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정운원,이승관,이창규,조경진,김성욱,하주희,서장훈 高麗大學校 倂設 保健大學 保健科學硏究所 2000 保健科學論集 Vol.26 No.1
Corticotropin-releasing hormone(CRH) is a major regulator of the hypothalamic-pituitaryadrenal axis(HPA). In inflammatory stress, the cytokines TNF-, IL-6 stimulate the production of CRH, a 41 amino acids neuropeptide, in the hypothalamus. The release of CRH leads to pituitary production of adrenocorticotropic hormone, followed by glucocorticoid secretion by the adrenal cortex. Glucocorticoids suppress namy components of the inflammatory process. Recently, CRH and CRH receptor were reported to be located in the periphery such as Immune system and chronic inflammatory sites as rheumatoid arthritis (RA). Cyclooxygenase consisted of two isoforms, COX-1 and COX-2, converts arachdonate to prostaglandins(PGs) which are important mediators of inflammation. insymoviocyte in RA, it was described that COX-2 mRNA was markedly increased by inflammatory agents, PMA or IL-1 and COX-1 transcripts were not modulated. We examined the modulation of COX by immune CRH in cultured normal and rheumatoid synoviocytes. Our results were shown that COX-1 mRNA expression decreased with the each stimulation of PMA and IL-1 in normal synoviocyte. In RA synoviocyte, PMA and IL-1 were increased mRNA expression of COX-1. In simultaneous treatment with CRH, PMA group was decreased, but IL-1 group was increased mRNA expression of COX-1. COX-2 mRNA expression was slightly increased by the treatment with PMA and highly increased by IL-1. After CRH treatment, PMA and IL-1 addictively increased COX-2 mRNA expression. We think that these results are contributed to the influence of increased cANP by CRH on the promoter of COX-2 in normal and synoviocytes. Because many cytokines, neuropeptides, and signal transduction pathways are involved in chronic inflammation, the exact role of CRH on inflammation is not fully elucidated. To achieve this goal, further experiments are needed.
박운용,정성모,곽두호,이흥규 東亞大學校 大學院 1999 大學院論文集 Vol.24 No.-
Real Time Kinematic GPS will allow a multitude of monitoring, navigation and engineering applications. Applications inclued real time deformation and movement monitoring and real time automated plant control. In a low dynamic environment, with a short baseline length, it is possible to position a roving receiver to an approximate accuracy of less than 5mm within a few seconds of thestart of the ambiguity. One Engineering application is the monitoring of the movement of cable suspension bridges. Such structures are capable of movements of up to a few meters under adverse wind conditions or heavy traffic loads. The use of relative OTF positioing at strategic points upon the bridge would allow close monitoring of the bridge's movements and calculate deformation and long-term deterioration factors for the bridge. Future bridge designs and traffic management schemes could also benefit from the monitoring system.
박운용,김정동,이흥규 동아대학교 건설기술연구소 1999 硏究報告 Vol.23 No.2
In this study, the attitude estimation software using direct and least square computation was developed, then the field tests were performed so as to assess the effects and characteristics which influence on accuracy of determined attitude by GPS observation errors like multipath, receiver noise, antenna phase center variation, and by elements which ought to be considered to operate systems like baseline length, number of satellite, geometry, and antenna configuration. As a result, it could be concluded that the multipath of GPS signal is the most important error and the accuracy of the estimated attitude parameters from GPS carrier phase is inversely proportional to baseline length through the accuracy analysis of attitude parameters from GPS. It was shown that the usage of much longer baseline was the easiest and most efficient method to determine attitude parameters of supra-accuracy.
邊龍聖,洪慶和,金東奭,崔雲行 弘益大學校 1989 弘大論叢 Vol.21 No.2
The purpose of this paper is to improve General Mathematics education programs for engineering students based on an experimental study in the fall semester of 1988. Freshmen classes for General Mathematics course were divided into two groups. One of them, "Special class," was for highly motivated students and the other "Ordinary class," for less motivated students. Both classes had the same basic calculus textbooks. "Special class" students, however, had an extra textbook on elementary linear algebra. Analyzing two examinations and surveys on other university curricula, we concluded that there was no significant difference between two groups. It is suggested that one or two chapters on differential equations and elementary linear algebra should be included in the freshmen general mathematics course.
Canine Distemper Virus 검출을 위한 정량 Real-time PCR
이승관,이창규,정운원,조경진,김현숙,강영대,서장훈 高麗大學校 倂設 保健大學 保健科學硏究所 2002 保健科學論集 Vol.28 No.2
Canine distemper virus(CDV) infection causes a fatal systemic disease in wide range of carnivore species, including domestic dogs. It has been a highly contagious disease of veterinary importance for centurise. Recently many researches show that qualitative RT-PCR for the detection of CDV was sensitive and specific method for the early and safe antemortem diagnosis of distemper by using whole blood regardless of clinical sign and pathological finding. Recently, results were correlated to clinical findings, anti-CDV neutralizing antibody titers, postmortem findings, and demonstration of CDV NP(nucleoprotein) antigen by immunohistochemistry. We have studied a quantitative real-time PCR assay for CDV in order to improve and broaden the clinical usefulness of RT-PCR assay. Total 37 samples including 9 clinically positive and 29 randomly selected ones have investigated. CDV RNA was extracted from whole blood. The isolated RNA was reverse-transcripted into cDNA followed by PCR amplification. The assay based on real-time PCR using SYBR Green I dye as quantitative method with a LightCycler. Calibration curves covered 30-3×10^(8) copies of CDV were created using cloned 240bp CDV cDNA of viral RNA. CDV was detected all in 8 positive samples whereas 8 in 29 randomly collected ones. The detection ranges of clinical CDV specimens were various from 3×10² to 3×10⁴ copies. Comparision of real-time PCR to conventional PCR showed equal sensitivity and specificity. But real-time PCR method has a merit of quantification as well as more rapid results than those of common RT-PCR. CDV can be accurately detected and quantified in the whole blood from the dog infected with CDV. This quantitative technique may improve the clinical utility of RT-PCR for the detection of CDV.
사고사례를 통한 재가치매환자의 위험요소 추출 및 그 활용에 관한 연구
이행운 ( Hang Woon Lee ),엄진섭 ( Jin Sup Eom ),최미현 ( Mi Hyun Choi ),이수정 ( Soo Jeong Lee ),최진승 ( Jin Seung Choi ),문석우 ( Seok Woo Moon ),탁계래 ( Gye Rae Tack ),정순철 ( Soon Cheol Chung ) 한국감성과학회 2009 감성과학 Vol.12 No.1
본 연구의 목적은 재가치매노인에게 발생한 사고사례들의 조사를 통해 치매노인에게 위험요소로 작용 될 수 있는 요인들을 추출하고, 이를 바탕으로 치매노인 보호를 위해 고려해야 할 모니터링 요소의 결정에 필요한 기초 정보를 제공하고자 하는 것이다. 재가치매노인 55명(남자 16명, 여자 39명)을 대상으로 설문지를 이용하여 기본특성, 행동특성, 노인인지기능(Short form of Samsung Dementia Questionnaire: S-SDQ), 일상생활 수행능력(Activities of Daily Living: ADL), 사고사례를 조사하였다. 설문조사내용을 바탕으로 위험인자로 작용하는 요소들을 추출하고, 추출된 요소들의 발생빈도, 공발생빈도, 발생장소, 신체손상유무, 손상부위, 손상정도를 분석하였다. 그리고 행동특성, ADL, S-SDQ와 위험요소간의 발생빈도를 교차빈도분석을 통해 알아보았다. 분석결과 12개의 위험요소가 추출되었으며, 이 중 ‘나감’의 빈도가 가장 많았고, 신체적 손상이 발생한 위험요소는 넘어짐, 부딪힘, 미끄러짐, 떨어짐이었다. 공발생빈도 분석 결과, 넘어짐, 나감, 가스방화, 폭력이 다른 요인과 함께 발생하는 빈도가 높았다. 위험요소의 발생장소는 집주변이 가장 많았으며, 손상부위로는 무릎, 손상정도는 타박상이 가장 많았다. 교차빈도분석결과 위험요소의 발생빈도에 차이가 발생한 항목은 행동장애, 일상생활수행장애 그리고 ADL이였다. 행동장애와 일상생활수행장애의 정도에 따라 빈도의 차이를 보인 요인은 나감이었고, ADL의 정도에 따라 빈도의 차이를 보인 요인은 미끄러짐과 가스방화였다. The purpose of this study was, first, to extract the risk factor by investigating several cases of accident of senile dementia patient at home, and second, based on these results to provide basic information for the determination of monitoring factor for the care of senile dementia patient. Basic and behavioral characteristics, Short form of Samsung Dementia Questionnaire (S-SDQ), Activities of Daily Living (ADL), and cases of accident were investigated with 55 senile dementia patient at home (16 male, 39 female). Based on these questionnaires, risk factors were extracted and frequency, cooccurrence frequency, and occurring place of risk factors, presence or not, region, and degree of injury were investigated. Frequency between risk factors and behavioral characteristics, ADL, and S-SDQ was analyzed by crosstabulation frequency analysis. Results showed that 12 risk factors were extracted, and the frequency of `going out` was the highest, and risk factors for injury were `tumble`, `bump`, `slip`, and `fall`. Cooccurrence frequency analysis showed that the occurrence of `fall`, `going out`, `fire of gas`, and `violence` with other factors was relatively higher than others. The occurring place of risk factor was the highest in home neighborhood, and the region of injury in knee, and the degree of injury with bruise. Crosstabulation frequency analysis showed that factors which had difference in frequency of risk factor were behavioral disorder, disorder of daily living and ADL. Factor which had difference in frequency due to the degree of behavioral disorder and disorder of daily living was `going out`, and factors which had difference in frequency due to the degree of ADL were `slip` and `fire of gas`.
부력기구를 활용한 수중운동 프로그램이 편마비 환자의 보행 동작에 미치는 효과
홍승범,조효구,정태운 용인대학교 특수체육연구소 2009 특수체육연구 Vol.6 No.-
본 연구는 부력기구를 활용한 수중운동 프로그램이 편마비 환자의 보행동작에 미치는 효과를 분석하는데 목적이 있다. 대상자는 S시 B복지관을 이용하고 독립보행이 가능하지만 수중운동 프로그램에 참여 경험이 없는 뇌졸중 좌측편마비 환자 21명중 7명을 무선표집법에 의해 선정하였다. 수중운동 프로그램을 실시 한 후 신체중심 이동, 보행 주기, 다리관절각, 다리관절 각속도의 자료를 분석하기 위하여 SPSS ver. 13.0 통계프로그램을 이용하여 대응표본 t-test를 실시하였다. 이상의 자료 분석 결과를 기초로 도출한 연구의 결론은 다음과 같다. 첫째, 보행주기는 환측의 입각기와 단일지지기의 비율이 향상되고, 환측과 건측의 비율 차이가 줄어들어 보행주기가 개선된 것으로 나타났다. 둘째, 신체중심의 이동은 거리가 늘어나고 시간은 줄어들어 속도가 빨라지는 결과는 수중운동프로그램이 편마비 환자의 보행 동작에서 신체중심 이동에 영향을 미친것으로 나타났다. 셋째, 관절각은 환측의 사전 측정결과 보다 관절각이 커지고 건측의 사전 측정결과 보다 작아져 수중운동 프로그램 참여 후에 환측과 건측의 좌우불균형이 개선된 것으로 나타났다. 넷째, 관절각속도는 보행주기에서 나타난 근력향상과 관절각 결과에서 나타난 관절가동범위 향상으로 인해 관절각속도 또한 긍정적인 결과를 보이며, 특히 모든 관절이 입각기 시 보다 유각기에서 각속도가 개선된 것으로 나타났다. The purpose of this research is to investigate the effects of the underwater exercise program that utilizes buoyancy appliances on the hemiplegics’ walking. The subjects are selected randomly among 21 patientswho have had been hemiplegic more than 5 years in B Rehabilitation Center in Seoul. The final 7 patients who had no exercise with left side hemiplegia were selected. After they have participated in 8-week underwater exercise program, central body movement, gait cycle, the angle of legs joints and the angular speed of leg joints are analyzed with paired t-test using statistics program, SPSS 13.0. Based on the analysis of collected data, this research makes following conclusions. First, while the subject is walking, there is increase in displacement for central body movement and decrease in time resuted in increase in speed. This result made the central body movement affected the gait. Second, Improvement in the ratio of stance phase to single needling support phase and decrease in the ratio difference between hemiplegic and normal side leads to improvement of gait cycle. Third, the disparity between hemiplegic and normal side have improved with increase of the angle of leg joint for hemplegic side and decrease of the normal side after participating in the underwater exercise program. Lastly, as a result of muscular strengthening from gait cycle and range increase of joint angle, angular speed also shows improvement, especially in the swing phase compared to stance phase.