한국인의 연, 망간, 알루미늄 및 실리콘의 혈중 농도

김정만,안정모,김원술,김정일,신해림,정갑열,김준연 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

Blood Lead, Manganese, Aluminium and Silicon Concentrations in Korean Adults Jung Man Kim, Jung Mo Ahn, Won Sul Kim1), Jung Il Kim2), Hai Rim Shin, Kap Yeol Jung2), Joon Youn Kim Department of Preventive Medicine, College of Medicine and Industrial Medicine Research Institute. Dong-A University Department of Health Care, Handong University Sunlin Presbyterian Hotpital1) Department of Occupational Medicine, College of Medicine, Dong-A University2) 0bjectives : This study was performed to determine the reference values of blood lead, manganese, aluminium, and silicon in healthy adults. Methods : The subjects were 132 (67 male and 65 female), and classified to three age groups (≤39,40∼49, and 50≤). Hood lead, manganese and aluminium were analyzed by atomic absorption spectrophotometer, and blood silicon was analyzed by direct current plasma optical omission spectrometer. Results : Blood lead levels(geometric mean, S.D) were (3.49, 1.70) ㎍/dL in male auld (3.04, 1.65) ㎍/dL in female, but the difference is not significant, and there was no significant difference between age groups. Mean blood manganese level was 0.99±0.41㎍/dL, and there was no significant difference between sex or age groups. Mean blood aluminium level was 0.59±0.35㎍/dL and there was no significant difference between sex or age groups. Mean blood silicon level was 54.41±27.64㎍/dL in male and 43.34±23.51㎍/dL in female, and the level in male was significantly higher than that in female (p〈0.05). There was significant difference between age groups, and the oldest showed the highest level in male (p〈0.05), but no significant difference between age groups in female. Conclusions : Authors hope that this study would provide basic data for determininig reference values and evaluating health effects.

韓國의 經濟發展과 金融産業의 效率化 方案

林海正,黃廷虎 군산대학교 산업개발연구소 1987 産業開發硏究 Vol.6 No.-

租稅의 所得再分配效果에 대한 硏究

林海正,黃廷虎 군산대학교 산업개발연구소 1989 産業開發硏究 Vol.8 No.-

학교장면에서의 단기상담 : 대학장면

최해림 漢陽大學校 學生生活硏究所 1991 大學生活硏究 Vol.9 No.-

암의 위험요인과 예방

유근영,신해림 한국역학회 2003 Epidemiology and Health Vol.25 No.1

Cancer is one of the main cause of death worldwide. There are about 10 million new cases every year, and more than 6 million persons will die of the disease in a year. Many factors are responsible for the recent increase in cancer. Changing lifestyles, in particular as regards tobacco smoking, alcohol drinking and diet, also play a crucial part. Several different types of scientific studies contribute to identifying the causes of human cancer. IARC's prestigious series of Monographs on the Evaluation of Carcinogenic Risks to Humans publishes authoritative reports on the risks posed by potentially carcinogenic agents and exposures. Most cancers are thought to be caused by factors related to lifestyle and environment. In particular, tobacco, chronic infections and diet are involved in a substantial number of new cancers. Tobacco is responsible for about 15% of all cancers throughout the world. Chronic infections with viruses, bacteria and parasites are responsible for 16% of all cancers. It has been hypothesized that 30% of all cancers could be prevented by appropriate diet and physical activity. Other known causes of cancer, such as occupational, genetic, and reproductive factors, plays a lesser role in the global burden of cancer. Many types of cancer seem to be cluster in families, occurring more often in close relatives of affected individuals. The risks that a person inheriting a defect in a person inheriting a defect in a cancer susceptibility gene will develop a certain type of cancer must be estimated, and the role of environmental factors in modifying these risks must be ascertains. Researches into the causes of cancer has revealed how many of the most common cancers can be prevented. Detection of many forms of the disease at an early stage can greatly improve the prospects for effective treatment, reducing deaths and enhancing quality of life.

음식물 섭취에 따른 요중 마뇨산 배설량의 변화

김정일,박태혁,정갑열,신해림,김준연 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

Objectives ; Urinary hippuric acid levels have been usually determined to evaluate workers exposes to toluene. Food and drink intake could affect urinary hippuric acid excretion and chi study was carried out to investigate what kinds of food and drink would affect urinary hippuric acid excretion. Methods ; The subjects were 136 medical school students. Authors measured urinary hippuric acid levels three times from 10 a. m. to noon; before, one hour after and two hours after food or drink-intake, and they were asked not to eat from the previous night(9 p. m) of testing. We selected six diets(bread and coffee, brown sauce noodle, Korean style meal, noodle, pork-galbi and rice and soybean stew and rice) , six fruits(apple, grape, orange, pear, persimmon and plum) and five beverages(Alps-D□, Demisoda□, Orange juice□, Pear juice□ and Pocari sweat□). Analysis of urinary hippuric acid was performed by high performance liquid chromatography. Results ; Intake of popular Korean diets, fruits and some drinks didn't affect urinary hippuric acid excretion. But intake of sodium benzoate-contained Alpa-D□ increased urinary hippuric acid excretion. Conclusions ; For the health examination on workers exposed to toluene, the history of diet and fruit intake can be negligible, but that of beverage intake should be included.

Cancer Incidence in Korea

Hai-Rim Shin,Yoon-Ok Ahn,Jong-Myon Bae,Myung-Hee Shin,Duk-Hee Lee,Choong-Won Lee,Heechoul Ohrr,Don-Hee Ahn,Jacques Ferlay,Dornald Maxwell Parkin,Dae-Kyu Oh,Jae-Gahb Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.6

Purpose: We estimated the incidence of cancer inKorea.Materials and Methods: The indicence of cancer wasestimated using national mortality data, and the incidencedata from four frontier regional cancer registries,including Kangwha, Seoul, Busan and Deagu. These fourregistries served a population about seventeen million,which is almost 38% of entire population in Korea.Results: The overall age-standardized incidence rates(ASR) were 287.0 and 163.1 per 100,000 for males andfemales, respectively. Among males, stomach cancer wasthe most frequent (ASR 69.6), followed by lung cancers,including bronchus cancer (ASR 54.5), liver cancer (ASR47.0) and colo-rectal cancer (ASR 25.2). The most frequentsites of cancer in females, by rank order, were stomach(ASR 26.8), breast (ASR 20.1), uterine cervix (ASR 18.0),colo-rectum (ASR 15.9), lung (ASR 13.0) and liver (ASR12.0).Conclusion: It is hoped that these results will providevaluable leads for cancer research and cancer control inKorea. (Cancer Res Treat. 2002;34:405-408)

National Cancer Incidence for the Year 2002 in Korea

Hai-Rim Shin,Kyu-Won Jung,Young-Joo Won,Hyun-Joo Kong,Seon-Hee Yim,Joohon Sung,Sun-Won Seo,Ki-Young Kim,Sang-Yi Lee,In-Sik Kong,In Kyoung Hwang,Choong Won Lee,Ze-Hong Woo,Tae-Yong Lee,Jin-Su Choi,Cheo 대한암학회 2007 Cancer Research and Treatment Vol.39 No.4

2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals

Hai-Rim Shin,Kyu-Won Jung,Young-Joo Won,Jae-Gahb Park 대한암학회 2004 Cancer Research and Treatment Vol.36 No.2

Purpose: To estimate the number of cancer cases during 2002 in Korea through a nationwide hospital based cancer registration by the Korea Central Cancer Registry (KCCR). Materials and Methods: One hundred and thirty nine hospitals participated in the KCCR program in 2002. Cancer cases were coded and classified according to the International Classification of Diseases for Oncology 2nd edition (ICD-O-2). The software program "IARC Check " was used to evaluate the quality of registered cancer cases. Of the 122,770 malignancies registered, 11,732 (9.6%) duplicated malignancies were excluded. Among the remaining 102,677 malignancies, 3,652 (3.6%) cases with carcinoma in situ (Morphology code/2) were separated. Finally, 99,025 malignancies were analyzed. Results: Of the total of 99,025 malignancies, 55,398 (55.9%) cases were males and 43,627 (44.1%) were females. More than one third of cases were from the elderly (65 years old and more). The six leading primary cancer sites in the order of their relative frequency, were stomach (24.0%), followed by the lung (16.0%), the liver (15.4%), the colorectum (11.6%), the bladder (3.2%), and the prostate (3.0%) among males. In females, the breast (16.8%) was the common cancer site, followed by the stomach (15.3%), the colorectum (10.7%), the thyroid gland (9.5%), the cervix uteri (9.1%), and the lung (6.6%). Conclusion: With the continued increase in cancer cases especially prostate cancer among males and thyroid cancer among females, the total number of registered cancer cases in Korea continues to rapidly increase.(Cancer Res Treat. 2004;36:103-114)

Nationwide Cancer Incidence in Korea, 1999~2001; First ResultUsing the National Cancer Incidence Database

Hai-Rim Shin,Young-Joo Won,Kyu-Won Jung,Hyun-Joo Kong,Seon-Hee Yim,Jung-Kyu Lee,Hong-In Noh,Jong-Koo Lee,Paola Pisani,Jae-Gahb Park,Yoon-Ok Ahn,Soon Yong Lee,Choong Won Lee,Ze-Hong Woo,Tae-Yong Lee,최진 대한암학회 2005 Cancer Research and Treatment Vol.37 No.6

Purpose: The first Korean national population- based cancer registry using nationwide hospital-based recording system and the regional cancer registries provided the source to obtain national cancer incidences for the period 1999∼2001.Materials and Methods: The incidence of cancer in Korea was calculated based on the Korea Central Cancer Registry database, data from additional medical record review survey, the Regional Cancer Registry databases, site-specific cancer registry databases, and cancer mortality data from the Korea National Statistical Office. Crude and age-standardized rates were calculated by sex for 18 age groups.Results: The overall crude incidence rates (CR) were 247.3 and 188.3 per 100,000 for men and women and the overall age-standardized incidence rates (ASR) were281.2 and 160.3 per 100,000, respectively. Among men, five leading primary cancer sites werestomach (CR 58.6, ASR 65.6), lung (CR 42.1, ASR 50.9), liver (CR 41.9, ASR44.9), colon and rectum (CR 24.2, ASR 27.3) and bladder (CR 7.7, ASR 9.2). Among women, the most common cancers were stomach (CR 30.8, ASR 25.8), breast (CR25.7, ASR 21.7), colon and rectum (CR 19.6, ASR 16.7), uterine cervix (CR 18.4, ASR 15.5), and lung cancer (CR 15.1, ASR 12.4). In 0∼14 age group, leukemia was mostcommon for both sexes. For men, stomach cancer was most common in 15∼64 age group, but lung cancer was more frequent for over 65 age group. For women, thyroidcancer in 15∼34 age group, breast cancer in 35∼64 age group, and stomach cancer in over 65 age group were most common for each age group. The proportions ofdeath certificate only were 7.5% for men and 7.4% for women.Conclusion: This is the first attempt to determine the national cancer incidence and this data will be useful to plan for research and national cancer control in Korea.