to identify how the small firm entrepreneurs in Pusan City perceive their locational environment within which they operate, and further to clarify how it does differently in accordance with firm characteristics, managerial personal characters, and zoning areas, In order to implement the purpose of research, data are collected from small firm entrepreneurs sampled on the basis of questionnaire. The main results are summarized as follows. It is identified that small firm industrialists, as a whole, didn't show any attitudinal differentiation toward locational environment of region and place, presumably reflecting their lack of regional level of locational judgement. As far as the locational environment of place is concerned, availability of the electricity and water supply drew the most positive evaluation from the entrepreneurs, with showing positive trends on the items of transportation, materials, market, infrastructure, and personal preference of the place, whereas availability of plant site drew the most negative evaluation. In relation to the characters of enterprises, smaller firms show more positive attitude. On the other hand, the ranges of positive evaluation of locational environment, in short, are varied in terms of the kinds and the time of the establishment of the firm. As regard the character of top managements, the aged or experienced of highly educated managers show more positive attitude of the existing locational environment. Viewed from the zoning areas, non-industrial areas such as commercial area, residential area evoke more favorable evaluation toward the locational environment than industrial area; especially commercial area is favored for factors such as transportation, market, materials, labor fores, infrastructure, and services while residential area is preferred for non-economic factors of residential liveability and personal reasons.

미테랑 대통령 재임 14년간 프랑스 경제정책의 평가

채희율 한국EU학회 2000 EU학연구 Vol.5 No.1

Based on the historical survey of the evolution of the French economic policy, this study identifies its main characteristics and tasks for the future. The period covered is centered on Mitterand's 14 years presidency. Among diverse policies, the focus is given to the industrial policy. During socialist presidency, France was able to overcome the economic crisis and expect to enter into a stable growth path. This study argue that such an outcome have to do with the fact that the economic policies of the government were largely appropriate and timely. In particular the state played an important role in establishing market economy order and corporate governance mechanism. Nonetheless, French state have yet a lot to do in order to establish a democratic and effcient corporate governance mechanism. Finally, French state have to overcome a leadership crisis due to the dismissal of statist pattern of economic policy making caused by both ongoing europeanization of economic policy and loss of policy tools along with privatization and deregulation.

釜山市 小規模工業의 構造와 立地類型

이희열 부산대학교 1993 地域經濟硏究 Vol.- No.2

This study is aimed to analyze the locational patterns of the intraurban small firms in Pusan. Main features of the results for which the research carried out are summerized as follows. first, it is found that small industrial firms tend to be in more dispersed location than the large and medium ones, with an explicit inner city based locational tendency in the case of tiny firms. Second, based on the distributional character in terms of the type of establishment unit, the distributional pattern of the small firm industries in Pusan City can be divided into two major parts : the western part of the city's fringe area along the Naktong river coast where the urbanization economy prevails and the inner city area of the northeast-southwest where the localization economy dominated.

광주시내 업종별 음식점의 주방기구와 관련된 주요 세균 및 이들의 계절별 변화

이홍열,유맹자,정해진,김근영,정희종 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

업종별 음식점에서 사용중인 주방기구 가운데 개숫물중에 존재하는 세균들을 분리·동정한 결과, 한색음식점에서 37균주, 일식음식점에서 23균주, 및 중식음식점에서 33균주가 분리되었고 이들 중 한식음식점에서 E. coli 등 16균주, 일식음식점에서 Listeria sp. 등 20균주, 중식음식점에서 Micrococcus sp. 등 15균주를 각각 동정하였다. 이들 세균들은 업종별 음식업소에서 주로 사용되는 색품재료에 존재하는 세균들과 밀접한 관계가 있는 것으로 밝혀졌고 E.coli와 같은 일부 세균들은 주방의 불결한 환경이나 종사자로부터 오염된 것으로 추정되었다. 업종별 음식점에서 사용중인 개숫물, 행주, 칼, 및 도마에 존재하는 세균의 분포는 일반세균수 및 대장균수가 모두 2월에서 8월까지 점점 증가하다가 11월에는 다시 감소하는 경향을 보였다. 특히 이같은 경향은 일반세균은 개숫물에서 대장균군은 칼에서 가장 뚜렷하게 나타났다. 따라서 식중독 발생 가능성이 가장 높은 여름철에는 칼, 도마 등 주방기구들은 정기적으로 열탕소독하는 철저한 위생처리가 필수적인 것으로 생각되었다. Thirty-seven, twenty-three, and thirty-three bacterial strains were isolated from dish-washing water which was selected as a kitchen supply commonly loaded the highest level of bacteria among various supplies using at Korean style, Japanese style, and Chinese style restaurants. Among these isolates, sixteen strains including Esherichia coli, twenty strains including Listeria sp., and fifteen strains including Micrococcus sp. were identified from Korean style, Japanese style, and Chinese style restaurants, respectively. This result suggested that most isolated bacteria were closely related to bacterial flora of raw food materials used in each style of restaurants and others could be contaminated from the surrounding environment and the employees. Total and coliform bacterial counts distributed in dish washing water, wiping cloths, knives, and cutting boards used at different types of restaurants were gradually increased from February to August and then decreased until November. This changing tendencies of total bacterial counts and coliform group counts were obvious in dish-washing water and in knives, respectively. Therefore, kitchen supplies such as wiping cloths, cutting boards, and knives should be treated carefully with hot water of above 45℃ at every certain period of time to kill some of these potential hazardous bacteria and to prevent outbreaking foodborne-illness by them, especially during Summer.

제7차 교육과정과 지리교육의 과제

이희열 釜山大學校 사범대학 지리교육과 2000 釜山地理 Vol.9 No.1

This paper examines the characteristics of the 7th Curriculum and discusses the tasks in geography education of middle and high school in Korea. The major content which were dealt are as follows. First, social studies curriculum in the 7th curriculum is much emphasized the character of the integrated social studies. As result, the role and status of geography in social studies curriculum is weakened in middle and high school education as comparison with the 6th curriculum. Second, for the strengthening of the role and status of geography in social studies in new circumstances such as integrated social studies, it is required to raise the social utilities of geography, and necessary to establish firmly the true character of geography education. At the same time, the positive attitude of geography teachers is very important for the development of geography education.

총상에 의한 하악결손의 재건술

황오열,박치영,김용배,안희창 大韓成形外科學會 1987 Archives of Plastic Surgery Vol.14 No.3

Most mandibulr reconstructions are performed primarily or secondarily for bony defects caused by injuries or removal of tumors. An autogenous bone greft is still the method of choice for the restoration of mandibular defec. But a conventional autogenous free bone graft does not possess an intact blood supply and is dependent on local nutrition to survive. Severely scarred or radiated tissue are unfavorable beds for bone graft and even more the risk of resorption and infection is inceased in these kinds of a pooly vascularized bed. To overcome this difficulty, free vascularized bone graft has been tried with microsurgical gical technuque. A free vascularized bone graft has significantly higher rate of survival, with less resorption and higher resistance to infextion than a connentional free bone graft. A free vascularized iliac bone graft pedicled on deep circumflex iliac vessels is used widely, as it have many advantages such as, availability of large bloc of composite tissue, simplicity of donor dissection, large and long vascular pedicle and few donor site morbidity. In this paper, we represent 4 cases of reconstruction of wide mandibular defects using free vascularized iliac bone graft and free dsteocutaneous groin flap, and review the characteristics of gunshot wound. The result is satisfactory.

居住選好의 Mental Map과 情報面의 形成 및 그 關係 : 釜山 學生들을 中心으로 In Case of Pupils and Students in Pusan City

李熙悅 부산대학교 사범대학 1985 교사교육연구 Vol.10 No.-

The aim of this paper is to investigate the mental maps of the residential preference and the information surfaces, and their's relationships in Korea. The data were collected in Pusan City, from July to September, 1983. The respondents were pupils and students, who had continuously resided in Pusan City since their birth. They were asked to take a piece of papers, and then write down as quickly as they could, in a timed five minutes, all the names of towns they could think of in Korea. Next, map-questionnaires that the national-scale space is divided into 30 sub-regions were given out to them, and then were asked to record their rank-order preferences based on the residential desirability. The main results are summarized as follows. 1) The Pusan region, the perception point, is the most desirable at all the age level, and regions located on the Kyung-Pu Axis that Seoul, Taegeon, Taegu and Pusan region are contineously linked are estimated more and more desirbly with an increase of age. In contrast, the desirability for the regions such as Youngsuh, inland of Youngnam, Honam and the adjacent area of the D.M.Z. is lowed with age. (Fig.2∼Fig.5) 2) With an increase of age, the geographic information is acquired gradually, therefore the information surface is risen. Such tendency appeared distinctively in the regions that the larger cities are located or the recreational image is apparent. Consequently, the information surface of the regions located on the Kyung-Pu Axis and the southeastern coast region is distinctively formed very high. (Fig.6∼Fig.9) 3) The relationships of the mental maps and the information surfaces are considerably high at all the age level. And the gain of the information on each regions with age are not always positively related to the desirability. It is found that the regions located on the Kyung-Pu Axis and the East Coast show a positive correlation, but inland of Youngnam, Honam and the adjacent area of D.M.Z. are negative. (Fig.2∼Fig.9) As a conclusion, it is inferred that such results are to be related closely to the characteristics of present spatial system in Korea.

광주시내 업종별 음식점의 위생상태 및 식중독원인 세균의 분포 특성

이홍열,유맹자,정해진,김근영,정희종 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

업종별 음식점 주방의 위생상태는 일식>중식>한식의 순이었고 개인위생의 경우는 일식>한식>중식의 순이었는데 주방 및 종업원의 위생상태를 향상시키기 위해서는 음식점 규모의 대형화, 45℃ 이상의 온수공급, 주방시설의 표준화, 위생비닐장갑의 착용, 및 유니폼 착용이 신속하게 이루어져야 할 것이다. 업종별 대중음식점의 주방기구중의 세균분포는 전반적으로 일반세균수가 높게 나타났고 특히 대장균군수가 높게 나타났는데 음식물이 아니고 조리기구이긴 하지만 우리 음식점의 위생상 문제가 많은 것으로 생각된다. 미국 육군 Natick연구소가 제시한 음식물의 미생물 기준한계인 1 ×10??마리 이하, 대장균수가 100마리 이하와 비교할때 일반세균수의 경우는 아주 만족할만한 위생상태로 평가되었으나 대장균수는 개숫물의 경우 업종과 관계없이 높게 나타났고 행주와 칼의 경우 일식음식점에서만 높게 나타났으며 도마의 경우는 모두 100마리 이하로 양호한 위생상태로 평가되었다. 한식 전문음식점간의 세균수가 큰 차이를 보인 것은 규모와 운영방법이 서로 다르기 때문으로 앞으로 한식음식점에 대한 시설 및 환경개선에 대한 노력이 요구되었다. 또한 일식음식점간에는 일반세균수의 분포가 크게 다는 것으로 조사되었는데 특히 개숫물, 행주 및 도마중에 존재하는 미생물수가 크게 차이가 있었다. 등급별 한식음식점의 세균분포는 호텔급 음식점> 일반대중급 음식점> 여관급 음식점의 순으로 나타나 업소규모가 클수록 위생시설 및 위생습관의 수준이 높아 위생상태가 양호한 것으로 분석되었고 여관급음식점의 경우 위생상태가 낮은 것은 이용빈도가 낮은 것이 그 원인이 아닌가 생각되었다. Sanitary evaluation of kitchen area in different types of restaurants was the best at Japanese style restaurants and the worst aat Korean style restaurants. In personal hygiene Japanese style restaurant were evaluated as the best, but Chinese style restaurants were evaluated as the worst. Total and coliform bacterial counts were mostly showed high levels at all types of restaurants and especially this tendency was predominated in coliform counts. As compared to the standards suggested by U.S. Army Natick, however, total bacterial counts in all of supplies were evaluated as the satisfactory state. On the other hand, coliform counts in dish-washing water were much higher than the standard, which were not affected by the types of restaurant, and Japanese style restaurants were higher in wiping cloths and knives, but cutting boards were evaluated as satisfactory state with the counts less than 1.0 ×10².Bacterial counts in Korean style restaurants were greatly different depended on the size or type of restaurant. Total bacterial counts in Japanese style were also different among restaurants, especially in dish-washing water, wiping cloths, and cutting boards. According to the results of the evaluation of Korean style restaurant, bacterial distribution based on the class of restaurants, classified as hotel, motel, and public classes, hotel class restaurants showed lower levels of bacterial counts than public class. This result suggested that the larger and higher classes of restaurants maintained the satisfactory state without potential hazards.

機能性胃腸障碍 및 急性肝炎 患者에서 Clebopride에 依한 症狀의 好轉과 胃內容物排出 時間과의 關係

范熙承,金成烈,鞠敦杓,朴光淑,尹鍾晩,崔元,金文烈 최신의학사 1985 最新醫學 Vol.28 No.6