Polymorphism of Cefotaxime sodium

Sohn, Young-Taek,Park, Sun-Hee 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1

Three crystal forms of cefotaxime sodium have been isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. The dissolution patterns of three crystal forms of cefotaxime sodium were studied in water at 37±0.5℃, 90rpm for 180 minutes. Three crystal forms of cefotaxime sodium showed difference in dissolution rate and solubility. After storage of two months at 52% RH (saturated solution of Na_(2)Cr_(2)O_(2).2H_(2)O / 20℃), all crystal forms showed no transformation.

프리미돈의 한국인에서의 생체이용율시험

권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.

질소농도에 따른 두메부추와 파드득나물의 생장과 흡수양상 및 Nitrate Reductase 활성의 변화

장매희,설종호,이택주,이종석 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.9 No.-

본 실험은 우리나라 자생 산채류인 두메부추(Allium tuberosum Rott)와 파드득나물(Cryptotaenia japonica)에 대한 효율적인 재배법을 확립하는 한편 수경재배의 가능성을 검토하고자 실시하였으며, 특히 배양액내 질소의 농도가 두메부추와 파드득나물의 생육과 효소활성 등에 미치는 영향을 평가하여 질소 시비에 따른 체내 질소 대사의 기초자료를 얻고자 수행하였다. 파드득나물은 4.3meq·L^-1 질소처리구에서 생육이 양호하고 생체중이 높았으며, 건물중은 8.6meq·L^-1 처리구에서 가장 좋았고, 엽록소와 비타민 C함량은 34.6meq·L^-1 질소처리구에서 높았다. 잎과 엽병의 NR활성은 8.6meq·L^-1 처리구가 높았으며, 파드득나물 식물체내의 질산염 농도는 잎은 8.6meq·L^-1 질소처리구, 엽병과 뿌리는 4.3meq·L^-1 질소처리구에서 가장 높게 나타났다. 두메부추는 저농도처리구인 4.3meq·L^-1 질소처리구에서 엽수, 엽폭, 엽초기부 직경 및 지상부의 생체중도 높아졌고, 8,6meq·L^-1 질소처리구에서도 분지수와 근장 및 뿌리 생체중이 증가하는등 뿌리발달이 양호하였다. 초장은 34.6meq·L^-1 질소처리구에서 증가하였으며, 비타민 C 함량은 8.6meq·L^-1 질소처리구에서 가장 많았다. NR활성은 고농도 질소처리구인 34.6meq·L^-1 처리구에서 현저히 감소한 반면 잎과 뿌리 모두 4.3meq·L^-1 질소처리구에서 가장 높았다. 이러한 결과를 종합해 볼 때 파드득나물 및 두메부추의 수경재배시 효율적인 배양액내 질소농도는 4.3meq·L6-1 또는 8.6meq·L^-1의 저농도 처리인 것으로 보인다. Allium tuberosum Rott and Cryptotaenia japonica was grown for 49 days hydroponically in nutrient solutions composed of different concentration of nitrogen, like 34.6(2X), 17.3(1X), 8.6(1/2X) and 4.3(1/4X) meq·L-1. Control (1X) was a standard nutrient solution of Japanese Horticultural Experimental Station. Uptake response, growth and nitrate reductase activity were investigated to understand the basic knowledge of nitrogen metabolism. Cryptotaenia japonica grew best when they were supplied with a 4.3 meq·L-1 nitrogen solution, whereas the chlorophyll and vitamin C increased by 34.6 meq·L-1 treatment. In leaf and petiole extracts, the nitrate reductase activity was higher at 8.6meq·L-1 nitrogen solution than control. Nitrate concentration was high in plants grown under favorable growing condition. In Allium tuberosum Rott, the better top growth and vitamin C were observed in 8.6 meq·L-1 nitrogen solution. The higher the concentration of N in the nutrient solution, the lower nitrate reductase activity in leaf and root: the activities of NR was the highest in 4.3 meq·L-1 and the lowest in 34.6 meq·L-1. These results indicated that the growth of Allium tuberosum Rott and Cryptotaenia japonica in low nitrogen treatment was better than those in high.

디지틀 이동통신망의 인증기법연구

이택희 湖南大學校 1996 호남대학교 학술논문집 Vol.17 No.2

CDMA mobile network offers security and authentication functions to protect the unauthorized or illegal use of a cellular telephone or cellular network resources. This paper forcused on the analysis of authentication techniques and load for authentication services. Various network models are presented to compare the merit on some check points. The following items are the results of analysis. 1) Authentication center should be an isolated entity. 2) There should be connections between AC and MSC/VLR, HLR respectively. 3) All authentication related functions are performed by AC. 4) Good selection of subscriber and time is needed to reduce the network load. More work on authentication policy for selection is needed to reduce the authentication load Authentication load for network is the biggest problem to provide authentication services.

방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계

정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.

無定形 실리카(왕겨재 및 실리카 흄)를 添加한 슬래그 시멘트의 蒸氣 養生에 의한 機械的 性質

申鉉澤,鄭喜天 慶尙大學校 1991 論文集 Vol.30 No.2

슬래그 시멘트에 무정형 실리카로서 왕겨재 및 실리카홈을 혼화재로 첨가한 조합물을 양생온도 90℃, 120℃, 양생시간 6,9,12hrs.로 변화시켜 증기양생한 경화체의 압축강도 및 미세조직을 관찰한 실험 결과는 다음과 같다. 1. 슬래그 시멘트에 왕겨재 또는 실리카 홈 0,3,5,7we.% 양생 조건 120℃-6,9,12hrs. 일때 9시간 증기양생시 가장 높은 압축강도를 나타낸다. 2. 동일한 상기 조건에서 혼합재료로서 왕겨재가 실리카 홈보다 높은 압축강도를 나타낸다. 3. 왕겨재 5%첨가시 120℃-9hrs 양생조건 일때 최고 압축강도는 793kg/㎠을 나타내었다. 4. SEM 미세조직 관찰에서 최고 압축강도가 높은 왕겨재의 경우는 미세기공이 적고 조직이 치밀함을 보여주었다. The mechanical properties and SEM micrograph of portland slag cement-amorphous silica(rice husk ash and silia fume) systems were studied with various compositions. Samples were steam cured at 90 and 120℃ for 6, 9, and 12hrs., respectively. The highest compressive strength (793 kg/ ㎠) was abtained the composition in weight ratio of portland slag cement : rice husk ash = 95 : 5 at 120℃-9hr steam curing. SEM micregraphs of the specimens with 5 wt.% RHA steam curing at 120℃-9hrs were more dense than specimen with 5 wt.% SF.

조도 센서를 이용한 단일 광원 대응 실내 위치 추정 기술

김택성, 황영수, 우상희 忠北大學校 農業科學硏究所 2017 農業科學硏究 Vol.33 No.1

In this paper, we tried to acquire the spatial information of unmanned mobile objects from the changes of measured values of illuminance sensor attached to unmanned moving objects in the indoor environment restricted by place and time. Therefore, the correlation of illuminance sensor according to single light source according to the position of unmanned mobile object is deduced. From this correlation, indoor positioning technique of unmanned mobile object is developed. As a result, the correlation between the illuminance sensor and the illumination position increased as the illuminance became closer to the light source. The correlation between data of illumination sensor and location of unmanned vehicles was increased as the distance from the light source was increased. There was less relationship between direction of sensor and distance from the light. The relationship between the distance from the light source and the data of illumination sensor was shown as a sixth polynomial equation. The illumination sensor under single light source might be used for indoor location information of unmanned vehicles. The additional experiment of finding position need to be verified to the in multiple source using illumination sensor.

피부미용에 사용 가능한 10종 한방 약물에 대한 고찰

김희택 世明대학교 한의학연구소 2003 韓醫學硏究所 論文集 Vol.5 No.-

Interested in beauty and skin care go on increasing, many functional cosmetics are out of the market recently. Many medical herbs are used for development of cosmetics and inquire into a literatual study on the ten herbs used for beauty and skin care from old times.

질편모충(Trichomonas vaginalis)의 시험관내에서의 용혈능

안명희,류재숙,홍택원,민득영 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2

To evaluate the hemolytic activity of T. vagindlis from Korean women and fresh human RBC of A type were nsed for hemolytic assay. RBC(1×10 /ml) was added to RPMI-TPS media(RPMI 1840:TPS-1= 20 : 1) containing T. vaginalis(2×10 ) and incubated at 37℃, 5% CO₂incubator for 6hr and hemolysis was measured by spectrophotometer at 412m. We investigated the parasite to erythrocyte ratio and lemperature needed for hemotysis. Optimal erythrocyte lysis by T. vaginalis was achieved at ratio of 1 : 5 and optimol temperature 37℃. Minimal hemolytic activity was detected in lysates of T. vaginalis. No hemolysis occured when a membrane a 3㎛ pore size was nsed to prevent contact between parasites and erythrocytes. These data suggest a need for contact for trichomonol hemolysis. Hemolytic activity did not correlated with the production of subcutaneous abscess in mice.

膳物行爲의 理論的 考察

黃命澤,姜希淑 全北大學校 1993 論文集 Vol.35 No.-

The authors do a literature review on gift exchange behavior. Despite its prevalence and importance to marketers, gift exchange behavior has drawn little attention among marking researchers. Traditionally, they have been interested in commercial exchange behavior. This review shows that marketing can learn much from such related disciplines as anthropology, sociology, and psychology. One the basis of their pioneering works, including a comprehensive review by Sherry Jr., key aspects of gift exchange including its functions, processes, self-gift, cultural differences, and women's roles are discussed. Some implications for further empirical as well as theoretical research constitute the conclusion section of this paper.