액체 주방세제 전과정평가에 관한 연구

이재란,안석원,김한수,노승호 한국전과정평가학회 2001 한국전과정평가학회지 Vol.3 No.1

LG생활건가에서 생산되는 액체 주방세제의 환경성을 조사하기 위하여 전과정평가를 실시하였다. 제품별 전과정목록표를 도출하였으며, 이를 이용하여 수계생태독성, 지구온난화, 광화학스모그, 인간독성, 산성화, 부영양화에 대한 영향평가를 수행하였다. 그 결과, 제품 전과정 가운데 제품 계기단계에서 환경영향이 가장 높게 나타났고, 특히 수계생태독성에 의한 영향이 높게 나타났다. 주방세제의 환경지수에 영향을 미치는 원인물질을 찾아내고 개선물질로 대체하여 환경지수가 18% 감소한 제품을 개발하였다. With the kitchen detergents produced by LG Household & Healthcare, we performed life cycle assessment to examine their environmental properties. Life cycle inventories of kitchen detergent were drawn, and the impact assessment on six categories including aquatic eotoxicity, global warming, photochemical oxidant formation, human toxicity, acidification, and eutrophication was made using the inventories. As a result, it was found that environmental load is the highest at the end of life, and the worst impact category is aquatic ecotoxicity. We found the major ingredient determining environmental indicator and replaced it with more environmentally friendly material, so that the product of 18%-improved environmental indicator was developed.

세포브러쉬와 면봉도말법에 의한 부인과 세포학적 검사의 효율비교

김정란,김성숙,배한익,김용탁,심재철,임문환,윤혜원,이상식 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

A study was undertaken to evaluate the efficiency of the sytobrush compared with the cotton swab for obtaining cells from the uterine cervix. In 300 patients, the cytobrush technique was employed and in control 300 patients was smeared by the cotton swab. In 12 out of 300 patients(4%) endocervical cells were found on the cotton swab technique. A total of 252 out of 300 cytobrush sampler specimen(84%) contained endocervical cells. With the X²method for statistical comparison, the difference in endocervical cell yield between the cotton swab and the cytobrush sampler was significantly different(p<0.01). This was particularly true in older patients. We conclude from study that the cytobrush sampler is of value for obtaining as adequate cervical cytologic specimen.

남성 알코올 의존 환자의 삶의 질과 정신-사회-영적 특성과의 관계

최삼욱,나란희,김한오,최성빈,최영숙 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

Objectives : This study was designed to evaluate the relationship between quality of life (QOL) and psycho-socio-spiritual characteristics in male patients with alcohol dependence. Methods : The sample consisted of 109 men with alcohol dependence defined by DSM-IV criteria. We assessed QOL by the WHO QOL assessment instrument-BREF (WHOQOL) and SmithKline Beecham QOL (SBQOL). Sociodemographic and alcohol related data were collected, and 7 questionnaires were administered : MAST, BDI, STAI, Drinker Inventory of Consequences (DrInC), Scale of Social Support (SSS), Religious Beliefs and Behaviors (RBB) and Spiritual Well-being Scale (SWBS). The correlations between each QOL score and other variables were examined, and stepwise multiple regression analysis was performed. Results : The WHOQOL score positively correlated with education level, SSS (support) and RBB and negatively correlated with MAST, DrInC, BDI, STAI (trait) and SSS (conflict) scores. In stepwise regression analysis, the scores on the STAl and BDI contributed to the score on the WHOOOL. The SBQOL score correlated with the income level, and negatively correlated with BDI and STAI score. STAI score was a weak predictor of SBQOL score. Conclusion : The significant predictors of QOL in patients with alcohol dependence were psychological factors such as anxiety and depression.

한강둔치에서 재배된 농작물 중의 미중금속 함량에 관한 연구

김연천,전옥경,양혜란,최영희,한선희,이강문,Kim, Youn-Choen,Chun, Ock-Kyoung,Yang, Hae-Ran,Choi, Young-Hee,Han, Sun-Hee,Lee, Kang-Moon 한국식품위생안전성학회 2000 한국식품위생안전성학회지 Vol.15 No.3

한강 고수부지 및 지천인 안양천, 탄천, 중랑천변의 경작지에서 채집된 36종 285건의 농작물에 대한 Pb, Cr, Cd, Fe, Zn, Mn, Cu. Hg의 농도를 측정하고 그 결과를 채집 시기, 채집 지역 및 작물별로 비교, 분석한 결과, 작물 중의 중금속 함량은 평균치를 기준으로 볼 때 Fe(34.592 ppm)>Mn(11.071 ppm)>Zn(8.853 ppm)>Cu(1.795 ppm)>Cr(0.237 ppm)>Pb(0.100 ppm)>Cd(0.011 ppm)>Hg(0.003 ppm) 순으로 곡류 및 두류에서는 Zn의 함량이 Mn보다 높고, 채소류와 과실류에서는 Mn의 함량이 Zn보다 높은 양상을 나타냈다. 또한 각 지역에서 채취한 작물의 미량금속 함량의 경우 Fe은 0.004∼203.083 ppm, Cu은 0.017∼22.727 ppm. Mn은 0.000∼74.373 ppm. Zn은 0.080∼37.166 ppm으로 비교적 고농도로 존재하고 있는 반면 유해중금속류인 Pb은 0.000∼0.654 ppm, Cd은 0.000∼0.270 ppm, Cr은 0.000∼l.229 ppm, Hg은 0.000∼0.037 ppm으로 비교적 미량으로 존재함을 알수 있었다. 대상 농작물을 잎, 줄기, 뿌리, 열매로 분류하여 미량금속 함량을 분석한 결과, 분석 대상 금속의 농도가 잎>줄기>뿌리>열매의 순으로 나타났다. 무등의 뿌리 작물에 있어서 Pb은 잎(0.055 ppm))뿌리(0.035 ppm), Cr은 잎(0.118 ppm))뿌리(0.031 ppm), Cd은 잎(0.004 ppm)1뿌리(0.001 ppm), Hg은 잎(0.004 ppm))뿌리(0.001 ppm)으로 뿌리보다 잎에 많은 것으로 나타났는데 이러한 결과로 보아 뿌리는 금속 이온이 흡수되는 기관일 뿐 축적은 잎에 비해 상대적으로 적게 됨을 알 수 있었다. This study was conducted to determine the content of trace metals in crops cultivated in Han-riverside, Anyang stream, Tan stream, and Jungryang stream. Trace metals (Pb, Cr, Cd, Fe, Zn, Cu, Hg) were detected in 36 crops, 285 samples by Atomic Absorption Spectrophotometer and Mercury Analyzer. The average concentration of trace metals in crop samples was in the order of Fe (34.592 ppm)>Mn (11.071 ppm)$\geq$Zn(8.853 ppm)>Cu(1.795 ppm)>Cr(0.237 ppm)>Pb(0.100 ppm)>Cd(0.011 ppm)>Hg(0.003 ppm). In crop samples, the contents of Fe, Cu, Mn, and Zn, which ranges were 0.004-203.083 ppm, 0.017~22.727 ppm, 0.000~74.373 ppm, 0.080~37.166 ppm, respectively, were relatively higher than those of Pb, Cd, Cr, and Hg, which ranges were 0.000~0.654 ppm, 0.000~0.270 ppm, 0.000~l.229 ppm, 0.000~0.037 ppm, respectively. The concentration of trace metals in crop samples was in the order of leafy vegetables > stem vegetables > root vegetables > fruity vegetables. In the root vegetables, such as radish, the content of Pb was leaf(0.055 ppm)>root(0.035 ppm), that of Cr, leaf (0.118 ppm)>root(0.031 ppm), that of Cd, leaf(0.004 ppm)>root(0.001 ppm), that of Hg, leaf(0.004 ppm)>root(0.001 ppm). As the results, it could be thought that root is the organ which doesn't accumulate the heavy metal ions, but absorb them.

Structural insights into the binding of lauric acid to CYP107L2 from <i>Streptomyces avermitilis</i>

Han, Songhee,Pham, Tan-Viet,Kim, Joo-Hwan,Lim, Young-Ran,Park, Hyoung-Goo,Jeong, Dabin,Yun, Chul-Ho,Chun, Young-Jin,Kang, Lin-Woo,Kim, Donghak Elsevier 2017 Biochemical and biophysical research communication Vol.482 No.4

<P><B>Abstract</B></P> <P> <I>Streptomyces avermitilis</I> is an actinobacterium known to produce clinically useful macrolides including avermectins. CYP107L2 from <I>S. avermitilis</I> shares a high sequence similarity with the PikC (CYP107L1) from <I>S. venezuelae</I>. To elucidate the structural features of CYP107L2, we conducted biochemical and structural characterization of CYP107L2 from <I>S. avermitilis</I>. The CYP107L2 gene was cloned, and its recombinant protein was expressed and purified. The CYP107L2 showed a low-spin state of heme, and the reduced form yielded the CO difference spectra with a maximal absorption at 449 nm. Binding of pikromycin and lauric acid yielded the typical type I spectra with <I>K</I> <SUB>d</SUB> values of 4.8 ± 0.3 and 111 ± 9 <I>μ</I>M, respectively. However, no metabolic product was observed in the enzyme reaction. X-ray crystal structures of the ligand-free CYP107L2 and its complex with lauric acid were determined at the resolution of 2.6 and 2.5 Å, respectively. CYP107L2 showed a well-conserved CYP structure with a wide-open substrate-binding cavity. The lauric acid is bound mainly via hydrophobic interactions with the carboxylate group of lauric acid coordinated to the heme of P450. Glu-40 and Leu-382 residues in the CYP107L2 complex with lauric acid showed significant conformational changes to provide plentiful room for the lauric acid in the substrate-binding site.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CYP107L2 from <I>S. avermitilis</I> shares a high sequence similarity with the PikC. </LI> <LI> Purified CYP107L2 yielded a typical type I binding spectra to pikromycin and lauric acid. </LI> <LI> Crystal structure of CYP107L2 complex with lauric acid was determined at 2.5 Å resolution. </LI> <LI> Laurate is bound mainly via hydrophobic interactions in the substrate binding cavity of CYP107L2. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Involvement of GADD153 and Cardiac Ankyrin Repeat Protein in Hypoxia-induced Apoptosis of H9c2 Cells

Han, Xue-Ji,Chae, Jei-Keon,Lee, Mi-Jin,You, Kyung-Ran,Lee, Byung-Ho,Kim, Dae-Ghon American Society for Biochemistry and Molecular Bi 2005 The Journal of biological chemistry Vol.280 No.24

Physiological Activity of Soybean Resources, Identification of the Relationship between Individual Isoflavone Derivatives and Genetic Traits, and Their Differences by Cultivation Year

Han-Na Chu,Eun-Suk Jung,Mi-Kyung Seo,Kyeong-A Jang,Haeng-Ran Kim 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

간호대학생의 사회적 관심, 사회봉사활동에 대한 동기 및 태도 관한 연구

한영란,이홍자,주혜주,조경미,김은주,황승숙 이화여자대학교 간호과학연구소 1998 Health & Nursing Vol.10 No.2

This study treated nursing student's general social interest, the motivation and attitude to voluntary service before and after participation in volunteer activity class. The concerns for voluntary service which is the base of social responsibility and solidarity have been increased in recent year. Voluntary service make students to practice what they learned in volunteer activity class and to have a chance to help people with others. The puepose of this study is to investigate nursing student's volutary service motivation and attitude, social interest before and after volunteer activity. Therefore it can give the founmental data to plan institutional volunteer curriculumn in university. This study is based on the questionaire that was consisted of general characters, social interests, motivations and attitudes to voluntary service. For this study. 179 nursing students were answered before voluntary service, 164 same nursing students were answered after voluntary service. The results of this study are as follows 1) In general character, 43.1% students are christian, 14% students are catholic and 37.1% students do'nt have religion. 40.2% students have no voluntary service experience before. 2) The result of social interest comparision between before and after voluntaey service showed that the mean of after voluntary service (7.24) is higher than before(7.05), but there is no significant statistical difference. 3) The motivations of voluntary service are classified two, altruistic and selfish motivation. The mean of altruistic motivation is changed from 21.0 to 23.1, the mean of selfish motivation 31.29 to 33.29. This result is statistically significant defferent(p=.007, p=.017). 4) The attitudes of voluntary service also classified two, altruistic and selfish attitude. The mean of altruistic attitude is changed from 40.97 to 41.30, the mean of selfish attitude is 36.32 to 36.15. This result is no significant defference. 5) The students who have the experience of voluntary service in social welfare agency are showed higher selfish motivation than others(F=2.77, p=.044). 6) The students who are satisfied in nursing have higher altruistic motivation (p=.001), and altruistic attitude (p=.004) than non satisfacted students. 7) After voluntary service, the students who participated in voluntary service over one week to 3 months have higher social interest, altruistic and selfish motivation than under one week and over 3 months participated students. According to this result, the students have but only altruistic motivation not also various selfish motivations. Therefore it is needed to reflect the students motivationanr needs when the voluntary service plan in university. It is also suggested to give a voluntary service chance to the nursing students.

고령자를 위한 건강관리 시스템 Health Manager의 사용성 평가 및 분석

Han Woong Kim,Da Sue Ran Kim,Jung Min Yun,Suk Wha Kim,Hyoun-Joong Kong,Peom Park 대한인간공학회 2013 대한인간공학회 학술대회논문집 Vol.2013 No.10

Objective: 본 연구의 목적은 고령자를 위한 건강관리 시스템인 Health Manager의 UI를 평가한 후 문제점 추출 및 개선방안을 찾아내고자 하는 것이다. Background : Health Manager는 고령의 사용자들이 주 사용자이고, 터치 기반의 PC를 활용하여 혈압, 혈당, 산소포화도 등의 신체 상태를 측정하고 관리해주는 시스템이다. 본 시스템은 대부분의 사용자들이 고령의 노인들이기 때문에 사용함에 있어서 오류나 불편함이 많이 발생하여 기존 시스템의 문제점을 분석이 필요하였다. Method : 고령의 사용자들이 Health Manager를 사용하는데 있어서 기존 시스템의 문제점을 분석하기 위해 Health Manager의 화면 구성, 작업 흐름, 폰트 구성 세가지 항목에 대해서 Jakob Nielson이 정의한 사용성의 5가지 개념을 기반으로 평가를 진행하였다. 시스템 사용에 있어서 숙련자와 비숙련자 집단을 비교 평가하기 위해 T-검정을 실행하였고, 각 평가 항목들이 사용자들의 시스템에 대한 만족도에 미치는 영향을 알아내고자 회귀분석을 실행하였다. Conclusion : 본 연구를 통해서 고령의 사용자들이 Health Manager를 사용하는데 발생하는 문제점을 찾아내고 문제점을 개선하기 위한 방안을 찾아내고자 한다.

Association Between Subcutaneous Implantable Cardioverter Defibrillator Preimplantation Screening and the Response to Cardiac Resynchronization Therapy

Ran Jing,Han Jin,Wei Hua,Shengwen Yang,Yiran Hu,Shu Zhang 대한심장학회 2020 Korean Circulation Journal Vol.50 No.12

Background and Objectives: Preimplantation QRS-T morphology screening (TMS) is a composite tool for selecting subcutaneous implantable cardioverter defibrillator (S-ICD) candidates. However, its role in predicting the patient's response to cardiac resynchronization therapy (CRT) is uncertain. Methods: A total of 55 consecutive de novo CRT candidates were enrolled between January 2016 and March 2017. Electrocardiogram (ECG) and TMS were performed before and soon after implantation. The ECG parameters were recorded, including QRS duration and morphology (such as ΔQRS_Index, QTc during biventricular pacing mode [BiV pacing QTc], and QRS/T ratio during biventricular pacing mode [BiV pacing QRS/T ratio]). TMS monitored three sensory vectors of the S-ICD. Six months after implantation, the responses to CRT were evaluated. Results: Thirty-nine patients (70.9%) passed the TMS during biventricular pacing mode. At the six-month follow-up, the number of responders and super-responders was significantly higher in the passing group than in the non-passing group (responders: 31/39 [79.5%] vs. 5/16 [31.3%], p<0.001; super-responders: 9/39 [23.1%] vs. 1/16 [6.3%], p=0.020). The super-response rate was higher among patients who passed all three vectors than among those who passed 1 or 2 vectors (3 vs. 2 vectors, p=0.018; 3 vs. 1 vector, p=0.003). A smaller left atrial diameter, vectors that passed TMS during biventricular pacing mode, and larger ΔQRS_Index values were independently associated with good CRT response. Conclusions: Our study demonstrated that patients on CRT who pass the TMS during biventricular pacing mode are more likely to respond and super-respond to CRT.