흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

On the Interpretive Complex Phenomena in terms of Apparent Imperfections

Kim, Sung Hun,Choe, Hee Sook 한국현대언어학회 2001 언어연구 Vol.17 No.1

Kim, Sung-Hun & Choe, Sook Hee. 2001. 의미해석 복합체에 관한 고찰: 외견상 비완벽성을 중심으로. 언어연구 17-1, 297-311. 본 논문에서는 Chomsky(1998, 1999)의 외견상 비완벽성 개념에 의하여 설명될 수 있는 문법 현상인 의미해석 복합체에 관하여 조사한다. 한국어의 격 첨사들이 초점과 같은 정보 구조에 미치는 효과들을 최소주의 이론에서 어떻게 설명하고 있는지를 논의한다. 특히, 어떤 문맥에서는 격 첨사의 초점 정보 효과들이 외견상 비 완벽성에 의하여 포착되는 의미해석 복합체 현상(Chomsky 1999)이라고 제안한다. 또한 한국어에서 어떤 장거리 뒤섞기 현상들은 외견상 비완벽성에 기인하는 정보 구조 효과를 일으키는 것으로 간주한다. 다시 말해서, 장거리 뒤섞기는 비완벽성이지만 장거리 뒤섞기의 초점 효과들은 외견상 비완벽성을 이끈다고 주장한다. (단국대학교/한국과학기술원)

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

정보보호경영시스템 규격분석에 관한 연구

황희두,추현민,김종훈 동아대학교 정보기술연구소 2006 情報技術硏究所論文誌 Vol.14 No.1

In the information society, security policy must be prepared in order to manage organization's information safely and by the security policy, security system must be developed and security management must be done. In order to do that, Understanding is required about International Organization for Standardization's Information Security Management System(ISO/BS17799:2002) and the organization that wants to certificate by using that understanding or the cooperation's security environment must magnify Security System's Correctness and Effectiveness. In this paper, We will analysis Information Security Management System's concept and then show you analysis about standard item of the cooperation that wants to certificate or the organization certification.

GIS와 데이터베이스를 이용한 가로수정보 관리프로그램 구축

김희년,정성관,박경훈,유주한 경북대학교 농업과학기술연구소 2008 慶北大農學誌 Vol.26 No.-

The purpose of this research is to develops street trees management program for more an effective street trees management. The principal point of this program is to relate spatial data and attribute data that is the main concept in GIS(Geographic Information System). To do this function, MapObjects which is ESRI's mapping and GIS components was used to process spatial data and Access which had been developed by MS was used to manipulate attribute data in this program. Visual Basic also was used to design and develop user interfaces and procedures, relate two sort of data , and lastly complete Application. Relational data model was adopted to design tables and their relation, Antenucci's GIS development model was selected to design and complete this program. The configuration of this application is composed of management data and reference data. The management data includes the location of street tree, a growth condition, a surrounding environment , the characters of tree, an equipments, a management records and etc. The reference data include general information about tree, blight and insects.

차세대 전자식 보안등 및 가로등 자동 점멸기 개발

서희돈,박차훈,양승학 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

In this paper we describes a next generation electronic security-light and street-light that is controlled remotely by the pager system. Especially, the time in the system is equal to current time. The used protocol is POCSAG(Post Office Code Standardization Advisory Group). Because PSTN is applied practically in the developmented system, we improve a communication quality and minimize to equipment investment. We can minimize the manufacturing cost and the development cost in the manufacturing of light control system.

공급사슬관리의 전략적 과제에 관한 탐색적 연구

안병훈,이승규,정희돈,안현수 한국경영과학회 1997 經營 科學 Vol.14 No.1

This study addresses strategic issues related to the question of "how can a supply chain become more competitive?" We examine several cases of manufacturing supply chains. Results show that each constituent firm is required to maintain different manufacturing capabilities and to play different roles by its position (up/mid/down-stream) in a chain. Furthermore, there are patterns of required capabilities by the positions in a chain. These findings imply that the "position in a chain" should be treated as one of the strategic factors when discussing the buyer-seller relationship. It is also shown that different action programs are required for building different manufacturing capabilities of individual firms in a supply chain. Additionally, we argue that some programs need to be done simultaneously, by all the members of the chain, while some need to be carried out by only a small group or an individual firm. Finally, we propose a direction for a theoretical framework for analyzing supply chain structures and strategies.

Acidic primer를 이용한 교정용 브라켓 접착의 전단결합강도

김진희,진훈희,오장균 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.1

Acidic primer는 하나의 용액으로 conditioning과 priming을 동시에 시행하는 새로운 접착 시스템으로 치질의 손상이 적고 처리 과정이 간단한 특징을 지닌다. 본 실험은 acidic primer를 이용하여 치면처리를 시행한 후 기존의 접착제로 브라켓을 접착할 때 적절한 결합강도를 지니는지 평가하기 위하여 고안되었다. 50개의 사람 소구치를 5개군으로 나누어 4개군은 acidic primer로 법랑질을 처리한 후 Clearfil Liner bond 2R(1군), Transbond XTR(2군), Panavia 21R(3군), Fuji Ortho LCR(4군)로 브라켓을 접착하였고 1개군은 Transbond XTR를 통상적인 산부식 방법을 이용하여 접착(5군)한 후 전단 결합 강도를 측정하고 접착 파절의 양상을 평가하여 다음과 같은 결론을 얻었다. Acidic primer로 처리한 4개의 군 가운데 광중합형 글래스 아이오노머를 사용한 군(4군)의 전단결합강도(9.72 ± 3.16 MPa)와 Panavia 21R을 사용한 군(3군)의 전단 결합 강도(8.69 ± 2.72 MPa)는 37% 인산으로 처리한 후 광중합형 레진(Transbond XTR)을 사용한 군(5군)의 전단결합강도(10.48 ± 2.60 Mpa)와 유의성있는 차이를 보이지 않았다 (P〉0.05). 2. Acidic primer로 처리한 4개의 군 가운데 광중합형 글래스 아이오노머를 사용한 군(4군)과 Panavia 21R을 사용한 군(3군)의 전단 결합 강도는 Clearfil Liner bond 2R를 사용한 군(1군)의 전단 결합 강도(1.09 ± 0.53Mpa)와 광중합형 레진(Transbond XTR)을 사용한 군(2군)의 전단 결합 강도(2.70 ± 1.46Mpa)에 비해 유의하게 큰 강도를 보였다 (P〈0.05). 3. 접착제 잔류지수 측정 결과 4군(2.1 ± 1.1)과 5군(2.9 ± 0.3)의 경우 1군(0,2 ± 0.4), 2군(0.3 ± 0.9), 3군(0.2 ± 0.4)에 비해 접착제 잔류지수가 유의하게 높았다 (P〈0.05). 4. 4군과 5군의 접착제 잔류 지수간에는 유의한 차이가 없었다 (P〉0.05). 따라서 acidic primer로 치면을 처리하는 방법은 시용되는 접착제에 따라 기존의 산부식 접착법과 유사한 결합강도를 얻을 수 있어 교정용 브라켓 접착시 산부식 단계를 생략할 수 있는 가능성을 보여준다. Acidic primer is the bonding agent which combines the conditioning and priming agent into the single solution and was originally developed for the dentin bonding system. It is less harmful to the tooth structure and more convenient to manipulate than the traditional etching procedure. The purpose of this study is to evaluate the shear bond strength of various bonding materials when the enamel is treated with acidic primer for the bracket bonding procedure. Fifty recently extracted human premolars were randomly separated into five groups : Group I using Clearfil Liner Bond 2 adhesive system to the enamel treated with acidic primer, Group II using Transbond XT adhesive system to the enamel treated with acidic primer, Group III using panavia 21 adhesive system to the enamel treated with acidic primer, Group IV using Fuji-Ortho LC adhesive system to the enamel treated with acidic primer, Group V using Transbond XT adhesive system to the enamel treated with 37% phosphoric acid. The shear bond strength was measured with Instron universal testing machine after storing in 37℃ water bath for 48 hours. After debonding, the teeth and brackets were examined under scanning electron microscope (SEM) and assessed with the adhesive remnant index (ARI). The results were as follows : 1. There were no significant differences in shear bond strength between group III (8.69 ± 2.72 MPa), group IV (9.7 ± 3.16 MPa), and group V (10.48 ± 2.60 Mpa) (p〉0.05). 2. The shear bond strength of group III and group IV was significantly higher than that of group I (1.09 ± 0.53 Mpa), and Group II (2.70 ± 1.46Mpa) (p〈0.05). 3. The ARI of group IV (2.1 ± 1.1) and group V (2.9 ± 0.3) was significantly higher than that of group I (0.2 ± 0.4), group II (0.3 ± 0.9) and group III (0.2 ± 0.4) (p〈0.05). 4. There were no significant difference between the ARI of group IV and group V (p〉0.05). This result suggests that the combination of acidic primer and some bonding adhesive can provide sufficient shear bond strength for clinical orthodontics.

경주지역 서비스산업에 대한 서비스 만족도 조사

박종희,하헌국 동국대학교 관광산업연구소 1999 관광·호텔경영연구 Vol.1 No.1

This study investigated the service quality level of service industry in Kyoungju. Ten different service categories were selected for this study: hotel, restaurant, bank, taxi, local bus, express bus, airlines, hospital, private education institute, and community bureau. To test service quality, five dimensions of service were used: reliability, responsiveness, assurance, empathy and tangibles. In general, people in Kyoungju perceived the service quality of Kyongju as poor. In particular, among 10 different service industry, they evaluated the services of taxi and local bus industry as worst. Tangibles, reliability, assurance, responsiveness and empathy were listed in order of declining relative satisfaction to customers. The main reason of the poor service in Kyoungju is the management's lack of understanding the importance of service.

전처리방법에 따른 새송이 된장절임의 품질특성 변화

황성희,정헌식,윤광섭 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.3

This study was conducted to find the optimum pretreatment method to improve the quality of Pleurotus eryngii pickled with the fermented soybean paste. Blanching(70 , 10min), salting(5%, 20 , 72hr) and drying(50 , 3hr) were used as pretreatment methods. The moisture loss of the mushrooms during pickling was accelerated more by salting and drying. Salinity increase was retarded by salting. Surface and internal browning of the mushrooms were suppressed by blanching. Hardness tended to increase sharply until 20 days of pickling and then slowly decreased. In the sensory evaluation, mushrooms pickled for 40 days were scored as the highest. Blanching was a superior treatment compared to the others in term of color, taste, flavor, texture and overall acceptability.