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Xin Xie,Wanzhi Tu,Chenwen Huang,Ziyang Chen,Xinyue Ren,Bingqing He,Xiaoyan Ding,Yuelei Chen,Xin Xie 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in applications such as regenerative medicine, cardiac disease modeling, and in vitro drug evaluation. However, hPSC-CMs are immature, which limits their applications. During development, the maturation of CMs is accompanied by a decline in their proliferative capacity. This phenomenon suggests that regulating the cell cycle may facilitate the maturation of hPSC-CMs. Aurora kinases are essential kinases that regulate the cell cycle, the role of which is not well studied in hPSC-CM maturation. Here, we demonstrate that CYC116, an inhibitor of Aurora kinases, significantly promotes the maturation of CMs derived from both human embryonic stem cells (H1 and H9) and iPSCs (induced PSCs) (UC013), resulting in increased expression of genes related to cardiomyocyte function, better organization of the sarcomere, increased sarcomere length, increased number of mitochondria, and enhanced physiological function of the cells. In addition, a number of other Aurora kinase inhibitors have also been found to promote the maturation of hPSC-CMs. Our data suggest that blocking aurora kinase activity and regulating cell cycle progression may promote the maturation of hPSC-CMs.
PROXIMAL POINTS METHODS FOR GENERALIZED IMPLICIT VARIATIONAL-LIKE INCLUSIONS IN BANACH SPACES
He, Xin-Feng,Lou, Jian,He, Zhen The Youngnam Mathematical Society 2012 East Asian mathematical journal Vol.28 No.1
In this paper, we study generalized implicit variational-like inclusions and $J^{\eta}$-proximal operator equations in Banach spaces. It is established that generalized implicit variational-like inclusions in real Banach spaces are equivalent to fixed point problems. We also establish relationship between generalized implicit variational-like inclusions and $J^{\eta}$-proximal operator equations. This equivalence is used to suggest a iterative algorithm for solving $J^{\eta}$-proximal operator equations.
PROXIMAL POINTS METHODS FOR GENERALIZED IMPLICIT VARIATIONAL-LIKE INCLUSIONS IN BANACH SPACES
Xin-feng He,Zhen He,Jian Lou 영남수학회 2012 East Asian mathematical journal Vol.28 No.1
In this paper, we study generalized implicit variational-like inclusions and J^n-proximal operator equations in Banach spaces.It is es-tablished that generalized implicit variational-like inclusions in real Ba-nach spaces are equivalent to xed point problems.We also establish a relationship between generalized implicit variational-like inclusions and J^n-proximal operator equations. This equivalence is used to suggest an iterative algorithm for solving J^n-proximal operator equations.
Xin-feng He,Yong-chun Xu,Zhen He 영남수학회 2011 East Asian mathematical journal Vol.27 No.1
In this paper, we consider an iterative scheme for finding a common element of the set of fixed points of a asymptotically quasi-nonexpansive mapping and the set of solutions of the variational inequality for an inverse strongly monotone mapping in a Hilbert space. Then we show that the sequence converges strongly to a common element of two sets. Using this result, we consider the problem of finding a common fixed point of a asymptotically quasi-nonexpansive mapping and a strictly pseudocontractive mapping and the problem of finding a common element of the set of fixed points of a asymptotically quasi-nonexpansive mapping and the set of zeros of an inverse-strongly monotone mapping.
On the existence of solutions of extended generalized variational inequalities in Banach spaces
Xin-feng He,Xian Wang,Zhen He 영남수학회 2009 East Asian mathematical journal Vol.25 No.4
In this paper, we study the following extended generalized variational inequality problem, introduced by Noor (for short, EGVI) : Given a closed convex subset K in q-uniformly smooth Banach space B, three nonlinear mappings T :K → B*, g:K → K, h:K → K and a vector ξ ∈ B*, find x ∈ K, h(x) ∈ K such that [수식], for all y ∈ K, g(y)∈K.[see [2]: M. Aslam Noor, Extended general variational inequalities, Appl. Math. Lett. 22 (2009) 182-186.] By using sunny nonexpansive retraction QK and the well-known Banach's fixed point principle, we prove existence results for solutions of (EGVI). Our results extend some recent results from the literature.
Xin Xie,Wanzhi Tu,Chenwen Huang,Ziyang Chen,Xinyue Ren,Bingqing He,Xiaoyan Ding,Yuelei Chen,Xin Xie 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in applications such as regenerative medicine, cardiac disease modeling, and in vitro drug evaluation. However, hPSC-CMs are immature, which limits their applications. During development, the maturation of CMs is accompanied by a decline in their proliferative capacity. This phenomenon suggests that regulating the cell cycle may facilitate the maturation of hPSC-CMs. Aurora kinases are essential kinases that regulate the cell cycle, the role of which is not well studied in hPSC-CM maturation. Here, we demonstrate that CYC116, an inhibitor of Aurora kinases, significantly promotes the maturation of CMs derived from both human embryonic stem cells (H1 and H9) and iPSCs (induced PSCs) (UC013), resulting in increased expression of genes related to cardiomyocyte function, better organization of the sarcomere, increased sarcomere length, increased number of mitochondria, and enhanced physiological function of the cells. In addition, a number of other Aurora kinase inhibitors have also been found to promote the maturation of hPSC-CMs. Our data suggest that blocking aurora kinase activity and regulating cell cycle progression may promote the maturation of hPSC-CMs.
Xin-Feng He,Yong-Chun Xu,Zhen He 영남수학회 2008 East Asian mathematical journal Vol.24 No.1
The approximate solvability of a generalized system for nonlinear variational inequality in Hilbert spaces was studied, based on the convergence of projection methods. But little research was done in Banach space. The primary reason was that projection mapping lacked preferably property in Banach space. In this paper, we introduced the generalized projection methods. By using these methods, the results presented in this paper extended the main results of S. S. Chang [3] from Hilbert spaces to Banach space.
ON THE EXISTENCE OF SOLUTIONS OF EXTENDED GENERALIZED VARIATIONAL INEQUALITIES IN BANACH SPACES
He, Xin-Feng,Wang, Xian,He, Zhen The Youngnam Mathematical Society 2009 East Asian mathematical journal Vol.25 No.4
In this paper, we study the following extended generalized variational inequality problem, introduced by Noor (for short, EGVI) : Given a closed convex subset K in q-uniformly smooth Banach space B, three nonlinear mappings T : $K\;{\rightarrow}\;B^*$, g : $K\;{\rightarrow}\;K$, h : $K\;{\rightarrow}\;K$ and a vector ${\xi}\;{\in}\;B^*$, find $x\;{\in}\;K$, $h(x)\;{\in}\;K$ such that <Tx-$\xi$, g(y)-h(x)> $\geq$ 0, for all $y\;{\in}\;K$, $g(y)\;{\in}\;K$. [see [2]: M. Aslam Noor, Extended general variational inequalities, Appl. Math. Lett. 22 (2009) 182-186.] By using sunny nonexpansive retraction $Q_K$ and the well-known Banach's fixed point principle, we prove existence results for solutions of (EGVI). Our results extend some recent results from the literature.
Acoustic Effect on Induction of Cerium Carbonate in Reaction Crystallization
He, Xin-Kuai,Kim, Rayoung,Shin, Dongmin,Kim, Woo-Sik The Society of Chemical Engineers, Japan 2012 Journal of chemical engineering of Japan Vol.45 No.4
<P>The influence of ultrasonication and agitation on the induction of nucleation in the reaction crystallization of cerium carbonate has been investigated in a semi-batch crystallizer. When the cerium chloride and sodium carbonate reactants are constantly injected, the induction time depends significantly on ultrasonication and agitation. Due to the acoustic cavitation of ultrasonication promoting micromixing of the reactants, the induction time of cerium carbonate is markedly reduced. Simultaneously, the acoustic cavitation appears to reduce the energy barrier of nucleation, inducing nucleation at a lower supersaturation level than with the turbulent fluid motion of agitation. However, the acoustic stream of ultrasonication does not promote the induction of nucleation. Meanwhile, agitation also facilitates the induction of nucleation due to turbulent mixing of the reactants. The micromixing resulting from agitation meant the supersaturation in the solution increases rapidly when increasing the agitation speed, thereby reducing the induction time. The influence of ultrasonication and agitation on the induction of nucleation has also been compared in terms of the energy dissipation. With the same energy dissipation, ultrasonication is much more effective than agitation for induction, possibly due to its unique feature of acoustic cavitation.</P>