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      • 두 마리의 면역매개성 혈고판감소증 개에서의 MMF를 이용한 치료

        손혜진,박형진,서경원,송근호 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

        Two dogs (case 1: 4-years-old female Dachshund, case 2: 1-years-old male maltese) were reffered with petechia. Result of blood analysis and coagulation test reveled immune-mediated thrombocytopenia in all dogs. Treatment with MMF for them, case 1 present steroid-induced hepatopathy, case 2 present anemia, so treated with Human IgG and blood transfusion. 3(case 1) or 2(case 2) months after initial treatment, clinical features were improved, and continuous monitoring is needed.

      • 어머니의 신경증적 성향과 완벽주의 및 심리적 통제가 유아의 내면화 문제행동에 미치는 영향

        왕해경, 한세영 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.1

        The purpose of this study was to examine the effects of mother's neuroticism, perfectionism and psychological control on children's internalized problem behaviors such as depression, anxiety, and withdrawal. The subjects of this study were 373 mothers of 3, 4, and 5-years-old children who were attending to 7 public kindergartens and 1 private kindergartens located in Cheongju city. The results of this study were as follows: First, it indicated that mother's neuroticism, self-oriented perfectionism, criticism, and unstable emotion had statistically significant effects on young children's depression. That is, the more neuroticism, the less self-oriented perfectionism, and the more psychological control like criticism and unstable emotion mothers showed, the higher young children's depression was. Second, it revealed that mother's neuroticism and criticism and love withdrawal had statistically significant effects on young children's anxiety. That is, children of mothers with more neuroticism and psychological control like criticism and love withdrawal showed higher anxiety. Third, it was found that only mother's neuroticism had a statistically significant effect on young children's withdrawal. That is, the more neuroticism mothers showed, the higher young children's withdrawal was.

      • KCI등재후보
      • KCI등재후보
      • Ethyl 2-Methyl-3-Pyrazinyl-3-oxopropionate의 합성과 케토-엔올 토토머화현상

        권순경,박명숙,박해선 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1

        Ethyl 2-methyl-3-pyrazinyl-3-oxopropionate is a key intermediate for the development of new drugs and can be synthesized through Claisen condensation from methyl pyrazine carboxylate and ethyl propionate. Even though in β-diketones esters in general the amount of enol form present at equilibrium is far higher than keto form, this key compound showes that the keto concentration is high. It can be explained because of the electron-releasing effect of α-methyl group.

      • Infant Tendernerness Scale의 타당도 및 신뢰도 조사

        이혜경,전동희 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

        The purpose of this study was to evaluate a new instrument, the Blank Infant Tenderness Scale (BITS), designed to measure mother's perceptions of infant tenderness needs. These infant needs include physiological requirements, such as nourishment and adequate body temperature, and contact requirements, such as physical closeness and manipulation. Guided by Sullivan's theorem of tenderness, a 36-item instrument was constructed. To assess realiability and validity of the BITS used to factor analysis, known groups techniques, Cronbach's Alpha coefficient, Spearman-Brown Split-half coeffcient, Guttman Split-half coefficient. The results of the study are as follows: 1. Factor analysis was performed first, using prinicipal factoring with interaction (PA 2) followed by orthogonal (Varimax) rotation. Using these procedures, two factors were retained: Factor I with 4 variable sets and Factor II with 3 variable sets. 2. T-test indicated a statisti-fically significant difference in maternal perception based on parity. 3. The result demonstrated that there is food internal consistency for the total BITS and moderate to high internal consistency for the two retained factors.

      • 분만시 진통정도 예측을 위한 연구

        이혜경 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

        The purpose of this study made assessment tool to predict a patient's pain level during labor. Independent variables were the muscle tension which she's experienced over the past 2 weeks and the emotiohal tension on admission in labor and dependent variable was pain self-report. VSA (Visual Analogue Scale) used as a study tool for measurement childbirth pain. The muscle tension which she's experienced over the past 2 weeks and the emotional tension on admission in labor used as a study tool for measurement anxiety in labor which was made by Judith E. Meissner. 91 subjects were surveyed and T-test and Pearson's Product Moment Correlations were used to test specific hypotheses. The result of this study were summarized as follows. 1. 32 women answered they experienced about tense, restless, and unable to relax over the past 2 weeks 2. 62 women expressed fear for baby or self. 3. 85 women expressed one or more of behavioral signs and 83 womon's pulse rate on admission in labor was less than 87. 4. Correlation coefficient between pain self-report at labor and the muscle tension, emotional tension on admission in labor was significant. 5. level of muscle tension and the emotional tension were identified as significantly related to pain self-report at labor. In conclusion we can say this assessment tool predict a patient's pain level during labor but in the future study this tool should Retested with many samples.

      • KCI등재후보

        Quartz 자극에 의한 iNOS 발현의 자가조절

        김경아,남혜윤,문제혁,정진숙,임영,정치경 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

        목적 : Rat2 섬유모세포에서 α-quartz에 의해 유도된 NOS의 조절기전을 알아보기 위하여 본 연구가시도 되었다. 방법 : Rat2 세포에 있어서 α-quartz 자극에 의한 NO와 H₂O₂의 분비 및 iNOS의 발현을 관찰하였고, iNOS 억제제인 L-NIL과 H₂O₂ 억제제인Catalase를 전처리하고 마찬가지로 NO와 H₂O₂분비 그리고 iNOS의 단백발현 정도를 western blot-ting을 이용하여 관찰하였다. 결과 : o-quartz는 Rat2 세포에서 iNOS에 의한NO와 H₂O₂의 분비를 유도하였다. L-NIL은 R3t2세포에서 D-quartz에 의한 H₂O₂의 분비와 iNOS발현을 완전히 억제하였다. Catalase로 전처리 하였을 때 o-quartz로 유도된 iNOS에 의하여 생산증가된 H2Oa가 iNOS를 억제하는 autoinhibitorypathway가 차단되어 결과적으로 H₂O₂의 분비와 iNOS의 발현이 증가하였다. 결론 : Rat2 세포에서 α-quartz에 의하여 유도된iNOS는 H₂O₂의 분비를 촉진하고 이 H₂O₂는 iNOS기능을 조절하는 자가조절기전에 중요한 역할을 하는 것으로 생각된다. Objectives : This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase (NOS) induced by α-quartz in Rat2 fibroblast. Methods : α-quartz-induced nitric Oxide (NO) anti H₂O₂ formation anti α-quarts-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor (L-N6- (1-iminoethyl) lysine hydrochloride, L-NIL) or antioxidant (catalase), we observed NO and H₂O₂ formation and iNOS protein expression in Rat2 fibroblast stimulated with α-quartz. Results : α-quartz stimulated iNOS-induced NO and H₂O₂ formation in Rat2 fibroblast. L-NIL inhibited H₂O₂ formation and iNOS protein expression by α-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOS-induced H₂O₂ therefore H₂O₂ and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with α-quartz Conclusion : α-quartz-induced iNOS Stimulated H₂O₂ formation in Rat2 fibroblast. INOS-induced H₂O₂ by α-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast

      • KCI등재
      • 인천지역의 관광환경개선에 관한 연구

        김혜숙,오수경 한국관광정책학회 2001 觀光政策學硏究 Vol.7 No.1

        Korean peninsula is geographically situated as a gateway to China, Russia and Japan. Historically, Incheon has been the gateway city to Seoul, the capital city of Korea, due to its location as a port. Recent opening of the Incheon International Airport confirms more evidently that she will become the center of international traffics and exchanges, not only by traditional way but by new means. In this regard, Incheon will have a lot of potential role as a hub airport connecting all over the world in the near future, and help accelerating the globalization. Also it is just the peaceful opening period between the South and North Korea and the end of cold war around the world. This study will analyze the environment of tourism in Incheon area, find problems and help establish the development of Incheon. The result shows that many problems regarding the accommodation facility, the insufficiency of professional manpower and the tourism marketing have been brought out. To solve this kind of problems, many approaches are needed in the coming days.

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