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이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4
본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.
최승윤,배상희,송유한,Choi Seung Yoon,Bae Sang Hee,Song Yoo Han 한국응용곤충학회 1970 한국식물보호학회지 Vol.9 No.1
본 시험은 유기인계 살충제인 Terracur P입제 및 Lebaycid 입제와 유기염소계 살충제인 상감마입제$(\gamma-BHC 입제)$를 수면시용 하였을때 수도요해충인 이화명충, 끝 동매미충, 애멸구 및 흰둥멸구에 대한 동시방제가능성과 방제적기를 구명하고 약제간의 방제효과를 비교코저 실시하였다. 얻어진 시험결과는 다음과 같다. 1) 약제처리후 부화직후 이화명충 접종 시험에 있어서 상감마와 Terracur P는 높은 살충율을 보였으나 Lebaycid의 살충율은 낮았다. 約 $50\%$ 살충력 잔효일수에 있어서 상감마는 8-14日이었고 Terracur P는 6일간이었다. 2) 당초 계획된 방제적기에 관한 정보는 얻을 수 없었다. 즉 주어진 일간격이 좁아 유의한 차를 얻을 수 없었다. 3) 1,2화기 이화명충에 대한 방제효과는 Terracur P=상감마>Lebaycid의 순이었다. 4) Terracur P와 Lebaycid 입제의 처리는 끝동매미충의 방제효과가 좋았으나 상감마$(\gamma-BHC 입제)$의 방제효과는 기대할 수 없었다. 끝동매미충에 대한 Terracur P와 Lebaycid입제의 잔효력은 30일 이상이었다. 5) 애멸구와 흰등별구에 대한 시험은 충의 서식밀도가 낮기 때문에 약제간 방제효과를 얻을 수 없었다. 6) 공시약제중 Terracur P와 Lebaycidd입제는 이화명충과 끌동매미충의 동시방제제로서 사용할 수 있을 것 같다. This experiment was conducted to find out the simultaneous control effect of granulated insecticides on the several major rice insect pests in Korea. The granulated insecticides used were Terracur P$5\%$ (one of the phosphoric insecticides), Lebaycid $5\%$, and Sang-gamma (gamma-BHC) $6\%$. Those insecticides were broadcasted by hand on the paddy field at the ratio of 3kg. in June and 4kg. in August per 10 a, and the date of insecticidal application was based on the maximum moth occurrence of the rice stem borer in 1969. The rice insect pests tested in this study were rice stem borer (Chilo suppressalis W.), green rice leafhopper (Nephotettix bipunctatus cincticeps U.), smiller brown planthopper (Laodelphax striatellus F.), and white back planthopper (Sogotella furcifera H.). For the study of residual effectiveness of the insecticides, the rice stem borer larvae just hatched from the eggs were installed on the sheath of rice plants collected from the paddy field after insecticidal treatment, and the mortality was made at 48 hours after installation. High mortality was observed in Terracur P and Sang-gamma treatments and low mortality in Lebaycid treatment. The duration of residual effects giving about 50% mortality was about 14 days in Sang-gamma and about 6 days in Terracur P treatments. The study on the effectiveness of the insecticides to the rice stem borer in the paddy field was made by the number of dead blades and white heads of the rice plants injured by the larvae, and the number of survival larvae in the straws after crop harvest. The order of insecticidal effectiveness to the rice stem borer was Terracur P=Sang-gamm>Lebaycid. The study on the effectiveness of the insecticides to the leafhoppers and planthoppers in the paddy field was made by the population density by sweeping (5 times) at the given day intervals after treatments. Terracur P was highly effective for the control of the green rice leafhoppers and Lebaycid was moderately effective, but Sang-gamma seemed not to be effective. The effectiveness of the insecticides tested to the planthoppers was not clear, and it seemed to related with the low insect population density. Study on the determination of proper timing of insecticidal application was not also made clear, and it seemed to be short in the range of day intervals in the insecticidal application. For the study on the control effects of the rice insect pests, rice yield per 100 hills per plot was observed. There was no statistically significant difference among the treatments in rice yields, but the order of yield (Terracur P>Sang-gamma>Lebaycid>Control) was paralleled with the tends of control effects above mentioned. In a view point of simultaneous control of the rice stem borers and green rice leafhoppers by the application of granulated insecticides, Terracur P and Lebaycid were more effective than Sang-gamma which have been used.
표면근전도의 근육 긴장도를 이용한 컴퓨터 단말기 작업자세 평가
임상혁,박희석,김현욱 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4
목 적 : 본 연구는 VDT작업에서 작업동안 영향을 받는다고 알려진 5개의 근육을 표면근전도를 이용하여 근육의 긴장도를 측정, 평가하고자 하였다. 방 법 : 전화교환 및 고객상담 업무를 담당하고 있는 여성 작업자 11명을 대상으로, 책상의 높이, 모니터의 위치, 키보드의 거리를 달리하여 근육의 긴장도를 측정하였다. 실험장(workstation) 설계에서 높은 책상은 대상자가 속한 사업장의 책상으로 하였으며 높이는 72.8 cm이었고, 미국 국립표준원의 기준에 맞게 제작한 표준 책상의 높이는 65.0 cm이었다. 모니터의 위치는 목을 비틀지 않고 모니터를 주시하고 있는 경우와 약 45도 비틀면서 주시하는 경우로 나누어서 실험하였고, 키보드의 거리는 책상의 끝에서 15 cm 떨어진 것과 30 cm 떨어진 경우로 실험하였다. 실험에 사용된 근육은 paraspinal muscles, upper trapezium muscle, supraspinatus muscle, infrasplnatus muscle, rhomboid muscle이었으며, 실험은 하나의 조건에 대해 각각 5분씩 수행하였고, 각 실험후 10분간 손을 다리 위에 올려놓고 쉬게 하였다. 결 과 : Paraspinal muscles의 표면근전도 값은 모니터가 작업자로부터 45˚측면에 위치할 때가 작업자 중앙에 위치할 때보다 유의하게 높게 나타났다. Upper trapezium muscle, supraspinatus musscle, infraspinatus muscle의 표면근전도 값은 높은 책상에서 미국 국립표준연구원이 제시한 표준책상보다 유의하게 높게 나타났다. Rhomboid musscle은 책상의 높낮이에 따라 표면근전도 값이 차이가 있었으나 통계적 인 의미는 없었다. 결 론 : 이러한 결과로 볼 때 책상의 높낮이가 VDT 작업에서의 어깨 근육 긴장도에 중요한 영향을 미친다고 생각되며, 또한 표면근전도를 이용한 근육 긴장도의 평가가 인간공학적으로 적합한 VDT작업장 설계에 유용할 것으로 생각된다. Objects : Thls study was designed to assess muscle tensions while working at a YDT workstation with surface electromyography (SEMG). Methods : Variables texted were desk height, monitor positon on the desk, distance from edge of the desk to the keyboard. Eleven female volunteers working in the tele-com munication company were seated at an ergonomically adjusted workstation. They were assigned to a task of typing for 5 minutes and were given a 10 minutes resting with hands in their lap. For the initial experiment, the desk height was fixed to standard desk height(65.0 cm) recommended by ANSI and latter adjusted to a higher desk height (72.8 cm) for this study such that the subjects experienced slight elevation of shoulders. The monitor position initially at the center on the desk and latter left site of the desk (45o from monitorneck axles). The keyboard was positioned to an optimal distance (15 cm from the desk edge) and an abnormal distance (30 cm). Five muscle groups (paraspinal muscles, upper trapezium muscle, supraspinatus muscle, infraspinatus muscle, and rhomboid muscle) were selected for the study. The data of SEMG were analyzed by 2×2×2xs mixed factorial design. Results : The results were as follows: 1. SEMG activity recorded from the paraspinal muscles were significantly higher when the angle of the monitor adjusted to 45 degree from the center of the desk.. 2. SEMG activity recorded from the upper trapezius/supraspinatus/infraspinatus muscles were significantly higher when the hight of the desk was elevated from the recommended height. 3. SEMG activity from the rhomboid muscle showed no significantiy difference in all test conditions. Conclusions : The results of thls study confirm that the helght of a VDT workstation and the angle of the monitor are risk factors of upper extremity cumulative trauma disorders. Also SEMG would be useful for measuring muscle activities during workstation assessment.
성희자,고유나 위덕대학교아시아태평양연구소 2004 아태연구 Vol.3 No.-
사회복지 서비스 자원이 열악한 농어촌 소도시에서 학생상담 자원봉사활동은 청소년문제와 욕구를 해결하기 위한 청소년복지 서비스자원으로서 중요한 역할을 담당한다. 이에 본 연구에서는 농어촌 지역의 청소년들에게 양질의 상담 서비스를 제공하기 위한 토대를 마련하기 위해 동사섭 소집단 훈련을 통한 학생상담 자원봉사자의 자아존중감과 내외통제력의 변화를 살펴보았다. 분석결과 학생상담 자원봉사 참여자들의 자아존중감과 내적 통제성은 대체로 높은 편이었으며 동사섭 소집단 활동을 실시한 후 이들의 자아존중감과 내적 통제성은 유의미한 수준은 아니지만 전반적으로 향상된 것을 관찰할 수 있었다. 동사섭 소집단 활동을 통한 상담훈련은 학생상담 자원봉사자들에게 상담자로서 자긍심을 향상시키고, 내적 통제성을 향상시켜 자신의 삶에 발생하는 사건에 대해 스스로 책임지고, 삶의 문제에 대한 통제력을 향상시키는데 효과가 있었다. 본 연구결과를 통해 학생상담 자원봉사자들을 상담자로서의 자질을 향상시키고, 양질의 상담 서비스를 제공할 수 있는 복지자원으로 지속적으로 활용하기 위한 방안으로 동사섭 소집단 활동의 활용가능성을 확인하였다.
좌승희, 조성봉(Sung-Hee JWA),Sung Bong CHO 한국경제연구원 2004 한국경제연구원 연구보고서 Vol.2004 No.-
Sung-Hee JWA and Sung Bong CHO The establishment of the rule of law in the social and economics spheres is fundamental towards effective and practical reform of a country’s legal and institutional environment. Such reform must take place under the rule of law, and not through human or administrative discretion. We claim that establishing ‘a law-governed economy,’ which is defined as the operation of an economy under the rule of law, is an indispensible feature for Korea’s proper economic reform. In Korea, many factors presently hinder the establishment of a law-governed economy, of which the most important are the persistent government intervention into markets, the government’s excessive discretionary power, the weak check and balance among the three government branches, the absence of regulatory bodies’ independence, the unclear division of labor among government bodies, and the ‘egalitarian trap’ embedded in the Korean culture. We argue in this paper that political reform is a prerequisite to a law-governed economy. There should be a conscious effort to remove entry and exit barriers in political markets, as well as reduce significantly its high-cost structure. Through such a process, and by improving the country’s economic institutional environment, more effective economic reform, especially of corporations, will then become possible. Regarding corporate sector reform, there is a need to establish a proper market disciplinary system by strengthening the monitoring roles of various market participants, thus replacing the existing regulatory framework that aims to directly control corporate behavior.
성상율,구자섭,조근호,원승희,이종훈,박종한 대한생물치료정신의학회 2004 생물치료정신의학 Vol.10 No.1
Objectives : Nowadays many studies with MRI have reported structurai abnormalltles of corpus callosum of schizophrenic patients. However, the results are various and inconstant. In this study, we attempted to identify structural change of C O ~ U S cailosurn. Method : We measured the size of corpus callosum of the 24 schizophrenia patients (male 11, female 18) who were diagnosed by DSM-IV (19943, visited at department of psychiatry, catholic university hospital of Daegu from January 2002 to December 2003, by using midline sagittal slice of MRI. These results were compared with the size of corpus callosum of 25 controls (male 7, female 78). We divided corpus callosurn into 7 areas. We calculated and compared the areas of each subregion, mid-sagittal cerebral area, and entire corpus callosum. The results were analyzed by independent t-test. Result :When we compared subregion to corpus callosum adjusted wth mid-sagittal cerebral area, schlzoph-renia patients had significantly smaller genu (1.64k0.32 vs. 1.43k0.26 p<O.O5) and splenium (2.16f0.27 VS. 1.96+0.30 ; ~(0.05). Similarly, the ratio of total corpus callosum to midline sagittal cerebral area (%)(7.50*0.72 vs. 6.90t0.82 ~(0.05) was significantly smaller In schizophrenia than control group. Conclusion : In this study, we found significant differences in corpus callosum between schizophrenic patients and normal control group.