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정병천,배호상,곽동훈,김영태,배용학,황종현,임현주,류재근,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2
목적 : 급성하벽심근경색증 환자에서 심전도상 흔히 동반되는 전흉부유도 ST절 하강의 의의를 알아보았다. 방법 : 심근경색후 24시간에서 48시간에 얻은 심전도를 기준으로 52명의 급성하벽심근경색증 환자를 전흉부유도에서 ST절의 하강이 있는 군과 없는 군으로 나누었으며 심도자, 관상동맥조영술, 심초음파도 및 방사성 핵종을 이용한 좌심구혈율 측정 등을 시행하였다. 결과 : 1) 좌심실확장기말압은 전흉부유도에서 ST절의 하강이 있는 경우에서 16.9±5.33mmHg로 없는 경우의 11.0±4.02mmHg보다 유의하게 높았다(p<0.05). 그러나 운동량 및 좌심구혈을은 흥부 유도상 ST절의 하강이 있는 경우 7.6±3.0 METs 및 53.9±9.1%로 없는 경우의 9.1±2.7 METs 및 54.6±9.5%보다 낮았으나 통계적 유의성은 없었다(p=0.180, p=0.823). 2) 관상동맥조영술상 전흉부 ST절의 하강이 동반된 군에서는 유의한 좌전하행지나 좌회선지의 협착이 있는 경우가 60.9% 및 57.9%로 ST절의 하강이 없는 군에서의 34.5% 및 7.7%와 비교해 좌관상동맥에 협착이 동반된 경우가 많았다(p=0.050, p=0.001). 3) 관상동맥조영술상 세 혈관질환의 빈도는 흉부유도상 ST절의 하강을 보인 23예에서 10예로 ST절 하강이 없었던 29예중 2예에 비하여 유의하게 많았고(P=0.007), 단 혈관질환의 빈도는 ST절의 하강을 보인 군에서 23예중 5예로 ST절 하강이 없었던 29예중 17예에 비하여 유의하게 적었다(P=0.002). 두 혈관질환의 경우에는 각각 8예와 10예로 양군간에 유의한 차이가 없었다. 4) 흉부유도상 ST절 하강의 빈도는 단 혈관질환 22예 중 5예에서, 두 혈관질환 18예중 8예, 세 혈관질환 12예 중 10예에서 관찰되어 협착이 있는 관상동맥의 수가 많을수록 ST절의 하강이 나타나는 빈도가 많음을 보였다(p=0.00308). 그러나 흉부유도상 나타난 ST절의 하강을 모두 합하여 구한 ST절 하강의 합은 협착이 있는 관상동맥의 수와 통계적인 유의성이 없었다. 5) 심초음파도상 좌심실 하벽의 벽운동은 ST절 하강을 보인 군에서는 akinesia가 83.3%, hypokinesia가 11.1%, 정상 벽운동이 5.6%로, ST절 하강이 없었던 군에서의 dyskinesia가 3.6%, akinesia가 39.3%, hypokinesia가 25.0%, 정상 벽운동이 32.1%와 비교하여 ST절의 하강이 있는 군에서 유의하게 벽운동의 장애가 빈번함을 보였다(p=0.03891). 그러나 좌심실전벽, 측벽 및 중격부위에서는 유의한 벽운동의 차이가 없었다. 결론 : 급성하벽심근경색증 환자의 전흉부유도에서 ST절의 하강이 동반되는 경우 다혈관 질환의 가능성이 높으며 좌심실확장기말압이 상승되었고 운동능력은 감소되어 있었다. 또한 심초음파도상 좌심실하벽의 벽운동장애도 심하였다. 따라서 전흉부 ST절의 하강을 동반한 급성하벽심근경색증 환자는 전흉부유도에 ST절 하강이 없는 경우보다 예후가 불량할 것으로 생각되며, 보다 적극적인 치료가 필요할 것으로 생각된다. The purpose of this study was to determine the significance of precordial ST segment depression appearing during acute inferior myocardial infarction and to assess the correlation of that with angiographic finding. 52 patients were allocated into two groups based on the existence of precordial ST segment depression : 23 patients with ST segment depression and 29 patients without ST segment depression. The extent of coronary artery disease as well as the prevalence of significant stenosis (≥70%) in left anterior descending artery were more frequent in patients showing precordial ST segment depression than in patients not showing them (p=0.050) and the result were similar in cases of left circumplex artery (p=0.001). On echocrdiographic examination of left ventricular (LV) wall motion, it showed more severely decreased inferior LV wall motion in patients showing precordial ST segment depression than in patients not showing them (p=0.03891) even though the other segment of LV wall motion didn't show the statistical difference between both groups. The other cardiac parameters such as LVEDP, exercise amount (METs) and ejection fraction were tend to showing bad profile in patients with precordial ST segment depression. From the above results, we could deduce that patients with precordial ST segment depression have relatively large infarction or concomitant left coronary artery disease, so they need more caution and intensive theraphy.
아치 리브를 따라 작용하는 등분포 하중을 받는 포물선 아치 리브의 비탄성 면내좌굴 강도
윤기용,문지호,김성훈,이학은,Yoon. Ki-Yong,Moon. Ji-Ho,Kim. Sung-Hoon,Lee. Hak-Eun 한국방재학회 2005 한국방재학회논문집 Vol.5 No.1
포물선 아치 리브는 원형 아치 리브와 더불어 실무에 폭넓게 적용되고 있는 아치 형상이다. 원형 아치 리브의 비탄성 면내 거동에 관한 연구는 1990년대 Trahair(1996)를 중심으로 연구가 진행되었으며, Yong-Lin Pi와 Bradford(2004)에 의하여 최근까지 연구가 활발히 진행 되고 있다. 포물선 아치 리브의 비탄성 면내 거동에 관한 연구는 일본의 연구자(Sinke, Kuranishi)을 중심으로 1970년대 후반부터 1980년대 초반에 이르기까지 많은 연구가 진행되었다. 이러한 포물선 아치 리브에 관한 일본에서의 연구는 대부분 라이즈비가 <TEX>$0.1{\sim}0.2$</TEX>에 국한 되어있다. 본 연구에서는 비탄성 유한요소해석을 이용하여 라이즈비가 0.1에서 0.4에 이르는 박스형태의 단면을 갖는 포물선 아치 리브의 면내 거동에 관하여 연구를 수행하였다. 연구 결과 라이즈비가 증가할수록 아치 단면에 휨모멘트가 증가하였으며, 압축력이 수직 등분포 하중을 받는 포물선 아치 리브의 면내 좌굴 안정성에 미치는 영향은 감소하였다. 마지막으로 본 연구에서는 아치 리브를 따라 작용하는 수직등분포 하중을 받는 포물선 아치의 좌굴 곡선을 제안하였다. Parabolic arch ribs are widely used in practical. In case of circular arch ribs. Inelastic in-plane buckling behaviors were investigated by Trahair(1996). Recently Yong-lin Pi & Bradford(2004) investigated about in-plane design equation for circular arch ribs. In <TEX>$1970{\sim}1980$</TEX>. In-plane buckling strength about parabolic arch ribs were studied by some japan researchers (Sinke, Kuranishi). Study results of Sinke & kuranishi are only valid for rise-span ratio <TEX>$0.1{\sim}0.2$</TEX>. In this paper. The researchers investigated about in-plane inelastic buckling behaviors of parabolic arch ribs having rise-span ratio from 0.1 to 0.4. From the results. When the rise-span ratio increase, flexural moments increase and influence of axial force to in-plane buckling strength decrease. Finally, buckling curves for parabolic arch ribs subjected distributed loading along the axis were suggested.
위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구
노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.
비구조적 퍼지 의사결정지원시스템을 활용한 건설재해 예방대책에 관한 연구
이용준,정성춘,이학기 東亞大學校 建設技術硏究所 2004 硏究論文集 Vol.27 No.2
The hazard factors in building construction project are various and their bad effects with regard to project's efficiency are increasing due to its enlargement and complexity. However. the assessment of the construction safety is commonly dependent upon the statistical and historical information. since the existing systematic tool assisting to the effective decision making for estimating the safety prior to construction phase is inaccurate. In addition. it is true that there are the various difficulties to analyze and diagnosis the construction safety with the probabilistic approach. because there are the many vague factors and limited resources. Therefore. the purpose of this research is to provide the way to establish the efficient preventable countermeasure against the hazard factors. corresponding to the category of the hazard characteristic. by using non-structural fuzzy decision support system for diagnosing effectively the construction project safety.
생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구
김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.
광고 노출시점의 소비자 기분이 광고효과에 미치는 영향 : 인지적 및 감정적 반응, 광고 및 상표태도, 그리고 기억성과
이학식,전용석 한국방송광고공사 2005 광고연구 Vol.0 No.66
본 연구는 인지심리학 분야에서의 기존 연구 성과를 토대로 소비자의 기분에 따라 광고효과가 어떻게 달라지는지를 인지적 및 감정적 반응, 광고 및 상표태도, 그리고 기억성과 측면에서 조사한 것이다. 피실험자들의 기분을 긍정적 혹은 부정적으로 조작한 다음 실험용광고를 노출시키고 설문지를 이용하여 자료를 수집하였다. 본 연구에서 설정한 모든 가설은 지지되었는데, 이를 요약하면 다음과 같다. 첫째, thought positivity index와 feeling positivity index, 두 가지 모두 소비자의 기분이 긍정적인 경우 부정적인 경우보다 더 높게 나타났다. 둘째, 인지적 반응 → 상표태도의 관계는 소비자의 기분이 부정적인 경우, 그리고 감정적 반응 → 광고태도의 관계는 소비자의 기분이 긍정적인 경우 더 높게 나타났다. 셋째, 기억성과는 소비자의 기분이 부정적인 경우 긍정적인 경우보다 더 높게 나타났다. 추가적으로, 인지적 반응은 소비자의 기분이 부정적인 경우, 그리고 감정적 반응은 소비자의 기분이 긍정적인 경우 더 많이 유발된다는 것이 발견되었다. 본 연구의 결론에는 연구의 요약, 공헌점, 그리고 한계점을 논의하였으며, 끝으로 미래연구에 대한 제언을 하였다. This research is to investigate how advertising effects vary with consumers’ mood based on the findings in cognitive psychology. Advertising effects are examined in the aspects of cognitive and emotional responses, ad and brand attitudes, and memory performance. Subjects were exposed to an experimental ad and answered questionnaires after their mood was manipulated to be either positive or negative. The results indicate that (1) both thought positivity index and feeling positivity index are higher with consumers’ positive mood, (2) the relationship between cognitive responses and brand attitudes is higher with consumers’ negative mood while the relationship between emotional responses and ad attitudes is higher with positive mood, (3) memory performance is higher with consumers’ negative mood. In addition, it was found that more cognitive responses were made with consumers’ negative mood while more emotional responses were made with positive mood. In the conclusions, the authors discuss theoretical contributions and limitations and offer suggestions for future research.