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Jhun, Byung Woo,Moon, Seong Mi,Kim, Su-Young,Park, Hye Yun,Jeon, Kyeongman,Kwon, O Jung,Huh, Hee Jae,Ki, Chang-Seok,Lee, Nam Yong,Chung, Myung Jin,Lee, Kyung Soo,Shin, Sung Jae,Daley, Charles L.,Koh, American Society for Microbiology 2018 Antimicrobial agents and chemotherapy Vol.62 No.2
<P>Intermittent, three-times-weekly oral antibiotic therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic (NB) Mycobacterium avium complex (MAC) lung disease. However, intermittent therapy is not recommended for patients who have been previously treated. We evaluated 53 patients with recurrent noncavitary NB MAC lung disease who underwent antibiotic treatment for >= 12 months with daily therapy (n = 26) or intermittent therapy (n = 27) between January 2008 and December 2015. Baseline characteristics were comparable between daily therapy and intermittent therapy groups. Sputum culture conversion rates did not differ between daily therapy (21/26, 81%) and intermittent therapy (22/27, 82%) groups. Compared to the etiologic organism at the time of previous treatment, recurrent MAC lung disease was caused by the same MAC species in 38 patients (72%) and by a different MAC species in 15 patients (28%). Genotype analysis in patients with sequenced paired isolates revealed that 86% (12/14) of cases with same species recurrence were due to reinfection with a new MAC genotype. In conclusion, most recurrent noncavitary NB MAC lung disease cases were caused by reinfection rather than relapse. Intermittent antibiotic therapy is a reasonable treatment strategy for recurrent noncavitary NB MAC lung disease.</P>
( Hee Yoon ),( Se Jin Kim ),( Kang Kim ),( Ji Eun Lee ),( Byung Woo Jhun ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Thoracic ultrasound (TUS) is an easy-to-use imaging modality and aids physicians in the differential diagnosis of various respiratory diseases. However, the advantages afforded by TUS in terms of the diagnosis and follow-up of acute eosinophilic pneumonia (AEP), an uncommon inflammatory lung disease, remain poorly understood. Thus, we evaluated typical TUS findings and serial changes during treatment of AEP patients. Methods: Patients with suspected AEP were screened, and those with confirmed AEP were included in the present study. Data on TUS findings at diagnosis and serial changes were prospectively evaluated. Results: In total, 22 AEP patients were identified; all recovered after 2-weeks of corticosteroid treatment. Upon TUS examination, all exhibited diffuse anterolateral-predominant bilateral B-lines and lung sliding, with or without pleural effusion. During hospitalization, B-line numbers fell, and the lines became thinner and fainter. At day 7 of hospitalization, A-lines were evident in 19 patients but B-lines had disappeared in 13, and all pleural effusions had resolved (n =15). All patients exhibited complete ultrasonic resolution by day 14, accompanied by clinicoradiological improvement. However, discrepancies were evident between TUS findings and follow-up chest radiography data. In five patients, chest radiographs taken on day 7 seemed to show complete resolution, but several abnormal B-lines were evident on TUS performed on the same day. TUS detected abnormal findings more reliably than did chest radiography in the five patients. Conclusions: We described the typical TUS findings of AEP and suggest that TUS is clinically valuable for diagnosis and follow-up in AEP.
Jhun, Hyung-Joon,Seo, Hong-Gwan,Lee, Do-Hoon,Sung, Moon-Woo,Kang, Yoon-Dan,Syn, Hee Chul,Jun, Jong Kwan The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.5
<P>This study examined urinary cotinine levels and self-reported smoking among pregnant women in Korea and the factors associated with smoking during pregnancy. The subjects were selected from pregnant women who visited 30 randomly sampled obstetric clinics and prenatal care hospitals in Korea in 2006. Smoking status was determined by self-reporting and urinary cotinine measurement. A total of 1,090 self-administered questionnaires and 1,057 urine samples were analyzed. The percentage of smoking revealed by self-reporting was 0.55% (95% confidence interval [CI], 0.11-0.99) and that revealed by urinary cotinine measurement (>100 ng/mL) was 3.03% (95% CI, 1.99-4.06). The kappa coefficient of agreement between self-reported smoking status and urinary cotinine measurement was 0.20 (95% CI, 0.03-0.37). Multiple logistic regression analysis revealed that early gestational period, low educational level, and being married to a smoker were significant risk factors for smoking during pregnancy. Smoking among pregnant women in Korea is not negligible, and those who are concerned to maternal and child health should be aware of this possibility among pregnant women in countries with similar cultural background.</P>
( Hee Yoon ),( Se Jin Kim ),( Kang Kim ),( Ji Eun Lee ),( Byung Jhun ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Thoracic ultrasound (TUS) is an easy-to-use imaging modality and aids physicians in the differential diagnosis of various respiratory diseases. However, the advantages afforded by TUS in terms of the diagnosis and follow-up of acute eosinophilic pneumonia (AEP), an uncommon infi ammatory lung disease, remain poorly understood. Thus, we evaluated typical TUS fi ndings and serial changes during treatment of AEP patients. Methods: Patients with suspected AEP were screened, and those with confirmed AEP were included in the present study. Data on TUS fi ndings at diagnosis and serial changes were prospectively evaluated. Results: In total, 22 AEP patients were identifi ed; all recovered after 2-weeks of corticosteroid treatment. Upon TUS examination, all exhibited diffuse anterolateral-predominant bilateral B-lines and lung sliding, with or without pleural effusion. During hospitalization, B-line numbers fell, and the lines became thinner and fainter. At day 7 of hospitalization, A-lines were evident in 19 patients but B-lines had disappeared in 13, and all pleural effusions had resolved (n =15). All patients exhibited complete ultrasonic resolution by day 14, accompanied by clinicoradiological improvement. However, discrepancies were evident between TUS fi ndings and follow-up chest radiography data. In fi ve patients, chest radiographs taken on day 7 seemed to show complete resolution, but several abnormal B-lines were evident on TUS performed on the same day. TUS detected abnormal fi ndings more reliably than did chest radiography in the fi ve patients. Conclusions: We described the typical TUS fi ndings of AEP and suggest that TUS is clinically valuable for diagnosis and follow-up in AEP.
( Hee Yeon Kim ),( Jong Young Choi ),( Chang Wook Kim ),( Chang Don Lee ),( Seung Kew Yoon ),( Si Hyun Bae ),( Nam Ik Han ),( Joo Yeon Jhun ),( Mi La Cho ),( Yang Mi Heo ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: High-mobility group box 1 (HMGB1), a ligand for receptor for advanced glycation end products (RAGE), is released from necrotic hepatocytes, and contribute to the pathogenesis of chronic hepatitis. T helper 17 cells (Th17) also have been suggested to participate in the pathogenesis of chronic hepatitis B (CHB) infection. We investigated the role of HMGB1-RAGE-Th17 axis in the pathogenesis of CHB. Methods: The levels of HMGB1 and IL-17 expression were detected by Western blotting and real-time RT-PCR in patients with CHB. The effect of HMGB1-RAGE on the immune activity of Th17 cells and vice versa, was assessed by an induction assay. The levels of IL-17 expression was determined by RT-PCR and Western blotting after blocking RAGE. Results: The levels of HMGB1 and IL-17 expression were higher in CHB patients than in controls. The levels of IL-17 were significantly elevated when PBMCs were stimulated with HMGB1 in vitro, and vice versa. The levels of IL-17 expression was significantly reduced when PBMCs were treated with competitors for RAGE in vitro. Conclusions: HMGB1-RAGE induces the generation of IL- 17, which mediates the pathogenesis of CHB infection. It is suggested that HMGB1 might be a potential target for controlling hepatitis B infection by suppressing Th17 activity.
Kim, Hee Yeon,Jhun, Joo Yeon,Cho, Mi-La,Choi, Jong Young,Byun, Jae Kyeong,Kim, Eun-Kyung,Yoon, Seung Kew,Bae, Si Hyun,Chung, Byung Ha,Yang, Chul Woo Springer International 2014 Journal of gastroenterology Vol.49 No.8
<P>Interleukin (IL)-17-producing CD4(+) T cells (Th17) have been shown to play crucial roles in the pathogenesis of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (ACLF). However, the mechanism underlying the enhanced Th17 responses in these patients remains elusive. In this study, the relevance of the IL-6/signal transducer and activator of transcription 3 (STAT3)/mammalian target of rapamycin (mTOR)/Th17 loop in HBV-associated ACLF was investigated.</P>