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Curcumin reduces cold storage-induced damage in humancardiac myoblasts
Hadil Abuarqoub,Colin J. Green,Roberta Foresti,Roberto Motterlini 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.2
Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant pro-perties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1). The objective of this study was to investigate whether curcumin protects against cold storage-mediated damage of human adult atrial myoblast cells (Girardi cells) and to assess the potential involvement of HO-1 in this process. Girardi cells were exposed to either normothermic or hypothermic conditions in Celsior preservation solution in the presence or absence of curcumin. HO-1 protein expression and heme oxygenase activity as well as cellular damage were by re-warming. In additional experiments, an in-hibitor of heme oxygenase activity (tin protopor-phyrin IX, 10 M) or siRNA for HO-1 were used to investigate the participation of HO-1 as a mediator of curcumin- induced effects. Treatment with curcumin produced a marked induction of cardiac HO-1 in normothermic condition but cells were less re-sponsive to the polyphenolic compound at low temperature. Cold storage-induced damage was markedly reduced in the presence of curcumin and HO-1 contributed to some extent to this effect. Thus, curcumin added to Celsior preservation solution effectively prevents the damage caused by cold- storage; this effect involves the protective enzyme HO-1 but also other not yet identified mechanisms.
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Botagoz Zhuman,Hadil Abu Khalifeh,Ioannis Zuburtikudis,Mahendra Kumar,Hassan A. Arafat,Enas Nashef 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.5
The development of an efficient adsorbent for removal of Ca2+ and Mg2+ ions using ionic liquid (IL) (1-Ethyl-3-methylimidazolium amino acetate) functionalized graphene oxide (GO) (IL-GO) is reported. The formation of IL-GO adsorbent was confirmed by FTIR, Raman, TGA, TEM and SEM-EDX analysis. The loading of IL within the IL-GO adsorbent was found to be 39 wt%. A minimum amount of IL (∼2%) leached from IL-GO after continuous stirring in DI water for 24 h. The IL-GO adsorbent exhibited high adsorption capacity towards Ca2+ and Mg2+ ions and stable recovery without cross-contamination of the feed water. The structural integrity of IL-GO was preserved after functionalization and adsorption of Ca2+ and Mg2+ from aqueous solution. Adsorption kinetics results show that the adsorption rates of Ca2+ and Mg2+ follow a pseudo second-order kinetic model. Moreover, the adsorption data of both Ca2+ and Mg2+ on IL-GO is well fitted using the Langmuir isotherm, implying that active sites for adsorption are homogeneously distributed on the IL-GO surface. IL-GO adsorbent shows promise in the removal of Ca2+ and Mg2+ ions from saline water, as part of a pretreatment process in reverse osmosis (RO) desalination plants, to control the inorganic fouling of RO membranes. Finally, since the adsorption capacity of IL-GO for Ca2+ and Mg2+ has been found to be much greater than that for Na+, the developed adsorbent could be a very good candidate for the separation of monovalent and divalent cations from an aqueous feed.
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Variation in wind load and flow of a low-rise building during progressive damage scenario
Ahmed Elshaer,Girma Bitsuamlak,Hadil Abdallah 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.28 No.6
In coastal regions, it is common to witness significant damages on low-rise buildings caused by hurricanes and other extreme wind events. These damages start at high pressure zones or weak building components, and then cascade to other building parts. The state-of-the-art in experimental and numerical aerodynamic load evaluation is to assume buildings with intact envelopes where wind acts only on the external walls and correct for internal pressure through separate aerodynamic studies. This approach fails to explain the effect of openings on (i) the external pressure, (ii) internal partition walls; and (iii) the load sharing between internal and external walls. During extreme events, non-structural components (e.g., windows, doors or roof tiles) could fail allowing the wind flow to enter the building, which can subject the internal walls to lateral loads that potentially can exceed their load capacities. Internal walls are typically designed for lower capacities compared to external walls. In the present work, an anticipated damage development scenario is modelled for a four-story building with a stepped gable roof. LES is used to examine the change in the internal and external wind flows for different level of assumed damages (starting from an intact building up to a case with failure in most windows and doors are observed). This study demonstrates that damages in non-structural components can increase the wind risk on the structural elements due to changes in the loading patterns. It also highlights the load sharing mechanisms in low rise buildings.
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Ali, Rosidi bin,Gambang, Albert Chuan,Rajali, Hadil bin,Hassan, Raja Bidin bin Raja,Basir, Samusudin bin,Shiomi, Kunimune,Fujiwara, Shunji 한국수산자원학회 1998 한국수산자원학회지 Vol.1 No.-
Acoustic resource surveys were conducted by M/V SEAFDEC in the Gulf of Thailand and off the east coast of Peninsular Malaysia from September 5 to 28, 1995 for pre-NE monsoon season and from April 24 to May 17, 1996 for post-NE monsoon season, using the scientific echosounder FQ-70 (Furuno Electric Co.). Raw values of backscattering strength (SV) from the 200 ㎑ were carefully corrected and filtered to eliminate the influence of plankton. These corrected SV values were sorted out into pelagic and demersal fish, and were used to estimate biomass for each category of multi-species fish. Biomass of pelagic and demersal fish for each season was estimated both in the Gulf of Thailand within Thai EEZ and in the east coast of Peninsular Malaysia within Malaysian EEZ waters due to the availability of previous fisheries statistics and biological data. Dominant species were selected based on the fisheries statistics and landing place survey. Length (L) and weight were obtained from previous literature. Target strength (TS) of these dominant species were calculated as TS = 20 log (L) - 66. The distribution of the SV values for pelagic fish showed a distinct difference between pre and post monsoon seasons. Greater concentrations of SVs were observed from offshore compared to the nearshore waters in pre monsoon season. The distribution for the demersal fish showed that there was no clear difference between pre and post monsoon. The estimated biomass of multispecies fish in the Gulf of Thailand within Thai EEZ for the pre and post monsoon seasons was 9.2 × 10^5 tonnes (5.5 × 10^5 tonnes of pelagic fish and 3.7 × 10^5 tonnes of demersai fish) and 4.7 × 10^5 tonnes (2.0 × 10^5 tonnes of pelagic fish and 2.7 × 10^5 tonnes of demersal fish), respectively. The estimated biomass of multi-species fish off the east coast of Peninsular Malaysia within Malaysian EEZ for the pre and post monsoon seasons was 4.4 × 10^5 tonnes (2.3 × 10^5 tonnes of pelagic fish and 2.1 × 10^5 tonnes of demersal fish) and 3.1 × 10%5 tonnes (1.9 × 10^5 tonnes of pelagic fish and 1.2 × 10^5 tonnes of demersal fish), respectively.
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