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한국 자생 구절초 종류의 정유성분 비교분석 및 항생제 내성 Salmonella 속 균주에 대한 억제효과
변연희,정은영,정하숙,이연희,신승원 德成女子大學校 藥學硏究所 2008 藥學論文誌 Vol.19 No.-
The essential oils from the aerial parts of three varieties of Chrysanthemum zawadskii cultivated in the herbal garden of Duksung Women' s University were extracted by steam distillation method and their compositions were compared by GC-MS analysis. The composition of essential oil fractions from the three varieties of C. zawadskii significant differences in their compostion. While the predominant components of C. zawadskii were camphor and borneol, C. zawadskii var. tenuisectum contained myrtenol and germacrene D as representing compound of its essential oil. C. zawadskii var. nakdongense oil showed higher contents of germacrene D than other two varieties of C. zawadskii. As the results of the determination of the effects of this oil and its main components on antibiotic-susceptible and -resistant strains of Salmonella enteritidis and S. typhimurium, the main components of C. zawadskii oil fraction, borneol and camphor, significantly inhibited all strains of the two Salmonella species examined, while its oil fraction showed relatively weak activity. In evaluation tests of the combination effects of the oils with kanamycin or streptomycin using a checkerboard microtiter assay, C. zawadskii oil fraction combined with streptomycin resulted the most significant synergism in this study with the fractional inhibiting concentration index (FICI) of 0.19.
이웅재,정희연,김희연,김혜주 서울여자대학교 자연과학연구소 2001 자연과학연구논문집 Vol.13 No.-
In order to understand natural language, we have to follow the process "Input → Lexical Analysis → Syntactic Analysis → Semantic Analysis". Among those, "syntactic analysis" plays the most important role since it is able to be applied to various fields such as natural language query systems, natural language interface systems, text summary systems, and machine translation systems. It is also important to analyze a sentence containing ambiguity. In this paper, we propose an algorithm to parse the Korean language using chart. It is implemented using Prolog programming language.
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
윤희상,이화용,정백호 湖西大學校 工業技術硏究所 2002 工業技術硏究所論文集 Vol.21 No.-
In the paper, we present a time-domain combined field integral equation(CFIE) formulation for analyzing transient electromagnetic responses from three-dimensional(3-D) closed conducting bodies. Instead of the conventional marching-on in time(MOT) technique, the solution method in this paper is based on the Galerkins method that involves separate spatial and temporal testing procedure. Triangular patch basis functions are used for spatial expansion and testing functions for arbitrarily shaped 3-D structures. The time-domain unknown current coefficient is approximated by using an orthonormal basis function set that is derived from the Laguerre functions. These basis function are also used as temporal testing functions. The method to be described results in very accurate and stable transient responses from conducting objects without an internal resonance. Detailed mathematical steps are included and representative numerical results are presented and compared.
Back Propagation 알고리즘을 이용한 산업용 로봇의 견실제어
윤주식,이희섭,윤대식,한성현 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-
Neural networks are works are used in the framework of sensor based tracking control of robot manipulators. They learn by practice movements the relationship between PSD(an analog Position Sensitive Detector) sensor readings for target positions and the joint commands to reach them. Using this configuration, the system can track or follow a moving or stationary object in real time. Furthermore, an efficient neural network architecture has been developed for real time learning. This network uses multiple sets of simple back propagation networks one of which is selected according to which division(corresponding to a cluster of the self-organizing feature map) in data space the current input data belongs to. This lends itself to a very training and processing implementation required for real time control.
온라인 필기인식에 관한 방법연구와 이를 활용한 응용프로그램 제작
윤상인;유진식;공희경;김흥식 인제대학교 2012 仁濟論叢 Vol.27 No.1
Recently with the spread of smart phones is increasing the importance of handwriting recognition technology. Therefore, we studied these online handwriting recognition technology for real-time input. In this research process we study the distance filtering method, the catching feature points, chain code, and similarity matching techniques and make possible the actual coded. We implemented the on-line symbol recognition method which recognize up to 91% of the capital letter. That you can use handwriting recognition to target programs, the children learn to play program planning and production.