Microarray 자료의 통계적 표준화 방법의 비교

송혜향,윤상헌,김제석 한국보건통계학회 2003 보건정보통계학회지 Vol.28 No.1

Microarrays can provide detailed information of the expression patterns of thousands of genes in tumours, but due to systematic variations such as dyes, hybridization and processing precedures, and technical attefacts, true biological differences in gene expression levels cannot easily be detected. If the vast quantity of these microarray data can be suitably normalized, the impact of this genomic expression data on the understanding of diagnosis and treatment of disease will be profound. Statistical normalization approaches to microarray data are not as yet fully explored and need to be continuously evaluated. We compared the currently much used normalization methods and recently proposed statiostical normalization methods of ANOVA with oligonucleotide microarray data of hepatic nocular lesions indluding hepatocellular carcinoma. This article proposes combined normalization methods of ANOVA after a robust local lowess, intensity and print- tip dependent, regression.

두경부 암환자의 항암화학요법에 따른 삶의 질 변화

신혜숙,박혜자,박명희,연기순,김훈교,문한림,송혜향 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1999 호스피스논집 Vol.4 No.-

The purpose of this study was to assess the changes in quality of life wish elapse of chemotherapy in head and neck cancer patients. This study was a longitudinal descriptive design. The subjects were 9 patients who had stage III and stage IV head and neck cancer and received neoadjuvant cisplatin and 5-fluorouracil chemotherapy. Linear Analogue Self Assessment Scale (LASA) of the QOL which it includes eleven items(seven physical items appetite, nausea/vomiting, physical well-being, vigor activity, energy, sleepiness, fatigue and four mental items anger, anxiety, depression & vital power) were used to assess the quality of life eleven times(once in the prechemotherapy period and from the 1st day to 10th day postchemotherapy). The means of scores at each time were analyzed by repealed measures of ANOVA and Bonferroni multiple comparison method. The results are as follows : 1. The degree of appetites decreased significantly on the period between third and sixth day compared with that of appetites on the prechemotherapy day (p<0.001). 2. The degree of physical well-being decreased significantly on the period between first and fifth day compared with that of physical well-being on the prechemotherapy day (p<0.001). 3. The degree of nausea/vomiting decreased significantly on the period between first and fourth day compared with that of appetites on the prechemotherapy day (p<0.001). 4. The degree of anger decreased significantly on the second, fourth, eighth and ninth day after chemotherapy compared with that of anger on the prechemotherapy day(p<0.001). 5. The degree of fatigue decreased significantly on the fourth day compared with that of fatigue on the prechemotherapy day(p<0.001). 6. The increment of nausea/vomiting and poor appetite started on the 2.89th day and 3.67th day after chemotherapy, respectively. 7. The increment of sleepiness started on the 2.56th day after chemotherapy. 8. The increment of depression and anxiety started on the 2.33th day and 3.33th day after chemotherapy, respectively. 9. The lowest degrees of nausea/vomiting and poor appetite were 37.00±17.9 % and 28.64±14.94 % after chemotherapy compared with those of nausea/vomiting and poor appetite on the prechemotherapy day, respectively. 10. The lowest degrees of anger and vigor activity were 48.12±28.3 % and 39.83±24.9 % after chemotherapy compared with those of anger and vigor activity on the prechemotherapy day, respectively. 11. The recovery rates of eight items of quality of life (appetite, vigor activity, energy, fatigue, anger, anxiety, depression & vital power) were shown to reach a peak on the tenth day after chemotherapy and be reached to almost 84 % compared with those of quality of life on the prechemotherapy day. 12. The recovery rates of physical well-being and sleepiness were shown to reach to 67.75 % and 95.68 % on the 10th day after chemotherapy compared with those of physical well-belong and sleepiness on the prechemotherapy day. 13. The recovery rates of seven physical items were faster than those of four mental items on the 10th day after chemotherapy. In conclusion, it is suggested that nursing care strategies to improve the quality of life in patients with chemotherapy would be established both physically and mentally, and be extended at least ten days when patients stayed their home after chemotherapy.

혈압의 역학적 연구와 지속성(tracking)에 대한 통계적 분석 에 대하여

송혜향(Hae Hiang Song),김병수(Byung Soo Kim) 한국통계학회 1993 응용통계연구 Vol.6 No.2

Statistical Bias and Inflated Variance in the Genehunter Nonparametric Linkage Test Statistic

Song, Hae-Hiang,Choi, Eun-Kyeong The Korean Statistical Society 2009 Communications for statistical applications and me Vol.16 No.2

Evidence of linkage is expressed as a decreasing trend of the squared trait difference of two siblings with increasing identical by descent scores. In contrast to successes in the application of a parametric approach of Haseman-Elston regression, notably low powers are demonstrated in the nonparametric linkage analysis methods for complex traits and diseases with sib-pairs data. We report that the Genehunter nonparametric linkage statistic is biased and furthermore the variance formula that they used is an inflated one, and this is one reason for a low performance. Thus, we propose bias-corrected nonparametric linkage statistics. Simulation studies comparing our proposed nonparametric test statistics versus the existing test statistics suggest that the bias-corrected new nonparametric test statistics are more powerful and attains efficiencies close to that of Haseman-Elston regression.

A Factor Analytic Approach to Understand the Relationship between Pulmonary Function Indices and Arterial Blood Gas Pressure

Song,Hae-Hiang 가톨릭대학산업의학센타 산업의학연구소 1983 韓國의 産業醫學 Vol.22 No.3

Interrelationships among simple indices of pulmonary function and blood gas pressures were investigated by performing a factor analysis on a data obtained from a population of coal mine workers. Among pulmonary function indices minute volume was independent of all other measures, while forced vital capacity, one-second forced expiratory volume, maximal breathing capacity, breath reserve index and ventilation index were highly intercorrelated. Pulmonary function indices were largely independent of blood gas pressures. Factor scores derived from pulmonary function tests and from smoking measurements were significantly different among various types of pneumoconiosis. The methods and results presented prove to be useful in the understanding of the relationship among different measures of pulmonary function indices and arterial blood gas pressures.

Identifying Copy Number Variants under Selection in Geographically Structured Populations Based on F-statistics

Song, Hae-Hiang,Hu, Hae-Jin,Seok, In-Hae,Chung, Yeun-Jun Korea Genome Organization 2012 Genomics & informatics Vol.10 No.2

Large-scale copy number variants (CNVs) in the human provide the raw material for delineating population differences, as natural selection may have affected at least some of the CNVs thus far discovered. Although the examination of relatively large numbers of specific ethnic groups has recently started in regard to inter-ethnic group differences in CNVs, identifying and understanding particular instances of natural selection have not been performed. The traditional $F_{ST}$ measure, obtained from differences in allele frequencies between populations, has been used to identify CNVs loci subject to geographically varying selection. Here, we review advances and the application of multinomial-Dirichlet likelihood methods of inference for identifying genome regions that have been subject to natural selection with the $F_{ST}$ estimates. The contents of presentation are not new; however, this review clarifies how the application of the methods to CNV data, which remains largely unexplored, is possible. A hierarchical Bayesian method, which is implemented via Markov Chain Monte Carlo, estimates locus-specific $F_{ST}$ and can identify outlying CNVs loci with large values of FST. By applying this Bayesian method to the publicly available CNV data, we identified the CNV loci that show signals of natural selection, which may elucidate the genetic basis of human disease and diversity.

Studies of Obesity Indices on Height and Weight Relationship

Song , Hae Hiang 한국보건통계학회 1985 한국보건정보통계학회지 Vol.10 No.1

The ponderal and body mass index are the most frequently used, simple measures of relative body weight, when height and weight alone being provided. The question of the best index gas baffled the researchers for a long time. It is shown that the examination of the simple and partial correlation coefficients does not help us choose the best index between the ponderal and body mass index. However, the difference between the ponderal and body mass index are apparent in Figure 3. An analysis of a sample data demonstrates that the ponderal index if the poorer one th fit to the standard height-weight curve (or to the upper 10th percentile curve). The body mass index curves give a better fit and an improvement of the fit can be attained by insisting that weight be related to height by a power of less than 2.0. For our sample data the standard height-weight curve (or toe upper 10th percentile curve) fits best to a series of curves of Weight/Height^1.8. This report deals exclusively with the data of men. There is a pressing nee d for the accumulation of the standard height-weight pattern for different sex, age and population.

Goodness of Fit Tests of Cox's Proportional Hazards Model

Song, Hae-Hiang,Lee, Sun-Ho The Korean Statistical Society 1994 Journal of the Korean Statistical Society Vol.23 No.2

Graphical and numerical methods for checking the assumption of proportional hazards of Cox model for censored survival data are discussed. The strenths and weaknessess of several goodness of fit tests for the propotional hazards for the two-sample problem are evaluated with Monte Carlo simulations, and the tests of Schoenfeld (1980), Andersen (1982), Wei (1984), and Gill and Schumacher (1987) are considered. The goodness of fit methods are illustrated with the survival data of patients who had chronic liver disease and had been treated with the endoscopy injection sclerotheraphy. Two other examples of data known to have nonpropotional hazards are also used in the illustration.

단변량 및 이변량 순위변수의 비모수적 윌콕슨 검정법에 의한 표본수 결정방법

박해강(Hae Gang Park),송혜향(Hae Hiang Song) 한국통계학회 2009 응용통계연구 Vol.22 No.6

대장암 cohort 자료로부터 표본추출하는 여러 case-control 계획의 효율성 비교

송혜향 ( Hae Hiang Song ),김삼숙 ( Sam Sook Kim ) 한국보건정보통계학회 (구 한국보건통계학회) 2004 보건정보통계학회지 Vol.29 No.1