원발성 두개강내종양 2,616례의 통계학적 연구(1976-1995)

황승균,정희원,오창완,양희진,남도현,이상형,정영섭,김동규,왕규창,한대희,최길수,조병규 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.7

두개인두종의 임상양상 및 수술적 치료성적 : 102례의 분석 Analysis of 102 Cases

백선하,오창완,정영섭,양희진,한대희,조병규,왕규창,정희원,김현집,최길수 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.7

인체 헤모글로빈의 효소반응성에 대한 연구

이동섭,안희중,김응수,이영보,최상규 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

어떤 흰쥐 뇌에서 부신절제가 전기경련 충격에 의한 조기유전자 발현에 미치는 영향

하규섭,강웅구,정희연,주연호,조수철,박주배,김용식 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

부신피질 호르몬이 70g 이내의 어린 흰쥐의 뇌에서 전기경련 충격에 의한 조기유전자(IEG)의 발현에 미치는 급성 효과 및 만성 효과를 살펴보기 위하여 본 연구를 수행하였다. 70g 이내의 생식선이 발달하지 않은 수컷 Sprague-Dawley 흰쥐에서 양측 부신을 절제한지 3일과 14일 후에 전기경련 충격으로 경련을 유발시켜 대뇌 피질과 해마에서 c-fos, jun B, TIS 1 의 발현 양상을 관찰하고 이를 대조군과 비교하여 다음과 같은 결과를 얻었다. 1) 부신절제 후 대뇌 피질에서 전기경련 충격에 의한 c-fos와 jun B mRNA 발현은 일찍 최대치에 도달하고 일찍 감소하는 경향을 보였으며, 초기의 발현이 강화되는 경향을 보였다. 이러한 경향은 jun B가 c-fos 보다 뚜렷하였으며, 부신절제 후 3일이 경과된 경우보다 14일이 경과된 경우가 뚜렷하였다. 2) TIS 1의 경우에는 대뇌 피질에서 이러한 초기 발현의 강화가 관찰되지 않았으며, 부신절제 14일된 어린 흰쥐에서만 발현이 억제되는 경향을 보였다. 3) 부신절제는 해마에서는 전기경련 충격에 의한 c-fos와 jun B의 발현에 영향을 미치지 않았다. 부신절제 3일 후 전기경련 충격에 의한 TIS 1의 발현은 억제되는 경향이 관찰되었으나, 부신절제 14일 후에는 이러한 경향이 관찰되지 않았다. 이상의 결과로부터 부신절제는 전기경련 충격에 의한 IEG의 발현에 영향을 미치며, 그 영향은 흰쥐의 뇌의 부위, IEG의 종류에 따라 차이가 있음을 알수 있었고, 흰쥐의 연령 및 부신피질 호르몬을 제거한 기간 등의 영향도 있음을 확인할수 있었다. To evaluate the influences of adrenocortical hormone on the signal transduction system in young brain, the authors observed the effects of bilateral adrenalectomy on the induction of immediate early genes(IEGs) such as c-fos, jun B, and TIS 1 by electroconvulsive shock(ECS) in the young rats. The young(70g) male Sprague-Dawley rats were treated with ECS(130V, 0.5sec) at day 3 or 14 after bilateral adrenalectomy. They were sacrificed at 0, 15, 30, 45, and 60 minutes after ECS and cerebral cortex and hippocampus were dissected from their brans . The induction of IEGs were assessed with northern by hybridization. The band intensities of the autoradiographs measured by densitometer were compared between adrenalectomized group and sham-operated control group. In the cerebral cortex, c-fos and jun B appeared and disappeared earlier, and enhanced in the earlier phase of the induction in the adrenalectomized group. These trends were more prominent for jun B than for c-fos, and were more prominent at day 14 than at day 3 after adrenalectomy. The induction of TIS 1 was attenuated at day 14 after adrenalectomy. In the hippocampus, the induction of c-fos and jun B by ECS was not influenced by adrenalectomy. The induction of TIS 1 was attenuated at day 3 after adrenalectomy. These results suggest that adrenalectomy has influences on the induction of IEGs by ECS in rat brain differently, depending on the brain region, the kind of IEGs, the age of the rats, and the time passed after adrenalectomy.

청신경초종의 수술에서 골미로를 통한 접근법 : 후하골을 통한 접근법과의 비교 Comparison with the Suboccipital Approach

정희원,이정일,김종수,오창완,정영섭,장선오,김종선,최길수 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.10

The results of a series of thirteen translabyrinthine removals of acoustic neurinomas are reported From 1990 March to 1993 May, thirteen patients with acoustic neummas underwent translabyrinthine removal at Seoul National University Hospital with cooperation of Department of Neurosurgery and Otolaryngology. In four patients with the medium-sized(ll-20mm) tumors, complete removal with preservation of the facial nerve was possible. In nine patients with the large(21-4Omm) tumors, complete removal of the tumor was possible in seven. Preservation of the facial nerve was possible in all but one, whose facial nerve was incidentally transected at the distal intracanalicular portion and was anastomosed end-to-endly. In one, postoperative leakage of cerebrospinal fluid required reoperation. The results of translabyrinthine approaches were compared With those of suboccipital approaches performed during the same period. In medium-sized or large acoustic tumors, translabyrinthine approach was comparable with suboccipital approach in the rate of total tumor removal, preservation of the facial nerves, and complication.

변칙용언의 형태음소론

김희섭 釜慶大學校 1997 釜慶大學校 論文集 Vol.2 No.1

The morphophonemics of P-irregulars has been one of the favorite issues in Korean phonology. Nontheless, the solutions proposed by many researchers under traditional and generative phonologies were not satisfactory. This study attempts to view the P-irregulars in a new framework, called OT (Optimality Theory). OT is not a derivational theory. Moreover it allows violations of constraints to generalize the outputs from inputs. To explain the irregularity of P-verbs and P-adjectives, first, the stem-final input of the irregulars is assumed /w/, instead of /p/, and two groups of constraints are proposed : Faithfulness Constraints (FC : PL, VOI, CONT, NAS) and Identical Cluster Constraints (ICC: NAS, CONT, VOI, PL). The ICCs dominate the FCs in Korean. OT is a very favorable theory since it explains many phonological processes in terms of (violable) constraints, not inviolable rules. It is too early to criticize the general aspects OT. More studies are needed to reveal the underlying genelizations in Korean and to evaluate fairly the methods in OT.

부신절제가 전기경련 충격에 의한 흰쥐 뇌의 조기유전자 발현에 미치는 영향

하규섭,강웅구,정희연,주연호,박주배,김용식 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

부신피질 호르몬이 뇌에서 전기경련 충격(ECS)에 의한 조기유전자(IEG)의 발현에 미치는 영향을 살펴보기 위하여 본 연구를 수행하였다. 양측 부신을 절제한 수컷 Sprague-Dawley 흰쥐에서 부신을절제한 지 3일 후에 ECS로 경련을 유발시켜 대뇌 피질, 해마 및 소뇌에서 c-fos, jun B, TIS 1의 발현 양상을 관찰하고 이를 대조군과 비교하여 다음과 같은 결론을 얻었다. 1) 부신절제 후 대뇌 피질에서 ECS에 의한 c-fos와 jun B 및 TIS 1 mRNA 발현은 대조군에 비하여 억제되었다. 2) 해마와 소뇌에서는 IEG의 종류에 상관없이 부신절제가 ECS에 의한 IEG의 발현에 별 영향을 미치지 않았다. 이상의 결과로부터 부신절제는 ECS에 의한 IEG의 발현에 영향을 미치며, 그 영향은 뇌의 부위에 따라 다름을 확인할 수 있었다. 부신피질 호르몬이 IEG 발현에 영향을 미치는 기전에 대하여 고찰하였다. The adrenocortical hormones have been known to be related with the pathogenesis of mental disorders and individual vulnerability to stress. To evaluate the influences of adrenocortical hormone on the signal transduction system in rat brain, the authors observed the effects of bilateral adrenalectomy on the induction of immediate early genes(IEGs) after electroconvulsive shock(ECS). Male Sprague-Dawley rats(200 - 250g) were treated with ECS(130V, 0.5sec) at day 3 after bilateral adrenalectomy. Rats were sacrificed at 0, 15, 30, 45, and 60 minutes after ECS, and cerebral cortex, hippocampus, and cerebellum were dissected from the brain. The induction of IEGs was assessed with northern hybridization. The band intensities of the autoradiographs measured with densitometer were compared between adrenalectomized group and sham-operated control group. After adrenalectomy, the c-fos, jun B, and TIS 1 induction by ECS was generally attenuated in the cerebral cortex. The induction of IEGs in the hippocampus and in the cerebellum was not influenced by adrenalectomy. These results suggest that adrenalectomy has differential influences on the induction of IEGs by ECS in the rat brain depending on the region of brain.

육상 단거리 차렷 자세 동작에서 팔 넓이가 운동학적 요인에 미치는 영향

윤희중,장영섭 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 육상 단거리 차렷 자세 동작에서 팔넓이와 출발 동작의 운동학적 요인과의 관계를 규명하는데 그 목적이 있다. 이를 위하여 2000년 현재 선수등록이 되어 있는 대학 · 실업 선수 5명을 선정하였으며, 평상시 취하는 팔넓이에 ±2.5㎝를 계산하여 실험을 실시하였다. 이를 두 대의 비디오카메라로 녹화하여 DLT 기법을 통하여 3차원영상분석을 실시한 후 각 요인들을 분석한 결과 다음과 같은 결론에 도달하였다. 1. 인체 중심의 이동 변위는 저자세(-2.5m), 중자세 그리고 고자세(+2.5m) 순으로 가장 많은 이동 변위를 나타냈으며, 국면별로는 3국면, 1국면 그리고 2국면 순으로 많은 이동 변위를 나타냈다. 2. 보폭은 저자세(-2.5m), 고자세(+2.5m) 그리고 중자세 순으로 긴 보폭을 나타냈으며, 구면별로는 3국면,1국면 그리고 2국면의 순으로 많은 이동 변위를 보이고 있었다. 3. 인체 중심 이동 소요 시간은 중자세, 저자세(-2.5m) 그리고 고자세(+2.5m)순으로 빠르게 나타났다. 4. 인체 중심과 몸통의 순간 속도는 중자세와 저자세에서 빠르게 나타났다. 5. 발분절의 순간 속도는 고자세(+2.5m), 저자세(-2.5m) 그리고 중자세 순으로 빠르게 나타났다. 6. 몸통의 각도는 고자세(+2.5m)에서 몸통을 가장 많이 숙이는 것으로 나타났다. The purpose of this study is to investigate the relationship between the width of the arm joint at attention and displacement, time, angle and velocity factors of starting motion for male sprinters. 2 S-VHS video cameras were used for the data collection. The following conclusions were drawn : 1. In the displacement of CG according to width of the arm joint was shown longest displacement in low position(-2.5㎝) medium position and high position(+2.5㎝), By the phase, it was shown longest diplacement in 3 phase, 1 phase and 2 phase. And in the height of CG was alike form of change. But medium position was shown faster form of change than other position. 2. In the length of stride was shown longer in low position(-2.5㎝), high position(+2.5㎝) and medium position. By the phase, it was shown longest displacement in 3 phase, 1 phase and 2 phase. 3. In the time of CG was shown shorter in medium position, low position(-2.5㎝) and high position(+2.5㎝). 4. In the velocity of CG and trunk was shown faster in low position(-2.5㎝) and medium position. 5. In the velocity of the foot segment was shown faster in high position(+2.5㎝), low position(-2.5㎝) and medium position. 6. In the angle of trunk was shown smallest angle in high position(+2.5㎝).

캐싱 알고리즘 동작 확인용 시뮬레이터 설계 및 구현

송태섭,천희식 진주여자전문대학 1999 論文集 Vol.22 No.-

The design of a multi-processor system is based on one of the two approaches: a message-passing mechanism, and a shared-memory architecture[1]. The latter alternative gains an advantage over the former in that it can eliminate problems from the data partitioning and simplify dynamic load balancing so that a system adopting the architecture may be scaled with ease. On the other hand, if a certain shared-memory multiprocessor is allowed t o have its own private cache memories, a problem how to keep the consistency between a block in main memory and the copy of the block in a cache shall arise[21[41. This paper designs and implements a dedicated bus system supporting the DASH protocol. a prototype of a shared-memory multiprocessor consisting of processing nodes and high-bandwidth low-latency interconnection networks, in accordance with the completely open IEEE Future bus+ Standards. The effectiveness and appropriateness of the bus system are verified through a simulation applied to the DASH protocol. In conclusion, the parallel processing of activities related to cache coherency and those elated to existing common bus systems surpass the hardware redundancy induced by the dedicated bus system in performance.

한국산 배의 Polyphenol 화합물군이 쥐의 면역기능에 미치는 영향

최희진,한호석,박정혜,배종호,우희섭,안봉전,배만종,김현구,최청 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.4

This study was conducted to investigate immunofunctional activity of the polyphenol fractions isolated from Korean pear. In the experimental of Rosette forming cell, the results showed that all the polyphenol fractions enhance the cell count compared with the control group. Especially polyphenol fraction II and III showed highly significant effect on Rosette forming cell, and allergy inhibition. After antigen challenge, histamine content of blood of the polyphenol groups was lowered to near the normal group.