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Cahe, Yang Seok,Hedley-Whyte, E. Tessa 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.2
Flow cytometric analysis was applied to embedded tissue to measure the proliferative activity and the DNA ploidy of sixteen recurrent and seventeen nonrecurrent pituitary adenomas. The results were compared with data from a previous study which demonstrated that proliferationg cell nuclear antigen (PCNA) labelling index was higher in recurrent adenomas than in nonrecurrent adenomas. Flow cytometric analysis as a tool for predicting aggressive behavior has been useful in a variety of human tumors, however its prognostic value in pituitary adenoma is controversial. Therefore we decided to explore the relationship of the results of flow cytometry and proliferating cell nuclear antigen labelling indices with the prognosis of pituitary adenomas. Three out of 16 recurrent adenomas and five out of 17 nonrecurrent adenomas demonstrated a DNAaneuploid pattern. All the nonfunctional recurrent adenomas had a diploid pattern, while only 40% of the functional recurrent adenomas had a diploid pattern. The G0/Gl phase fraction was higher in the recurrent adenomas than in the non- recurrent ones. (p=0.0005) In contrast, the S phase fraction and the coefficient of variation were 1 higher in the nonrecurrent adenomas (5.9 1.0%, 7.0 0.75, respectively) than in the recurrent ones(2.5 0.6%, 4.0 0.2%, respectively) (P=0. 003 and p=0. 001, respectively). The proliferating cell nuclear antigen lavelling indices were higher in the recurrent adenomas (18.9 4.5%) than in the nonrecurrent adenomas (2.6 1.6%) (P=0.003). The S phase of flow cytometry correlated weakly with the proliferating cell nuclear antigen labelling indices when the recurrent and the nonrecurrent adenomas were considered as one group. (r=-0. 356, p=0.033) But no significant correlations were observed when the groups of recurrent (r=0.311, p=0.195) and nonrecurrent tumors (r=-0.019, P=0. 942) were compared separately. The results of flow cytometric analysis suggests that recurrent adenomas may have a higher proportion of cells in the presynthetic phase than the nonrecurrent adenomas. This study suggests that flow cytometric analysis is of limited value in predict- ing recurrence of pituitary adenomas.