http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Han, Bo,Yoon, Soonseek,Su, Jingliang,Han, H.R.,Wang, Mei,Qu, Weijie,Zhong, Daibin Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.12
The antioxidant enzymes, lipid peroxidation and free radicals assessment were made of the effects of selenium, copper and magnesium on bovine endemic fluorosis under high fluoride, low selenium and low copper productive conditions. Thirty-two beef cattle were selected from high fluoride area, and randomly divided into four groups with eight cattle each as follows: (1) high fluoride control group (HFC); (2) supplemented group with 0.25 mg/kg selenium (HFSe); (3) supplemented group with 15 mg/kg copper (HFCu) and (4) supplemented group with 0.25 mg/kg selenium+15 mg/kg copper+1 mg/kg magnesium (HFSeCuMg) per day for 83 days. Moreover, eight beef cattle were selected from non-high fluoride area as normal control group. Blood samples were collected from cattle on 0 d, 30 d and 83 d respectively, to analyze the enzyme activities and concentration of GSH-px, CAT, SOD, MDA and free radicals. The results showed that the contents of free radicals and MDA in HFC group were significantly higher, and the whole blood GSH-px, CAT, erythrocyte SOD activities were lower than the normal control group. Free radicals, metabolic imbalance and antioxidant disorder therefore, play an important role in fluorosis. However, GSH-px, CAT and SOD activities in HFSe group and HFSeCuMg group at 30 d and 83 d were markedly higher than the same groups at the 0 d and the HFC group at the same time. Likewise, there was a corresponding reduction in the contents of free radicals and MDA. These findings indicated that supplementation with selenium, copper and magnesium elevated high fluoride bovine antioxidant enzymes, and decreased MDA and free radicals contents. But, the activities of supplementation selenium group did not increase until day 83. These results demonstrated that fluorosis was associated with lower serum Se and Cu levels than in the control, and it was therefore concluded that fluorosis is associated with decreased serum levels of these minerals. Long-term high fluoride intake under productive condition enhances oxidative stress in the blood, thereby disturbing the antioxidant defense of cattle. Increased oxidative stress could be one of the mediating factors in the pathogenesis of toxic manifestations of fluoride. It is benefical for high fluoride cattle supplemented with proper selenium, copper and magnesium to increase fluoride excretion and obtain the protective impact of the activity of oxidative enzymes, and to decrease lipid peroxidation and free radicals contents.
Oscillation Criteria of Hyperbolic Equations with Continuous Deviating Arguments
Han, Zhong Yue,Yu, Yuan Hong Department of Mathematics 2007 Kyungpook mathematical journal Vol.47 No.3
In this paper, we shall consider a class of hyperbolic nonlinear differential equations with continuous deviating arguments. Some new sufficient conditions for oscillation of all solutions with two kinds of boundary conditions are obtained.
( Han Zhong ) 인문사회과학예술융합학회 2020 인문사회과학예술융합학회지 Vol.4 No.1
The innovation and entrepreneurship education system in colleges and universities is a guiding channel to strengthen the innovation ability of talents and to expand their employment scope. It has the characteristics of diversity, innovation and adaptability. Based on this, taking local colleges and universities in China as an example, this article summarizes the current situation of the construction of innovation and entrepreneurship education system, and puts forward relevant suggestions for the practices of system promotion, so as to bring the advantages of the system into full play and realize the comprehensive utilization of talents in colleges and universities.
A 90-day Repeated-Dosed Toxicity Study of Euphorbiae kansui radix Extract in Fischer 344/N Rats
Zhong-Ze Han,Hu-Song Zhang,Ki-Hyun Gil,Joo-Young Lee,Kwang-Han Kong,Myoung-Kyu Han,Hyun-Ju Yang,Hak-Soo Kim,Do-Hyung Kim,Tae-Hwan Ahn,Jin-Sook Bae,Hyun-Kyu Ko,Jung-Woon Lee,Moon-Soon Kim,Si-Whan Song 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
This study was performed to evaluate repeated-dose toxicities of Euphorbiae kansui radix extract in F344/N rats. Euphorbiae kansui radix extract was administered orally to rats at dose levels of 0, 37, 111, 333, 1,000 and 2,000 ㎎/㎏/day. Each group consisted of 10 rats of each gender. The Euphorbiae Kansui, Radix extract was given once a day, 5 times a week, for 90 day repeatedly. This study was conducted in accordance with the Protocol of Korea National Toxicology Program (issued by National Institute of Toxicological Research) and The Standards of Toxicity Study for Medicinal Products (issued by Korea Food and Drug Administration). In the present study, there were no dose-related changes in mortality, clinical signs, body weights, ophthalmoscopy, urine analysis, hematological findings, estrus cycle and sperm examination of all animals treated with Euphorbiae kansui radix extract. There were increases of liver weights in 2,000 ㎎/㎏/day groups of males and in 333, 1,000 and 2,000 ㎎/㎏/day groups of females. There were decreases of alkaline phosphatase levels in 1,000 and 2,000 ㎎/㎏/day groups of both sexes. These results suggest that the oral no-observed-adverse-effect level (NOAEL) of the test item, Euphorbiae kansui radix extract, in rats is 2,000 ㎎/㎏/day in both genders; no-observed-effect level (NOEL) is 1,000 ㎎/㎏/day in male and 111 ㎎/㎏/day in female. The target organs were thought to be liver and thymus.
Zhong-Ze Han,Hong-De Xu,Kwang-Ho Kim,Tae-Hwan Ahn,Jin-Sook Bae,Ji-Young Lee,Ki-Hyun Gil,Joo-Young Lee,Su-Jung Woo,Hyun-Jung Yoo,Hyun-Kul Lee,Kap-Ho Kim,Chan-Koo Park,Hu-Song Zhang,Si-Whan Song 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.2
The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to “the standards of Toxicity Study for Medicinal Products” (2005) and The KFDA Notification No. 2000-63 ‘Good Laboratory Practice (GLP)’ (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.