한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계

여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.

정상인 집단과 성인병 집단의 심폐기능과 혈액성분에 관한 연구

정한종,박철빈 경희대학교 체육과학연구소 1996 體育學論文集 Vol.24 No.-

To study effects of cardiorespiratory function and blood components in normal and degenerative disease groups, 36 men who aged 40-60yrs were checked by medical process and exercise stress testing. Subjects were divided into five groups that were control, activity, obesity, hypertension and diabetes group. Results of this study are following, 1.%Body fat is 19.7% in control groups, 17.4% in activity group, 30.1% in obesity group, 26.0% in hypertension group and 27.1% in diabetes group. Control and activity group are significantly leaner than obesity, hypertension and diabetes group(p〈0.05). 2.It is not significantly different in amounts of WBC and RBC between groups. But obesity group has a significantly more amount of hemoglobin than control group(p〈0.05). 3.Glucose is 164.83mg/dℓ in diabates group, which is the significantly most plentiful among groups(p〈0.05). But in Calcium and Pi, it is not significantly different between groups. 4.In serum cholesterol, total cholesterol is 179.0mg/dℓ in activity group, which is the significantly least amount among groups(p〈0.05). LDL-C(101.3mg/dℓ) and triglycerides(135.5mg/dℓ) of activity group are the significantly least amount among groups, too(p〈0.05). Amount of HDL-C of activity group is greater than obesity, hypertension and diabetes group, but not significant. 5.Resting HR is 60.6beats/min in control group and 57.1beats/min in activity group, that are significantly lower than those of hypertension and diabetes(p〈0.05). Resting SBP/IDBP is 160.7/107.9mmHg in hypertension group, which is the highest among groups(p〈0.05), but blood pressure of other groups are normal. 6.Resting rate pressure product(RPP ; myocardial oxygen consumption) is 6.60×103mmHg·bpm in activity group, which is less than those in obesity, hypertension and diabetes group(p〈0.05). Values of hypertension group, 10.91×103mmHg·bps, are the greatest among others(p〈0.05). 7.Maximal oxygen consumption(Vo2max) of activity group is 37.3㎖/kg/min, that is significantly greater than degerative groups(p〈0.05). 8.Correlation coefficients with Vo2max have significance(p〈0.001); TCH(r=-0.853), HDL-C(r=0.633), LDL-C(r=-0.813), Triglycerides(r=-0.844), TCH/HDL-C (r=-0.862), LDL-C/HDL-C (r=-0.834). 9.Correlation coefficients with resting RPP have significance; (p〈0.001) TCH(r=0.732), LDL-C (r=0.699) , Triglycerides (r=0.705), TCH/HDL- C (r=0.736) , LDL-C/HDL-C (r=0.713) ; (p〈0.001) HDL-C(r=-0.483). Results of this study indicate that improvement of cardiorespiratory function induces significant changes of serum lipids in middle and elderly men, implicate that modern degenerative diseases are decrease according to cardiorespiratory function. Conclusionally, elderly men must increase their activities in daily life for improving their cardiorespiratory function and protecting degenerative disease. This study is expected to contribute the area of exercise prescription, hereaftar more effort is required to establish the relation between serum lipids and exercise amount.

감염질환에 의한 변사자의 장기조직에서 결핵균의 검출에 관한 연구

이한영,엄용빈,최철호,김영주,권태정 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

염산에 의한 부식성 위염에 동반된 고도 이형성증 1예

김한성,박성혜,전영빈,장석효,김용일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

A 80 year-old man ingested hydrochloric acid as suicidal purpose and as a result developed an epigastric fullness and pain. Marked stricture of esophagogastric junction and gastric outlet were found by endoscopic examination after 20 days of admission. A total gastrectomy and Roux-en-Y esophagojejunostomy was performed. Grossly, resected stomach revealed redness and erosion especially over antrum and pylorus. On cross section, a flat elvated lesion measuring 0.7×0.5 cm was incidentally found on high body along lesser curvature. On microscopic examination, the mass consisted of atypical epithelial glands having increased cellularity and round hyperchromatic nuclei without invasive foci. The lesion was diagnosed with ‘epithelial dysplasia, high grade’. Corrosive gastritis and submucosal epithelial heterotopia were found in surrounding mucosa also.

발파진동 제어에 의한 특수구간 터널굴착에 관한 연구

최형빈,임한욱 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A

It was difficult to apply conventional excavation methods in some sections from Seoul to Pusan high speed rail road construction of 1 lot 2, due to highway concrete road. gas pipe, water pipe and nearby factories with automatic control system machine. To excavate safely and efficiently in these sections new blast patterns were employed within allowable blast vibration level, by test blast and controlled vibration by sequential blast. Behaviors of the rock mass including convergence and displacement around tunnel were measured with construction works and the crack width in concrete wall also monitored for controlling allowable limits. The results can be summarized as follow : 1. The allowable blast vibration level in structure site is less 1.0cm/sec for highway concrete, 0.5 cm/sec for gas pipe, water pipe and building housing and 0.3 cm/sec for automatic control system machine. 2. The convergence displacement, sing rod extensometer and multi rod extensometer around tunnel and cracks in concrete wall were measured, it was confirmed that the measured values were converged within allowable level. 3. The empirical formular of ground vibrations with 90% confidence lines for PD-3 was given as follow. V_90%=45.549(??)^-1.353

순천향대학교 사회과학대 학생의 진로인식 및 진로지도개선에 관한 연구

심영수,차석빈,김용하,최한준 순천향대학교사회과학연구소 2003 순천향 사회과학연구 Vol.9 No.1

This study conducted an empirical research to find ways to guide the career of college students in the social science at Soonchunhyang university. Research findings are as follows. 1) About 42% respondents answered that they did job-seeking efforts. 2) With regard to job preparing efforts, students spent their time on improving their English ability, major classes, computer ability, and license obtaining. 3) Job-related information sources in the school were not fully utilized by the students. 4) In the future, students hope that our school strengthen its PR efforts, open more English-related classes, improve its school image as a local university, and provide more job-related information The study concludes with implications of the study results and suggestions for career guidance of students.

남성 알코올 의존 환자의 삶의 질과 정신-사회-영적 특성과의 관계

최삼욱,나란희,김한오,최성빈,최영숙 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

Objectives : This study was designed to evaluate the relationship between quality of life (QOL) and psycho-socio-spiritual characteristics in male patients with alcohol dependence. Methods : The sample consisted of 109 men with alcohol dependence defined by DSM-IV criteria. We assessed QOL by the WHO QOL assessment instrument-BREF (WHOQOL) and SmithKline Beecham QOL (SBQOL). Sociodemographic and alcohol related data were collected, and 7 questionnaires were administered : MAST, BDI, STAI, Drinker Inventory of Consequences (DrInC), Scale of Social Support (SSS), Religious Beliefs and Behaviors (RBB) and Spiritual Well-being Scale (SWBS). The correlations between each QOL score and other variables were examined, and stepwise multiple regression analysis was performed. Results : The WHOQOL score positively correlated with education level, SSS (support) and RBB and negatively correlated with MAST, DrInC, BDI, STAI (trait) and SSS (conflict) scores. In stepwise regression analysis, the scores on the STAl and BDI contributed to the score on the WHOOOL. The SBQOL score correlated with the income level, and negatively correlated with BDI and STAI score. STAI score was a weak predictor of SBQOL score. Conclusion : The significant predictors of QOL in patients with alcohol dependence were psychological factors such as anxiety and depression.

만성 승모판 패쇄부전증 환자에서의 안지오텐신 전환효소 억제제의 장기 투여 효과

김대희,이명묵,이해영,조현재,박승정,서재빈,서정원,양한모,윤창환,조상호,이준희,김용진,김명아,손대원,오병희,박영배 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

Varicella zoster virus infection after allogeneic hematopoietic cell transplantation in children using a relatively short duration of acyclovir prophylaxis : A retrospective study

Han, Seung Beom,Kim, Seong koo,Lee, Jae Wook,Lee, Dong-Gun,Chung, Nack-Gyun,Jeong, Dae Chul,Cho, Bin,Kang, Jin-Han Williams & Wilkins Co 2017 Medicine Vol.96 No.14

<P><B>Abstract</B></P><P>Although acyclovir prophylaxis against varicella zoster virus (VZV) infection for ≥1 year is recommended after allogeneic hematopoietic cell transplantation (HCT), the emergence of acyclovir-resistant viruses and adverse drug effects cannot be ignored. We investigated the cumulative incidence of VZV infection after allogeneic HCT in children receiving a shorter duration of acyclovir prophylaxis than recommended and evaluated the appropriateness of the short duration of acyclovir prophylaxis.</P><P>Medical records of 217 children who received allogeneic HCT were retrospectively reviewed until a median of 25 months (range = 1–59 months) after HCT. Acyclovir prophylaxis was given for a median of 9 weeks (range = 3–24 weeks) after HCT.</P><P>VZV infection was diagnosed in 33 (15.2%) children at a median time of 5 months (range = 2–41 months) after HCT. The 1-year and 2-year cumulative incidences of VZV infection after allogeneic HCT were 11.2% and 15.5%, respectively. These incidences were between the previously reported 1-year incidence of 25% to 30% in patients not receiving prophylaxis and 1-year incidence of 4% to 5% in patients receiving ≥1 year duration of prophylaxis. Male sex and older age were significantly associated with VZV infection after allogeneic HCT. Only 1 chickenpox patient experienced severe complications because of VZV infection, and there were no deaths attributable to VZV infection.</P><P>In conclusion, a shorter duration of acyclovir prophylaxis may be appropriate for children receiving allogeneic HCT, based on the rare occurrence of severe complications because of VZV infection and the expected discomfort because of daily oral medication for a long time.</P>

Theoretical Analysis of a Spark Ignition Engine by the Thermodynamic Engine Model

Han, Sung Bin The Korean Society for Energy 2015 에너지공학 Vol.24 No.3

Recent engine development has focused mainly on the improvement of engine efficiency and output emissions. The improvements in efficiency are being made by friction reduction, combustion improvement and thermodynamic cycle modification. Computer simulation has been developed to predict the performance of a spark ignition engine. The effects of various cylinder pressure, heat release, flame temperature, unburned gas temperature, flame properties, laminar burning velocity, turbulence burning velocity, etc. were simulated. The simulation and analysis show several meaningful results. The objective of the present study is to develop a combustion model for a spark ignition engine running with isooctane as a fuel and predicting its behavior.